CURRICULUM VITAE Mustafa F. Lokhandwala, Ph.D. EDUCATION Degree Year Institution Field B.Pharm 1966 L.M.College of Pharmacy Pharmacy Ahmedabad, India M.S. l968 Columbia University Pharmacology New York, New York Ph.D. 1975 University of Houston Pharmacology Houston, Texas PROFESSIONAL APPOINTMENTS Title Institution Dates Dean College of Pharmacy 2008-2009 University of Houston Director Heart and Kidney Institute 2006-present University of Houston Executive Vice Dean College of Pharmacy 2003-present For Research University of Houston Dean College of Pharmacy 1991-2002 University of Houston Professor Department of Pharmacology 1989-present University of Houston Chairman Department of Pharmacology 1980-1991 University of Houston Associate Professor Department of Pharmacology 1981-1989 University of Houston Assistant Professor Department of Pharmacology 1975-1981 University of Houston Research Assistant Department of Pharmacology 1970-1971 Columbia University/Ciba-Geigy New York and Tuckhoe, N.Y. OTHER APPOINTMENTS Adjunct Professor Hypertension & Clinical Pharmacology 1989-present Baylor College of Medicine Houston, Texas Adjunct Associate Hypertension & Clinical Pharmacology 1986-1989 Professor Baylor College of Medicine Houston, Texas Visiting Professor University of Rome September, 1989 Rome, Italy Visiting Professor The Third Military Medical University March, 2007 Chongqing, P.R.China RESEARCH INTERESTS, TRAINING AND TECHNIQUES Cardiovascular and Renal Pharmacology Hypertension and Antihypertensive Drug Mechanisms Central and peripheral control of the cardiovascular and renal function Role of oxidative stress in hypertension, diabetes and aging - receptor-G protein coupling - drug responsiveness - antioxidant supplementation - redox imbalance and role of transcription factors - activators of antioxidant responsive elements Dopamine, Dopamine Receptor Agonists and Cardiovascular Function Dopamine receptor function in obesity, diabetes, hypertension and aging Dopamine receptor mediated cellular signalling mechanisms in the proximal tubule Role of kidney dopamine in sodium balance and control of blood pressure Oxidative stress and D1 receptor signal transduction in the kidney Research Techniques Measurements of inflammatory, reactive oxygen species and several biomarkers in hypertension, aging and diabetes In vivo measurements of cardiac function including output, contractility Measurements of venous return and vascylar rsistance in various beds Sympathetic nerve stimulation induced changes in cardiac and renal function Measurements of renal function including renal plasma flow, glomerular filtration rate, sodium excretion, pressure natriuresis relationships 2 Cardiovascular and renal responses to drugs and other maneuvers in models of diabetes, hypertension and aging. Research Accomplishments Identification of presynaptic dopamine receptors on sympathetic nerve terminals under in vivo conditions and the demonstration that activation of these receptors was responsible, at least in part for the vasodilator action of dopamine. Demonstration of the uncoupling of D1 receptor in proximal tubule from the G-protein in hypertension and in aging Hyperglycemia and hyperinsulinemia contribute to receptor-G protein uncoupling in type I and type II diabetes, respectively. Improvement of insulin sensitivity in diabetic rats with drug therapy restores D1 receptor-G protein coupling and renal responsiveness to dopamine. The mechanism by which oxidative stress and inflammation contribute to various diseases: Studies on the role of NFkB, Nrf2 and Phase II antioxidant enzymes. AWARDS & HONORS University of Houston chapter of Sigma Xi, The Scientific Research Society’s Research Excellence Award for 1993. Individual Educational Excellence Award, Texas Pharmacy Foundation, 2000 Robert A. Boblitt Rho Chi Lectutre, 2004 TEACHING EXPERIENCE Pharmacology Principles of Drug Action Hypertension/Antihypertensive Agents Angina/Antianginal Agents Graduate Courses Adrenergic/Cholinergic Pharmacology Cardiovascular pharmacology Cardiovascular research techniques Advances in renal pharmacology GRADUATE STUDENTS 3 A. A. Martinez, Ph.D. (l980) Dissertation title: Involvement of sympathetic nervous system in the cardiovascular actions of 5-hydroxytryptamine G. J. Hom, M.S. (l980) Thesis title: Presynaptic inhibition of sympathetic nervous system by adenosine: physiological & pharmacological implications S. J. Augustine, M.S. (l98l) Thesis title Characteristics and mechanisms of clonidine withdrawal in normotensive and hypertensive rats A.T. Hamed, Ph.D. (l98l) Dissertation title: Pharmacological significance of cardiovascular dopamine receptors R. J. Barrett, Ph.D. (l982) Dissertation title: Role of sympathetic nervous system dopamine receptors in