Supplementary Table S4. FGA co-expressed gene list in LUAD tumors Symbol R Locus Description FGG 0.919 4q28 fibrinogen gamma chain FGL1 0.635 8p22 fibrinogen-like 1 SLC7A2 0.536 8p22 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 DUSP4 0.521 8p12-p11 dual specificity phosphatase 4 HAL 0.51 12q22-q24.1histidine ammonia-lyase PDE4D 0.499 5q12 phosphodiesterase 4D, cAMP-specific FURIN 0.497 15q26.1 furin (paired basic amino acid cleaving enzyme) CPS1 0.49 2q35 carbamoyl-phosphate synthase 1, mitochondrial TESC 0.478 12q24.22 tescalcin INHA 0.465 2q35 inhibin, alpha S100P 0.461 4p16 S100 calcium binding protein P VPS37A 0.447 8p22 vacuolar protein sorting 37 homolog A (S. cerevisiae) SLC16A14 0.447 2q36.3 solute carrier family 16, member 14 PPARGC1A 0.443 4p15.1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha SIK1 0.435 21q22.3 salt-inducible kinase 1 IRS2 0.434 13q34 insulin receptor substrate 2 RND1 0.433 12q12 Rho family GTPase 1 HGD 0.433 3q13.33 homogentisate 1,2-dioxygenase PTP4A1 0.432 6q12 protein tyrosine phosphatase type IVA, member 1 C8orf4 0.428 8p11.2 chromosome 8 open reading frame 4 DDC 0.427 7p12.2 dopa decarboxylase (aromatic L-amino acid decarboxylase) TACC2 0.427 10q26 transforming, acidic coiled-coil containing protein 2 MUC13 0.422 3q21.2 mucin 13, cell surface associated C5 0.412 9q33-q34 complement component 5 NR4A2 0.412 2q22-q23 nuclear receptor subfamily 4, group A, member 2 EYS 0.411 6q12 eyes shut homolog (Drosophila) GPX2 0.406 14q24.1 glutathione peroxidase 2 BMP6 0.405 6p24-p23 bone morphogenetic protein 6 TTC39C 0.402 18q11.2 tetratricopeptide repeat domain 39C CATSPERB 0.401 14q32.12 catsper channel auxiliary subunit beta XBP1 0.401 22q12.1|22q12X-box binding protein 1 PIM3 0.398 22q13 Pim-3 proto-oncogene, serine/threonine kinase ID1 0.396 20q11 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein AKR1C2 0.396 10p15-p14 aldo-keto reductase family 1, member C2 ATP2A2 0.395 12q24.11 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 EPAS1 0.395 2p21-p16 endothelial PAS domain protein 1 C2CD4D 0.393 1q21.3 C2 calcium-dependent domain containing 4D SHTN1 0.391 10q25.3 shootin 1 GK 0.391 Xp21.3 glycerol kinase PDIA3P1 0.385 1q21.1 protein disulfide isomerase family A, member 3 pseudogene 1 CHMP1B 0.385 18p11.21 charged multivesicular body protein 1B PCSK9 0.384 1p32.3 proprotein convertase subtilisin/kexin type 9 PDIA3 0.384 15q15 protein disulfide isomerase family A, member 3 DACT2 0.381 6q27 dishevelled-binding antagonist of beta-catenin 2 HSP90B1 0.38 12q24.2-q24.3heat shock protein 90kDa beta (Grp94), member 1 PRR26 0.379 10p15.3 proline rich 26 MISP 0.378 19p13.3 mitotic spindle positioning KSR1 0.375 17q11.2 kinase suppressor of ras 1 TC2N 0.375 14q32.12 tandem C2 domains, nuclear CPE 0.374 4q32.3 carboxypeptidase E SCARB1 0.372 12q24.31 scavenger receptor class B, member 1 SPINK1 0.372 5q32 serine peptidase inhibitor, Kazal type 1 LGSN 0.371 6pter-q22.33lengsin, lens protein with glutamine synthetase domain FRAT2 0.37 10q24.1 frequently rearranged in advanced T-cell lymphomas 2 GK3P 0.369 4q32.1 glycerol kinase 3 pseudogene