Short Biography Anna Maria Papini, PhD Professor and Chair of Bioorganic Chemistry _______________________________________________________________________________________ Interdepartmental French-Italian Laboratory of Peptide & Protein Chemistry & Biology www.peptlab.eu Education and Scientific Graduation Since 2013: Scientific National Habilitation to the function of Full Professor of Organic Chemistry of the Italian Universities. Since 2001: Habilitation to the function of Full Professor of Organic Chemistry of the French Universities. 1985-1989: International Ph.D. in Chemical Biology of the Italian Ministry of Education. 1985-1986 Department of Biochemistry, University of Sherbrooke, Québec, Mentor Prof. Dr. Gilles Dupuis; 1986-1988 Dept. of Organic Chemistry, University of Florence, Mentor: Prof. Gianfranco. Rapi and 1988-1989 Department of Peptide Chemistry, Max Planck Institute für Biochemie, Martinsried Bei Muenchen, Mentor Prof. Dr. Luis Moroder. 1977-1983: Italian “Laurea” in Chemistry, Curriculum Organic Chemistry & Chemical Biology of the University of Florence (Italy). Research Experience and Employment History Since 2002 to date: Associate Professor and Chair of Bioorganic Chemistry of the University of Florence. Since 2008 to date: Full Professor and Chair of Bioorganic Chemistry of the University of Cergy-Pontoise. Since 2010 to date: Founder and coordinator of the French-Italian Laboratory of Peptide & Protein Chemistry & Biology ( www.peptlab.eu ) University of Florence & University of Cergy-Pontoise. Since 2013 to date: Director of the Platform PeptLab@UCP at the University of Cergy-Pontoise. Since 2004 to date: Co-founder and head of the Interdepartmental Laboratory of Peptide & Protein Chemistry & Biology, Polo Scientifico of the University of Florence associating the Departments of Chemistry, Pharmaceutical Sciences & Neurosciences of the University of Florence. 1991-2001: Researcher at the Department. of Organic Chemistry, University of Florence. Awards and Activities in the Scientific Community 2009-2014: Chaire d’excellence of the French Agence Nationale de la Recherche . 2008: Leonidas Zervas Award for outstanding contribution to peptide chemistry, 30th EPS, Helsinki. 2008: 1st D. Theodoropoulos Memorial Lecture Award for outstanding achievements in Peptide Sciences, 6th Hellenic Forum on Bioactive Peptides, Patras. 2005: Bert Schram Price. Honorable Mention, 19th APS, San Diego, CA, USA. 2005: Best Poster Award “Glyco XVIII”, Firenze. 1999: Bruce W. Erickson Award for outstanding achievement in peptide sciences, 16th APS, Minneapolis, Minnesota, USA. 2012-2016: Panel Member for ERC Advanced Grant evaluation PE5 – Synthetic chemistry and materials. 2016: Chairperson of the 2016 GRC: Chemistry & Biology of Peptides with Prof. Dr. P. Dawson. 2014: Chairperson of the Symposium & Training Course Peptides in Paris PIPS 2014 (Co-chairs Prof. S. Lavielle & Prof. W.D. Lubell), October 5-10, 2014, Institute if Advanced Studies, University of Cergy-Pontoise (France). 2014: Responsible of the thematic semester Peptides & Proteins Molecules of Life at the University of Cergy-Pontoise. 2014: Vice-chair of the GRC: Peptide Science in the Era of Synthetic Biology. Ventura, CA, 23-28/02/2014. 2011-2020: Treasurer and member of the Executive Committee of the European Peptide Society. February 2011: Member of the AERES Committee for evaluation of the ICM of the University of Reims. March 2010: Member of the AERES Committee for evaluation of iBiTecc-S Equipe SIMOPRO (CEA, Saclay). Since 2013: Coordinator of the International Affairs of the School of Sciences of the University of Florence. Since 2005: Delegate of Chemistry of the Erasmus Programme of the Faculty of Sciences of the University of Florence. Responsible of the Erasmus students 2009: Vespucci Award for founding the startup Toscana Biomarkers. 2008: Frost & Sullivan Excellence in Research Award in the European autoimmune disease diagnostics market presented to AMP for the startup Toscana Biomarkers. 2006: Start-Cup for business plan of the start-up Toscana Biomarkers. 2004: Vespucci Award, Research & Ethical Innovation to AMP as inventor of PCT (2003) WO 03000733 A2 . 2007 to date: Founder & Chief Scientific Officer of the startup Toscana Biomarkers (www.toscanabiomarkers.com ) 2003: Founder and member of the Board of EspiKem, 1st spinoff of the University of Florence (www.espikem.com) Recent Research Funding 2009-2014: “Chaire d’Excellence” (ANR-09-CEXC-013-01). PepKit: Development of peptide-based- diagnostic kits for autoimmune diseases. 999.998,00 Euro for the PeptLab@UCP platform. 