. Europe’s journal on infectious disease epidemiology, prevention and control Special edition: Food- and waterborne outbreaks caused by Salmonella and Listeria May 2018 Featuring • Ongoing nationwide outbreak of Salmonella Agona associated with internationally distributed infant milk products, France, December 2017 • Cross-border outbreak of listeriosis caused by cold-smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017 • and more... www.eurosurveillance.org Editorial team Editorial advisors Based at the European Centre for Albania: Alban Ylli, Tirana Disease Prevention and Control (ECDC), Austria: Maria Paulke-Korinek, Vienna 169 73 Stockholm, Sweden Belgium: Koen de Schrijver, Antwerp; Tinne Lernout, Brussels Telephone number Bosnia and Herzegovina: Sanjin Musa, Sarajevo +46 (0)8 58 60 11 38 Bulgaria: Iva Christova, Sofia E-mail Croatia: Sanja Music Milanovic, Zagreb [email protected] Cyprus: Maria Koliou, Nicosia Czech Republic: Jan Kynčl, Prague Editor-in-chief Denmark: Peter Henrik Andersen, Copenhagen Dr Ines Steffens Estonia: Kuulo Kutsar, Tallinn Senior editor Finland: Outi Lyytikäinen, Helsinki Kathrin Hagmaier France: Judith Benrekassa, Paris Germany: Jamela Seedat, Berlin Scientific editors Greece: Rengina Vorou, Athens Janelle Sandberg Hungary: Ágnes Hajdu, Budapest Karen Wilson Iceland: Gudrun Sigmundsdottir, Reykjavík Assistant editors Ireland: Lelia Thornton, Dublin Alina Buzdugan Italy: Paola De Castro, Rome Ingela Rumenius Latvia: Dzintars Mozgis, Riga Associate editors Lithuania: Saulius Čaplinskas, Vilnius Tommi Asikainen, Brussels, Belgium Luxembourg: Thérèse Staub, Luxembourg Magnus Boman, Stockholm, Sweden The former Yugoslav Republic of Macedonia: Aziz Pollozhani, Skopje Mike Catchpole, Stockholm, Sweden Malta: Tanya Melillo Fenech, Msida Natasha Crowcroft, Toronto, Canada Montenegro: Senad BegiĆ, Podgorica Christian Drosten, Berlin, Germany Netherlands: Barbara Schimmer, Bilthoven Karl Ekdahl, Stockholm, Sweden Norway: Emily MacDonald, Oslo Johan Giesecke, Stockholm, Sweden Poland: Malgorzata Sadkowska-Todys, Warsaw David Heymann, London, United Kingdom Portugal: Paulo Jorge Nogueira, Lisbon Irena Klavs, Ljubljana, Slovenia Romania: Daniela Pitigoi, Bucharest Karl Kristinsson, Reykjavik, Iceland Serbia: Mijomir Pelemis, Belgrade Daniel Lévy-Bruhl, Paris, France Slovakia: Lukáš Murajda, Bratislava Jacob Moran-Gilad, Beer-Sheva, Israel Slovenia: Maja Sočan, Ljubljana Panayotis T. Tassios, Athens, Greece Spain: Josefa Masa Calle, Madrid Hélène Therre, Paris, France Sweden: Anders Wallensten, Stockholm Henriette de Valk, Paris, France Turkey: Fehminaz Temel, Ankara Sylvie van der Werf, Paris, France United Kingdom: Nick Phin, London Design / Layout World Health Organization Regional Office for Europe: Robb Fabrice Donguy / Dragos Platon Butler, Copenhagen Online submission system http://www.editorialmanager.com/eurosurveillance/ www.eurosurveillance.org © Eurosurveillance, 2018 Contents special edition: food- and waterborne outbreaks caused by salmonella and Listeria Rapid communication Ongoing nationwide outbreak of Salmonella Agona associated with internationally distributed infant milk products, France, December 2017 2 Jourdan-da Silva N et al. Cross-border outbreak of listeriosis caused by cold- smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017 7 Schjørring S et al. Surveillance and outbreak report Outbreak of Salmonella Bovismorbificans associated with the consumption of uncooked ham products, the Netherlands, 2016 to 2017 12 Brandwagt D et al. Re-evaluation of a 2014 multi-country European outbreak of Salmonella Enteritidis phage type 14b using recent epidemiological and molecular data 18 Hörmansdorfer S et al. Investigation using whole genome sequencing of a prolonged restaurant outbreak of Salmonella Typhimurium linked to the building drainage system, England, February 2015 to March 2016 25 Mair-Jenkins J et al. Outbreak of febrile gastroenteritis caused by Listeria monocytogenes 1/2a in sliced cold beef ham, Italy, May 2016 34 Maurella C et al. Research Articles Rise and fall of outbreak-specific clone inside endemic pulsotype of Salmonella 4,[5],12:i:-; insights from high-resolution molecular surveillance in Emilia- Romagna, Italy, 2012 to 2015 43 Morganti M et al. © Eurosurveillance www.eurosurveillance.org 1 Rapid communications Ongoing nationwide outbreak of Salmonella Agona associated with internationally distributed infant milk products, France, December 2017 Nathalie Jourdan-da Silva¹, Laetitia Fabre², Eve Robinson1,3, Nelly Fournet¹, Athinna Nisavanh¹, Mathias Bruyand¹, Alexandra Mailles¹, Estelle Serre², Magali Ravel², Véronique