AKR1C1 0.369 10p15-p14 aldo-keto reductase family 1, member C1 MSMB 0.367 10q11.2 microseminoprotein, beta- FAAH2 0.366 Xp11.21 fatty acid amide hydrolase 2 SEMA4G 0.366 10q24.31 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G HHIPL2 0.364 1q41 HHIP-like 2 LINC00319 0.363 21q22.3 long intergenic non-protein coding RNA 319 PPP1R3B 0.363 8p23.1 protein phosphatase 1, regulatory subunit 3B SLC7A11 0.361 4q28.3 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 NR4A1 0.361 12q13 nuclear receptor subfamily 4, group A, member 1 MAP2K6 0.359 17q24.3 mitogen-activated protein kinase kinase 6 BASP1 0.358 5p15.1 brain abundant, membrane attached signal protein 1 CARD14 0.357 17q25 caspase recruitment domain family, member 14 ITIH2 0.357 10p15 inter-alpha-trypsin inhibitor heavy chain 2 GABARAPL10.355 12p13.2 GABA(A) receptor-associated protein like 1 MAPK4 0.355 18q21.1 mitogen-activated protein kinase 4 MTMR7 0.355 8p22 myotubularin related protein 7 RASD1 0.353 17p11.2 RAS, dexamethasone-induced 1 PLEKHG2 0.352 19q13.2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 PITPNC1 0.352 17q24.2 phosphatidylinositol transfer protein, cytoplasmic 1 CLPX 0.352 15q22.31 caseinolytic mitochondrial matrix peptidase chaperone subunit HNF1A 0.351 12q24.2 HNF1 homeobox A FXR2 0.35 17p13.1 fragile X mental retardation, autosomal homolog 2 BHLHA15 0.349 7q21.3 basic helix-loop-helix family, member a15 CHML 0.349 1q43 choroideremia-like (Rab escort protein 2) PDE3B 0.348 11p15.1 phosphodiesterase 3B, cGMP-inhibited CABYR 0.348 18q11.2 calcium binding tyrosine-(Y)-phosphorylation regulated TRIM31 0.348 6p21.3 tripartite motif containing 31 AVPI1 0.347 10q24.2 arginine vasopressin-induced 1 RFK 0.347 9q21.13 riboflavin kinase TMEM254 0.347 10q22.3 transmembrane protein 254 NNMT 0.345 11q23.1 nicotinamide N-methyltransferase NARS 0.344 18q21.31 asparaginyl-tRNA synthetase KCTD3 0.343 1q41 potassium channel tetramerization domain containing 3 RDH10 0.343 8q21.11 retinol dehydrogenase 10 (all-trans) CSGALNACT10.342 8p21.3 chondroitin sulfate N-acetylgalactosaminyltransferase 1 THPO 0.341 3q27 thrombopoietin DLGAP1-AS10.341 18p11.31 DLGAP1 antisense RNA 1 KIAA1549 0.341 7q34 KIAA1549 ATP8B1 0.34 18q21.31 ATPase, aminophospholipid transporter, class I, type 8B, member 1 FAM46A 0.339 6q14 family with sequence similarity 46, member A ZBED1 0.338 Xp22.33;Yp11zinc finger, BED-type containing 1 WDR72 0.337 15q21.3 WD repeat domain 72 RPH3AL 0.337 17p13.3 rabphilin 3A-like (without C2 domains) CNPY2 0.337 12q15 canopy FGF signaling regulator 2 AMBP 0.336 9q32-q33 alpha-1-microglobulin/bikunin precursor PRKAA2 0.335 1p31 protein kinase, AMP-activated, alpha 2 catalytic subunit KIT 0.335 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog GPT2 0.335 16q12.1 glutamic pyruvate transaminase (alanine aminotransferase) 2 CYP24A1 0.335 20q13 cytochrome P450, family 24, subfamily A, polypeptide 1 DHTKD1 0.335 10p14 dehydrogenase E1 and transketolase domain containing 1 FECH 0.335 18q21.3 ferrochelatase PNKD 0.334 2q35 paroxysmal nonkinesigenic dyskinesia BPIFA1 0.334 20q11.2 BPI fold containing family