Seventh Congress of the International BioIron Society (IBIS) Biennial World Meeting (BioIron 2017) May 7 – 11, 2017 UCLA Meyer & Renee Luskin Conference Center | Los Angeles, USA Featuring Special Events: Introductory Course – May 7, 2017 “Essentials of BioIron for Clinicians and Scientists” “Meet the Expert” Sessions for Trainees May 10 – 11, 2017 INTERNATIONAL BIOIRON SOCIETY PROGRAM BOOK Acknowledgments IBIS This conference has received support from the NIH NCATS UCLA CTSI Grant Number UL1TR0001881. This conference has received support from the NIH/NIDDK R-13 Grant. This conference has received support from the NIXHNHLBI-R-13 Grant. Seventh Congress of the International BioIron Society Page 2 Table of Contents IBIS Seventh Congress of the Internationl BioIron Society (IBIS) Biennial World Meeting (BioIron 2017) May 7 - 11, 2017 UCLA Meyer & Renee Luskin Conference Center | Los Angeles, USA Welcome Message ..............................................................................................................................Page 4 Board of Directors ................................................................................................................................Page 5 General Meeting Information ...............................................................................................................Page 6 Special Events .....................................................................................................................................Page 8 Local Activities .....................................................................................................................................Page 9 Acknowledgments .............................................................................................................................Page 10 Program Schedule .............................................................................................................................Page 11 Keynote Speaker ...............................................................................................................................Page 51 Abstracts ............................................................................................................................................Page 52 Featured Podium/Poster Abstracts .......................................................................................Page 52 Podium Abstracts ..................................................................................................................Page 61 Poster Abstracts .................................................................................................................Page 116 Late-Breaking Abstracts .....................................................................................................Page 325 Alphabetical Index of Presenters .....................................................................................................Page 378 Meeting Title Page 3 Welcome IBIS Dear Friends and Colleagues, Welcome to the Seventh Congress of the International BioIron Society (IBIS) being held at the University of California, Los Angeles. In keeping with the character of the organization, the BioIron 2017 Meeting is held is a different continent every biennial cycle, returning to North America for the first time since Vancouver in 2011. This continues to be an exciting time in the field of iron research. Molecular discoveries over the past two decades have led to a rapid expansion in the number of potential biomarkers and targets for treatment for iron-related diseases. Indeed many of these discoveries hold promise to make major contributions to the well-being of a large number of people suffering from iron-related disorders across the globe. The program planned by the IBIS Board and Local Organizing Committee reflects this broadening character of the most compelling questions in iron research. This year, we are including two celebratory sessions: The 30-year anniversary of the discovery of the iron responsive elements, which laid the foundation for understanding cellular iron regulation, and the 50-year anniversary of therapeutic iron chelation which improved and prolonged the lives of so many patients with iron overload. These sessions feature outstanding presentations highlighting not only why these events were so seminal, but where they provide opportunities for future application. We especially welcome participants new to iron research. In keeping with past several meetings, the first day will be an introductory course to provide a helpful framework for critical understanding of the research to be presented during the main meeting. The course is intended for an audience of diverse backgrounds, and provides ample time for questions. We strongly