WALTER GILBERT Curriculum Vitae Personal Data: Born: March 1932, in Boston, Massachusetts, U.S.A. Married: Celia Stone Gilbert, two children Website: http://wallygilbert.com Education: 1953 B.A. Harvard College, summa cum laude , Chemistry and Physics 1954 M.A. Harvard University, Physics 1957 Ph.D. Cambridge University, Mathematics (Thesis: On Generalized Dispersion Relations for Pion-Nucleon Scattering) Appointments: 1953-57 NSF predoctoral fellowships held at Harvard University and Cambridge University 1957-58 NSF postdoctoral fellowship held at Harvard in Physics 1958-59 Assistant to Professor Schwinger at Harvard and Lecturer in Physics 1959-64 Assistant Professor of Physics, Harvard University 1964-68 Associate Professor of Biophysics, Harvard University 1968-72 Professor of Biochemistry, Harvard University 1972-81 American Cancer Society Professor of Molecular Biology, Harvard University 1978-83 Chair, Scientific Board of Directors, Biogen N.V. 1979-81 Co-Chair, Supervisory Board of Directors, Biogen N.V. 1981-84 Chair, Supervisory Board of Directors and Principal Executive Officer, Biogen N.V. 1985-86 Professor of Biology, Harvard University 1986-87 H. H. Timken Professor of Science, Dept. of Cellular and Developmental Biology, Harvard University 1987-93 Chair, Dept. of Cellular and Developmental Biology, Harvard University 1987-02 Carl M. Loeb University Professor, Dept. of Molecular and Cellular Biology, Harvard University 1992- Vice Chair, Board of Directors, Myriad Genetics, Inc. 1994-14 Member, Board of Scientific Governors, The Scripps Research Institute 1996-02 Chair, Board of Directors, NetGenics, Inc. 1996- 16 Chair, Board of Directors, Paratek Pharmaceuticals, Inc. 1998-10 Member, Board of Directors & Scientific Advisory Board, Memory Pharmaceuticals, Inc. 1999-04 Chair, Board of Directors and member of Scientific Advisory Board, Pintex Pharmaceuticals, Inc. 2000-04 Member, Board of Directors and Scientific Advisory Board, Transkaryotic Therapies, Inc. 2001-05 Member, Board of Directors, HospitalCareOnline.com, Inc. 2001- Managing Director, BioVentures Investors 2003-04 Carl M. Loeb University Research Professor, Dept. of Molecular and Cellular Biology, Harvard University 2004- Carl M. Loeb University Professor Emeritus, Harvard University 2015- Director, Amylyx, Inc. 1 Awards: United States Steel Foundation Award in Molecular Biology of the National Academy of Sciences, 1968 Elected American Academy of Arts and Sciences, 1968 Guggenheim Fellowship, 1968-69, Paris Ledlie Prize, Harvard University, 1969 (with M. Ptashne) Elected National Academy of Sciences, 1976 V.D. Mattia Lectureship, Roche Institute of Molecular Biology, 1976 Smith Kline & French Lecturer, U.C. Berkeley, 1977 Warren Triennial Prize, Massachusetts General Hospital, 1977 (with S. Benzer) Louis and Bert Freedman Award, New York Academy of Sciences, 1977 Prix Charles-Leopold Mayer, Academie des Sciences, Institut de France, 1977 (with M. Ptashne and E. Witkin) Doctor of Science (Honorary), University of Chicago, 1978 Doctor of Science (Honorary), Columbia University, 1978 Harrison Howe Award of the Rochester Branch of the American Chemical Society, 1978 Doctor of Science (Honorary), University of Rochester, 1979 Louisa Gross Horwitz Prize, Columbia University, 1979 (with F. Sanger) Gairdner