OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] AR51498PU-S Human XAF1 (His-tag) - Purified Alternate names: BIRC4-binding protein, BIRC4BP, XIAP-associated factor 1, XIAPAF1 Quantity: 0.1 mg Concentration: 1.0 mg/ml (determined by Bradford assay) Background: XAF1 is a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. Uniprot ID: Q6GPH4 NCBI: NM_017523.2 Species: Human Source: E. coli Format: State: Liquid purified protein Purity: >90% by SDS - PAGE Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol 0.15M NaCl, 1mM DTT Description: Recombinant human XAF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEGD FSVCRNCKRH VVSANFTLHE AYCLRFLVLC PECEEPVPKE TMEEHCKLEH QQVGCTMCQQ SMQKSSLEFH KANECQERPV ECKFCKLDMQ LSKLELHESY CGSRTELCQG CGQFIMHRML A Molecular weight: .6 kDa (161aa) confirmed by MALDI-TOF Storage: Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: Liston P., et al (2001). Nat. Cell Biol. 3:128-133 Leaman D.W., et al (2002). J. Biol. Chem. 277:28504-28511 For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MP/20131001 1 / 2 AR51498PU-S: Human XAF1 (His-tag) - Purified Pictures: For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MP/20131001 2 / 2 Powered by TCPDF (www.tcpdf.org).