A0A0Q9QYU5 A0A109KXU6 AAB53445.1 0.25 0.20 ● 0.15 ● ● 0.10 ● ● 0.05 ● ● ● ● ● ● 0.00 ● ● ● ● AAC43969.1 AFU35065.1 D3V1W5 0.25 ● ● 0.20 0.15 ● 0.10 classScore ● 0.05 ● ● ● ● ● 0.00 ● ● NP_251217.1 NP_253677.1 YP_002635521 0.25 0.20 ● ● ● 0.15 0.10 ● ● 0.05 ● ● ● ● ● ● 0.00 ● drug drug drug emre emre emre − − − peptide peptide peptide triclosan triclosan triclosan antibiotic antibiotic antibiotic unknown unknown unknown multidrug multidrug multidrug macrolide macrolide macrolide polymyxin polymyxin polymyxin polyamine polyamine polyamine lactamase lactamase lactamase tigecycline tigecycline tigecycline multi multi multi nucleoside nucleoside nucleoside − − − nitrofuratoin nitrofuratoin nitrofuratoin betalactams betalactams betalactams beta_lactam beta_lactam beta_lactam streptothricin streptothricin streptothricin streptogramin streptogramin streptogramin drugresistance drugresistance drugresistance − − − tetracenomycin tetracenomycin tetracenomycin aminoglycoside lactamantibiotic aminoglycoside lactamantibiotic aminoglycoside lactamantibiotic beta beta beta − − − chloramphenicol chloramphenicol chloramphenicol − − − polymyxinantibiotic polymyxinantibiotic polymyxinantibiotic nucleosideantibiotic nucleosideantibiotic nucleosideantibiotic multi multi multi beta beta beta lincosamide lincosamide lincosamide − − − cationicantimicrobialpeptides cationicantimicrobialpeptides cationicantimicrobialpeptides macrolide macrolide macrolide factor(class) AAK51920 AAM15533.1 AAN80811 0.25 ● 0.20 ● ● 0.15 0.10 ● 0.05 ● ● ● ● 0.00 ● AAR84672.1 ABA71733.1 ABB43029.1 0.25 0.20 ● ● 0.15 ● 0.10 classScore 0.05 ● ● ● ● ● ● ● ● 0.00 ● ● ● ● ● B5ULZ6 F0JWD5 NP_358469.1 0.25 0.20 ● ● 0.15 ● 0.10 ● ● 0.05 ● ● ● ● ● ● 0.00 ● other other other peptide peptide peptide triclosan triclosan triclosan acriflavin acriflavin acriflavin antibiotic antibiotic antibiotic multidrug multidrug multidrug quinolone quinolone quinolone polymyxin polymyxin polymyxin polyamine polyamine polyamine beta_lactam beta_lactam beta_lactam glycopeptide glycopeptide glycopeptide glycopeptides glycopeptides glycopeptides drugresistance drugresistance drugresistance tetracenomycin tetracenomycin tetracenomycin aminoglycoside aminoglycoside aminoglycoside − − − flouroquinolones fluoroquinolones flouroquinolones fluoroquinolones flouroquinolones fluoroquinolones aminoglycosides aminoglycosides aminoglycosides multi multi multi glycopeptideantibiotic glycopeptideantibiotic glycopeptideantibiotic aminoglycosideantibiotic aminoglycosideantibiotic aminoglycosideantibiotic streptococcuspneumoniae streptococcuspneumoniae streptococcuspneumoniae cationicantimicrobialpeptide cationicantimicrobialpeptide cationicantimicrobialpeptide antibioticinactivationenzyme antibioticinactivationenzyme antibioticinactivationenzyme factor(class) A0A0D0NPG2 A0A127SI91 AAC76733.1 0.20 ● 0.15 ● 0.10 ● ● ● 0.05 ● ● ● ● ● ● 0.00 ● ● ● ● ● ABQ96629 BAC11911.1 NP_415434.1 ● 0.20 ● 0.15 ● 0.10 classScore 0.05 ● ● ● ● ● ● ● ● ● ● 0.00 ● Q1RPS3 ZP_02377226 ZP_04003442 ● 0.20 ● ● 0.15 0.10 ● 0.05 ● ● ● ● ● 0.00 ● yes yes yes bl1_ec bl1_ec bl1_ec peptide peptide peptide antibiotic antibiotic antibiotic multidrug multidrug multidrug quinolone quinolone quinolone polymyxin polymyxin polymyxin polyamine polyamine polyamine tetracycline tetracycline tetracycline thiostrepton thiostrepton thiostrepton nitrofuratoin nitrofuratoin nitrofuratoin sulfonamide sulfonamide sulfonamide betalactams betalactams betalactams beta_lactam beta_lactam beta_lactam antimicrobial antimicrobial antimicrobial sulfonamides sulfonamides sulfonamides roxithromycin roxithromycin roxithromycin pyrazinamide pyrazinamide pyrazinamide streptogramin streptogramin streptogramin escherichiacoli escherichiacoli escherichiacoli drugresistance drugresistance drugresistance − − − aminoglycoside aminoglycoside aminoglycoside − − − chloramphenicol chloramphenicol chloramphenicol aminoglycosides aminoglycosides aminoglycosides multidrugresistance multidrugresistance multidrugresistance multi multi multi sulfonamideantibiotic sulfonamideantibiotic sulfonamideantibiotic aminoglycosideantibiotic aminoglycosideantibiotic aminoglycosideantibiotic lincosamide lincosamide lincosamide − − − macrolide macrolide macrolide factor(class) AAC60781.1 ABC54722 J2LT98 0.25 ● 0.20 0.15 ● ● 0.10 ● 0.05 ● ● ● ● ● ● 0.00 YP_001693238 YP_042788 YP_490697.1 0.25 ● ● 0.20 0.15 ● 0.10 classScore ● 0.05 ● ● ● ● ● ● ● ● ● ● ● 0.00 ● ZP_02685589 ZP_04679156 mls 0.25 ● antibiotic multidrug quinolone polymyxin puromycin thiostrepton betalactams 0.20 ● beta_lactam fosmidomycin streptogramin drugresistance − fluoroquinolone aminoglycoside lactamantibiotic fluoramphenicol − fluoroquinolones aminoglycosides − 0.15 multi beta 0.10 pump/potassiumantiporter lincosamide − cationicantimicrobialpeptides 0.05 ● ● ● 0.00 ● ● majorfacilitatorsuperfamilytransporter macrolide mls mls antibiotic antibiotic multidrug multidrug quinolone quinolone polymyxin polymyxin puromycin puromycin thiostrepton thiostrepton betalactams betalactams beta_lactam beta_lactam fosmidomycin fosmidomycin streptogramin streptogramin drugresistance drugresistance − − fluoroquinolone fluoroquinolone aminoglycoside lactamantibiotic aminoglycoside lactamantibiotic fluoramphenicol fluoramphenicol − − fluoroquinolones fluoroquinolones aminoglycosides aminoglycosides − − multi multi beta beta pump/potassiumantiporter pump/potassiumantiporter lincosamide lincosamide − − cationicantimicrobialpeptides cationicantimicrobialpeptides majorfacilitatorsuperfamilytransporter majorfacilitatorsuperfamilytransporter macrolide macrolide factor(class).