CANCER DISCOVERY EDITORS-IN-CHIEF SCIENTIFIC EDITORS Robert T. Abraham Dmitry I. Gabrilovich Nickolas Papadopoulos Ash A. Alizadeh Jennifer R. Grandis D. Williams Parsons James P. Allison Nathanael S. Gray David R. Piwnica-Worms Carlos L. Arteaga Daniel A. Haber Helen M. Piwnica-Worms Alan Ashworth William C. Hahn Kornelia Polyak Alberto Bardelli Kevin M. Haigis Carol Prives David Barrett Douglas Hanahan Antoni Ribas Himisha Beltran Matthew D. Hellmann Jeremy N. Rich René Bernards Helen E. Heslop Lewis C. Cantley Luis A. Diaz Charles W.M. Roberts Elizabeth H. Blackburn Manuel Hidalgo Jeffrey M. Rosen EDITORIAL STAFF John Blenis Patrick Hwu Mark A. Rubin SENIOR EXECUTIVE EDITOR Paolo Boffetta David M. Hyman Yardena Samuels Robert Kruger Joan S. Brugge Tyler Jacks Charles L. Sawyers EXECUTIVE Editor John C. Byrd Elizabeth M. Jaffee Alice T. Shaw Elizabeth S. McKenna Andrea Califano William G. Kaelin Margaret A. Shipp Hannah Carter Alec C. Kimmelman SENIOR EDITORS Kevan M. Shokat Arul Chinnaiyan Theodore S. Lawrence Michele M. Hartsough M. Celeste Simon Heather R. Christofk Jonathan D. Licht I-Mei Siu Lillian L. Siu Karen Cichowski Christine M. Lovly ASSOCIATE EDITOR Mark J. Smyth Ryan B. Corcoran Douglas R. Lowy David B. Solit Avital Lev Sara A. Courtneidge Ravindra Majeti Jean-Charles Soria SENIOR Editor, SCIENCE AND Medical NEWS Lisa Coussens Tak W. Mak Laura Soucek Suzanne L. Rose Christina Curtis Sami N. Malek Kimberly Stegmaier WRITER/REPORTER, SCIENCE AND Medical NEWS Alan D. D’Andrea Richard M. Marais Charles Swanton Ralph J. DeBerardinis Elaine R. Mardis Catherine C. Caruso Josep Tabernero Johann S. DeBono John M. Maris SCIENCE WRITER Craig B. Thompson David G. DeNardo Joan Massagué Nicole Haloupek Ronald A. DePinho Frank McCormick Nicholas C. Turner SENIOR EDITORIAL ASSOCIATE Maximilian Diehn Ignacio Melero David A. Tuveson Ingrid Lin Susan M. Domchek Ingo K. Mellinghoff Robert H. Vonderheide Karen H. Vousden SENIOR PRODUCTION PROJECT Editor Olivier Elemento Ari M. Melnick Jennifer A. Wargo Julie Ehlers Matthew J. Ellis Gordon B. Mills Jeffrey A. Engelman Sean J. Morrison Ashani T. Weeraratna Douglas T. Fearon Yael Mosse Kathryn E. Wellen Howard A. Fine Benjamin G. Neel E. John Wherry Silvia C. Formenti Olufunmilayo I. Olopade Eileen White Lori Friedman Pier Paolo Pandolfi Monte M. Winslow Stephen Frye William Pao Timothy A. Yap EDITORIAL OFFICE: Cancer Discovery [ISSN 2159-8274 (Print); ISSN 2159-8290 (Online)] is published monthly, one volume per year, by the American Association for Cancer Research, Inc., 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404. Periodicals postage paid at Philadelphia, PA, and additional mailing offices. POSTMASTER: Send address changes to Cancer Discovery, AACR Member Services, 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404 or E-mail: [email protected]. Copyright 2020 by the American Association for Cancer Research, Inc. The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper). JULY 2020 CANCER DISCOVERY CANCER PUBLISHING INFORMATION DISCOVERY ISSN 2159-8274 (PrinT) ≠ ISSN 2159-8290 (ONLINE) readers to keep them informed about AACR Members AACR OFFICERS the latest findings in the field. Topics AACR members may opt to receive either Antoni Ribas, President David A. Tuveson, President-Elect span the spectrum of cancer research a print subscription with online access to Elaine R. Mardis, Past President and medicine from the laboratory to content or an online-only subscription. William N. Hait, Treasurer the clinic and epidemiologic studies. Contact [email protected] or