the cardiovascular actions of lergotrile and pergolide E. J. Peter, M.S. (l984) Thesis title: Pharmacological analysis of the actions of calcium entry blockers felodipine, nifedipine and verapamil: Interactions with pre and postsynaptic alpha adrenoceptors. S. Sengupta, M.S. (1985) Thesis title: Pharmacological characterization of the cardiovascular actions of dopamine receptor agonists, fenoldopam and quinpirole in rats. M. H. Sabouni, Ph.D. (1986) Dissertation title: Pharmacological characterization of dopamine receptors in the sympathetic ganglia G. Kavukondala, M.S. (1986) Thesis title: The role of Na+-K+-ATPase in the regulation of sympathetic neuro- effector function in the isolated perfused rat kidney S. S. Hegde, Ph.D. (1990) Dissertation title: Renal dopamine in the regulation of sodium and water excretion during acute volume expansion S. J. Vyas, Ph.D. (1992) Dissertation title: Involvement of tubular DA-1 receptors in the natriuretic and diuretic responses to dopamine and dopexamine: Role of Phospholipase-C in cellular signaling events C. J. Chen, M.D. Ph.D. (1992) Dissertation title: Dopamine receptor- coupled cellular signaling mechanisms in renal proximal tubules of spontaneously hypertensive rats S. Gopalakrishnan, M.S. (1994) Thesis title: Alpha-1 adrenoceptors in the renal proximal tubules: Characterization and cellular signaling mechnisms 4 U. Venkatakrishnan, M.S. (1994) Thesis title: The role of nitric oxide in the diuretic and natriuretic responses to dopamine-1 receptor activation V. Kansra, M.S. (1995) Thesis title: Dopamine stimulates protein kinase C activity in normotensive but not in hypertensive rats M. Bharatula, M.S. (1996) Thesis title: Characterization of Angiotensin Type I (AT1) Receptor Subtypes in the Biphasic Effect of Angiotensin II on Renal Proximal Tubular Sodium Potassium ATPase V. Kansra, Ph.D. (1997) Dissertation title: Renal dopamine receptor signaling mechanisms in Fisher 344 old rats S. Beheray, Ph.D. (1999) Dissertation title: Age related alterations in dopamine receptor-mediated signaling pathways in renal proximal tubules M. Becker M.S. (1999) Alterations in angiotensin II receptor mediated signaling pathways in the renal proximal tubules of obese Zucker hypertensive rats V. Narkar Ph.D. (2002) Dissertation title: Dopamine D2 receptor signaling and function in renal proximal tubules M. Menezes M.S. (2002) Thesis title: Alterations in dopamine D2-like receptor signaling mechanisms in renal proximal tubules of Fischer 344 rats. M. Trivedi Pharm.D. / Ph.D. (2004) Renal dopamine receptor dysfunction in obese Zucker rats. A. Marwaha Ph.D. (2005) Renal dopamine D1 receptor function in hyperglycemia associated oxidative stress R. Fardoun Pharm.D. / Ph.D. (2006) Cellular mechanisms of oxidative stress-induced defective renal dopamine D1 receptor function A. B. Muhammad Ph.D. (2010) Effect of exercise and caloric restriction on renal dopamine D1 receptor function in obese Zucker rats. L. George Pharm.D. / Ph.D. (2010) Mechanism of exercize-mediated restoration of renal dopamine D1 receptor function in aging. 5 S. Bhatt Ph.D. (2011) Vascular oxidative stress in hyoertension G. Chough Ph.D. (2011) Role of age-associated oxidative stress in altered renal D1 and AT1 receptor fuhctions and hypertension. A. Javedhkar Ph.D. (2011) Oxidative stress and renal AT1 receptor function during hypertension. POSTDOCTORAL FELLOWS AND RESEARCH FACULTY Dr. R. D. Ekas 1978-1982 Dr. D. C. Eikenburg 1979-1981 Dr. A. L. Jadhav 1981-1988 Dr. S. Tachikawa 1981-1982 Dr. J. L. Montastruc 1982 Dr. H. O. Watkins 1982-1990 Dr. A. F. Ansari 1984-1985 Dr. G. D. Adjei 1984 Dr. A. T. Hamed 1985 Dr. M. L. DeFeo 1986-1987 Dr. T. Sakamoto 1991-1992 Dr. A. T. Hamed 1992-1993 Dr. C. J. Chen 1992-1994 Dr. T. Hussain 1995-2001 Dr. M. Asghar 1999-present Dr. L. Zhang 2001-2002 Dr. A. Banday 2001-present Dr. A Marwaha 2005-2006 6 GRANT & CONTRACTS Studies on the mechanisms of antihypertensive action of various beta adrenergic blocking agents From: New Research Opportunities Program University of Houston $4,518; 1/1/76 to l2/31/76 Studies on the functional role of presynaptic beta adrenergic receptor mechanism in sympathetic neurtoransmission From: Pharmaceutical Manufacturers Association Foundation Washington, DC $10,000; 1/1/77 to 12/31/78 Vascular reactivity in experimental hypertension From: American Heart Association; Texas Affiliate, Inc. Austin, Texas $12,685; 7/l/78 to 6/30/79 Presynaptic regulatory mechanisms in hypertension From: National Heart, Lung and Blood Institute; National Institutes of Health Bethesda, MD $194,242; 7/l/78 to l2/31/82 The role of sympathetic nervous system in the cardiovascular actions of dopaminergic agents From: Eli Lilly & Co. Indianapolis, Indiana $7,l75; 7/1/81 to 6/30/84 Studies