An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_900635165Cyc: Escherichia coli servovar O2:K1:H4 str. NCTC11151 Cellular Overview Connections between pathways are omitted for legibility. 4-amino-4- deoxy-α-L- arabinopyranosyl ditrans,octacis -undecaprenyl putrescine putrescine glutathione thiosulfate a hexose 6- poly-β-1,6- phosphate L-tartrate N,N'- 3+ 3+ a dipeptide L-homoserine O-acetyl-L-serine O-acetyl-L-serine 1-(β-D 1-(β-D spermidine spermidine cys glutathione sulfate sulfate phosphate phosphate Fe Fe D-cellobiose an aromatic an aromatic thr diacetylchitobiose phosphate phosphate phosphate N-acetyl-D- thiamine thr (R)- cys cys spermidine spermidine succinate molybdate protoheme a hydroxamate a tripeptide amino acid amino acid shikimate ribofuranosyl) ribofuranosyl) ammonium sulfate sulfate sulfate phosphate (S)-lactate Fe 3+ glucosamine arbutin a dipeptide diphosphate pantothenate nicotinamide nicotinamide sulfate dCTP Fe 3+ salicin 4-amino-4-deoxy- predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted L-arabinose- ABC ABC ABC ABC ABC ABC PEP-driven ABC ABC ATP-driven RS19820 RS16350 RS24005 RS10085 RS02420 phosphoundecaprenol RS06595 RS12535 RS22665 RS16660 transporter transporter RS12370 RS12375 transporter RS17955 transporter RS03340 RS04550 transporter RS07310 RS23450 RS23545 transporter RS20775 transporter of N,N'- RS00160 RS01195 RS03765 transporter RS22890 RS00585 RS08605 RS19380 RS17400 transporter transporter RS12190 RS15340 RS05700 RS00885 RS19605 RS12815 flippase of spermidine/ of spermidine/ of L-cysteine/ of glutathione of sulfate/ of sulfate diacetylchitobiose of phosphate of Fe3+ of Fe3+ putrescine putrescine glutathione thiosulfate poly-β-1,6- L-homoserine O-acetyl-L-serine O-acetyl-L-serine 1-(β-D 1-(β-D spermidine spermidine phosphate phosphate protoheme D-cellobiose 6'-phosphate an aromatic an aromatic thiamine thr (R)- molybdate dCTP a hydroxamate 3+ N-acetyl-D- thr shikimate cys cys ammonium succinate sulfate sulfate sulfate (S)-lactate Fe a tripeptide a dipeptide amino acid amino acid 4-amino-4- ribofuranosyl) ribofuranosyl) phosphate phosphate 3+ glucosamine arbutin-6-phosphate diphosphate pantothenate sulfate N,N'- a hexose 6- Fe deoxy-α-L- nicotinamide nicotinamide L-tartrate 3+ 3+ a dipeptide salicin 6-phosphate putrescine putrescine glutathione glutathione thiosulfate sulfate phosphate phosphate Fe Fe arabinopyranosyl diacetylchitobiose spermidine spermidine cys sulfate ditrans,octacis 6'-phosphate -undecaprenyl phosphate Cofactor, Carrier, and Vitamin Biosynthesis Nucleoside and Nucleotide Degradation Degradation/ Metabolic Regulator Biosynthesis Utilization/ an inactive a peptidoglycan dimer an O 6 - a nascent sn-glycero-3- UDP-N-acetyl- a holo-[EntF a [protein] N-acetyl-α- an N ω -(1- Assimilation - Other a reduced a [protein]- ditrans,octacis- peptidoglycan D- a lipid II a ribonucleoside an L-asparaginyl- an L-alanyl- superpathway of ubiquinol- superpathway of pyrimidine ribonucleoside methylguanine α formate Fermentation mixed acid fermentation