Guibert², Sylvie Issenhuth-Jeanjean², Charlotte Renaudat², Mathieu Tourdjman¹, Alexandra Septfons¹, Henriette de Valk¹, Simon Le Hello² 1. Santé publique France, Saint-Maurice, France 2. Institut Pasteur, Centre National de Référence des Salmonella, Paris, France 3. European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden Correspondence: Nathalie Jourdan-da Silva ([email protected]) Citation style for this article: Jourdan-da Silva Nathalie, Fabre Laetitia, Robinson Eve, Fournet Nelly, Nisavanh Athinna, Bruyand Mathias, Mailles Alexandra, Serre Estelle, Ravel Magali, Guibert Véronique, Issenhuth-Jeanjean Sylvie, Renaudat Charlotte, Tourdjman Mathieu, Septfons Alexandra, de Valk Henriette, Le Hello Simon. Ongoing nationwide outbreak of Salmonella Agona associated with internationally distributed infant milk products, France, December 2017. Euro Surveill. 2018;23(2):pii=17-00852. https://doi.org/10.2807/1560-7917.ES.2018.23.2.17-00852 Article submitted on 21 Dec 2017 / accepted on 11 Jan 2018 / published on 11 Jan 2018 On 1 December 2017, an outbreak of Salmonella Agona January 2017. A confirmed case is a probable case with infections among infants was identified in France. To a Salmonella Agona isolate belonging to the outbreak date, 37 cases (median age: 4 months) and two further cluster by whole genome sequencing (WGS) or, if WGS international cases have been confirmed. Five differ- has not been performed, an isolate which does not ent infant milk products manufactured at one facility produce H2S and gas after 18 h incubation on Kligler were implicated. On 2 and 10 December, the company iron agar (see Microbiological investigations for further recalled the implicated products; on 22 December, all details). Cases were excluded if they had a history of products processed at the facility since February 2017. travel abroad in the 7 days before symptom onset and Trace-forward investigations indicated product distri- probable cases were excluded if after WGS, they were bution to 66 countries. not within the outbreak cluster. Identification of the outbreak As at 11 January 2018, 37 cases have been identified in At the end of November 2017 the French National France, all of whom were confirmed (Figure 1). All cases Reference Centre (NRC) for Salmonella noted an unusual had gastrointestinal symptoms, and there was no case increase in Salmonella Agona among infants, with 22 of bloodstream infection or meningitis. Almost all cases cases identified between August and November 2017 had diarrhoea (34 cases), 23 had bloody diarrhoea, 26 in children younger than six months. On 1 December, fever and 13 vomiting. One case had symptom onset interviews with the caregivers of eight of these infants in April while the remaining cases had onset of symp- by the French National Institute for Public Health (Santé toms between mid-August and 2 December. The cases Publique France (SPF)) identified infant milk products included 21 girls and 16 boys. The median age was 4 from a single company as a potential source. All but months (range: 2 weeks–9 months). The cases were one of the first eight investigated cases had consumed scattered across 10 different regions of France. products manufactured at a single facility operated by this company. This facility had previously been asso- Among 36 cases whose caregivers have been inter- ciated with an outbreak of Salmonella Agona in 2005 viewed to date, 18 were hospitalised for their illness, [1]. An outbreak investigation is currently ongoing in all of whom have recovered at the time of writing this conjunction with the NRC, SPF, the Ministry of Health report. Eleven cases had underlying medical condi- and the Ministry of Economy in charge of consumers’ tions. These conditions were not associated with an affairs. increased risk of salmonellosis. However, they may have increased the likelihood of presentation to a Epidemiological investigations healthcare provider and of diagnostic investigations. The operational definition for probable cases as at In the 3 days before symptom onset, 35 of the 36 cases 11 January 2018 includes children younger than two had consumed infant milk products intended for babies years with a laboratory-confirmed Salmonella Agona aged 0–6 months manufactured by the same company. infection and with a date of onset of symptoms since 1 Five different products have been implicated to date: 2 www.eurosurveillance.org Figure 1 Epicurve of Salmonella Agona confirmed cases in infants by week of diagnosis at the National Reference Centre, France, 2017 (n = 37) 10 s 9 e s 8 a c 7 f o 6 r e 5 mb 4 u N 3 2 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23