Table S1. Genes significantly altered in the thyroid glands of RccHan Wistar rats after a sub-chronically exposed to AA (3 mg/Kg bw/day) in drinking water. Fold Fold Fold Entrez Change Change Change Probe Name Gen bank Accession GeneID Gene Symbol Gene Name p-value MN MN p-value FN FN p-value FM FM A_64_P120327 XM_001078857 29605 Myh13 myosin, heavy chain 13, skeletal muscle 4.99E-02 -12.5 2.85E-01 NS 9.39E-02 NS A_44_P124219 NM_001013247 367086 Sln sarcolipin 3.51E-03 -6.8 2.48E-01 NS 7.88E-02 NS A_44_P435713 NM_001010970 24203 Amy1a amylase, alpha 1A (salivary) 2.13E-02 -6.7 3.06E-01 NS 5.04E-02 NS heat shock protein family, member 7 A_43_P15812 NM_031607 50565 Hspb7 (cardiovascular) 3.56E-02 -6.4 2.37E-02 -2.6 6.54E-02 NS A_64_P116108 XR_008539 4.43E-02 -5.9 2.54E-01 NS 4.31E-02 2.4 A_44_P116652 NM_019298 54240 Chrnd cholinergic receptor, nicotinic, delta 4.28E-02 -5.8 2.22E-01 NS 1.39E-02 2.5 A_42_P600215 NM_175844 286965 Abra actin-binding Rho activating protein 2.44E-02 -5.8 1.35E-01 NS 1.92E-01 NS A_44_P142837 XM_236702 316071 Xirp1 xin actin-binding repeat containing 1 3.79E-02 -5.8 1.62E-01 NS 2.08E-01 NS similar to Myosin light polypeptide 4 A_42_P643349 NM_001109495 688228 LOC688228 (Myosin light chain 1, atrial isoform) 3.98E-02 -5.6 1.52E-01 NS 1.35E-01 NS A_64_P107409 XM_001071732 498267 Dusp27 dual specificity phosphatase 27 (putative) 4.78E-02 -5.5 1.36E-01 NS 5.32E-02 NS A_64_P029501 NM_001034105 290561 Tnnc1 troponin C type 1 (slow) 4.95E-02 -5.5 1.69E-01 NS 2.93E-01 NS A_44_P217919 NM_001106148 291605 Myot myotilin 4.88E-02 -5.0 1.13E-01 NS 8.19E-02 NS A_64_P022654 NM_001109085 498316 LOC498316 hypothetical LOC498316 1.30E-02 -4.9 1.34E-01 NS 6.69E-02 NS SH3 domain binding glutamic acid-rich A_44_P471450 NM_001127682 498066 Sh3bgr protein 4.29E-02 -4.8 1.62E-01 NS 5.02E-02 NS A_44_P532133 XR_008863 1.80E-02 -4.8 2.44E-01 NS 1.02E-01 NS A_64_P102049 NM_001109401 680319 LOC680319 hypothetical protein LOC680319 3.67E-02 -4.7 1.17E-01 NS 2.69E-01 NS A_64_P042586 NM_001013039 259167 Art5 ADP-ribosyltransferase 5 1.47E-02 -4.6 6.83E-02 NS 8.88E-02 NS ubiquitin-conjugating enzyme E2Q family- A_64_P042302 NM_001145163 679949 Ube2ql1 like 1 2.05E-02 -4.6 9.87E-02 NS 1.64E-01 NS A_44_P352331 NM_001077590 365603 Bves blood vessel epicardial substance 2.85E-02 -4.5 9.05E-02 NS 6.22E-02 NS A_64_P130627 NM_001013930 298139 LOC298139 similar to RIKEN cDNA 2310003M01 4.52E-02 -4.5 2.48E-01 NS 5.16E-02 NS fibronectin type III and SPRY domain A_44_P503708 XM_001062337 308779 Fsd2 containing 2 4.42E-02 -4.4 9.03E-02 NS 4.75E-02 4.5 A_64_P102043 NM_001109401 680319 LOC680319 hypothetical protein LOC680319 4.62E-02 -4.4 8.25E-02 NS 4.34E-01 NS A_64_P060094 NM_001012001 301033 Lrrc2 leucine rich repeat containing 2 3.57E-02 -4.4 9.66E-02 NS 1.20E-01 NS A_44_P389448 XM_228900 317454 RGD1560334 similar to Myosin light chain 1 slow a 4.12E-02 -4.3 4.94E-01 NS 3.87E-01 NS A_64_P026858 NM_001106451 295315 Tbx15 T-box 15 4.39E-02 -4.3 1.39E-01 NS 2.99E-02 3.3 A_64_P100059 XM_213443 287659 Socs7 suppressor of cytokine signaling 7 4.44E-02 -4.2 1.47E-01 NS 2.80E-02 3.4 A_64_P165386 NM_001109333 502225 Lrrc14b leucine rich repeat containing 14B 