Proceedings of the IV Symposium of Tropical Health/COST Action CM 1307 (WG3 and WG4) Joint Meeting Priorities in Tropical Health and parasite- borne disease: new drugs with new targets, and how to deliver them Programme, Abstracts and List of participants Chief Editors: Paul Nguewa, Philippe M. Loiseau, Juan Manuel Irache Recommended citation: Nguewa P., Loiseau M. P., Irache J.M. eds. (2017). Proceedings of the IV Symposium of Tropical Health/COST Action CM 1307 (WG3 and WG4) Joint Meeting. Priorities in Tropical Health and parasite- borne disease: new drugs with new targets, and how to deliver them. Servicio de Publicaciones. University of Navarra Citation to individual contributions recommended: Renz A. (2017). New drugs against filarial parasites: lessons from the bovine onchocerca ochengi model in Cameroon. P. 18 in Nguewa P., Loiseau P., Irache J.M. eds. (2017). Proceedings of the IV Symposium of Tropical Health/COST Action CM 1307 (WG3 and WG4) Joint Meeting. Priorities in Tropical Health and parasite-borne disease: new drugs with new targets, and how to deliver them. Servicio de Publicaciones. University of Navarra Published by Servicio de Publicaciones. University of Navarra. June 2017. DL NA 1301-2017 ISBN: 978-84-8081-556-7 2 INDEX Committees ......................................................................................... 5 Welcome ............................................................................................. 9 Venue ................................................................................................ 10 Information ....................................................................................... 11 Programme ....................................................................................... 12 Oral Communications ........................................................................ 18 Posters .............................................................................................. 45 List of participants ............................................................................. 80 3 4 Committees Honor committee Uxue Barkos President of the Government of Navarra (Spain) Joseba Asirón Mayor of Pamplona (Spain) Fernando Domínguez Cunchillos Councilor of Health for the Government of Navarra (Spain) Alfonso Sánchez-Tabernero President of the University of Navarra (Spain) Iciar Astiasarán Vice-President for Research. University of Navarra (Spain) Secundino Fernández Dean of the School of Medicine. University of Navarra (Spain) Adela López de Cerain Dean of the School of Pharmacy. University of Navarra (Spain) María Pilar Civeira Director of the Center for Applied Medical Research (CIMA) (Spain) Luis Montuenga Dean of the School of Sciences. University of Navarra (Spain) Mercedes Pérez Diez del Corral Dean of the School of Nursing. University of Navarra (Spain) 5 Organization committee Paul Nguewa Institute of Tropical Health. University of Navarra (Spain) Juan Manuel Irache Institute of Tropical Health. University of Navarra (Spain) Socorro Espuelas Institute of Tropical Health. University of Navarra (Spain) Carmen Sanmartin Institute of Tropical Health. University of Navarra (Spain) Silvia Pérez Institute of Tropical Health. University of Navarra (Spain) Silvia Galiano Institute of Tropical Health. University of Navarra (Spain) Ignacio Moriyón Institute of Tropical Health. University of Navarra (Spain) Carlos Gamazo Institute of Tropical Health. University of Navarra (Spain) Silvia Carlos Institute of Tropical Health. University of Navarra (Spain) Gabriel Reina Institute of Tropical Health. University of Navarra (Spain) Esther Larrea Institute of Tropical Health. University of Navarra (Spain) Philippe M. Loiseau Université Paris-Sud (France) 6 Scientific committee Philippe M. Loiseau Université Paris-Sud (France) Ana Tomas Institute for Molecular and Cell Biology. University of Porto (Portugal) Francisco J. Otero Espinar Spanish Society of Pharmaceutics and Pharmaceutical Technology (SEFIG) (Spain) Socorro Espuelas Institute of Tropical Health. University of Navarra (Spain) Vassilios Roussis University of Athens (Greece) Thomas J. Schmidt Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster (Germany) Harry P. de Koning University of Glasgow (United Kingdom) Juan Manuel Irache Institute of Tropical Health. University of Navarra (Spain) Paul Nguewa Institute of Tropical Health. University of Navarra (Spain) Technical committee Susana Murillo María Orbe María Paula Huguet María Asunción Labarta Patricia Sainz de Robredo Montserrat Royo 7 Invited speakers José Luis Arias Mediano. University of Granada (Spain) Josphat Matasyoh University of Egerton (Kenya) Xavier Fernández-Busquets Institute for Global Health (ISGlobal). University of