Department of Biostatistics 1 methodology. Prerequisite: BIOS 714 or equivalent with permission of Department of instructor. LEC. BIOS 720. Analysis of Variance. 3 Hours. Biostatistics Methods for designed experiments including one-way analysis of variance (ANOVA), two-way ANOVA, repeated measures ANOVA, and analysis The mission of the Department of Biostatistics & Data Science is to of covariance are emphasized. Post- ANOVA tests, power and testing provide an infrastructure of biostatistical and informatics expertise to assumptions required in NOVA are discussed and applied. Outlier support and enhance the research, service and educational needs of detection using robust estimators also are incorporated. Boxplots, the University of Kansas Medical Center and its affiliates. The global histograms and scatterplots are used to display data. Prerequisite: PRE objectives of the department are as follows: 710/711 or BIOS 714/717 or equivalent. Preferred: BIOS 715. Knowledge of statistical software, basic statistical plotting methods, p-values, two- • To provide a leadership role in biostatistical and informatics research sample t-test and simple linear regression is assumed. LEC. initiatives across the medical center. BIOS 725. Applied Nonparametric Statistics. 3 Hours. • To provide the biostatistics and informatics cores for major initiatives. This course will study nonparametric methods in many situations as • To ensure that researchers have ready access to biostatistical and highlighted by the following topics: Students will learn how nonparametric informatics resources and support. methods provide exact p-values for tests, exact coverage probabilities • To provide the infrastructure and expertise for centralized and project for confidence intervals, exact experimentwise error rates for multiple specific database development, management and analysis. comparison procedures, and exact coverage probabilities for confidence • To consolidate resources pertaining to biostatistics and informatics. bands. This course will be using EXCEL and SAS to conduct various procedures. Prerequisite: BIOS 714 or equivalent with permission of The innovative MS & PhD programs in Biostatistics and Applied Statistics instructor. LEC. & Analytics help meet the ever-increasing demand for statisticians and BIOS 730. Applied Linear Regression. 3 Hours. biostatisticians needed to take leadership roles in academia, government Simple linear regression, multiple regression, logistic regression, and industry. Faculty members are active researchers collaborating and nonlinear regression, neural networks, autocorrelation, interactions, and consulting in research projects and initiatives at the Medical Center, residual diagnostics. Applications of the methods will focus on health in addition to pursuing their own research agendas and participating related data. Prerequisite: 1) BIOS 714 or the equivalent and 2) BIOS 717 in curricular instruction. Expertise in the department includes linear, or BIOS 720 or equivalent with permission of instructor. LEC. nonlinear, and longitudinal modeling; clinical trial and experimental design; survival analysis; categorical data analysis; robust statistics; BIOS 735. Categorical Data and Survival Analysis. 3 Hours. psychometric methods; statistical 'omics; bioinformatics; Bayesian An intermediate level statistics course that provides an understanding methodology; data science; and machine learning. of the more advanced statistical methods to scientific research with emphasis on the application of statistical methodology to clinical Courses research, public health practice, public health research and epidemiology. Prerequisite: BIOS 714, BIOS 715, and BIOS 717 or permission of the BIOS 704. Principles of Statistics in Public Health. 3 Hours. instructor. LEC. Introductory course concerning the concepts of statistical reasoning and the role of statistical principles as the scientific basis for public health BIOS 740. Applied Multivariate Methods. 3 Hours. research and practice. Prerequisite: Permission of instructor. LEC. This course is an advanced statistical course for students who have had fundamental biostatistics and linear regression. Topics to be covered BIOS 714. Fundamentals of Biostatistics I. 3 Hours. include Hotelling's T-squared test, MANOVA, principal components, factor First-semester course of a two-semester introductory statistics course that analysis, discriminant analysis, canonical analysis, and cluster analysis. provides an understanding of the proper application of statistical methods More advanced topics such as Multidimensional Scaling or Structural to scientific research with emphasis on the application of statistical Equation Modeling might be introduced if time allows. Computers will be methodology to public health practice and research. This course focuses extensively used through the whole course, and students are suggested on basic principles of statistical inference with emphasis on one or two to be familiar with some statistical software before taking this course. sample methods for continuous and categorical data. This course fulfills Although students are allowed to use the software they are comfortable the core biostatistics requirement. Prerequisite: Calculus or Permission of with, SAS will be the primary statistical package used to demonstrate Instructor. LEC. examples in this course. Prerequisite: Corequisite: BIOS 730 or equivalent BIOS 715. Introduction to Data Management using RedCap and SAS. with permission of instructor. LEC. 3 Hours. BIOS 799. Introduction to Statistical Genomics. 3 Hours. This course will cover the utilization of Redcap and SAS for data This survey course will provide a high-level introduction of various management. Data collection and management using Redcap will be statistical and bioinformatics methods involved in the study of biological covered. Data cleaning and preparation for analysis will be covered using systems. In particular, this course will provide an overview of the SAS. In addition, some of the basic descriptive analysis procedures will analytical aspects involved in: the study DNA, RNA, and DNA methylation be covered in SAS. Prerequisite: Corequisite: BIOS 704 or BIOS 714 or data measured from both microarray and next-generation sequencing equivalent with permission of instructor. LEC. (NGS) technologies. During the last week of the summer semester, BIOS 717. Fundamentals of Biostatistics II. 3 Hours. students will be required to participate in a group seminar session in Second level statistics course that provides an understanding of more which they will present the results from their assigned genomics analysis advanced statistical methods to scientific research with an emphasis on projects. Prerequisite: Corequisite: BIOS 714 and BIOS 717 or equivalent the application of statistical methodology to public health practice, public with permission of instructor; Experience with a higher level programming health research, and clinical research. Special focus will be upon the language is preferred. LEC. utilization of regression methodology and computer applications of such 2 Department of Biostatistics BIOS 805. Professionalism, Ethics and Leadership in the Statistical BIOS 820 or equivalent (SAS Certified BASE programmer for SAS or at Sciences. 3 Hours. least one year of experience as a data analyst/programmer). LEC. This web-based course addresses issues in professionalism, leadership BIOS 823. Introduction to Programming and Applied Statistics in R. 3 and ethics that are specific to students training to become statisticians, Hours. biostatisticians, and data scientists. Topics include use of sound statistical This course will provide students with the opportunity to learn advanced methodology, common threats to valid inference, effective communication statistical programming. The development of new statistical or and collaboration with content-area experts, maintaining transparency and computational methods often implies the development of programming independence, reproducible research, the publishing process (including codes to support its application. Much of this type of development is authorship guidelines, plagiarism, peer review, intellectual property, etc.), currently carried out in the R (or S-Plus) language. Indeed much of the conflict of interest, data security, and properties of effective leaders, recent development of statistical genetics is based on the R programming among others. Prerequisite: Department consent. LEC. language and environment. This course provides an introduction to BIOS 806. Special Topics in Biostatistics. 1-3 Hours. programming in the R language and it's applications to applied statistical This course allows exploration of special topics that are not routinely a problems. Prerequisite: Corequisite: Some previous exposure to computer part of the curriculum. Prerequisite: Permission of the instructor. LEC. programming. Some basic statistics at the Applied Regression or Applied BIOS 810. Clinical Trials. 3 Hours. Design level and permission of instructor. LEC. The design, implementations, analysis, and assessment of controlled BIOS 825. Nonparametric Methods. 3 Hours. clinical trials. Basic biostatistical concepts and models will be emphasized. This course is an introduction to nonparametric statistical methods Issues of current concern to trialists will be explored. Prerequisite: By for data that do not satisfy the normality or other usual distributional permission of instructor. LEC. assumptions. We will cover most