3.61E-02 -4.2 1.02E-01 NS 2.25E-03 8.1 triggering receptor expressed on myeloid A_44_P354415 NM_001106885 301229 Trem1 cells 1 1.26E-04 -4.2 9.60E-01 NS 1.62E-01 NS A_64_P162476 NM_001107541 308873 Art1 ADP-ribosyltransferase 1 3.62E-02 -4.1 1.13E-01 NS 1.26E-01 NS potassium voltage-gated channel, Isk- A_64_P034740 NM_001101003 681190 Kcne1l related family, member 1-like 1.92E-02 -4.0 5.12E-01 NS 9.90E-03 4.7 acyl-Coenzyme A oxidase 2, branched A_44_P330188 NM_145770 252898 Acox2 chain 5.71E-03 -3.9 2.23E-03 -2.1 7.64E-02 NS A_44_P478313 XR_008378 4.72E-03 -3.9 2.44E-02 -1.6 6.03E-01 NS A_43_P12768 NM_053328 79431 Bhlhe40 basic helix-loop-helix family, member e40 9.78E-04 -3.9 1.78E-01 NS 1.73E-01 NS A_44_P1035007 NM_017194 29422 Chrne cholinergic receptor, nicotinic, epsilon 1.32E-02 -3.8 3.34E-01 NS 6.00E-03 4.0 ankyrin repeat and SOCS box-containing A_64_P099897 NM_001170749 680076 Asb14 14 3.63E-02 -3.7 8.52E-02 NS 3.86E-02 4.8 A_44_P384090 NM_022531 64362 Des desmin 4.91E-02 -3.6 6.76E-02 NS 9.33E-02 NS A_64_P311745 NM_001107987 313625 Myom3 myomesin family, member 3 1.52E-02 -3.6 1.09E-01 NS 1.72E-01 NS ATPase, (Na+)/K+ transporting, beta 4 A_43_P12790 NM_053381 84396 Atp1b4 polypeptide 3.51E-02 -3.6 1.08E-01 NS 1.40E-01 NS A_44_P390995 NM_013044 25566 Tmod1 tropomodulin 1 2.12E-02 -3.6 1.29E-01 NS 3.61E-02 3.6 C1q and tumor necrosis factor related A_44_P835847 NM_001134436 294806 C1qtnf3 protein 3 4.16E-03 -3.6 4.52E-02 -2.9 7.08E-02 NS A_64_P237784 XM_001073426 690139 Rbm24 RNA binding motif protein 24 1.11E-02 -3.5 2.03E-01 NS 4.51E-02 3.0 A_64_P082540 NM_145877 113886 Kif1c kinesin family member 1C 4.43E-02 -3.5 3.69E-02 -2.2 5.63E-01 NS A_44_P139291 NM_001135778 680409 Prodh proline dehydrogenase 3.76E-02 -3.5 1.28E-03 1.9 9.64E-01 NS A_44_P548611 XM_001054443 317224 Fndc3c1 fibronectin type III domain containing 3C1 1.62E-02 -3.5 8.68E-02 NS 9.89E-02 NS A_64_P137486 XM_001068161 688750 Cd209g CD209g molecule 8.19E-04 -3.5 3.06E-02 -2.0 1.04E-01 NS ankyrin repeat and SOCS box-containing A_64_P127488 XM_001055574 680076 Asb14 14 2.35E-02 -3.5 3.96E-02 -3.5 6.20E-02 NS A_43_P15638 NM_053861 116640 Tnc tenascin C 6.60E-03 -3.4 7.88E-01 NS 2.71E-02 5.1 A_44_P210852 NM_001034187 307472 Sh3rf2 SH3 domain containing ring finger 2 4.62E-02 -3.4 6.07E-02 NS 3.43E-02 2.6 A_43_P19787 XM_001054550 4.92E-02 -3.4 9.51E-01 NS 6.25E-01 NS A_42_P464434 XM_215498 7.25E-03 -3.4 4.75E-02 -3.9 2.09E-01 NS leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), A_64_P111058 NM_001037357 361493 Lilrb3l member 3-like 1.27E-02 -3.4 5.87E-02 NS 2.68E-01 NS cytochrome P450, family 2, subfamily e, A_44_P409232 NM_031543 25086 Cyp2e1 polypeptide 1 1.59E-03 -3.4 2.79E-01 NS 1.80E-02 2.4 glutamine-fructose-6-phosphate A_43_P18793 NM_001002819 360518 Gfpt2 transaminase 2 2.14E-02 -3.4 1.99E-02 -1.8 4.66E-02 2.2 A_42_P540920 NM_001135045 363153 Arpp-21 cyclic AMP-regulated phosphoprotein 4.51E-02 -3.4 1.51E-01 NS 3.74E-02 3.1 A_64_P074440 XM_001073426 690139 Rbm24 RNA binding motif protein 24 6.62E-03 -3.3 1.10E-01 NS 7.11E-02 NS A_64_P078862 NM_019183 29275 Actc1 actin, alpha, cardiac muscle 1 9.43E-03 -3.3 1.72E-01 NS 4.06E-02 3.3 A_44_P638191 XM_574086 