A student-led research publication of the George Washington University School of Medicine and Health Sciences | Spring 2019, Volume XII Table of Contents: ON THE COVER On the cover is a photograph of a section of A student-led research publication of the George Washington University School of Medicine and Health Sciences | Spring 2019, Volume XII healthy mouse hippocampus tissue (near the dentate gyrus) at 30 days of age. The tissue is stained for nuclei (blue), astrocytes (green), and glucose transporter GLUT8 (red). The image was produced during research conducted by Madhuri Rao, MSII. Photos like Rao’s, capturing the beauty and intricacy of science, are featured annually in the George Washington University (GW) School of Medicine and Health Sciences (SMHS) Art of Science Contest. The competition began in 2018 as a means of highlighting the research that SMHS medical students, graduate students, and postdoctoral fellows are conducting. This year, more than 17 images were submitted, an increase from last year’s competition, and fve entries were chosen as winners. A grand prize of $250 was awarded to Brett Eaton, a PhD student who submitted an image of Samantha Dow, Naemeh Pourshafe, and Jessica the Marburg virus budding from infected dendritic Schenck. cells. Prizes of $100 were awarded to four other The winning images will be displayed in Ross entrants, all GW PhD students — Rachel Burga, Hall, alongside the winners from last year. WILLIAM H. BEAUMONT BASIC SCIENCE Juan Nogues, The Effect of TET Mutations RESEARCH PRIZE WINNERS on DNA Methyltransferase Cytotoxicity and ERV Arjun Panda, A Machine Learning Approach Induction in B- and T-Cell Malignancies to Mapping Co-regulated Variant Loci and Gene p 20–21 Maria Abigail Cerezo, Expression over Time p 12–13 Evaluation of Longitudinal Madhuri Rao, A Developmental Profle of Antibody Responses in Caitlin Ward, Association of SREBF1 and Glucose Transport and Utilization in Mice Zika-Infected Individuals TOM1L2 Polymorphisms with Bone and Muscle p 22–23 from Colombia . p. 6–7 Phenotypes p 14–15 Mohamed Al-Amoodi, The Association Sharjeel Chaudhry, Daniel Bestourous, FAM210A and of Polymorphism rs3736228 Within the LRP5 Prevention of SOST Polymorphisms Are Associated with Gene with Bone Mineral Density in a Cohort of Cardiovascular Thrombosis Musculoskeletal Phenotypes in Healthy Young Caucasian Young Adults p 24–25 through Inhibition of Adults p 15–16 Coagulation Factor Ryan Lee, Association of GREB1 XII . p. 8–10 Gifty Dominah, Programmed Death Polymorphisms with Bone and Muscle Health Ligand 1 Is a Negative Prognostic Marker in Phenotypes p 25–26 Recurrent Isocitrate Dehydrogenase-Wildtype Neil Almeida, CyTOF Glioblastoma p 16–18 analysis provides insight into immune response Jeffrey Roberson, Molecular Examination CLINICAL RESEARCH to H3.327M neoantigen of Hidradenitis Suppurativa in Clinical Samples: Abigail Pepin, Evaluating Racial Disparities peptide vaccine in glioma Towards Understanding Mechanisms and in Breast Cancer Referrals for Hereditary Risk patients ......... p. 10 –11 Exploring Therapeutic Targets p 18–19 Assessment p 27–28 Fusion ♦ 2018 THE GEORGE Table of Contents: WASHINGTON UNIVERSITY Ari Mandler, Utilization of Ancillary Services Natalie Pudalov, Cortical Thickness THOMAS LEBLANC, PhD for Voice and Swallowing Outcomes Following Asymmetries in MRI-Abnormal Pediatric George Washington University (GW) Cardiothoracic Surgery p 29 Epilepsy Patients: A Potential Metric for Surgery President Outcome p 44 JEFFREY S. AKMAN, MD ’81, RESD ’85 Chantal Nguyen, Depth-Camera Measured Vice President for Health Afairs Biomechanics of the Lower Extremity Reveal Nikhil Gowda, Perioperative Complications Walter A. Bloedorn Professor of Movement Abnormalities and Targets for Associated with Congestive Heart Failure Administrative Medicine Prevention in ACL Reconstructed Patients in Elderly Patients Following Primary Hip Dean of the School of Medicine p 29–30 Hemiarthroplasty p 45–46 and Health Sciences (SMHS) ROBERT MILLER, PhD, Christina Darwish, Trends in Treatment Nisha Kapani, Impact of Mesenchymal Vice President for Research at GW, and Strategies and Comparison of Outcomes Stem/Stromal Cell Intra-Arterial Delivery During Senior Associate Dean for Research, in Lymph Node Positive Bladder Cancer Pediatric Cardiac Surgery on Neurogenesis in Vivian Gill Distinguished Research p 31–32 the Porcine Subventricular Zone p 47–48 Professor, Professor of Anatomy and Regenerative Biology at SMHS ALISON K. HALL, PhD Dana Perim, Impact of Smoking on Sowmya Mangipudi, Long-term Changes Outcomes Following Knee and Shoulder in Flow-Mediated Dilation Among Post- Associate Dean for Research Workforce Development, Professor of Neurology Arthroscopy p 32–33 Operative Abdominal Aortic