US009358295R2 (12) United States Patent (10) Patent No.: US 9,358,295 B2 Tygesen et al. (45) Date of Patent: *Jun. 7, 2016 (54) IMMEDIATE RELEASE COMPOSITION (56) References Cited RESISTANT TO ABUSEBY INTAKE OF ALCOHOL U.S. PATENT DOCUMENTS 2,685,553 A 8, 1954 Carroll et al. (71) Applicant: Egalet Ltd., London (GB) 3,835,221 A 9, 1974 Fulberth et al. 3,957,523 A 5, 1976 Ohno et al. (72) Inventors: Peter Holm Tygesen, Smoerum (DK), 4,330,3384,034,758 A 7,5, 19821977 TheeuwesBanker Jan Martin Oevergaard, Frederikssund 4.389,393 A 6, 1983 Schor et al. (DK); Joakim Oestman, Lomma (SE) 4.404,183 A 9, 1983 Kawata et al. 4,449,983 A 5/1984 Cortese et al. 4,503,067 A 3, 1985 Wiedemann et al. (73) Assignee: EGALET LTD., London (GB) 4,686,212 A 8, 1987 Ducatman et al. 4,824,675 A 4/1989 Wong et al. (*) Notice: Subject to any disclaimer, the term of this is: A 6. 3. Esthetricklet al. al. past list: sited under 35 4,892,742 A 1/1990 Shah M YW- 4,898,733. A 2f1990 De Prince et al. 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A6 IK9/20 (2006.01) Giunchedi et al "Hydrophilic matrices for the extended release of a A6 IK 47/10 (2006.01) model drug exhibiting pH-dependent solubility.” International Jour A6 IK 47/02 (2006.01) nal of Pharmaceutics, vol. 85, pp. 141-147 (1992). A6 IK 47/12 (2006.01) (Continued) (52) U.S. Cl. CPC ............... A61K 47/10 (2013.01); A61 K9/0007 Primary Examiner — Shirley V Gembeh (2013.01); A61 K9/2031 (2013.01); A61 K (74) Attorney, Agent, or Firm — Foley & Lardner LLP 9/2866 (2013.01); A61 K9/2893 (2013.01); A61 K3I/I67 (2013.01); A61 K3I/485 (57) ABSTRACT (2013.01); A61 K47/02 (2013.01); A61 K47/12 The present invention provides immediate release pharma (2013.01); A61 K9/2095 (2013.01) ceutical compositions for oral administration that are resis (58) Field of Classification Search tant to abuse by intake of alcohol. 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