ABSTRACTS DRAFT ANNUAL MEETING OF THE WHO GLOBAL BURULI ULCER INITIATIVE 15-17 MARCH 2006 GENEVA, SWITZERLAND 1 © World Health Organization 2006 All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. The named authors alone are responsible for the views expressed in this publication. 2 Table of content ENDEMIC COUNTRIES ACTIVITIES ............................................................................................ 6 Buruli ulcer in Cameroon: activities carried out in 2005 (C. Nsom Mba) ............................................. 8 Côte d'Ivoire - Annual overview 2005 (M. Diabaté)............................................................................ 12 New Buruli ulcer control activities conducted in 2005 in the Democratic Republic of the Congo (DRC): confirmation of Buruli ulcer cases by polymerase chain reaction (PCR) in former foci (cases in Bandundu province) (J. Singa Nyota).............................................................................................. 18 The Buruli ulcer situation in Gabon (L. Bayonne Manou).................................................................. 20 Programme activities: Buruli ulcer – Ghana, 2005 (E. Ampadu) ........................................................ 24 Buruli ulcer control in Guinea during 2005 (A. M. Bangoura) ........................................................... 27 Escalating Buruli ulcer situation in Nzara – Southern Sudan ((I. Sindani).......................................... 31 Status of Buruli ulcer disease in Moyo and Adjumani districts, Uganda (H. Wabinga)...................... 33 Review of the situation of Mycobacterium ulcerans infection (Buruli ulcer) in French Guyana in 2005.(P. Couppié) ................................................................................................................................ 34 Mycobacterium ulcerans in Australia – 2005 report (P. Johnson)....................................................... 36 NGO ACTIVITIES ............................................................................................................................. 38 Activities related to Buruli ulcer control carried out by ALES in 2005 in Cameroon (A. Um Boock) 40 Activities related to Buruli ulcer control, carried out by ALM (2005–2006) (P. Saunderson) ........... 43 ANESVAD (V. Malda) ........................................................................................................................ 45 Support provided by Luxembourg Raoul Follereau Foundation (FFL) to Buruli control activities in Benin in 2005 and prospects for the future (E. China/R. Kohll) . ...................................................... 50 Update on the project to treat Buruli ulcer using hyperbaric oxygen therapy, Allada, Benin (F. Poggio) ............................................................................................................................................ 51 ANTIBIOTIC TREATMENT AND OTHER TREATMENTS...................................................... 52 Antibiotic treatment at the Pobè center, Benin – update (A. Chauty).................................................. 54 Role of treatment with topical antibiotics (rifampicin and streptomycin) in the treatment of Mycobacterium ulcerans infection on a facial site (M. Phanzu).......................................................... 56 Clinical response and bacterial killing during antibiotic treatment of M. ulcerans disease (R. Phillips/M. Wansbrough-Jones)................................................................................................... 57 The in vitro and in vivo activities of rifampicin, streptomycin, amikacin, moxifloxacin, R207910, linezolid and PA-824 against Mycobacterium ulcerans (B. Ji) ............................................................ 59 Clinical and therapeutic trial of hydrated aluminium silicate to treat Buruli ulcer (J. Son) ................. 60 3 CASE MANAGEMENT ..................................................................................................................... 62 The benefits of controlled scar formation in surgical case management of Buruli ulcer (R. Zilliox) .. 64 Organization of case management of Buruli ulcer in the Democratic Republic of the Congo: the case of the IME/Kimpese hospital in Bas-Congo province (M. Phanzu). ................................................... 65 Advances in the treatment of Buruli ulcer with hyperbaric oxygen therapy in the CDTUB of Allada (Benin) – pilot study (G. Leigheb) ....................................................................................................... 67 Combination of surgery and chemotherapy in the management of Buruli ulcer: the benefits (P. Agbenorku). ................................................................................................................................... 68 PREVENTION OF DISABILITIES.................................................................................................. 71 Presentation of a tool to facilitate sharing of knowledge and know-how for the prevention of disabilities linked to BU (V. Simonet)................................................................................................ 733 How to organize and develop pod activities in Buruli ulcer management (L. Lehman).................... 766 Adequate positioning to prevent disabilities in Buruli ulcer (L. Lehman)........................................... 78 LABORATORY CONFIRMATION OF CASES ............................................................................ 79 How a diagnostic system operates in Ghana (G. Bretzel) .................................................................... 81 Benefits and drawbacks of pathological diagnosis of Buruli ulcer: partnership with an NGO in Benin (P. Chemaly) ........................................................................................................................................ 85 SURVEILLANCE AND TRAINING ................................................................................................ 87 Oral presentation at the annual meeting of the Global Buruli Ulcer Initiative – integrating BU control in peripheral level health facilities (A. Tiendreobeogo) ...................................................................... 89 The value of community mobilization for Buruli ulcer control: the case of the pilot project in Taabo, Côte d'Ivoire (J. Aké Aké).................................................................................................................... 90 ECONOMIC AND SOCIAL RESEARCH....................................................................................... 93 Buruli ulcer, poverty, and poverty reduction in rural Ghana, 2003 (G. Mumma) .............................. 95 Determinants of Buruli ulcer (BU) costs for households and treatment facilities, Ghana, 2000–2003 (G. Mumma) ........................................................................................................................................ 97 Buruli ulcer: an illness of exclusion. lived experiences and social isolation of Buruli patients in Cameroon (J. Muela Ribera) ............................................................................................................... 99 The socio-economic impact of Buruli ulcer on households and communities in Cameroon (K. Peeters)......................................................................................................................................... 100 4 "CAB – cost analysis buruli: development of a software to assess the clinical treatment costs of Buruli ulcer" (M. Stöcker)............................................................................................................................. 101 Disease and witchcraft in Ayos, Cameroon: an illustration of the complexity of the different thought patterns present among the population through an analysis of a debate between local elites (A. de Almeida).................................................................................................................................. 102 BASIC RESEARCH.......................................................................................................................... 105 Molecular characterization of Mycobacterium ulcerans strains from different geographical locations in Australia and South East Asia (J. Fyfe).............................................................................................