2011-2013: “Fondation Pierre-Gilles de Gennes”. Immune-mediated diseases: Glycopeptidomic-based diagnostics to follow-up disease activity. 2 post-doctoral fellows + 90.000 Euro for materials. 2010-2012: “Regione Toscana POR CReO FESR”. MARK: Identification of diagnostic biomarkers of autoimmune diseases. 450.000,00 Euro. 2005-2011: “Fondazione Cassa di Risparmio di Firenze”. Molecular characterisation of peptide-protein interaction in autoimmune diseases. 1.500.000 Euro for PeptLab at University of Florence. 2005-2007: International FIRB- Italian Ministry of University & Research and Harvard Medical School. 350.000,00 Euro. 2002-2003, 2005-2006, 2008-2009: PRIN-Italian Ministry of University & Research. Design, synthesis & immunological characterisation of modified peptides to follow up autoimmune diseases. 700.000,00 Euro. Selected topic-relevant research publications Author of 281 peer-reviewed articles: 111 articles in peer reviewed scientific journals and 170 articles in peer reviewed books. Author of 10 filed patents. Full paper list is available at www.peptlab.eu 1. A.M. Papini , F. Nuti, F. Real-Fernandez, G. Rossi, C. Tiberi, G. Sabatino, S. Pandey, S. Leoncini, C. Signorini, A. Pecorelli, R. Guerranti, S. Lavielle, L. Ciccoli, P. Rovero, C. De Felice, J. Hayek. Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction. J. Immunology Res. (http://www.hindawi.com/journals/jir/raa/260973/ ). Accepted 15 September 2014 . 2. A. Naegeli, C. Neupert, Y-Y Fan, C-W Chia-Wei Lin, K. Poljak, A.M. Papini , F. Schwarz, M. Aebi. Molecular analysis of an alternative N-glycosylation machinery by functional transfer from Actinobacillus pleuropneumoniae to Escherichia coli. J. Biol. Chem. (2014 ), 24, 289, 2170-2179. 3. S. Pandey, I. Dioni, D. Lambardi, F. Real-Fernandez, E. Peroni, G. Pacini, F. Lolli, R. Seraglia, A.M. Papini , and P. Rovero. Alpha actinin is specifically recognized by multiple sclerosis autoantibodies isolated using an N-glucosylated peptide epitope. Mol. Cell. Proteomics (2013) Feb;12(2):277-82. 4. S. Pandey, M.C. Alcaro, M. Scrima, E. Peroni, I. Paolini, S. Di Marino, F. Barbetti, A. Carotenuto, E. Novellino, A.M. Papini , A.M. D'Ursi, and P. Rovero. Designed glycopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. J.Med.Chem. (2012 ) Dec 13;55(23):10437-47. 5. C. Testa, F. Nuti, J. Hayek, C. De Felice, M. Chelli, P. Rovero, G. Latini, and A.M. Papini. Di(2- ethylhexyl)phthalate and Autism Spectrum Disorders. ASN NEURO (American Society for Neurochemistry) (2012 ) 4(4), 223-229 6. F. Nuti, E. Peroni, F. Real-Fernández, M.A. Bonache, A. Le Chevalier-Isaad, M. Chelli, N. Lubin-Germain, J. Uziel, P. Rovero, F. Lolli, and A.M. Papini . Post-translationally modified peptides efficiently mimicking neo- antigens: a challenge for theragnostics of autoimmune diseases. Biopolymers: Peptide Science (2010 ) 94, 6, 791-799. 7. A.M. Papini . The use of post-translationally modified peptides for detection of biomarkers of immune- mediated diseases. J. Pept. Sci . ( 2009), 15, 621-628. 8. A. Carotenuto, M.C. Alcaro, M.R. Saviello, E. Peroni, F. Nuti, A.M. Papin i, E. Novellino, and P. Rovero. Designed glycopeptides with different β-turn types as synthetic probes for the detection of autoantibodies, biomarkers of Multiple Sclerosis. J. Med. Chem . ( 2008 ) 51 , 5304-5309. 9. A. Carotenuto, A.M. D’Ursi, B. Mulinacci, I. Paolini, F. Lolli, A.M. Papini , E. Novellino, and P. Rovero. Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. J. Med. Chem . (2006 ) 49 , 5072-5079. 10. F. Lolli, B. Mulinacci, A. Carotenuto, B. Bonetti, G. Sabatino, B. Mazzanti, A.M. D’Ursi, E. Novellino, M. Pazzagli, L. Lovato, M.C. Alcaro, E. Peroni, M.C. Pozo-Carrero, F. Nuti, L. Battistini, G. Borsellino, M. Chelli, P. Rovero, and A.M. Papini . An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of Multiple Sclerosis. Proc. Natl. Acad. Sci., U.S.A. (2005 ) 102 (29 ), 10273-10278. 11. A.M. Papini . Simple test for Multiple Sclerosis. Nature Medicine (2005 ) 11(1), 13. 12. F. Lolli, B. Mazzanti, M. Pazzagli, E. Peroni, M.C. Alcaro, R. Lanzillo, V. Brescia Morra, L. Santoro, C. Gasperini, S. Galgani, M.M. D’ Elios, V. Zipoli, S. Sotgiu, M. Pugliatti, P. Rovero, M. Chelli, and A.M. Papini . The glycopeptide CSF114(Glc) detects serum antibodies in Multiple Sclerosis. J. Neuroimmunol. (2005 ) 167 (1-2), 131-137. Communication of the scientific activity 2001-2014: invited to present 94 lectures in International Symposia, Universities and Research Centres. 1997-2014: 38 oral & 206 poster communications selected in international symposia. 2009-2013: invited to present 10 lectures aimed to technology transfer in the global space of R&D (2 in extra-European