visit Margaret Foti, Chief Executive Officer the membership page at www.aacr.org Cancer Discovery is abstracted and/or for more information. Publications COMMITTEE indexed in Current Contents/Clinical Victor E. Velculescu, Chairperson Medicine, MEDLINE, Science Citation Single Issue Sales Dafna Bar-Sagi Index, Scopus, and Web of Science. Subject to their availability, single or Mary Helen Barcellos-Hoff Michael E. Berens back issues may be purchased for $60 John D. Carpten SUBMISSION OF MANUSCRIPTS (U.S.) or $65 (outside the U.S.) each. Maura L. Gillison Manuscript submission is welcomed The cost must be prepaid. Contact Rakesh K. Jain online at http://cd.msubmit.net. Before [email protected]. Pasi A. Jänne submitting a manuscript, please read Gerrit A. Meijer Claims the Instructions for Authors, which are Gordon B. Mills One-time claims for missing issues Steffi Oesterreich available from the Journal’s home page at made within 120 days of the issue’s William Pao http://cancerdiscovery.aacrjournals.org. Gloria M. Petersen publication will be honored, subject to David R. Piwnica-Worms availability. No credit or refund will be Publication CHARGES Charles W.M. Roberts given if an issue is out of print at the Alice T. Shaw Articles are published with the time of claim. Lillian L. Siu understanding that the author(s) Saraswati V. Sukumar AACR Members Toshikazu Ushijima must pay both a publication fee of $2,500 and, if applicable, a color figure [email protected] PUBLISHING STAFF handling fee of $450 per figure. Nonmembers and Institutions PUBLISHER [email protected] Christine Battle SUBSCRIPTION INFORMATION Director, JOURNAL Operations AND Systems ADVERTISING INFORMATION Daniel S. Evanko Nonmember Individuals For information about advertising Director, JOURNAL SALES AND MARKETING Subscriptions include print version Nicola L. Hill with online access. Contacts listed in AACR journals, contact The DIRECTOR, DIGITAL PUBLISHING below are for nonmember individual Walchli Tauber Group, Inc., 2225 Old Mark Jacobson subscriptions. Emmorton Road, Suite 201, Bel Air, MD Associate Director, PRODUCTION 21015; 443-512-8899; maura.paoletti@ Charlene Squibb USA and Rest of World (excluding Japan) wt-group.com ASSISTANT DIRECTOR, JOURNAL MARKETING American Association for Cancer Joanna Arnold Research, 615 Chestnut Street, COPYRIGHT AND PERMISSIONS Assistant Director, Institutional SALES & Philadelphia, PA 19106; 1-855-744- OutreacH Content printed in or disseminated 4667; [email protected] Karola Rac by Cancer Discovery is protected by Japan copyright. Authors who wish to [email protected]; journal@ publish material in Cancer Discovery SCOPE kinokuniya.co.jp; [email protected] must formally transfer copyright Cancer Discovery publishes high-impact, International print subscriptions include to the AACR. All authors must sign peer-reviewed articles describing major cost of surface mail. Expedited mailing copyright transfer forms before the advances in research and clinical trials. As is available. Contact the American AACR can proceed with publication. the premier cancer information resource, Association for Cancer Research for rates. the Journal also presents Review Articles, To read the complete AACR Copyright Per spectives and Commentaries, News Site Licenses and Permissions Policy, visit www. stories, and Research Watch summa- For information about institutional site aacrjournals.org/content/authors/ ries of important journal articles to its licenses, contact [email protected]. copyright-permissions-and-accesss JULY 2020 CANCER DISCOVERY | 889 .