Neurological Board Examination 2010 09 25 B-type: For each numbered item, select the heading most closely associated with it. Each heading may be selected once, more than once, or not at all Part 1 (1-4) Please match the term below: ( ) 1 Progressive supranuclear palsy ( ) 2 Dementia with Lewy body ( ) 3 Creutzfeldt-Jakob disease (CJD) ( ) 4 ALS with dementia A. Prionopathy B. β-Amyloidopathy C.α-synucleinopthy D. Tauopathy E. TDP-43 proteinopathy 解答：( D ) ( C ) ( A ) (E ) 題目之出處：Merritt’s Neurology, 12th edition, P710-722 題目屬性：Degenerative, genetic disease and pediatric neurology 題目難易：中 Part 2 (5-8) What is the specific neurological manifestation in heavy metal intoxication? ( ) 5 Lead ( ) 6 Manganese ( ) 7 Mercury ( ) 8 Aluminum A. Parkinsonism B. Tremor C. Radial palsy D. myelopathy E. Dementia 解答：( C ) (A ) ( B ) ( E ) 題目之出處：Merritt’s Textbook of Neurology 12th Edition 2010 p. 1093-1096 1 題目屬性：Metabolic & toxic disease, 題目難易：中等 Part 3 (9-12) Polyneuropathy type and its clinical/electrophysiologic pattern ( ) 9 Porphyria ( ) 10 Vasculitis ( ) 11 Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) ( ) 12 Organophosphate toxicity A. Sensorimotor, axonal, acute B. Sensorimotor, axonal, subacute or chronic C. Predominantly motor axonal, acute D. Predominantly motor axonal, subacute or chronic E. Sensory only, axonal 解答：( C ) ( A ) ( E ) ( B ) 題目之出處：Office Practice of Neurology, 2th, p571 題目屬性：Metabolic & toxic disease, 題目難易：中等 Part 4 (13-16) Myopathic syndrome and corresponding drug or toxin ( ) 13 Necrotizing myopathy ( ) 14 Hypokalemic myopathy ( ) 15 Antimicrotubular myopathy ( ) 16 Mitochondrial myopathy A. Licorice B. Zidovudine C. Statin drug D. Colchicine E. D-Penicilamine 解答：( C ) ( A ) ( D ) ( B ) 題目之出處： Principles of Neurology 9th 2009, p1394, table 51-2 題目屬性：Metabolic & toxic disease, 題目難易：中等 Part 5 (17-20) Please match the agent and its related clinical manifestation. ( ) 17 Carbon disulfide ( ) 18 Thallium ( ) 19 n-Hexane ( ) 20 Lead A. Giant axonal swellings B. Sacral sensory loss C. Parkinsonism D. Wrist drop E. Dysesthesia with alopecia 解答：(C) (E) (A) (D) 題目之出處：Neurology in Clinical Practice5th Edition, p. 1658-1662 題目屬性：Metabolic & toxic disease, 題目難易：易 Part 6 (21-24) About nutrition deficiency or toxicity: ( ) 21 Pellagra ( ) 22 Pseudotumor cerebri ( ) 23 A-ß lipoproteinemia ( ) 24 Wernike-Korsakoff syndrome A. Vitamin A B. Vitamin B1 C. Vitamin B6 D. Vitamin E E. Niacin 解答：( E ) ( A ) ( D ) (B ) 題目之出處：Merritt’s 12th p1035~1049 題目屬性：Metabolic & toxic disease, 題目難易：中 Part 7 (25-28) Select the appropriate term to match each disease ( ) 25 Lewy body dementia 3 ( ) 26 Cortical-basal ganglionic degeneration ( ) 27 Parkinsonism-dementia-ALS ( ) 28 Wilson’s disease A. Guamanian B. Eye-of-the-tigger signs C. Alien limb phenomena D. Formed visual hallucinations E. Kayser-Fleischer ring 解答：( D ) ( C ) ( A ) ( E ) 題目之出處：Merritt’s Neurology 12th p721, 773-774, 657 題目屬性：Movement disorder, 題目難易：中等 Part 8 (29-32) Side effects of anti-parkinsonian agents ( ) 29 Livedo reticularis ( ) 30 Fibrotic valvulopathy ( ) 31 Forgetfulness and psychosis ( ) 32 Impulse control problem A. Amantadine B. Anti-cholinergic drug C. Dopamine agonist D. Levodopa 解答：( A ) ( C ) ( B ) ( C ) 題目之出處：Merritt’s Neurology, twelfth edition, p. 761-763 題目屬性：Movement disorder, 題目難易：易 Part 9 (33-36) Please choose medication for involuntary movement disorders. ( ) 33 Segawa disease ( ) 34 Rapid-onset Dystonia-Parkinsonism ( ) 35 Paroxysmal kinesigenic dyskinesias ( ) 36 Paroxysmal nonkinesigenic dyskinesias A. Beta-Blockers B. Anti-convulsants C. Levodopa D. Clonazepam, benzodiazepins, acetazolamide, antimuscarinics E. No effect treatment 解答：(C ) (E ) (B ) (D ) 題目之出處：Merritt's Neurology 12th edition, p. 743,775 題目屬性：Movement disorder, 題目難易：中等 Part 10 (37-40) The side effects of medications used to treat neuropathic pain ( ) 37 Amitriptyline (TCA) ( ) 38 Venlafaxine (SNRI) ( ) 39 Gabapentine ( ) 40 Tramadol A. Hypertension, sexual dysfunction B. Arrhythmia, urinary retention C. Seizure, nausea, constipation D. Steven-Johnson rash E. Pedal edema, Somnolence 解答：( B ) ( A ) ( E ) ( C ) 題目之：Merritt’s Neurol0gy 12 edition P842 