498803 Otud1 OTU domain containing 1 1.48E-02 -3.3 3.21E-01 NS 2.02E-01 NS A_44_P135650 XM_001069604 311167 Smtnl1 smoothelin-like 1 3.77E-02 -3.3 1.49E-01 NS 7.14E-02 NS A_64_P161818 NM_001107985 313610 Extl1 exostoses (multiple)-like 1 4.03E-02 -3.3 1.59E-01 NS 3.37E-02 2.7 A_64_P023355 XM_001081149 4.71E-02 -3.3 1.58E-01 NS 2.32E-02 -2.4 A_64_P053785 NM_012739 25083 Adra2a adrenergic, alpha-2A-, receptor 6.63E-03 -3.3 2.33E-01 NS 1.98E-01 NS potassium voltage-gated channel, shaker- A_64_P000870 NM_001108914 365241 Kcna7 related subfamily, member 7 2.04E-02 -3.3 2.39E-02 -2.1 3.70E-01 NS A_64_P005581 NM_001038615 308099 Fndc1 fibronectin type III domain containing 1 1.85E-02 -3.3 4.97E-02 -1.6 3.58E-02 3.2 similar to Tumor necrosis factor, alpha- induced protein 3 (Putative DNA binding A_64_P101950 XM_001060914 683206 LOC683206 protein A20) (Zinc finger protein A20) 4.37E-02 -3.2 6.02E-01 NS 4.91E-01 NS A_64_P127789 XM_002729912 691933 LOC691933 similar to Protein C6orf142 homolog 4.00E-02 -3.2 8.47E-02 NS 1.08E-01 NS A_64_P095586 NM_001109085 498316 LOC498316 hypothetical LOC498316 6.93E-03 -3.2 1.19E-01 NS 1.05E-01 NS creatine kinase, mitochondrial 2, A_42_P615837 NM_001127652 688698 Ckmt2 sarcomeric 4.90E-02 -3.1 1.35E-01 NS 1.54E-01 NS A_44_P367761 NM_012923 25405 Ccng1 cyclin G1 2.10E-02 -3.1 3.78E-02 -3.9 1.48E-01 NS glutamic-oxaloacetic transaminase 1, A_44_P388973 NM_012571 24401 Got1 soluble (aspartate aminotransferase 1) 2.52E-02 -3.1 3.66E-01 NS 6.62E-02 NS A_44_P134143 NM_053612 113906 Hspb8 heat shock protein B8 4.12E-02 -3.1 1.53E-01 NS 4.11E-02 3.3 CAP, adenylate cyclase-associated protein, A_43_P12967 NM_053874 116653 Cap2 2 (yeast) 4.59E-02 -3.1 5.52E-02 NS 6.78E-02 NS similar to T-box transcription factor TBX15 A_64_P023715 XM_575564 500213 LOC500213 (T-box protein 15) (MmTBx8) 6.36E-04 -3.1 2.51E-01 NS 3.50E-01 NS ankyrin repeat and SOCS box-containing A_44_P621454 NM_001109216 499972 Asb10 10 3.41E-02 -3.1 4.19E-02 -2.1 8.64E-02 NS A_42_P476474 NM_001033926 25177 Fhl1 four and a half LIM domains 1 4.16E-02 -3.1 1.49E-01 NS 1.18E-01 NS A_64_P099452 NM_030828 58920 Gpc1 glypican 1 1.26E-02 -3.0 9.17E-02 NS 1.21E-01 NS A_64_P043161 NM_001127547 315191 Fbln1 fibulin 1 2.12E-02 -3.0 1.09E-01 NS 1.29E-01 NS ribonuclease, RNase A family, 2 (liver, A_42_P782235 NM_001007015 474169 Rnase2 eosinophil-derived neurotoxin) 1.97E-02 -3.0 1.97E-01 NS 6.02E-01 NS A_64_P100983 NM_001025008 314996 Klhl38 kelch-like 38 (Drosophila) 3.16E-02 -3.0 9.44E-02 NS 7.45E-02 NS A_64_P140275 NM_001107765 311348 Cdan1 congenital dyserythropoietic anemia, type I 4.82E-02 -3.0 5.64E-01 NS 6.89E-01 NS A_44_P112551 NM_001108180 315962 Ky kyphoscoliosis peptidase 1.91E-02 -3.0 3.14E-02 -2.5 4.14E-02 2.8 A_42_P765066 NM_021588 59108 Mb myoglobin 3.88E-02 -3.0 1.34E-01 NS 2.54E-01 NS wingless-type MMTV integration site family, A_64_P092782 NM_001109223 500047 Wnt16 member 16 1.34E-02 -3.0 1.70E-01 NS 7.50E-02 NS V-set domain containing T cell activation A_64_P078624 NM_001024244 295322 Vtcn1 inhibitor 1 1.89E-02 -2.9 1.29E-01 NS 4.06E-01 NS A_44_P478176 NM_001109637 691307 Lrrc39 leucine rich repeat containing 39 3.47E-02 -2.9 1.60E-01 NS 1.56E-01 NS