(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/191449 A2 17 December 2015 (17.12.2015) P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61Q 17/04 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/US20 15/034671 KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 8 June 2015 (08.06.2015) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (25) Filing Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/009,296 8 June 2014 (08.06.2014) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/082,026 19 November 2014 (19. 11.2014) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: SOLAZYME, INC. [US/US]; 225 Gateway DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Boulevard, South San Francisco, California 94080 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: SCHIFF-DEB, Celine; 225 Gateway GW, KM, ML, MR, NE, SN, TD, TG). Boulevard, South San Francisco, California 94080 (US). SHARMA, Suruchi; 225 Gateway Boulevard, South San Declarations under Rule 4.17 : Francisco, California 94080 (US). — as to applicant's entitlement to applyfor and be granted a (74) Agents: TERMES, Lance et al; Alston & Bird LLP, 101 patent (Rule 4.1 7(H)) South Tryon Street, Bank of America Plaza, Suite 4000, Published: Charlotte, North Carolina 28280-4000 (US). — without international search report and to be republished (81) Designated States (unless otherwise indicated, for every upon receipt of that report (Rule 48.2(g)) kind of national protection available): AE, AG, AL, AM, (54) Title: PERSONAL CARE PRODUCTS CONTAINING MICROALGAE OR EXTRACTS THEREOF (57) Abstract: Compositions and methods for their use as personal care products are disclosed. The compositions contain mi- croalgae or microalgal components and are MTT Assay beneficial for use in skin and hair care. Figure 1 PERSONAL CARE PRODUCTS CONTAINING MICROALGAE OR EXTRACTS THEREOF CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit under 35 U.S.C. 119(e) of US Provisional Patent Application No. 62/009,296, filed June 8, 2014 and US Provisional Patent Application No. 62/082,026, filed November 19, 2014, each of which is incorporated herein by reference in its entirety. BACKGROUND [0002] Consumer products for effectively maintaining or promoting healthy skin and hair are highly sought after. Skin and hair care products that can simultaneously prevent, improve, or reverse the effects of aging, ultraviolet radiation, and water loss are especially desirable, as are those that can also impart a luxurious feel and are absorbent and non-greasy. SUMMARY [0003] In an embodiment, the present invention provides compositions and methods for their use as personal care products. In some embodiments the compositions are formulated for topical administration. The compositions can contain cosmetic ingredients suitable for human use and are compatible with the microalgae or microalgal components provided herein. [0004] In one embodiment, provided is a method for preventing or treating ultraviolet radiation damage to human skin or hair, the method comprising applying to the human skin or hair an effective amount of a topical composition comprising one or more of a microalgae, an extract thereof, or a modified extract thereof, wherein the composition reduces thymine dimer formation and/or increases cell viability in the skin or hair. [0005] In one embodiment, provided is a method for increasing or controlling hydration in human skin or hair, the method comprising applying to the human skin or hair an effective amount of a topical composition comprising one or more of a microalgae, an extract thereof, or a modified extract thereof, wherein the composition increases hydration and/or limits water loss in the skin or hair. [0006] In one embodiment, provided is a method for improving appearance of skin in a human, the method comprising applying to the human skin an effective amount of a topical composition comprising one or more of a microalgae, an extract thereof, or a modified extract thereof, wherein the composition increases one or more of hyaluronic acid, collagen, or elastin in the skin. In some embodiments, the improvement in appearance comprises an improvement in one or more of fine lines, wrinkles, firmness, smoothness, softness, tone, radiance, luster, brightness, color, thickness, elasticity, or resiliency. [0007] In one embodiment, provided is a method for introducing or modifying a sensory property of a personal care composition, the method comprising blending a microalgae, extract thereof, or modified extract with the composition, wherein the sensory property is one or more of slipperiness, silkiness, absorbency, spreadability, moisture, or increased lather. [0008] In some embodiments, the composition is an emollient, a moisturizer, a cream, a liniment, a lotion, a soap, a balm, a shampoo, a hair conditioner, a hair mask, a skin oil, a hair oil, an ointment, a makeup, a sun care product, or a baby product. In some embodiments, the composition is a shaving cream, hand cream, or eye cream. [0009] In some embodiments, the composition is a skin toner. In some embodiments, the skin toner is applied after cleaning the skin to restore lost nutrients. [0010] In some embodiments, the composition is a nail care product. In other embodiments, the composition is a nail cream. [0011] In some embodiments, the composition is a makeup remover. In some embodiments, the makeup remover comprises a cell oil produced by a microalgae. In other embodiments, the makeup remover is a wipe or cream. In still other embodiments, the makeup remover is a mascara remover. In other embodiments, the makeup remover is a cold cream. [0012] In some embodiments, the compositions according to the present invention include, for example, skin cleaners such as soap, cleansing creams, cleansing lotions, cleansing milks, cleansing pads, facial washes, and body shampoos. In some cases, the composition is a cleansing oil or a face oil. [0013] In some embodiments, the compositions provided herein when applied to hair increases one or more of shine, combability, hair strength, resistance to UV damage, resistance to pollution damage, resistance to moisture loss, and resistance to split ends. In some embodiments, the makeup remover comprises a cell oil produced by a microalgae. [0014] In some embodiments, hair treated with a composition provided herein has one or more properties of: a) reduced entanglements; b) reduced snagging; c) reduced frizz; d) reduced split ends; e) less force required for brushing or combing; f) reduced breakage; g) increased resistance to heat damage such as from blow drying or hair irons; or h) increased shine as compared to untreated hair. [0015] In some embodiments, hair treated with a composition provided herein prevents or retards the progression of hair loss. [0016] In some embodiments, the composition is an exfoliant. The exfoliant is useful for removing skin cells such as dead skin cells, body oil, makeup, dirt, bacteria, and pore-occluding materials. In some embodiments the exfoliant is a facial scrub or a body scrub. In other embodiments the exfoliant can also be used in a facial mask or exfoliating serum. The exfoliant can be used to treat dry skin, psoriasis, rosacea, eczema, acne, acne scars, clogged pores (blackheads and whiteheads), and other skin conditions. The exfoliant can also have a moisturizing effect that eliminates the need to apply a separate moisturizer after use of the exfoliant. Use of the exfoliant compositions provided herein can be beneficial in allowing for one or more of the following features: cleaner skin, smoother skin, softer skin, improved complexion, improved luster, and greater resistance to skin blemishes and breakouts such as dry and/or colored patches, skin rashes, acne, blackheads, and whiteheads. In still other embodiments, the exfoliant compositions provided herein have an anti-microbial effect and can be used as a wound cleanser. [0017] In some embodiments, provided is a method for exfoliating skin, the method comprising: a) providing an exfoliant composition comprising microalgal cells, the cells comprising at least 10% oil by dry cell weight; b) applying the exfoliant composition to the skin; and c) rubbing the exfoliant composition against the skin, wherein friction between the microalgal cells and the skin removes at least the outermost layer of skin. [0018] The stratum corneum is the outer layer of dead skin cells and is typically 15-20 layers thick (10-20 micron thickness). In some embodiments of the exfoliant compositions and methods, at least two or more of the outermost skin layers are removed. In other embodiments, at least three or more of the outermost skin layers are removed. In other embodiments, at least four or more of the outermost skin layers are removed. In still other embodiments, up to 10 of the outermost skin layers are removed.