Foundation Annual Award, The Gairdner Foundation, 1979 Albert Lasker Basic Medical Research Award, The Albert and Mary Lasker Foundation, 1979 (with F. Sanger) Prize Biochemical Analysis, The German Society for Clinical Chemistry, 1980 (with A. Maxam, F. Sanger, and A. Coulsen) Sober Award, The American Society of Biological Chemists, 1980 Nobel Prize for Chemistry, 1980 (with F. Sanger and P. Berg) Doctor of Science (Honorary), Yeshiva University, 1981 Senior U.S. Scientist Humboldt Award, 1987 Foreign Member of the Royal Society, 1987 Honorary Fellow, Trinity College, Cambridge, England, 1991 New England Entrepreneur of the Year Award, 1991 Ninth National Biotechnology Ventures Award, 1997 The Fourth Annual Biotechnology Heritage Award, 2002 (with P. Sharp) Publications: In theoretical physics: 1. On generalized dispersion relations, II, A. Salam and W. Gilbert. Nuovo Cimento 3, 607 (1956). 2. Yang-Fermi ambiguity, W. Gilbert and G. Screaton. Phys. Rev. 104 , 1758 (1956). 3. New dispersion relations for pion-nucleon scattering, W. Gilbert. Phys. Rev. 108 , 1078 (1957). 4. Structure of the vertex function, S. Deser, W. Gilbert and E. Sudarshan. Phys. Rev. 115 , 731 (1959). 5. Structure of the forward scattering amplitude, S. Deser, W. Gilbert and E. Sudarshan. Phys. Rev. 117 , 266 (1960). 6. Integral representation of two-point functions, S. Deser, W. Gilbert and E. Sudarshan. Phys. Rev. 117 , 266 (1960). 7. Connection between gauge invariance and mass, D. Boulware and W. Gilbert. Phys. Rev. 126 , 1563 (1962). 8. Broken symmetries and massless particles, W. Gilbert. Phys. Rev. Lett . 12 , 713 (1964). In molecular biology: 9. Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli , F. Gros, H. Hiatt, W. Gilbert, C.G. Kurland, R.W. Reisbrough and J.D. Watson. Nature 190 , 581-585 (1961). 10. Molecular and biological characterization of messenger RNA, F. Gros, W. Gilbert, H.H. Hiatt, G. Attardi, P.F. Spahr and J.D. Watson. Cold Spring Harbor Symp . Quant. Biol. 26, 111-132 (1961). 11. Polypeptide synthesis in Escherichia coli . I. Ribosomes and the active complex, W. Gilbert. J. Mol. Biol. 6, 374-388 (1963). 2 12. Polypeptide synthesis in Escherichia coli . II. The polypeptide chain and S-RNA, W. Gilbert. J. Mol. Biol. 6, 389-403 (1963). 13. The binding of S-RNA by Escherichia coli ribosomes, M. Cannon, R. Krug and W. Gilbert. J. Mol. Biol. 7, 360-378 (1963). 14. Protein synthesis in Escherichia coli, W. Gilbert. Cold Spring Harbor Symp. Quant. Biol. 28 , 287-297 (1963). 15. Studies on methylated bases in transfer RNA, U.Z. Littauer, K. Muench, P. Berg, W. Gilbert and P.F. Spahr. Cold Spring Harbor Symp. Quant. Biol. 28 157-159 (1963). 16. Streptomycin, suppression and the code, J. Davies, W. Gilbert and L. Gorini. Proc. Natl. Acad. Sci. 51 , 883-890 (1964). 17. Isolation of the lac repressor, W. Gilbert and B. Müller-Hill. Proc. Natl. Acad. Sci. 56 , 1891-1898 (1966). 18. The lac operator is DNA, W. Gilbert and B. Müller-Hill. Proc. Natl. Acad. Sci. 58 , 2415-2421 (1967). 19. Mutants that make more lac repressor, B. Müller-Hill, L. Crapo and W. Gilbert. Proc. Natl. Acad. Sci. 59 , 1259-1264 (1968). 20. DNA replication: The rolling circle model, W. Gilbert and D. Dressler. Cold Spring Harbor Symp. Quant. Biol. 33 , 473-484 (1968). 21. Genetic repressors, M. Ptashne and W. Gilbert. Sci. Amer. 222(6) , 36-44 (1970). 