NT Neurotransmitter Pathways P5P Tryptophan Tryptamine MAO P5P Iron BH4 Vitamin D tryptophan hydroxylase Phenylalanine hydroxylase P5P Phenylalanine Tyrosine Tyramine P5P, Fe, BH4 aromatic MAO 5-Hydroxytryptophan P5P P5P amino acid (5-HTP) Iron decarboxylase aromatic amino acid BH4 P5P decarboxylase Phenethylamine Vitamin D tyrosine hydroxylase (PEA) MAO Serotonin B2 L-Dopa N-acetyl DOPAC B3 MAO transferase P5P aromatic amino acid Iron decarboxylase Acetylserotonin MAO 5-HIAA Dopamine 3-MT hydroxyindole-0- COMT SAMe Vitamin C dopamine methyltransferase Copper B-hydroxylase B3 Melatonin Norepinephrine COMT SAMe phenylethanolamine Cortisol N-methyltransferase Normetanephrine KEY Epinephrine COMT MAO = monoamine oxidase Cofactors for MAO: B2, B3, P5P, Fe, Mg COMT = catechol-o-methyl-transferase Metanephrine Cofactors for COMT: SAMe, Mg P5P = (pyridoxal-5-phosphate) activated form of vitamin B6 BH4 = (tetrahydrobiopterin) Endogenous levels can be supported with SAMe, vitamin B3, C, Mo, Zn MTHF = (methyltetrahydrofolate) active form of folate. SAMe = endogenous levels can be supported with Mg, MTHF, and methylcobalamin supplementation. Cofactors = Enzymes = NT Neurotransmitter Pathways Cysteine Taurine “glycine cleavage system” P5P, Fe, Mo, SAMe serine hydroxymethyl glycine transferase decarboxylase CO2 Serine Glycine SAMe P5P NH3 P5P Mg metabolites Histamine Histidine methyltransferase Decarboxylase SAMe Histidine Histamine Diamine oxidase P5P P5P, Copper, Iron, B12, vitamin C metabolites Glutamine KEY glutamine glutaminase MAO = monoamine oxidase synthetase Cofactors for MAO: B2, B3, P5P, Fe, Mg glutamate COMT = catechol-o-methyl-transferase dehydrogenase (B3) Cofactors for COMT: SAMe, Mg P5P = (pyridoxal-5-phosphate) activated form alpha-ketoglutarate Glutamate Glutamic Acid of vitamin B6 BH4 = (tetrahydrobiopterin) aminotransferase (P5P) Endogenous levels can be supported with SAMe, P5P glutamate vitamin B3, C, Mo, Zn Taurine decarboxylase (GAD) MTHF = (methyltetrahydrofolate) active form of folate. SAMe = endogenous levels can be supported with Mg, MTHF, and methylcobalamin supplementation. Note: aminotransferase aka transaminase GABA Cofactors = Enzymes =.