Journal of Animal Health and Production Review Article A Review on the Potential Effects of Mannheimia haemolytica and its Immunogens on the Female Reproductive Physiology and Performance of Small Ruminants 1,2 2 1,3 FAEZ FIRDAUS ABDULLAH JESSE *, MOHAMED ABDIRAHMAN BOOREI , ERIC LIM TEIK CHUNG , 2 4 2 2 FITRI WAN-NOR , MOHD AZMI MOHD LILA , MOHD JEFRI NORSIDIN , KAMARULRIZAL MAT ISA , 1 1 5 6 NUR AZHAR AMIRA , ARSALAN MAQBOOL , MOHAMMED NAJI ODHAH , YUSUF ABBA , ASINAMAI 7 6 6 2,6 ATHLIAMAI BITRUS , IDRIS UMAR HAMBALI , INNOCENT DAMUDU PETER , BURA THLAMA PAUL 1Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; 2Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; 3Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; 4Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; 5Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengakalan Chepa 16100, Kota Bharu, Kelantan, Malaysia; 6Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069 Maiduguri, Borno Nigeria; 7Faculty of Veterinary Science, University of Jos, P.M.B 2084 Jos, Plateau Nigeria. Abstract | Mannheimia haemolytica causes pneumonic pasteurellosis (mannheimiosis) in ruminants which is the most economically significant infectious disease. Mannheimia belongs to the family Pasteurellaceae, are nonmotile, non- spore-forming, facultatively anaerobic, oxidase-positive and fermentative gram-negative rods or coccobacilli which are frequent respiratory and digestive tract commensals in both domestic and wild animals. They can produce infection in animals with compromised immune states. The capsular polysaccharide, lipopolysaccharide and iron-regulated outer membrane proteins are the major virulent factors of organism stimulating the host immunity. There is a significant gap on the effects of the M. haemolytica and its’ immunogens on the physiology and performance of the reproductive system in small ruminants. Therefore, the goal of this review is to highlight the potential involvement of the female reproductive system with infection with M. haemolytica and its immunogens in small ruminants. Moreover, the review has directed the future research path to determine the role of this bacterium in the pathophysiology and performance of the female reproductive system. Keywords | Mannheimia haemolytica, Pneumonic pasteurellosis, Immunogens, Reproductive physiology, Small ruminants Received | March 19, 2020; Accepted | May 27, 2020; Published | June 04, 2020 *Correspondence | Faez Firdaus Abdullah Jesse, Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Email: [email protected] Citation | Jesse FAA, Boorei MA, Chung ELT, Wan-Nor F, Lila MAM, Norsidin MJ, Isa KM, Amira NA, Maqbool A, Odhah MN, Abba Y, Bitrus AA, Hambali IU, Peter ID, Paul BT (2020). A review on the potential effects of Mannheimia haemolytica and its immunogens on the female reproductive physiology and performance of small ruminants. J. Anim. Health Prod. 8(3): 101-112. DOI | http://dx.doi.org/10.17582/journal.jahp/2020/8.3.101.112 ISSN | 2308-2801 Copyright © 2020 Jesse et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. INTRODUCTION causes significant financial losses to the cattle, sheep and goat sectors with climatic and animal management factors Mannheimia (formerly known as Pasteurella) haemolytica participating in their pathogenesis (Zamri-Saad et al., is the causative agent of cattle and sheep pneumonic 1994; Chung et al., 2015; Jesse et al., 2019). Pasteurella and pasteurellosis (mannheimiosis), which is an infection that Mannheimia species are nonmotile, non-spore-forming, NE US Academic Publishers September 2020 | Volume 8 | Issue 3 | Page 101 Journal of Animal Health and Production facultatively anaerobic, oxidase-positive and fermentative highlight the importance of M. haemolytica infection small gram-negative rods or coccobacilli. Most of of female reproductive system in small ruminants to them are commensals on the upper respiratory mucous concentrate the researchers for further work on this membrane and the digestive tract of both domestic and neglected area. wild animals (Wilson and Ho, 2013). In its typical clinical form, the disease is enormously infectious, often fatal and BIOLOGY OF MANNHEIMIA HAEMOLYTICA has a very severe financial effect on the animal industry HISTORY AND TAXONOMY OF MANNHEIMIA HAEMOLYTICA (Mohamed and Abdelsalam, 2008). The economic loss due Mannheimia haemolytica is the most prevalent etiological to pneumonia in ruminants is estimated to be 8% of the