22. The lactose repressor, W. Gilbert and B. Müller-Hill. In The Lactose Opero n (J. Beckwith and D. Zipser, eds.), Cold Spring Harbor Lab, New York, 93-109 (1970). 23. Repressors and genetic control, W. Gilbert. In The Neurosciences: Second Study Program (F.O Schmitt, ed.), The Rockefeller Univ. Press, New York, 946-954 (1970). 24. MSI and MSII made on ribosome in idling step of protein synthesis, W.A. Haseltine, R. Block, W. Gilbert and K. Weber. Nature 238 , 381-384 (1972). 25. The lac repressor and the lac operator, W. Gilbert. In CIBA Foundation Symp. 7: Polymerization in Biological Systems , Elsevier Publishing Co., Amsterdam, 245-259 (1972). 26. The nucleotide sequence of the lac operator, W. Gilbert and A. Maxam. Proc. Natl. Acad. Sci. USA 70 , 3581-3584 (1973). 27. Sequences of controlling regions of the E. coli lactose operon, W. Gilbert, N. Maizels and A. Maxam. Genetics 79, 227 (1975). 28. Lactose operator sequences and the action of lac repressor, W. Gilbert, J. Gralla, J. Majors and A. Maxam. In Protein-Ligand Interactions (H. Sund and G. Blauer, eds.), Walter de Gruyter, Berlin, 193- 210 (1975). 29. Contacts between the lac repressor and DNA revealed by methylation, W. Gilbert, A. Maxam and A. Mirzabekov. In Control of Ribosome Synthesis (N. Kjeldgaard and O. Maaloe, eds.), Munksgaard, Copenhagen, 139-148 (1976). 30. Preferential protection of the minor groove of non-operator DNA by lac repressor against methylation by dimethyl sulphate, A.M. Kolchinsky, A.D. Mirzabekov, W. Gilbert and L. Li. Nucl. Acids Res. 3(1) , 11- 18 (1976). 31. Starting and stopping sequences for the RNA polymerase, W. Gilbert. In RNA Polymerase (R. Losick and M. Chamberlin, eds.), Cold Spring Harbor Lab, New York, 193-205 (1976). 32. How proteins recognize DNA sequences, W. Gilbert, J. Majors and A. Maxam. In Organization and Expression of Chromosomes , Dahlem Workshop Report, Berlin, 167-178 (1976). 33. Construction of plasmids carrying the cI gene of bacteriophage lambda, K. Backman, M. Ptashne and W. Gilbert. Proc. Natl. Acad. Sci. USA 73 , 4174-4178 (1976). 34. A new method for sequencing DNA, A.M. Maxam and W. Gilbert. Proc. Natl. Acad. Sci. USA 74 , 560-564 (1977). 35. Rous sarcoma virus genome is terminally redundant: The 5' sequence, W.A. Haseltine, A.M. Maxam and W. Gilbert. Proc. Natl. Acad. Sci. USA 74 , 989-993 (1977). 36. Promoter region for yeast 5S ribosomal RNA, A. Maxam, R. Tizard, K.G. Skryabin and W. Gilbert. Nature 267 , 643-645 (1977). 37. Mapping adenines, guanines and pyrimidines in RNA, H. Donis-Keller, A.M. Maxam and W. Gilbert. Nucl. Acids Res. 4(8) , 2527-2538 (1977). 38. A promoter region for yeast 5S RNA, W. Gilbert, A.M. Maxam, R. Tizard and K.G. Skryabin. In Eucaryotic Genetic System (J. Abelson and G. Wilcox, eds.), Academic Press, 15-23 (1977). 39. Contacts between the lac repressor and thymines in the lac operator, R. Ogata and W. Gilbert. Proc. Natl. Acad. Sci. USA 74 , 4973-4976 (1977). 40. Why genes in pieces? W. Gilbert. Nature 271 , 501 (1978). 3 41. Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain, S. Tonegawa, A.M. Maxam, R. Tizard, O. Bernard and W. Gilbert. Proc. Natl. Acad. Sci. USA 75 , 1485- 1489 (1978). 42. Immunoglobulin screening method to detect specific translation products, S. Broome and W.