A, member 1 CCDC64 0.334 12q24.23 coiled-coil domain containing 64 PDE3A 0.334 12p12 phosphodiesterase 3A, cGMP-inhibited FAM222A 0.333 12q24.11 family with sequence similarity 222, member A PCSK1 0.332 5q15-q21 proprotein convertase subtilisin/kexin type 1 DOCK5 0.332 8p21.2 dedicator of cytokinesis 5 PPIB 0.331 15q21-q22 peptidylprolyl isomerase B (cyclophilin B) SMOC1 0.331 14q24.2 SPARC related modular calcium binding 1 FKBP11 0.331 12q13.12 FK506 binding protein 11, 19 kDa LARP4 0.33 12q13.12 La ribonucleoprotein domain family, member 4 CHL1 0.33 3p26.1 cell adhesion molecule L1-like MCF2L 0.33 13q34 MCF.2 cell line derived transforming sequence-like TMED6 0.33 16q22.1 transmembrane emp24 protein transport domain containing 6 SUDS3 0.329 12q24.23 suppressor of defective silencing 3 homolog (S. cerevisiae) GLCE 0.329 15q23 glucuronic acid epimerase CDH17 0.329 8q22.1 cadherin 17, LI cadherin (liver-intestine) SPTSSA 0.329 14q13.1 serine palmitoyltransferase, small subunit A DNAJC12 0.329 10q22.1 DnaJ (Hsp40) homolog, subfamily C, member 12 MPDU1 0.328 17p13.1-p12mannose-P-dolichol utilization defect 1 TAT 0.327 16q22.1 tyrosine aminotransferase VIMP 0.327 15q26.3 VCP-interacting membrane selenoprotein GLDC 0.327 9p22 glycine dehydrogenase (decarboxylating) AIFM2 0.326 10q22.1 apoptosis-inducing factor, mitochondrion-associated, 2 KCNK3 0.326 2p23 potassium channel, two pore domain subfamily K, member 3 GSTP1 0.324 11q13 glutathione S-transferase pi 1 AKR1C3 0.324 10p15-p14 aldo-keto reductase family 1, member C3 SLC45A4 0.324 8q24.3 solute carrier family 45, member 4 ATP2A3 0.324 17p13.3 ATPase, Ca++ transporting, ubiquitous KIF21A 0.323 12q12 kinesin family member 21A HYAL1 0.322 3p21.31 hyaluronoglucosaminidase 1 MCCC2 0.322 5q12-q13 methylcrotonoyl-CoA carboxylase 2 (beta) ODC1 0.322 2p25 ornithine decarboxylase 1 RIMKLB 0.321 12p13.31 ribosomal modification protein rimK-like family member B CHD1L 0.321 1q12 chromodomain helicase DNA binding protein 1-like COL25A1 0.32 4q25 collagen, type XXV, alpha 1 STARD10 0.32 11q13 StAR-related lipid transfer (START) domain containing 10 AACS 0.32 12q24.31 acetoacetyl-CoA synthetase VAPA 0.319 18p11.22 VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa IFT81 0.319 12q24.13 intraflagellar transport 81 CA8 0.318 8q12.1 carbonic anhydrase VIII ENO3 0.317 17p13.2 enolase 3 (beta, muscle) ISG20 0.317 15q26 interferon stimulated exonuclease gene 20kDa DCTN6 0.317 8p12 dynactin 6 ETS2 0.316 21q22.2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 DECR1 0.314 8q21.3 2,4-dienoyl CoA reductase 1, mitochondrial PCSK6 0.313 15q26.3 proprotein convertase subtilisin/kexin type 6 TRAF2 0.313 9q34 TNF receptor-associated factor 2 MUC5B 0.313 11p15.5 mucin 5B, oligomeric mucus/gel-forming PITX2 0.313 4q25 paired-like homeodomain 2 F7 0.312 13q34 coagulation factor VII (serum prothrombin conversion accelerator) GRAMD1A 0.312 19q13.13 GRAM domain containing 1A BTG1 0.312 12q22 B-cell translocation gene 1, anti-proliferative NOSTRIN 0.311 2q31.1 nitric oxide synthase trafficking ADSSL1 0.311 14q32.33 adenylosuccinate synthase like 1 BAG1 0.311