ISTH Couverture 6.6.2012 10:21 Page 1 ISTH Couverture 6.6.2012 10:21 Page 2 ISTH Couverture 6.6.2012 10:21 Page 3 ISTH Couverture 6.6.2012 10:21 Page 4 ISTH 2012 11.6.2012 14:46 Page 1 Table of Contents 3 Welcome Message from the Meeting President 3 Welcome Message from ISTH Council Chairman 4 Welcome Message from SSC Chairman 5 Committees 7 ISTH Future Meetings Calendar 8 Meeting Sponsors 9 Awards and Grants 2012 12 General Information 20 Programme at a Glance 21 Day by Day Scientific Schedule & Programme 22 Detailed Programme Tuesday, 26 June 2012 25 Detailed Programme Wednesday, 27 June 2012 33 Detailed Programme Thursday, 28 June 2012 44 Detailed Programme Friday, 29 June 2012 56 Detailed Programme Saturday, 30 June 2012 68 Hot Topics Schedule 71 ePoster Sessions 97 Sponsor & Exhibitor Profiles 110 Exhibition Floor Plan 111 Congress Centre Floor Plan www.isth.org ISTH 2012 11.6.2012 14:46 Page 2 ISTH 2012 11.6.2012 14:46 Page 3 WelcomeCommittees Messages Message from the ISTH SSC 2012 Message from the ISTH Meeting President Chairman of Council Messages Dear Colleagues and Friends, Dear Colleagues and Friends, We warmly welcome you to the elcome It is my distinct privilege to welcome W Scientific and Standardization Com- you to Liverpool for our 2012 SSC mittee (SSC) meeting of the Inter- meeting. national Society on Thrombosis and Dr. Cheng-Hock Toh and his col- Haemostasis (ISTH) at Liverpool’s leagues have set up a great Pro- UNESCO World Heritage Centre waterfront! gramme aiming at making our off-congress year As setting standards is fundamental to all quality meeting especially attractive for our participants. outcomes, our objective for this meeting in Liverpool Since 2008, beside the usual in-depth work of the will be to convey how the SSC is well-positioned to Subcommittees, our SSC meetings include a large translate new knowledge into better patient care. educational programme that targets young basic and Promoting cross-information exchange and engaging clinical scientists. Because of the smaller format of with external partners are key to deliver solutions for these meetings, compared to our biennial congresses, patients with haemostatic and thrombotic problems. it also allows to experiment with innovations. With a Developing future leaders is also key to the vitality of very encouraging number of abstracts submitted, we ISTH and this meeting will be rooted in the themes will have stimulating “hot topic abstracts” reporting of Education, Engagement and Translation.I am late-breaking results in basic and clinical science, and therefore delighted that SSC 2012 offers a coherent also regular abstracts featured as “e-posters”. These programme with a Trainees’ Day on Consultative Coagu- innovations will further foster the exchange of know- lation, an Education Day on Setting Standards of Care, ledge and the educational experience for our parti- a Presidential Plenary on Translational Thrombosis & cipants. Haemostasis and enhanced opportunities to Meet-the- I look forward to meeting you in the course of the week Experts. and attending and actively participating in what looks I look forward to greeting you personally and wish you like an outstanding program. the best of experiences in Liverpool ! Thank you for attending our 58th SSC meeting to With best wishes. experience the “science, culture, and friendship!”. Welcome to Liverpool ! CHENG-HOCK TOH HENRI BOUNAMEAUX M.D. M.D., FRCP, FRCPath 3 ISTH 2012 11.6.2012 14:46 Page 4 Welcome Messages Message from the SSC Chairman Dear Colleagues and Friends, Following the success of the SSC Professor Cheng-Hock Toh and his colleagues on the meeting in Kyoto, we are back in Local Organizing Committee have assembled a very Europe and I warmly welcome you to a high-level programme, which will also include for the new and very innovative meeting in first time “Hot topic abstracts” and regular abstracts Liverpool. that will be presented as e-posters. This novelty will As is the tradition of the SSC, the format of the 2012 help to highlight the most recent achievements in basic meeting is designed to favor an active exchange of new and clinical research and will be a great challenge for important information and topics of research, and to young investigators. stimulate cross-disciplinary collaborations. The confe- To maintain the high level reached by the SSC it is rence will start with a strong educational programme, important that those who are not currently a member, providing an opportunity of intensive training for our not only participate in the meeting, but make an active younger colleagues. Then the meetings of all sub- contribution, participating in the working projects and committees of the SSC will follow and the results of the registries, and become a member