Table 135.1 題目屬性：Miscellaneous, 題目難易：中等 Part 11 (41-44) Match the adverse effects with medications used to treat neuropathic pain. ( ) 41 Amitriptyline ( ) 42 Gabapentin ( ) 43 Topiramate ( ) 44 Lidocaine patch A. Kidney stone B. Application site reactions. C. Pedal edema 5 D. Urinary retention E. Diarrhea 解答：( D ) ( C ) ( A ) ( B ) 題目之出處：Merritt’s Neurology 12th edition, p 842 題目屬性：Headache & pain, 題目難易：易 Part 12 (45-48) Predominant mechanism of the drugs for treating neuropathic pain ( ) 45 Amitriptyline ( ) 46 Carbamazepine ( ) 47 Gabapentin ( ) 48 Lamotrigine A. Blocking voltage-gated sodium channels B. Blocking voltage-gated sodium and calcium channels C. Balanced monoamine reuptake inhibitor D. Binding to voltage-dependent calcium channels E. Pre-synaptically blocking sodium channels and inhibiting release of glutamate 解答：(C ) (A ) (D ) (E ) 題目之出處：Neurology in Clinical Practice 5th, p2260 題目屬性：Headache & pain, 題目難易：難 Part 13 (49-52) Which is the MOST proper description for each headache: ( ) 49 Unilateral lacrimation and rhinorrhea ( ) 50 Plasma interleukin-6 (IL-6) measurement may be the marker of disease activity ( ) 51 Meningeal enhancement on MRI ( ) 52 The progression of headache for weeks or months A. Spontaneous intracranial hypotension B. Brain tumor headache C. Cluster headache D. Giant cell arteritis 解答：( C )( D )( A )( B ) 題目之出處：Merritt’s Neurology, 12th edition, p.959 題目屬性：Headache & pain, 題目難易：易 Part 14 (53-56) Match the headache type and its lasting time ( ) 53 Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing SUNCT ( ) 54 Cluster headache ( ) 55 Tension type headache ( ) 56 Migraine without aura A. 15~180 minutes B. 2 ~ 30 minutes C. 30 minutes~7 days D. 4~72 hours E. 5~240 seconds 解答：( E ) ( A ) ( C ) ( D ) 題目之出處：ICHD-2 2004 題目屬性：Headache & pain, 題目難易：中等 Part 15 (57-60) Gait. ( ) 57 Muscular dystrophy ( ) 58 Unilateral cerebellar hemisphere lesion ( ) 59 Normal pressure hydrocephalus ( ) 60 Hereditary spastic paraplegia A. Ataxic gait and deviation to the lesion side B. Steppage gait C. Waddling gait D. Apraxic gait E. Scissor gait 解答：( C ) ( A ) ( D ) ( E ) 題目之出處：Merritt’s neurology, 12th edition (p. 58~61) 題目屬性：Laboratory & NE, 題目難易：易 Part 16 (61-64) Localization ( ) 61 Word deafness (auditory verbal agnosia) ( ) 62 Dysnomia or amnesic aphasia ( ) 63 Asomatognosia ( ) 64 Achromatopsia 7 A. frontal lobe B. left temporal lobe C. parietal lobe D. occipital lobe E. non-dominant temporal lobe 解答：( B ) ( B ) ( C ) ( D ) 題目之出處：Adams 9ed, p443-456 題目屬性：Laboratory & NE, 題目難易：中等 Part 17 (65-68) ( ) 65 Symptom suggestive of carotid transient ischemic attacks ( ) 66 Symptom suggestive of vertebrobasilar transient ischemic attacks ( ) 67 Symptom suggestive of bilateral ACA-MCA watershed infarction ( ) 68 Symptom suggestive of anterior thalamic infarction A. Binocular vision loss B. Amaurosis fugax C. Neuropsychiatrical disturbances D. Man-in-a-barrel 解答：( B ) ( A ) ( D ) ( C ) 題目之出處：Neurology in Clinical Practice 5th, p1171, 1177,1178 題目屬性：Stroke, 題目難易：中等 Part 18 (69-72) ( ) 69 Hypsarrhythmia ( ) 70 Slow generalized spike and wave (< 2 cps) ( ) 71 Focal centrotemporal epileptiform discharge ( ) 72 Generalized polyspike wave (often >3 cps) A. Absence seizure B. Benign rolandic epilepsy C. Juvenile myoclonic epilepsy D. Lennox-Gastuat syndrome E. West syndrome 解答：( E ) ( D ) ( B ) ( C ) 題目之出處：From Merritt’s 12th Chapter 15 p 77 題目屬性：Epilepsy, 題目難易：易 Part 19 (73-76) The adverse effects of antiepileptic drugs ( ) 73 Phenytoin. ( ) 74 Valproic acid. ( ) 75 Carbamazepine. ( ) 76 Topiramate. A. Impotence B. Acute pancreatitis C. Cognitive dysfunction D. Hyponatremia E. Megaloblastic anemia 解答：( E ) ( B ) ( D ) ( C ) 題目之出處：Adams, 8th ed, p.295 題目屬性：Epilepsy, 題目難易：易 Part 20 (77-80) The pharmacological mechanism of the following antiepileptic drugs ( ) 77 Oxcarbazepine ( ) 78 Vigabatrin ( ) 79 Tiagabin ( ) 80 Ethosuximide A. Blocking voltage-gated calcium channel B. Enhancing release of GABA C. Decreasing GABA reuptake D. Inhibition of GABA transaminase E. Blocking voltage-gated sodium channel 解答：(E) (D) (C) (A) 題目之出處：Neurology in Clinical Practice P.1935-1942 題目屬性：Epilepsy, 題目難易：中等 9 .