SAM with pentapeptide L-cysteine undecaprenyldiphospho- peptidoglycan phospho-N- -D-muramoyl- L-seryl-carrier ser C-terminal glu D-muramoyl- Asn hydroxy-2- Pro biotin biosynthesis I superpathway of menaquinol-8 biosynthesis I [2Fe-2S] iron-sulfur superpathway of flavin biosynthesis I (bacteria and plants) prenylated superpathway of tetrahydrofolate biosynthesis superpathway of coenzyme A biosynthesis I (bacteria) 2-carboxy-1,4- adenosylcobinamide-GDP superpathway of pyridoxal 5'-phosphate biosynthesis and salvage thiamine salvage II NAD de novo biosynthesis NAD salvage ppGpp metabolism superpathway of purine deoxyribonucleosides degradation purine nucleotides degradation II (aerobic) superpathway of pyrimidine uracil degradation III acetoacetate flavodoxin alanyl-DAP crosslink diphosphate [tRNA ] [tRNA ] ATP 8 biosynthesis (prokaryotic) citrate lyase activation trehalose biosynthesis I glycine betaine deoxyribonucleosides degradation triphosphate stems (meso- in DNA N-acetyl-(N- (meso-DAP (arachidonoyl) L-alanyl-γ-D- protein] L-glutamate class 1b L-alanine(1-) oxopropyl) biotin xanthine xanthine cluster biosynthesis demethylmenaquinol-8 biosynthesis I FMNH naphthoquinol biosynthesis salvage from cobinamide I I (from aspartate) pathway III (to mannosylglycerate ribonucleosides degradation degradation RS17645 2 3-methyl-2- a 5,10- 4-amino-2-methyl-5- biosynthesis I reductase diaminopimelate acetylglucosaminyl) containing) ethanolamine glutamyl-meso-2,6- ribonucleoside- -[protein]- uracil uracil biosynthesis D-erythrose nicotinamide riboside) biosynthesis I phosphoenolpyruvate 2'-deoxycytidine uracil (to acetyl CoA) bifunctional murein serine-type formate IPP a malonyl-[acp] chorismate cob(II)inamide pyrimidinemethanol pppGpp D-glucopyranose (Gram-negative cytidine containing) bifunctional muramoyl-L-alanyl-γ- diaminopimeloyl- L-arginine L-cysteine desulfurase chorismate oxobutanoate methylenetetrahydrofolate chorismate 3'-dephospho-CoA 4-phosphate asp GDP-α-D- enterobactin D-Ala-D-Ala 30S ribosomal diphosphate N-acetylmuramoyl- aminoacyl-tRNA Cys- malonyl-ACP O- GTP GTP NADP + UDP-α-D-glucose 2'-deoxyguanosine AMP cytidine β DD-endopeptidase/ dehydrogenase- prenol DMAPP isochorismate cob(I)yrinic acid bifunctional 6-phosphate bacteria) cytidine pyrimidine utilization acetoacetate anaerobic DNA-binding D-isoglutaminyl-N-( - membrane-bound glycerophosphodiester D-alanyl-D-alanine biosynthesis carboxypeptidase: protein S6--L- reductase: L-alanine hydrolase: tRNA(Pro) bifunctional isopentenyl- isochorismate erythrose-4- L-aspartate mannose deaminase: acetoacetyl-CoA murein LD- N subunit methyltransferase isochorismate 3-methyl-2-oxobutanoate synthase a,c-diamide 2-(5''-triphosphoribosyl)- hydroxymethylpyrimidine GTP choline pyruvate kinase: pyk phosphoenolpyruvate deaminase: 2'-deoxyadenosine ribonucleoside- transcriptional D-asparaginyl)-L-lysyl- phosphodiesterase: glutamate ligase: nrdF nrdE amidase EL024_RS14245 /Cys- biotin-- uracil RS06995 uracil choline RS18560 choline synthase cysteine GTP phosphate