Barcelona (Spain) Alfons Renz University of Tübingen (Germany) Ericsson Coy-Barrera Nueva Granada Military University (Colombia) Ignacio Moriyon Institute of Tropical Health, Department of Microbiology and Parasitology. University of Navarra (Spain) 8 Welcome On behalf of the Organising Committee, it is our great pleasure to invite you to the IV Symposium of Tropical Health/COST Action CM 1307 (WG3 and WG4) Joint Meeting Priorities in Tropical Health and parasite-borne disease: new drugs with new targets, and how to deliver them, which will be held on 4-5 May 2017 in Pamplona, Spain. The Symposium has been declared of sanitary interest by the Department of Health of the Government of Navarra. Six plenary lectures will be presented and up to sixteen talks from proffered abstracts will be selected and integrated into plenary sessions. In addition, one session of Poster Flash Presentations will take place. Pamplona, the capital of Navarra, is a modern and welcoming city that invites you to its many pleasures: enjoy its parks, stroll through the streets of its Old Quarter, walk around century-old walls and rest on its scenic terraces. Discover all of these particularities of Pamplona and do not forget to taste its gastronomy and its popular tapas (or pinchos as they are known locally). We are looking forward to seeing you enjoying the Symposium and all that Pamplona has to offer. Paul Nguewa President of the Organization Committee Philippe M. Loiseau Chair of the COST Action CM1307 9 Venue The 4th Symposium will take place at the the Instituto Cultura y Sociedad (Edificio Biblioteca de Humanidades), of University of Navarra. Participants will have access to free parking. For more information, please visit: http://www.simposiosaludtropical.com/venue-and-accommodation/ 10 Information REGISTRATION DESK The registration desk will be open at 9:00 on 4th and 5th May. NAME BADGES For identification and security purposes, name badges are mandatory for all participants when at venue (including coffee breaks and lunches). INTERNET ACCESS Wireless internet is freely available at the venue. PARKING Participants will be have access to free parking. For more information visit http://www.simposiosaludtropical.com/venue-and-accommodation/ PRESENTATIONS GUIDELINES Presentations must be handed in by the speakers on the presentation day, in the meeting room “Aula ICS”, before 9 am. The use of PowerPoint presentations is strongly encouraged. A Windows computer with USB ports, a projector and a laser pointer will be available. The computer will have Microsoft PowerPoint and PDF viewer software. Please arrive ahead of your scheduled time so as to have time to assure that your presentation will work with the equipment. Plenary speakers: 45 minutes presentation, including 5 minutes for questions. Oral communications (OC): 20 minutes per communication, including 5 minutes for questions. Poster Flash Presentations (PF): 5 minutes per presentation, including 1 minute for questions. Poster (P): The maximum allowed dimensions for posters are as follows: 174 cm (height) by 94 cm (width) and will be presented on the designated poster areas. Authors should remain next to their poster during the poster session. Posters may be hung up the day before (May 3rd, in the afternoon) the event. 11 Programme MAY 4th 9:00 Registration 9:15 Welcome and Opening Remarks A. MEDICINAL CHEMISTRY Chairpersons: Philippe M. Loiseau (Université Paris-Sud. France) and Thomas J. Schmidt (University of Münster. Germany) 9:30 Plenary Lecture A: New drugs against Onchocerca filarial parasites: Lessons from the bovine model in Cameroon Alfons Renz. University of Tübingen (Germany) 10:15 Coffee break-Poster viewing 10:45 Oral communications (OC), 15+5 min/ communication OC 1A: Looking for hits and leads through library screening in the NMTRYPI platform in the field of trypanosomatidic infections Maria Paola Costi. Università Degli Studi di Modena e Reggio Emilia (Italy) OC 2A: Antileishmanial activity of methylselenocarbamates Mikel Etxebeste. Institute of Tropical Health, Department of Microbiology and Parasitology. University of Navarra (Spain) OC 3A: Generating evidence for a single drug combination dose (ivermectin+albendazole) to improve mass drug administration programmes to control soil transmitedhelmints, strongyloidesstercoralis included, in Bahir Dar, Amhara region, Ethiopia Juan José de los Santos Sanz-Bustillo. Mundo Sano Foundation (Spain) 11:45 Poster Flash Presentation (PF), 4+1 min/ poster 12 PF 1 On the road to functional understanding the divergent actin 2, a new target for malaria transmission blocking Maria Andreadaki. Institute of Molecular Biology and Biotechnology. FORTH (Greece) PF 2: Leishmania major nucleus-located Yinp protein is a genotoxic