American Heart Association® Vascular Discovery: For information on upcoming From Genes to Medicine American Heart Association Scientific Conferences, visit professional.heart.org Cardiovascular diseases afflict people of all races, ethnicities, genders, religions, ages, sexual orientations, national origins and disabilities. The American Heart Association is committed to ensuring that our workforce and volunteers reflect the world’s diverse population. We know that such diversity will enrich us with VASCULAR DISCOVERY: the talent, energy, perspective and inspiration we need to achieve our mission: From Genes to Medicine building healthier lives, free of cardiovascular diseases and stroke. Scientific Sessions 2019 Final Program May 14-16, 2019 | Boston Marriott Copley Place Hotel | Boston, Massachusetts American Heart Association® Vascular Discovery: This annual scientific meeting of the American Heart Association is sponsored by the Council on Arteriosclerosis, From Genes to Medicine Thrombosis and Vascular Biology, Council on Peripheral Vascular Disease, and Council on Genomic and Precision Medicine, in collaboration with the Society of Vascular Surgery’s Vascular Research Initiatives Conference, and National Center 7272 Greenville Avenue the American Venous Forum. Dallas, Texas 75231-4596 ©2019, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. 3/19JN0960 Co-Director of the Fireman Vascular Center Department of Medicine Massachusetts General Hospital The Cardiology Division and the Fireman Vascular Center at the Massachusetts General Hospital are seeking an academic and clinical leader to serve as the Co-Director of the Fireman Vascular Center. Along with the Division Chief for Vascular Surgery, this individual will be jointly responsible for the full scope of clinical, research and educational activities of the Fireman Vascular Center as well as collaborative activities with the other components of the Center. (https://www.massgeneral.org/vascularcenter/ ) Appointment as a Professor or Associate Professor at Harvard Medical School will be commensurate with experience, training and achievements in addition to teaching activities. Suitable candidates must be board certified in internal medicine, cardiovascular diseases and in vascular medicine. Interested candidates should send a personal statement with research and academic interests, three potential referees and Curriculum Vitae to: The American Heart Association would like to thank Verve Therapeutics or its support of the Vascular Discovery 2019 Scientific Sessions. Chair, Fireman Vascular Center Co-Director Search Committee Massachusetts General Hospital 55 Fruit Street, GRB-800 Boston, MA 02114 [email protected] We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law. Contents Abstracts Abstracts .......................................................................................................................... 33 Author Index ..................................................................................................................... 90 Abstract Topic List ............................................................................................................ 33 Conference Highlights Early Career Activities ........................................................................................................ 13 Lectures and Awards ........................................................................................................ 15 Faculty Abstract Reviewers ............................................................................................................. 8 Invited Moderators .............................................................................................................. 7 Invited Presenters ............................................................................................................... 6 Program Committee ............................................................................................................ 5 General Information ................................................................................................................. 10 Learning Objectives ........................................................................................................... 10 Exhibits ............................................................................................................................. 10 Information for Presenters Speaker Resource Room .................................................................................................. 12 Poster Set-up/Tear-Down Schedule .................................................................................. 12 ePosters ........................................................................................................................... 12 Policy Information .................................................................................................................... 20 Program at a Glance .................................................................................................................. 2 Program Agenda Tuesday, May 14 ............................................................................................................... 21 Wednesday, May 15 .......................................................................................................... 25 Thursday, May 16 .............................................................................................................. 31 Room Locator ........................................................................................................................... 9 Ticketed Events Joint Council Dinner .......................................................................................................... 14 Mentor of Women Luncheon ............................................................................................. 14 Next Generation Technology Bootcamp ............................................................................ 14 Program at a Glance Monday Tuesday Wednesday Thursday May 13, 2019 May 14, 2019 May 15, 2019 May 16, 2019 7:00 AM Registration, Early Career Registration, Early Career Breakfast, Training Continental Training 7:30 AM 7:30-8:30 AM Exhibits Session 1 Breakfast, Session 2 SDG/CDA Exhibits Showcase 8:00 AM 8:00 AM-7:00 PM 8:00-10:00 AM 8:00-9:30 AM Vascular Conference Opening and Plenary Session III: 8:30 AM 8:30-10:30 AM Research Plenary Session I: Intersections Between the Poster Session 9:00 AM Initiatives Innovative Methods Vascular System and Cancer and Continental Conference in Vascular Discovery 9:30 AM 9:30-10:00 AM Breakfast 2019 Speakers Corner/Break/Exhibits 10:00 AM Separate 10:00-10:30 AM 10:00-11:45 AM registration Speakers Corner/Break/Exhibits Concurrent Session III required A – Therapeutic Targets in 10:30 AM 10:30 AM-12:15 PM 10:30 AM-12:00 PM Concurrent Session I Atherosclerosis Plenary Session V A – Molecular and Cellular B – Blood Coagulation and Invited Lecture Series Mechanisms of Antithrombotic Therapy Hoeg Award Lecture Atherosclerosis C – Translational Science in Keynote Lecture B – Molecular, Developmental Vascular Medicine: Vascular Distinguished and Cellular Biology of the Dysfunction Lecture 11:30 AM Vessel Wall 11:45 AM-1:00 PM C – Translational Science in Next-Generation Technology Vascular Medicine: Research Bootcamp: Single Cell Sequencing Priorities in Thrombosis Session sponsored by the ATVB 12:00 PM 12:00-6:00 PM 12:15-1:30 PM Early Career Committee and the Noon KinMet Next-Generation Technology Closing Remarks/ 12:30 PM Diversity Committee Bootcamp: Data Science Adjourn Separate 11:45 AM-1:45 PM 1:00 PM 1:00-6:00 PM PVD Annual Business Meeting 1:00-7:00 PM registration Or lunch on your own CAAC-CSVM and Networking Luncheon 8:00 AM-Noon required Symposium HDL Structure- 12:15-1:45 PM and China Function Workshop The Mentor of Women Award Night Luncheon Separate registration Separate 12:15-2:15 PM required registration Or lunch on your own required 1:30 PM 1:45-3:45 PM Plenary Session IV 2:00 PM 2:15-3:45 PM Plenary Session II: Young Investigator Award 2:30 PM Highlights from the ATVB Journal Competition – Brinkhous Prize and 3:00 PM 3:00-7:00 PM Page Award Vascular 3:30 PM 3:45-4:15 PM 3:45-4:15 PM Discovery Refreshment Break/Exhibits Refreshment Break/Exhibits Registration 4:00 PM 4:15-6:00 PM 4:15-6:00 PM Concurrent Session II Concurrent Session IV 4:30 PM A – Apolipoproteins, Lipoproteins A – Metabolic Disorders and 5:00 PM and Lipid Metabolism Atherosclerosis 5:30 PM B – Vascular Cells, Inflammation B – Platelet Production, Signaling and Thrombosis and Function C – Strategically Focused C – Translational Science in Research Network on Vascular Vascular Medicine: Pro/Con Disease Debate – The Utility of Genomics in the Future of Medicine 6:00 PM 6:00-8:00 PM 6:00-8:00 PM Poster Session 1 and Reception Poster Session 2 and Reception 6:30 PM Sponsored by the ATVB Journal 7:00 PM 7:00-11:30 PM CAAC 7:30 PM Reception 8:00 PM 8:00-10:30 PM Joint Council Dinner 8:30 PM (ticket required) 9:00 PM 10:00 PM 2 Become an AHA/ASA Professional Member and save up to $300 off next year’s registration. Questions and Information Questions If you have questions after