Endocrine Abstracts November 2019 Volume 65 ISSN 1479-6848 (online) Society for Endocrinology BES 2019 11–13 November 2019, Brighton published by Online version available at bioscientifica www.endocrine-abstracts.org Volume 65 Endocrine Abstracts November 2019 Society for Endocrinology BES 2019 11–13 November 2019, Brighton VOLUME EDITORS The abstracts submitted were marked by the Abstract Marking panel, selected by the Programme Organising Committee. Programme Committee D Bassett (Programme Secretary) (London) Laura Matthews (Leeds) Andrew Childs (Programme Co-ordinator) (London) Carla Moran (Cambridge) Nils Krone (Programme Co-ordinator) (Sheffield) Annice Mukherjee (Salford) Helen Simpson (Programme Co-ordinator) (London) Francesca Spiga (Bristol) Davide Calebiro (Birmingham) Jeremy Tomlinson (Oxford) Ben Challis (Cambridge) Jennifer Walsh (Sheffield) Mandy Drake (Edinburgh) Abstract Marking Panel Ramzi Ajjan (Leeds) Neil Gittoes (Birmingham) John Newell-Price (Sheffield) Richard Anderson (Edinburgh) Helena Gleeson (Birmingham) Mark Nixon (Edinburgh) Ruth Andrew (Edinburgh) Philippa Hanson (London) Finbarr O’Harte (Ulster) Weibke Arlt (Birmingham) Martin Hewison (Birmingham) Adrian Park (Cambridge) Mo Aye (Hull) Claire Higham (Manchester) Simon Pearce (Newcastle) Tom Barber (Warwick) Steve Hillier (Edinburgh) Andrew Powlson (Cambridge) Duncan Bassett (London) Andy James (Newcastle) Teresa Rea (Belfast) Roger Brown (Edinburgh) Channa Jayasena (London) Martin Read (Birmingham) Paul Carroll (London) Niki Karavitaki (Oxford) Aled Rees (Cardiff) Ben Challis (Cambridge) Nikki Kieffer (Leicester) Tristan Richardson (Bournemouth) Li Chan (London) Marta Korbonits (London) Philippa Saunders (Edinburgh) Krishna Chatterjee (Cambridge) Olympia Koulouri (Cambridge) Mark Sherlock (Dublin) Chantal Chenu (London) Gareth Lavery (Birmingham) Lisa Shepherd (Birmingham) Tony Coll (Cambridge) John Lazarus (Cardiff) Helen Simpson (Cambridge) Alex Comninos (London) Graham Leese (Dundee) Vicki Smith (Birmingham) Juliet Compston (Cambridge) Miles Levy (Leicester) Abd Tahrani (Birmingham) Sue Cox (Torquay) Kate Lines (Oxford) Angela Taylor (Birmingham) Anna Crown (Brighton) John Logan (London) Rajesh Thakker (Oxford) Eleanor Davies (Glasgow) Scott MacKenzie (Glasgow) Jeremy Tomlinson (Birmingham) Miguel De Bono (Sheffield) Craig A McArdle (Bristol) Andy Toogood (Birmingham) Ketan Dhataria (Norwich) Chris McCabe (Birmingham) Jeremy Turner (Norwich) Waljit Dhillo (London) Phil McTernan (Warwick) Bijay Vaidya (Exeter) Mandy Drake (Edinburgh) Anna Mitchell (Newcastle) Melissa Westwood (Manchester) Colin Duncan (Edinburgh) Rod Mitchell (Edinburgh) Graham Williams (London) Colin Farquharson (Edinburgh) Carla Moran (Cambridge) Jarod Wong (Glasgow) Fraser Gibb (Edinburgh) Daniel Morganstein (London) Phillip Yeoh (London) Christine Gibson (Manchester) Damian Morris (Ipswich) Nicola Zammitt (Edinburgh) Jacqueline Gilbert (London) Kevin Murphy (London) Society for Endocrinology BES 2019 The Society for Endocrinology would like to thank its Corporate Supporters for their generous financial assistance. Society Partner Pfizer Ltd Gold Supporters HRA Pharma IPSEN Novartis Sandoz Society for Endocrinology Tel: 144 (0) 1454 642210 Starling House Fax: 144 (0) 1454 642222 1600 Parkway North E-mail: [email protected] Bristol, BS34 8YU, UK Website: http://www.endocrinology.org Conference Secretariat: Bioscientifica Ltd Tel: 144 (0)1454 642240 Starling House Fax: 144 (0)1454 642222 1600 Parkway North E-mail: conferences@bioscientifica.com Bristol, BS34 8YU, UK Website: http://www.bioscientifica.com Endocrine Abstracts (2019) Vol 65 Society for Endocrinology BES 2019 CONTENTS Society for Endocrinology BES 2019 PLENARY LECTURES Clinical Endocrinology Trust Lecture . .......................................... PL1 Society for Endocrinology Starling Medal Lecture . PL2 Society for Endocrinology Dale Medal Lecture . PL3 Society for Endocrinology Transatlantic Medal Lecture . PL4 Society for Endocrinology International Medal Lecture . PL5 Society for Endocrinology European Medal Lecture . PL6 British Thyroid Association Pitt-Rivers Lecture . PL7 Clinical Endocrinology Trust Visiting Professor Lecture . PL8 Society for Endocrinology Medal Lecture . .......................................... PL9 Society for Endocrinology Jubilee Medal Lecture . PL10 DEBATE: NATURE vs NURTURE This house believes nature not nurture determines our bodyweight . D1.1–D1.2 SOCIETY FOR ENDOCRINOLOGY JOURNAL AWARDS Society for Endocrinology Journal Award – Journal of Endocrinology ............................. JA1 Society for Endocrinology Journal Award – Journal of Molecular Endocrinology ....................... JA2 Society for Endocrinology Journal Award – Endocrine-Related Cancer ............................. JA3 Society for Endocrinology Journal Award – Endocrine Connections .............................. JA4 Society for Endocrinology Journal Award – Clinical Endocrinology .............................. JA5 EARLY CAREERS AND PLENARY ORALS Early Career Prize Lecture Basic Science . ......................................... EC1.1 Early Career Prize Lecture Translational . ......................................... EC1.2 Clinical Endocrinology Trust Best Abstract Clinical . EC1.3 Clinical Endocrinology Trust Best Abstract Basic . EC1.4 SYMPOSIA Gut hormones physiology, pathology and pharmacology . S1.1–S1.3 New insights into PCOS . ...................................... S2.1–S2.3 Phosphate homeostasis physiology, pathology and pharmacology . S3.1–S3.3 Thyroid hormone a key regulator in inflammation . S4.1–S4.3 Stress – The rhythm of life . ...................................... S5.1–S5.3 New horizons in neuro-endocrine disease . ...................................... S6.1–S6.3 EARLY CAREER SYMPOSIA Engaging with the public . ....................................ECS1.1–ECS1.5 WHAT IS NEW? What is New? . .....................................WIN1–WIN2 CLINICAL MANAGEMENT WORKSHOPS Salt & Water . ..................................CMW1.1–CMW1.3 Hyperparathyroidism . ..................................CMW2.1–CMW2.3 Endocrine Abstracts (2019) Vol 65 Society for Endocrinology BES 2019 BASIC PHYSIOLOGY WORKSHOPS Modelling endocrinology in vitro, in vivo & in silico . BPW1.1–BPW1.3 Imaging endocrinology from networks to organelles . BPW2.1–BPW2.3 HOW DO I? SESSIONS How do I...?1 ................................................... HDI1.1–HDI1.6 How do I...?2 ................................................... HDI2.1–HDI2.6 INNOVATION SESSIONS Advances in understanding skeletal disease . IN1.1–IN1.3 Big data in space and time . ...................................... IN2.1–IN2.3 NIHR Pathways to clinical impact . ...................................... IN3.1–IN3.3 MEET THE EXPERT SESSIONS Thyroid disease after immune reconstitution . MTE1 Functional imaging of the adrenal . .......................................... MTE2 Updates on DSD genetics . .......................................... MTE3 Fighting liver fat . ....................................MTE4.1–MTE4.2 Novel epigenetic inhibitors . .......................................... MTE5 What have we learned from HR-pQCT? . .......................................... MTE6 CLINICAL SKILLS Being a consultant – How to get the job and keep it . SK1.1–SK1.3 BASIC SKILLS Introduction to teaching . ......................................SK2.1–SK2.2 TEACHING SKILLS Innovations in teaching . ......................................SK3.1–SK3.2 NURSE SESSIONS NICE & T3 . ......................................................NS1.1–NS1.3 Management of Hyper and Hypocalcaemia ......................................NS2.1–NS2.3 ENDOCRINOLOGY IN THE UK Workforce, Standards, and Quality Improvement . ROE1.1–ROE1.5 SENIOR ENDOCRINOLOGISTS’ SESSION . SE1.1–SE1.3 ORAL COMMUNICATIONS Metabolism and Obesity . ......................................OC1.1–OC1.6 Neuroendocrinology, Pituitary and Neoplasia . OC2.1–OC2.6 Bone and Calcium . ......................................OC3.1–OC3.6 Thyroid . ......................................................OC4.1–OC4.6 Adrenal and Cardiovascular . ......................................OC5.1–OC5.6 Reproductive Endocrinology and Biology . ......................................OC6.1–OC6.6 ORAL POSTER PRESENTATIONS Adrenal and Cardiovascular . ......................................OP1.1–OP1.4 Thyroid . ......................................................OP2.1–OP2.4 Metabolism and Obesity . ............. ........................OP3.1–OP3.4 Endocrine Abstracts (2019) Vol 65 Society for Endocrinology BES 2019 Bone and Calcium . ........... .........................OP4.1–OP4.4 Reproductive Endocrinology and Biology . .....................................OP5.1–OP5.4 Neuroendocrinology, Pituitary and Neoplasia . OP6.1–OP6.4 FEATURED CLINICAL CASE POSTERS ....................................... CC1–CC10 POSTER PRESENTATIONS Adrenal and Cardiovascular . ........................................P1–P78 Bone and Calcium . ...................................... P79–P129 Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer . P130–P165 Metabolism and Obesity . ..................................... P166–P269 Neuroendocrinology . ..................................... P270–P334 Nursing Practice . ..................................... P335–P342 Reproductive Endocrinology and Biology . ..................................... P343–P392 Thyroid . ........................................................ P393–P443 AUTHOR INDEX Endocrine Abstracts (2019) Vol