SCIENTIFIC REPORT 2015 1 TABLE OF CONTENT 2 The President Editorial 4 Message of The Scientific Director 6 Identity & Mission 8 The Smart Loire Valley Programmes 10 ARD 2020 Biopharmaceuticals 11 ARD 2020 LAVOISIER 12 ARD 2020 Cosmetosciences 13 ARD 2020 PIVOTS 14 Materials & Energy sciences 22 LIfe & Health sciences 46 Earth, Ecology & Environment sciences 56 Computer Science, Mathematics & Mathematical Physics 66 Human & Social Sciences 74 Transdisciplinary approach 76 Life of international researchers in the region Centre-Val de Loire 78 Good news stories in 2015 80 Governance 81 Scientific Council 82 LE STUDIUM Events in 2015 84 Statistics 2 1 THE PRESIDENT L’ÉDITO EDITORIAL DU PRÉSIDENT The year 2015 was marked by a substantial increase in the activities of LE STUDIUM Loire L’année 2015 aura été marquée par l’accroissement substantiel des activités du STUDIUM Valley Institute for Advanced Studies and the international visibility of its programmes with Loire Valley Institute for Advanced Studies et de la visibilité internationale de ses programmes the support of the Marie Skłodowska-Curie Actions COFUND from the European Union. avec notamment le cofinancement des Actions Marie Skłodowska-Curie COFUND de l’Union Européenne. Our main aim remains to contribute to the international renown of the research conducted in the region Centre-Val de Loire and the development of the territory. Notre ambition principale demeure de contribuer au rayonnement à l’international des Hundreds of international researchers have been hosted this year, for stays lasting a few recherches conduites en région Centre-Val de Loire, ainsi qu’au développement du territoire. days (Conference, Workshop), week (Consortium) or from several months to the whole La centaine de chercheurs internationaux accueillis cette année, pour des séjours d’une year (Fellowship, Chair, Professorship). In residence in 2015 at the University of Orléans, durée de quelques jours (Workshop, Conference), d’une semaine (Consortium), ou encore de University François-Rabelais of Tours, CNRS, INRA, CEA and Inserm, the researchers found, plusieurs mois à l’année entière (Fellowship, Chair, Professorship), y a largement contribué. as result of the environment created by LE STUDIUM, favourable conditions for the success of En résidence en 2015 à l’Université d’Orléans, l’Université François-Rabelais de Tours, au CNRS, their project, and more broadly to the enhancement of their stay in the region Centre-Val de Loire. à l’INRA, au CEA et à l’Inserm, ces chercheurs ont trouvé, grâce à l’environnement créé par LE STUDIUM, des conditions favorables à la réussite de leur projet, et plus largement à la valorisation Serving the regional scientific community, LE STUDIUM describes in this report scientific research de leur séjour en région Centre-Val de Loire. activities undertaken by the researchers during their stay. The report seeks to demonstrate the benefits derived from attracting international researchers to the region and how the different Au service de la communauté scientifique régionale, LE STUDIUM a fait à nouveau le choix de décrire instruments offered by LE STUDIUM contribute to desirable outcomes. We were also very careful dans ce rapport scientifique l’ensemble des activités de recherche développées par ces chercheurs to report the quality of the professional environment offered to these researchers by our different au cours de leur séjour. Ce choix répond à la volonté de rendre compte de la richesse de tels accueils member organisations in region Centre-Val de Loire. et de la façon dont les différents instruments proposés par LE STUDIUM y contribuent. Nous avons aussi été très attentifs à faire état de la qualité de l’environnement offert à ces chercheurs par nos In keeping with the commitments made by Professor Paul Vigny, founding President of LE différentes organisations membres en région Centre Val-de-Loire. STUDIUM, we continued in 2015 the development of LE STUDIUM SMART LOIRE VALLEY PROGRAMME, which includes the original General Programme and the research projects of the En continuité avec les engagements pris par le Professeur Paul Vigny, Président fondateur du Ambition Research Development 2020 programme supported by the Region Centre-Val de Loire, STUDIUM, nous avons poursuivi en 2015 le développement du LE STUDIUM SMART LOIRE VALLEY which represents the regional action in the frame of the Smart Specialisation Strategy of the PROGRAMME qui inclut le Programme Général initial et les programmes de recherche Ambition European Union. Recherche Développement 2020 soutenus par la Région Centre-Val de Loire, contributions à la déclinaison régionale de la Smart Specialisation Strategy de l’Union Européenne. Finally, as contained in this report the achievements for 