oxidase: EL024_RS08895 protein A: rutA N-acetylmuramoyl- lytic murein carboxypeptidase: bifunctional EL024_RS02795 protein alpha: fdnG diphosphate BioC: bioC synthase GTP hydroxymethyltransferase: adenosyltransferase: guanosine-5'- alpha,alpha- pyruvate kinase I: carboxylase: bifunctional UDP- transferase: regulator/O6- D-alanyl-D-alanine [acetyl-CoA- a malonyl-[acp] MenF: menF desulfurase MenF: menF 3'-dephosphocoenzyme- kinase/ EL024_RS06615 pyrophosphokinase: guanosine-3',5'- 2-O-(α-D- EL024_RS08895 thymidine triphosphate L-alanine transglycosylase EL024_RS08425 serine-type isochorismatase/ [+ 3 isozymes] EL024_RS16155 ribonucleotide- AmiB: amiB aminoacyl-tRNA deglycase tRNA(Cys) Delta-isomerase: cyclohydrolase dehydrogenase: + sugar hydrolase/ uridine EL024_RS08500 EL024_RS08725 formate MenF: menF cyclohydrolase panB isochorismate [corrinoid cobO A synthase: phosphomethylpyrimidine 2-iminosuccinate NAD EL024_RS05340 bis(diphosphate) triphosphate,3'- trehalose- EL024_RS11965 EL024_RS23235 purine-nucleoside reductase- methylguanine-DNA deacylase carboxylase] methyl ester CsdA: csdA mannosyl)- 5 amidase MltC: mltC glycerophosphodiester D-Ala-D-Ala aryl carrier diphosphate [+ 3 isozymes] hydrolase: HchA: hchA EL024_RS04755 isochorismate II: ribA I FolE: folE EL024_RS04575 diphosphate phosphate thymidine 5'-nucleotidase: uridine FMN-N -oxide (Z)-3-ureidoacrylate acetoacetyl-CoA methyltransferase murein DD- dehydrogenase- ligase/biotin adenosyltranferase]- EL024_RS17290 kinase: thiD 3'-diphosphatase: betaine aldehyde 2'-deoxyuridine adenosine phosphorylase: activating protein: protein EntB: YbaK: ybaK + + beta-ketoacyl- [+ 2 isozymes] isochorismate 2,5-diamino-6- 7,8- 4-phospho- NAD(+) 3-phospho- EL024_RS17810 AmiB: amiB peptidoglycan [+ 2 isozymes] phosphodiesterase: carboxypeptidase: a N- a [protein] C- reductase: EL024_RS19180 protein H RS10640 H formate RS15870 formate asp 2-succinyl-5- α quinolinate EL024_RS00360 diphosphatase: synthase: phosphorylase: deoD phosphorylase: Ada: endopeptidase N subunit operon DMAPP (5-phospho-D- cob(II)inamide 2'-(5''-triphospho- -D- D-glycerate pyruvate oxaloacetate deaminase: acetyl-CoA C- EL024_RS21500 [+ 3 isozymes] glycosyltransferase EL024_RS01455 EL024_RS02795 EL024_RS17375 acetylglucosamine- terminal α-L- EL024_RS08440 N-acetyl-D- deglycase ACP synthase II: 2-succinyl-5- an S-sulfanyl-[L- prenyl phosphate dihydroneopterin 2-dehydropantoate enolpyruvyl- D-erythronate HMP-P synthase diphosphatase: deoA [+ 4 isozymes] GMP EL024_RS23885 EL024_RS08545 MepM: mepM D-ala alpha: fdnG repressor 2-succinyl-5- ribosylamino) ribosyl)-3'-dephospho-CoA EL024_RS24240 EL024_RS10875 mannosyl-3- EL024_RS12250 pyrimidine/purine ureidoacrylate FtsI: ftsI glutamate-α- EL024_RS08445 EL024_RS15010 cysteine desulfurase] 3'-triphosphate aspartate 1- 6-hydroxy-3- 4-phosphoerythronate EL024_RS23015 acetyltransferase: a mature a nascent [+ 3 isozymes] [+ 2 isozymes] -N-acetylmuramyl- a 2'- ala muramate YajL: yajL enolpyruvyl- 5-(2-hydroxyethyl) NadA: nadA Pro BirA: birA 2-dehydropantoate