www.biossusa.com [email protected] 800.501.7654 [DOMESTIC] +1.781.569.5821 [INTERNATIONAL] bs-1356R Rabbit Anti-Integrin Alpha V + Beta 5 Polyclonal Antibody Size: 100ul or 100ug lyophilized Primary Antibodies Concentration: 1ug/uL Background: Host: Rabbit Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and Reactivities: Human,Mouse,Rat, recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and Application: metatastatic diffusion of tumour cells. ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V ELISA(1:500-1000) undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple IP(1:20-100) integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and IHC-P(1:100-500) 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 IHC-F(1:100-500) integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, IF(1:100-500) many integrins are known to facilitate signal transduction. Not yet tested in other applications. Source/Purification: Optimal working dilutions must be KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V C-terminus. Was purified determined by the end user. by Protein A and peptide affinity chromatography. Storage: Prepared as lyophilized powder or liquid and shipped on ice. Store at -20°C for one year. Antibody Type: Polyclonal Reconstitution: Isotype: IgG If the antibody is in liquid form, it is ready to use, no reconstitution needed. Molecular Weight: 88/121kDa Reconstitution is only required for the lyophilized antibody. Reconstitution instruction:Two additional vials are included in shipment for reconstitution purposes (double distilled H20 and sterile glycerol). Centrifuge all vials to Preservatives: ensure necessary quantities have settled. Add 50uL of sterile double distilled water to antibody. Mix thoroughly by 10ug/uL BSA and 0.1% NaN3. gently pipetting up and down. Then, add 50uL of sterile glycerol to antibody. Mix well and keep cold. For research use only. CAUTION: Not for human or animal therapeutic or diagnostic use. For full size images and description please click HERE. .