of one of the sub- new and on-going projects of each subcommittee will committees. be extensively discussed. This will provide the new The dynamic and energizing atmosphere of Liverpool insights into the most challenging practical issues in will provide the perfect setting for the offspring of new thrombosis and hemostasis, and also will grant an projects and collaborations, and will guarantee a great expert view on the standardization of basic and clinical success of the 2012 ISTH/SSC conference. research methods, nomenclature, preparation of Welcome to Liverpool ! reference reagents, and evaluation of new tests and new drugs. ANNA FALANGA M.D. 4 ISTH 2012 11.6.2012 14:46 Page 5 CommitteesCommittees Organizing Committee Factor VIII & Factor IX Flora Peyvandi (Italy) Cheng-Hock Toh, President (United Kingdom) Jecko Thachil (United Kingdom) Factor XI and the Contact System Simon Abrams (United Kingdom) Thomas Renne (Sweden) Tina Dutt (United Kingdom) Factor XIII and Fibrinogen Ian Greer (United Kingdom) Hans P Kohler (Switzerland) Colin Downey (United Kingdom) Fibrinolysis Officers of the Scientific and Standardization Ann Gils (Belgium) Committee Hemostasis & Malignancy Anna Falanga (Italy) Agnes Y Y Lee (Canada) Chairman (2010-2012) Lupus Anticoagulant/Phospholipid-dependent Committees David Lillicrap (Canada) Antibodies Secretary/Chairman-Elect (2010-2012 / 2012-2014) Thomas L Ortel (USA) Perinatal/Pediatric Hemostasis Subcommittees of the Scientific and Paul Monagle (Australia) Standardization Committee Animal, Cellular, and Molecular Models Plasma Coagulation Inhibitors of Thrombosis Steven Kitchen (United Kingdom) Susan S. Smyth (USA) Platelet Immunology Biorheology Yves Gruel (France) Michael R. King (USA) Platelet Physiology Control of Anticoagulation Paul Harrison (United Kingdom) Walter Ageno (Italy) Predictive Hemostatic Variables and Disseminated Intravascular Coagulation (DIC) Cardiovascular Disease Hideo Wada (Japan) James Douketis (Canada) Exogenous Hemostatic Factors, Registry of Jan Rosing (The Netherlands) 5 ISTH 2012 11.6.2012 14:46 Page 6 CommitteesCommittees Vascular Biology Class of 2014 Françoise Dignat-George (France) Nuala Booth (United Kingdom) Von Willebrand Factor Françoise Dignat-George (France) Jeroen CJ Eikenboom (The Netherlands) Nigel Key (USA) Robert Montgomery (USA) Women’s Health Issues in Thrombosis and Haemostasis Hugo ten Cate (The Netherlands) Sabine Eichinger (Austria) Class of 2016 SSC Working Group on Coagulation Standards Marco Cattaneo (Italy) Anthony Hubbard (United Kingdom) Björn Dahlbäck (Sweden) Andreas Greinacher (Germany) Council of the International Society on Paula Tracy (USA) Thrombosis and Haemostasis (ISTH) Yukio Ozaki (Japan) Chairman of Council (2010-2012) Henri Bounameaux (Switzerland) Ex-Officio Council Members Secretary/Chairman-Elect of Council Bruce Furie (USA) (2010-2012 / 2012-2014) Secretary General (2010-2014) Michael Berndt (Ireland) Frits R. Rosendaal (The Netherlands) Treasurer (2011-2015) President of the XXIV Congress (Amsterdam, 2013) & Immediate Past Chairman of Council Nuala Booth (United Kingdom) Class of 2012 Pieter Reitsma (The Netherlands) Vice-President of the XXIV (Amsterdam, 2013) Michael Berndt (Ireland) Congress Henri Bounameaux (Switzerland) Alan Nurden (France) Yasuo Ikeda (Japan) Bjarne Østerud (Norway) President of the XXIII Congress (Kyoto, 2011) Pieter Reitsma (The Netherlands) Mike Greaves and David Lane (United Kingdom) Editors-in-Chief, Journal of Thrombosis and Haemostasis Anna Falanga (Italy) Chairman, Scientific and Standardization Committee 6 ISTH 2012 11.6.2012 14:46 Page 7 Committees SSC 2012 Abstract Reviewers ISTH Future Meetings Calendar Ken Bauer (USA) XXIV ISTH Congress and 59th Annual SSC Meeting Nuala Booth (United Kingdom) Frits R. Rosendaal, President James Crawley (United Kingdom) Amsterdam, The Netherlands Françoise Dignat-George (France) 29 June - 4 July, 2013 Alison Goodall (United Kingdom) www.isth2013.com Tilman Hackeng (The Netherlands) Katherine Hajjar (USA) 60th Annual SSC Meeting Keith Hoots (USA) Robert R. Montgomery, President Bendt Jilma (Austria) Milwaukee, WI, USA Paul Kyrle (Austria) 2014 Nigel Mackman (USA) XXV ISTH Congress and 61st Annual SSC Meeting Committees Andrew Mumford (United Kingdom) XXV ISTH Congress and 61 Annual SSC Meeting Sam Schulman, President Bjarne Østerud (Norway) Toronto, Canada Evan Sadler (USA) 2015 Hugo ten Cate (The Netherlands) Jecko Thachil (United Kingdom) XXVI ISTH Congress and 63rd SSC Meeting Cheng-Hock Toh (United Kingdom) Johannes Oldenburg, President Theodore Warkentin (Canada) Berlin, Germany Steve Watson (United Kingdom) 2017 XXVII ISTH Congress and 65th SSC Meeting Robert Medcalf, President Melbourne, Australia 2019 7 ISTH 2012 11.6.2012 14:46 Page 8