encourage trainees in the audience to contribute to this discussion. In addition to scheduled opportunities for trainees to meet-the-experts, we have added two special “Interviews with the Masters” to share the wisdom provided by long and highly successful careers in iron research. The name of our organization serves as an acknowledgement that science is a social as well as investigative process. We hope you will take time to enjoy the wonderful setting the Southern California provides. We will have a communal outing to the beautiful and unique Getty Museum on Tuesday afternoon, and a fun, entertaining Gala and Awards Dinner to close the meeting. We wish to express our gratitude to all our sponsors for their generous contributions to this event. It is impossible to hold a meeting of this scope and caliber without the contributions from the biotechnology and pharmaceutical companies that ultimately translate scientific discovery into practical applications. We equally appreciate the support from National Institutes of Health in providing travel bursaries for trainees to attend this meeting. We would also like to express our thanks for the highly professional organizational work performed by Heather Swanson and her staff at W.J. Weiser. Most of all, we are grateful to each of you for contributing your time and effort to participate in this global sharing of ideas and discoveries. Thank you again for being part of BioIron 2017. Robert E Fleming, MD, IBIS President Elizabeta Nemeth, PhD and Tomas Ganz, MD, PhD, Co-Chairs of the Local Organizing Committee Ioav Cabantchik PhD, IBIS President-Elect Seventh Congress of the International BioIron Society Page 4 Board of Directors IBIS OFFICERS President Stefano Rivella, PhD Robert E. Fleming, MD Philadelphia, PA, USA St. Louis, MO, USA Laura Silvestri, PhD President-Elect Milan, Italy Ioav Cabantchik, MD, PhD Jerusalem, Israel Program Committee Robert E. Fleming, MD Secretary St. Louis, MO, USA Helene Coppin, PhD Toulouse Cedex, France Tomas Ganz, MD, PhD Los Angeles, CA, USA Treasurer Domenico Girelli, MD, PhD Elizabeta Nemeth, PhD Verona, Italy Los Angeles, CA, USA Past President Local Organizing Committee Greg Anderson, PhD Tomas Ganz, MD, PhD Brisbane, Australia Los Angeles, CA, USA Board Of Directors Elizabeta Nemeth, PhD Director Los Angeles, CA, USA Robert W. Evans, BA, PhD Uxbridge Middlesex, United Kingdom Headquarter Office WJ Weiser & Associates, Inc. Yelena Ginzburg, MD 1100 E. Woodfield Road, Suite 350 New York, NY, USA Schaumburg, IL 60173 Mitchell Knutson, PhD Executive Director Gainesville, FL, USA Heather Swanson Schaumburg, IL Elizabeta Nemeth, PhD Los Angeles, CA, USA ABSTRACT REVIEWERS Hossein Ardehali, MD, PhD Sonia Levi, PhD Paulo Arosio, PhD Sijin Liu, PhD Ioav Cabantchik, MD, PhD Bryan Mackenzie, PhD Clara Camaschella, MD Esther Meyron-Holtz, PhD Nica Cappellini, MD Elizabeta Nemeth, PhD Hal Drakesmith, PhD Guangjun Nie, PhD Caroline Enns, PhD Kostas Pantopoulos, PhD Mark D. Fleming, MD, DPhil Sant-Rayn Pasricha, MBBS, MPH, PhD Robert E. Fleming, MD John B. Porter, MA, MD, FRCP DRCPath Lucia De Franceschi, MD Grant Ramm, PhD Tomas Ganz, MD, PhD Marie-Paule Roth, MD, PhD Iqbal Hamza, PhD Tracey Rouault, MD Zoubida Karim, PhD Yatrik Shah, PhD Mitchell Knutson, PhD Laura Silvestri, PhD Jan Krijt, PhD V. Nathan Subramaniam, PhD Samira Lakhal-Littleton, PhD Dorine Swinkels, PhD Seventh Congress of the International BioIron Society Page 5 General Meeting Information IBIS Dates of the Conference May 7 – 11, 2017 On Sunday, May 7, 2017, registration will open at 9:00 and the Welcome Reception will begin at 18:30. The BioIron 2017 Meeting will begin with the Opening Ceremony on Monday, May 8, 2017 at 8:00 and will conclude on Thursday, May 11, 2017 at 19:00 with the Gala Dinner and Award Ceremony. Venue Meyer & Renee Luskin Convention Center 425 Westwood Plaza Los Angeles, California, 90095 (855) 522-8252 luskinconferencecenter.ucla.edu Language The official language of the BioIron 2017 Conference will be English. Weather Los Angeles averages a daily maximum temperature for May that's between 72 and 77 degrees Fahrenheit (22 to 25 degrees Celsius). The minimum temperature usually falls between 55 and 59 °F (13 to 15 °C). This time of year may also garner some rain, so waterproof wear is recommended. Money The official currency of Los Angeles, California, USA is the United States Dollar (USD). Notes: $100, $50, $20, $10, $5, $1 Coinage: quarter (25 cents), dime (10 cents), nickel (5 cents), penny (1 cent) Cards: Access, MasterCard, American Express, Diners Club, VISA are widely accepted in shops, restaurants, etc. Retailers now have the option to charge more for goods and services bought by credit card, although they are obliged to display a clear indication that