ARTHRITIS TREATMENT COMPARISON ARTHRITIS TREATMENT COMPARISON GENERIC OA of (BRAND) HOW SUPPLIED AS GA JIA JRA OA Knee PsA RA CHELATING AGENTS Penicillamine Cap: 250mg ✓ (Cuprimine) Penicillamine Tab: 250mg ✓ (Depen) CYCLIC POLYPEPTIDE IMMUNOSUPPRESSANTS Cyclosporine Cap: 25mg, 100mg; ✓ (Gengraf, Neoral) Sol: 100mg/mL CYCLOOXYGENASE-2 INHIBITORS Celecoxib Cap: 50mg, 100mg, ✓ ✓ ✓ ✓ (Celebrex) 200mg, 400mg DIHYDROFOLIC ACID REDUCTASE INHIBITORS Methotrexate Inj: 25mg/mL; ✓ ✓ Tab: 2.5mg Methotrexate Tab: 5mg, 7.5mg, ✓ ✓ (Trexall) 10mg, 15mg INTERLEUKIN RECEPTOR ANTAGONISTS Anakinra Inj: 100mg/0.67mL ✓ (Kineret) Tocilizumab Inj: 20mg/mL, ✓ ✓ (Actemra) 162mg/0.9mL GOLD COMPOUNDS Auranofin Cap: 3mg ✓ (Ridaura) Gold sodium thiomalate Inj: 50mg/mL ✓ ✓ (Myochrysine) HYALURONAN AND DERIVATIVES Hyaluronan Inj: 30mg/2mL ✓ (Orthovisc) Sodium hyaluronate Inj: 1% ✓ (Euflexxa) Sodium hyaluronate Inj: 10mg/mL ✓ (Hyalgan) Sodium hyaluronate Inj: 2.5mL ✓ (Supartz) HYLAN POLYMERS Hylan G-F 20 Inj: 8mg/mL ✓ (Synvisc, Synvisc One) KINASE INHIBITORS Tofacitinib Tab: 5mg ✓ (Xeljanz) MONOCLONAL ANTIBODIES Ustekinumab Inj: 45mg/0.5mL, ✓ (Stelara) 90mg/mL MONOCLONAL ANTIBODIES/CD20-BLOCKERS Rituximab Inj: 100mg/10mL, ✓ (Rituxan) 500mg/50mL (Continued) ARTHRITIS TREATMENT COMPARISON GENERIC OA of (BRAND) HOW SUPPLIED AS GA JIA JRA OA Knee PsA RA MONOCLONAL ANTIBODIES/TNF-BLOCKERS Adalimumab Inj: 20mg/0.4mL, ✓ ✓ ✓ ✓ (Humira) 40mg/0.8mL Golimumab Inj: 50mg/0.5mL, ✓ ✓ ✓ (Simponi) 100mg/mL Infliximab Inj: 100mg ✓ ✓ ✓ (Remicade) NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) Diclofenac potassium Tab: 50mg ✓ ✓ (Cataflam) Diclofenac sodium Tab, DR: 25mg, ✓ ✓ ✓ 50mg, 75mg Diclofenac sodium Sol: 1.5% ✓ (Pennsaid) Diclofenac sodium Gel: 1% ✓ ✓ (Voltaren Gel) Diclofenac sodium Tab, ER: 100mg ✓ ✓ (Voltaren-XR) Diflunisal Tab: 500mg ✓ ✓ Etodolac Cap: 200mg, 300mg; ✓ ✓ Tab: 400mg, 500mg Etodolac Extended- Tab, ER: 400mg, ✓ ✓ ✓ Release 500mg, 600mg Fenoprofen calcium Cap: 200mg, (Nalfon) 400mg; (Generic) ✓ ✓ Tab: 600mg Ibuprofen Tab: 400mg, 600mg, ✓ ✓ 800mg Indomethacin Sup: 50mg ✓ ✓ ✓ ✓ (Indocin) Indomethacin Extended- Cap, ER: 75mg ✓ ✓ ✓ Release Ketoprofen Cap: 50mg, 75mg ✓ ✓ Ketoprofen Extended- Cap, ER: 100mg, ✓ ✓ Release 150mg, 200mg Meloxicam Susp: 7.5mg/5mL; ✓ ✓ ✓ (Mobic) Tab: 7.5mg, 15mg Nabumetone Tab: 500mg, 750mg ✓ ✓ Naproxen (Naprosyn) (Naprosyn, EC-Naprosyn) Susp: 125mg/mL; Tab: 250mg, 375mg, 500mg; ✓ ✓ ✓ ✓ (EC-Naprosyn) Tab, DR: 375mg, 500mg Naproxen sodium Tab: (Anaprox) (Anaprox, Anaprox DS) 275mg; (Anaprox ✓ ✓ ✓ ✓ DS) 550mg Naproxen sodium Tab, CR: 375mg, ✓ ✓ ✓ (Naprelan) 500mg, 750mg Oxaprozin Tab: 600mg ✓ ✓ ✓ (Daypro) (Continued) ARTHRITIS TREATMENT COMPARISON GENERIC OA of (BRAND) HOW SUPPLIED AS GA JIA JRA OA Knee PsA RA NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) (Continued) Piroxicam Cap: 10mg, 20mg ✓ ✓ (Feldene) Salsalate Tab: 500mg, 750mg ✓ ✓ Sulindac Tab: 150mg, 200mg ✓ ✓ ✓ ✓ Tolmetin Cap: 400mg; ✓ ✓ ✓ Tab: 200mg, 600mg PHOSPHODIESTERASE-4 INHIBITORS Apremilast Tab: 10mg, 20mg, ✓ (Otezla) 30mg PURINE ANTAGONIST ANTIMETABOLITES Azathioprine Tab: 75mg, 100mg ✓ (Azasan) Azathioprine Tab: 50mg ✓ (Imuran) PYRIMIDINE SYNTHESIS INHIBITORS Leflunomide Tab: 10mg, 20mg, ✓ (Arava) 100mg QUININE DERIVATIVES Hydroxychloroquine Tab: 200mg sulfate ✓ (Plaquenil) SELECTIVE COSTIMULATION MODULATORS Abatacept Inj: 125mg/mL, ✓ ✓ (Orencia) 250mg 5-AMINOSALICYLIC ACID DERIVATIVES/SULFAPYRIDINES Sulfasalazine Tab, DR: 500mg ✓ ✓ (Azulfidine EN-tabs) TNF-RECEPTOR BLOCKERS Certolizumab pegol Inj: 200mg/mL ✓ ✓ ✓ (Cimzia) Etanercept Inj: 25mg, 50mg ✓ ✓ ✓ ✓ (Enbrel) COMBINATION PRODUCTS NSAIDs/H2-RECEPTOR ANTAGONISTS Ibuprofen/Famotidine Tab: 800mg/26.6mg ✓ ✓ (Duexis) NSAIDs/PROTON PUMP INHIBITORS Naproxen/Esomeprazole Tab, DR: magnesium 375mg/20mg, ✓ ✓ ✓ (Vimovo) 500mg/20mg NSAIDs/PROSTAGLANDIN ANALOGS Diclofenac sodium/ Tab: 50mg/200mcg, Misoprostol 75mg/200mcg ✓ ✓ (Arthrotec) Refer to full FDA-approved labeling for additional information. Abbreviations: AS = ankylosing spondylitis; DR = delayed-release; ER = extended-release; GA = gouty arthritis; JIA = juvenile idiopathic arthritis; JRA = juvenile rheumatoid arthritis; OA = osteoarthritis; PsA = psoriatic arthritis; RA = rheumatoid arthritis..