Electronic Supplementary Material (ESI) for Food & Function. This journal is © The Royal Society of Chemistry 2021 Supplementary File 1 Table S1 Targets corresponding to EACC components No. Gene ID Gene Symbol Description ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1A) (MDR1A) (Multidrug resistance 1 18671 Abcb1a protein 1A) (EC 7.6.2.2) (Multidrug resistance protein 3) (P-glycoprotein 3) (Phospholipid transporter ABCB1) (EC 7.6.2.1) ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1B) (Multidrug resistance protein 2 18669 Abcb1b 1B) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) 3 17250 Abcc1 (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette 4 26357 Abcg2 sub-family G member 2) (Breast cancer resistance protein 1 homolog) (Urate exporter) (CD antigen CD338) 5 27405 Abcg3 ATP-binding cassette sub-family G member 3 Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2- 6 66082 Abhd6 arachidonoylglycerol hydrolase) (Abhydrolase domain- containing protein 6) Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson 7 11350 Abl1 murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) 8 107476 Acaca (Acetyl-CoA carboxylase 265) Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD 9 11421 Ace antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 10 66190 Acer3 3.5.1.-) (EC 3.5.1.23) (Alkaline phytoceramidase) (aPHC) 11 11423 Ache Acetylcholinesterase (AChE) (EC 3.1.1.7) Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor 12 11477 Acvr1 R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L) Adenosine deaminase (EC 3.5.4.4) (Adenosine 13 11486 Ada aminohydrolase) Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha 14 11491 Adam17 convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'- 15 11534 Adk phosphotransferase) 16 11539 Adora1 Adenosine receptor A1 17 11540 Adora2a Adenosine receptor A2a 18 11541 Adora2b Adenosine receptor A2b 19 11548 Adra1b adrenergic receptor, alpha 1b Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) 20 11554 Adrb1 (Beta-1 adrenoceptor) Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) 21 11555 Adrb2 (Beta-2 adrenoceptor) Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) 22 11556 Adrb3 (Beta-3 adrenoceptor) Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) 23 269378 Ahcy (CUBP) (Liver copper-binding protein) (S-adenosyl-L- homocysteine hydrolase) Aldo-keto reductase family 1 member C21 (EC 1.1.1.-) (17-alpha-hydroxysteroid dehydrogenase) (17-alpha-HSD) (3(or 17)-alpha-hydroxysteroid dehydrogenase) (EC 24 77337 Akr1c21 1.1.1.209) (3-alpha-hydroxysteroid dehydrogenase) (Dihydrodiol dehydrogenase type 1) (DD1) (Dihydrodiol dehydrogenase type 3) (DD3) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B 25 11651 Akt1 alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene) ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic 26 11682 Alk lymphoma kinase) (CD antigen CD246) Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) 27 11689 Alox5 (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) Arachidonate 5-lipoxygenase-activating protein (FLAP) 28 11690 Alox5ap (MK-886-binding protein) Alkaline phosphatase, tissue-nonspecific isozyme (AP- 29 11647 Alpl TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase 2) (Alkaline phosphatase liver/bone/kidney isozyme) Aminopeptidase N (AP-N) (mAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) 30 16790 Anpep (Membrane protein p161) (Microsomal aminopeptidase) (CD antigen CD13) Membrane primary amine oxidase (EC 1.4.3.21) (Copper 31 11754 Aoc3 amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) Androgen receptor (Dihydrotestosterone receptor) 32 11835 Ar (Nuclear receptor subfamily 3 group C member 4) Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine 33 11886 Asah1 hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (N- 34 54447 Asah2 acylsphingosine amidohydrolase 2) [Cleaved into: Neutral ceramidase soluble form] Alkaline ceramidase 2 (AlkCDase 2) (Alkaline CDase 2) (maCER2) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine 35 230379 Asah3l deacylase 3-like) (Cancer-related gene liver 1 protein) (CRG-L1) (N-acylsphingosine amidohydrolase 3-like) Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora family kinase 1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora- related kinase 1) (Ipl1- and aurora-related kinase 1) 36 20878 Aurka (Serine/threonine-protein kinase 6) (Serine/threonine- protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (Aurora/IPL1- related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK- 37 20877 Aurkb 1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine- protein kinase aurora-B) Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic 38 54140 Avpr1a hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein 39 23821 Bace1 cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) Beta-secretase 2 (EC 3.4.23.45) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein 40 56175 Bace2 cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase) Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) 41 12038 Bche (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) Bcl-2-related protein A1 (A1-A) (Hemopoietic-specific 42 12044 Bcl2a1 early response protein) (Protein BFL-1) 43 12061 Bdkrb1 B1 bradykinin receptor (B1R) (BK-1 receptor) Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte 44 12143 Blk kinase) (p55-Blk) Serine/threonine-protein kinase B-raf (EC 2.7.11.1) 45 109880 Braf (Proto-oncogene B-Raf) 46 105246 Brd9 Bromodomain-containing protein 9 47 12209 Brs3 Bombesin receptor subtype-3 (BRS-3) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell 48 12229 Btk progenitor kinase) (BPK) (Bruton tyrosine kinase) (Kinase EMB) Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate 49 71934 Ca13 dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) Carbonic anhydrase 15 (EC 4.2.1.1) (Carbonate 50 80733 Ca15 dehydratase XV) (Carbonic anhydrase XV) (CA-XV) Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate 51 12354 Ca7 dehydratase VII) (Carbonic anhydrase VII) (CA-VII) Voltage-dependent calcium channel subunit alpha- 2/delta-1 (Voltage-gated calcium channel subunit alpha- 52 12293 Cacna2d1 2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] Calcitonin gene-related peptide type 1 receptor (CGRP 53 54598 Calcrl type 1 receptor) (Calcitonin receptor-like receptor) Calcium/calmodulin-dependent protein kinase type II 54 12322 Camk2a subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase type II 55 12323 Camk2b subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine 56 59035 Carm1 methyltransferase 1) (Protein arginine N- methyltransferase 4) Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting 57 12362 Casp1 enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p17, mature form; 58 12365 Casp14 Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP 59 12367 Casp3 cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase- 60 12370 Casp8 8 subunit p18; Caspase-8 subunit p10] Extracellular calcium-sensing receptor (CaSR) 61 12374 Casr (Parathyroid cell calcium-sensing receptor) (PCaR1) Cholecystokinin receptor type A (CCK-A receptor) (CCK- 62 12425 Cckar AR) (Cholecystokinin-1 receptor) (CCK1-R) Gastrin/cholecystokinin type B receptor (CCK-B receptor) 63 12426 Cckbr (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) C-C motif chemokine 2 (Monocyte chemoattractant