agent of pneumonia in sheep, goats and other species of total cost of production, that includes expenses in medical ruminants which cause economic losses worldwide due procedure, reduced food conversion, enhanced cost of to high mortality, cost of treatment, poor weight gain and production and reduced food supply for the people (Rico condition (Highlander, 2001). M. haemolytica formerly et al., 2017). was known as Pasteurella haemolytica, which is involved in the aetiology of ovine pneumonia or enzootic pneumonia Infections from Mannheimia pathogens are correlated with (Kumar et al., 2015) and bovine respiratory disease (BRD) poor management policies and develop as a secondary (Confer, 2009), and it is in the family of Pasteurellaceae, infection or as a result of acute stress. Transportation genus Mannheimia (Rice et al., 2007). stress, viral infections, congested pens, inadequate housing conditions, abrupt improvements to the environment There has been an extensive reclassification of the and other adverse situations improve the susceptibility of bacterium in the past; Theodore kit named it bacterium animals to M. haemolytica pneumonia (Abdullah et al., 2015; bipolare multocidum first in 1885, and ten years later Flugge Jesse et al., 2017a). Moreover, M. haemolytica has many renamed it bacillus boviseptica in 1896 and subdivided it potential immunogens, including capsular polysaccharides, further into various types triggering bovine fibrinous lipopolysaccharide (LPS), outer membrane proteins pneumonia (Pasteurella boviseptica) or hemorrhagic (OMPs), fimbriae, iron-regulated proteins and secreted septicaemia (now known as Pasteurella multocida) leukotoxin (Confer, 1993). (Highlander, 2001). Jones (1921) has reported three groups of bovine Pasteurella and stated that group I is different Animals infected with pneumonia develop clinical signs from other groups in its ability to hemolyze and its failure including high fever, extreme respiratory involvements to produce indole. Further characterisation of strains was established by nasal discharges, frothy mouth, cough carried on by Newson and Cross (1932), and for group I and dyspnoea (Mohamed and Abdelsalam, 2008). The of Bacillus bovisepticus they suggested the term Pasteurella diagnosis of pneumonic pasteurellosis is based on history of haemolytica, as this group caused pneumonia in calves the clinical manifestation, clinical signs, post-mortem and (Angen et al., 1999). Based on phenotypic epidemiological histopathological results, associated with the isolation of the and pathological characters, Smith (1959) identified two bacteria and confirmation with the use of PCR (Ahmed et biotypes of P. haemolytica. These biotypes were identified as al., 2017). Treatment can be achieved with a combination A and T, corresponding to either L-arabinose or trehalose of antimicrobials such as penicillin, ampicillin, ceftriaxone fermentation ability. Seventeen serotypes of P. haemolytica and enrofloxacin and suitable anti-inflammatory agents have been described, 13 identified as serotype A and four like flunixin meglumine, meloxicam (Rahal et al., 2014; serotype T (Younan and Fodor, 1995). Serotype T strains Thiry et al., 2014; Achard et al., 2018; Politis et al., 2019). were subsequently reclassified as Pasteurella trehalosi and However, prevention plans remain more efficient, which eventually Bibersteinia trehalose (Blackall et al., 2007). includes improving housing situations, sanitation and Serotype A strains of the old P. haemolytica with five biosecurity procedures. It is best to avoid stressors, such species namely Mannheimia haemolytica, Mannheimia as assembling animals of different backgrounds without glucosida, Mannheimia granulomatous, Mannheimia adequate quarantine (Taunde et al., 2019). ruminalis and Mannheimia varigena formed new genus called Mannheimia (Blackall et al., 2001; Angen et al., The pathophysiology of the respiratory system due to M. 2002; Ponnusamy et al., 2017). haemolytica was focused in previous studies (Abdullah et al., 2015). However, it is unknown whether M. haemolytica M. haemolytica serotypes A1 and A2 are the common have insidious effects on the reproductive system as it serotypes usually distributed all over the world. Serotype was often overlooked by the farmers and veterinarians. A1 is considered to be the most prevalent cause of bovine As far as we know, there is less information available on pasteurellosis, although certain serotypes, such as A6