2015 are very positive, thanks to the support of the Regional Council in Centre-Val de Loire, the City of Orléans, the Department of Enfin, si le bilan de l’année 2015 est très positif, ainsi qu’en atteste le contenu de ce rapport Loiret and the European Regional Development Fund, but also to the support of its members and d’activité, c’est grâce au soutien du Conseil Régional Centre-Val de Loire, de la Ville d’Orléans, du partners and the quality of work done by the entire team in Orléans and Tours by Professor Nicola Département du Loiret et du Fonds Européen de Développement Régional, mais aussi à l’appui de Fazzalari Scientific Director, Sophie Gabillet Secretary General, Dr Aurélien Montagu Manager of ses partenaires et membres et à la qualité du travail accompli par l’ensemble de l’équipe tant sur Scientific Relations, and our staff Marie-Frédérique Pellerin, Vincent Godard, Amélie Schneuwly les sites d’Orléans que de Tours par le Professeur Nicola Fazzalari, Directeur Scientifique, Sophie and Ludovic Michel. Gabillet, Secrétaire Générale, le Docteur Aurélien Montagu, Chargé de relations scientifiques, et nos collaborateurs Marie-Frédérique Pellerin, Vincent Godard, Amélie Schneuwly, et Ludovic Michel. I renew to our members, partners and donors, my sincere thanks for their commitment and to the entire team of LE STUDIUM. Je renouvelle à nos membres, partenaires et bailleurs, mes remerciements les plus sincères pour leur engagement à nos côtés ainsi qu’à toute l’équipe du STUDIUM. Professeur Ary Bruand President Professeur Ary Bruand Président 2 3 MESSAGE OF The format of LE STUDIUM Thursdays has changed to include an introduction by the host THE SCIENTIFIC laboratory Director or host scientist prior to the presentation by the Research Fellow. This format has been well accepted by both the host laboratory and the research fellows and DIRECTOR enables the fellows to gain a deeper understanding of the scope of regional research activities. LE STUDIUM Conferences continue to attract a large number of leading international researchers to the region Centre-Val de Loire. These conferences are multidisciplinary and are accompanied by dynamic discussion, which often results in new ideas for research and international collaborations. This has been a busy year for LE STUDIUM Loire Valley Institute for Advanced Studies, with our focus remaining on our mission to build the human capacity for research Public awareness of research being undertaken in the region is important. We live in a and scientific knowledge for socioeconomic development and innovation. We have time of rapid changes in technology, where the community at large quickly adopts new the expertise to attract, manage and grow a global research network, create new technologies. The evening Public Lectures, which are linked to LE STUDIUM Research scientific value chains, and contribute to the emergence of innovative, collaborative Conferences, keep the local community informed about the research activities in the research and enterprise activity. The impact of new knowledge on the economy is region. The Lectures have become increasingly popular following the implementation of incremental, but the cumulative effect of these changes is substantial. a new community linked strategy to promote the events. In March 2015, LE STUDIUM was awarded a COFUND grant in the category of the This past year we have also been pleased to partner with regional laboratories to hold Marie Skłodowska-Curie Actions. This European Union Horizon 2020 award will attract a number of affiliated scientific fora. These partnership events are an important new an increased number of experienced research fellows to the region Centre-Val de Loire. collaboration between LE STUDIUM and the laboratories of our regional members. The award represents the achievement of one of our strategic goals set two and a half years earlier. We accomplished this due to the high level commitment by LE STUDIUM team and Furthermore, this year’s annual report includes stories that demonstrate the local impact the support provided by the Regional Council of Centre-Val de Loire. Under the banner of of fellowships and the translation of fundamental knowledge into potential socioeconomic the SMART LOIRE VALLEY (SLV) Fellowship programme, the five years of funding provided outcomes for the region and beyond. These stories show the diverse pathways, involving by this award highlights substantial benefits available to all the laboratories of LE STUDIUM innovation, taken to translate fundamental research and bridge with the enterprise domain. members. The ARD 2020 programmes also continued to evolve, with the launch of the Cosmetosciences The SLV programme seeks to create synergies between disciplines and industry in order