Aneurysm Patients p 48–49 William H. Beaumont Medical David Daniel, Comparison Between Research Society Executive Board Medical Therapy and Endovascular Treatment of Stephanie Rodriguez, Racial disparities the Extracranial Atherosclerotic Vertebral Artery in Late-Stage Prostate Cancer: A SEER Database Abigail Pepin, Co-President Alva Powell, Outreach Ofcer Disease: A Systematic Review p 33–34 Analysis 2005–15 p 50–52 Neil Almeida, Co-President Nikhil Gowda, Fusion Ofcer Harleen Marwah, The Impact of Insulin Tess Whiteside, Developing a Method Dependence on Post-Operative Complications to Objectively Assess Sensory Nerve Fiber in Diabetic Patients Undergoing Anatomic Sensitivity: A Pilot Study p 52–53 Student Editorial Board: Pulmonary Resections p 35–37 Abby Pepin Andrea Klein Thomas Zaikos, Laparoscopic Hand- Armon Panahi Ishaan Dharia, Intubation Related Vocal Assisted Resection of a Rare Intra-Adrenal Dhanusha Subramani Cord Paresis: Outcomes from a Patient Cohort Schwannoma p 53–55 Diego Zegarra p 38 George Thomas Vikas Kotha, Risk Factors for Amputation Hira Mohyuddi Leora Aizman, Provider Differences Following Lower Extremity Free Tissue Transfer Murwarit Rahimi in Management of Normal Second Stage in a Chronic Wound Population p 55–56 Neil Almeida Nikhil Gowda p 39–40 Puneet Gupta Samantha Terhaar Melissa Peace, Screening for Vocal Cord MEDICAL EDUCATION Paralysis in High-Risk Premature Infants After Patent Ductus Arteriosus Ligation p 41 Tirsit Makonnen, Sustainable Project Management Team: Development Goals and Mental Health Thomas Kohout Knowledge Among First-Year Medical Students Michelle Peng, Rectus Fascia vs Fascial Katherine Dvorak p 56–57 Ashley Rizzardo Lata for Autologous Fascial Pubvaginal Sling: A Single-Center Comparison of Perioperative and Functional Outcomes p 42–43 Fusion is a publication of the George Washington University School of Medicine and Health Sciences William H. Beaumont Medical Research Honor Society. This research journal is published by students in collaboration with the Ofce of the Dean and the Ofce of Communications and Marketing. TABLE OF CONTENTS 1 Letters: From the Editors: As part of the George amongst our students, faulty, and staf. We Washington University aim to support GW’s goal to expand and (GW) School of Medicine enhance research experiences for its students and Health Sciences’ (SMHS) as an opportunity to learn and become future mission to educate, research, leaders in medicine and health sciences felds. and heal, GW medical stu- We would like to ofer our congratulations dents have the opportunity to to this year’s William H. Beaumont Medical conduct research in a multi- Honor Society Student Research Award win- tude of felds. The William H. ners. These individuals and their research Beaumont Medical Research projects stood out as exceptional in quality Honor Society aims to pro- among their peers. mote inquiry-based research This year’s edition would not have been pos- to train physician-scientists for sible without the support of many individuals. the future. This journal, run We would like to thank former presidents, Neil Almeida, MSII by the William H. Beaumont Janine Amirault and Sarah McCormack, for Society, is an entirely student- their continued involvement and support of run publication including this organization. We would like to thank research conducted by GW our faculty adviser, Dean Alison Hall, for her medical students while in wisdom and support. We would also like to medical school. This year’s thank the SMHS Ofce of Communications collection of abstracts refects and Marking for the design and produc- a sample of the diverse student tion of this year’s edition. Finally, we would research being conducted at like to thank our classmates and peers who SHMS from basic science to volunteered their time to edit the abstracts clinical research to public submitted, without whom this journal could health initiatives. not exist. As co-presidents of the On behalf of the William H. Beaumont William H. Beaumont Medical Medical Research Honor Society’s executive Research Honor Society, we board and members, we hope you enjoy the aim to provide a forum to learn 2019 edition of Fusion! Abby Pepin, MSII about peer research, inspire future and matriculating med- ical students, and serve as an outlet to share research experiences of GW Neil Almeida, MSII medical students. We hope that this journal Abby Pepin, MSII inspires a dialogue to continue the sharing Co-Presidents of the William H Beaumont of new knowledge and passion for research Medical Research Honor Society 2 Fusion ♦ 2019 Letters: From the Faculty Adviser: It’s an honor to assist with this edition of of each class joins the clinical Fusion magazine that highlights research done and translational research