CURRICULUM VITAE Name: FRANCO CELADA, M.D., Ph.D. Home Address: 345 East 12th Street, Apartment 15 New York, NY 10003 Phone: (212) 353-8308 Office Address: NYU Hospital for Joint Diseases Department of Rheumatology 301 East 17th Street, 16th Floor New York, NY 10003 Phone: (212) 598-6507 Fax: (212) 598-6168 Email: [email protected] Place of Birth: Milano, Italy Citizenship: Italy. U.S.A. Status: Permanent Resident Alien EDUCATION 1945-49 High School, Liceo Classico Gonzaga, Milano. 1950-56 Faculty of Medicine, University of Milano. 1956-59 Post-doctoral training, University of Milano (Medical Clinic). DEGREES 1956 Medical Doctor, University of Milano. 1961 Specialist in Internal Medicine, University of Milano. 1966 Docent in Immunology (Ph.D.), Karolinska Institutet, Stockholm. 1967 "Libero Docente" in Immunology, Rome, Ministry of Education. POSITIONS 2007-present Research Professor of Medicine, New York University School of Medicine, New York, NY, USA. 1987-present Senior Immunologist, NYU Hospital for Joint Diseases, New York, NY, USA. 1996-2007 Professor of Pathology (Adjunct), NYU School of Medicine, New York, NY, USA 1987-1996 Professor of Pathology, NYU School of Medicine, New York, NY, USA 1986 Visiting Professor, Department of Microbiology, Mount Sinai Medical Center, New York, NY, USA. 1982-87 Coordinator, Italian Ph.D. program in Immunological Sciences (Dottorato di Ricerca in Scienze Immunologiche). 1976-2006 Professor of Immunology, University of Genova and Director, Transplantation Immunology Service, Hospital San Martino, Genova, Italy. 1975 Visiting Professor, UCLA, Departments of Biological Chemistry and of Bacteriology, Los Angeles, CA. 1971 Director of Research, C.N.R. (Italian Research Council) and Head, Immunology Section, Laboratory of Cell Biology, Rome, Italy. 1970 Guest Investigator, Dept. de Biologie Moleculaire, Institut Pasteur, Paris. Franco Celada, M.D., Ph.D. CURRICULUM VITAE Page 2 POSITIONS - continued 1969-1972 Associate Professor, then, Full Professor in Immunology, Karolinska Institutet. (On leave, 1972) 1969 Personal Research Position in Immunology at Karolinska Institutet (Forskardocent). 1968 Research position in Immunology of the Swedish Medical Research Council (Forskartjanst i immunologi). 1968 Docent at the Karolinska Institutet (E.O. Docenttjanst, icke amnesbundet). 1967 Visiting Associate Professor, Department of Biological and Medical Sciences, Brown University, Providence, RI, USA (6 months). 1966 Guest Investigator at the Karolinska Institutet, supported by the Swedish Cancer Society 1962-1964 Assistant Professor, University of Torino, Italy (Institute of Medical Genetics). SCHOLARSHIPS AND FELLOWSHIPS 1955 Scholarship of the French Government to work at the Institut Pasteur, Paris (4 months). 1959 NIH International Post-doctoral Fellowship, to work at the Oak Ridge National Laboratory (renewed, 1960). 1964 Eleanor Roosevelt Fellowship awarded by UICC, to work at the Karolinska Institutet, Stockholm. 1970 Foreign-Exchange Fellowship of the DGRST (Délégation Générale pour la Recherche Scientifique et Technique) to work at the Institut Pasteur, Paris. 1975 Fellowship of the Italo-American Medical Education Foundation (10 months). 1986 NATO Senior Fellowship, to work at the Mount Sinai Medical Center, New York. PRE-DOCTORAL RESEARCH EXPERIENCE 1954-1956 Intern student, Istituto di Clinica Medica, University of Milano (Director: Prof. Luigi Villa). Physico-chemical characteristics of leukemic DNA. (Supervisor: Dr. E. Polli). 1955 Chercheur benevole, Institut Pasteur, Paris Service de chimie microbienne. (Director: Pierre Grabar). Antigens of human leukocytes by gel immunodiffusion. (Supervisor: Maxime Seligmann). POST-DOCTORAL RESEARCH AND PROFESSIONAL EXPERIENCE 1957 Investigator at the Istituto Sieroterapico Milanese, Milano, Dept. of Prof. R. Ceppellini. Anti-DNA antibodies in serum from patients with systemic lupus. 1959-1961 Post-doctoral fellow at the Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA, Radiation Immunology Group (Group Leader: Takashi Makinodan). - Quantitation of the homograft reaction by "in vivo culture" system of lymphoid cells - Purification and assay of transplantation antigens. - Differential radiosensitivity of homograft rejecting and antibody-forming cells. - Immunogenetics of male antigen in mice. 1962-1964 Institute of Medical Genetics of the University of Torino, Italy (Director: Prof. R. Ceppellini). Study of leukocyte antigens as an approach to transplantation in man. 1964-1967 Department of Tumor Biology, Karolinska Institutet, Stockholm (Director: Prof. George Klein). - Kinetics of immunological memory: evidence for a biphasic decay. - Linear transmission of specificity and heavy chain class in spleen colonies of repopulated mice. - Evidence of cell cooperation in the adoptive response to soluble antigens; maturation of avidity. Franco Celada, M.D., Ph.D. CURRICULUM VITAE Page 3 POST-DOCTORAL RESEARCH AND PROFESSIONAL EXPERIENCE - continued 1967 Division of Biological and Medical Sciences, Brown University, Providence, RI. - Interaction of wild type anti-ß-galactosidase antibody with a Z gene product of an E. coli mutant ß-galactosidase of resulting in enzyme activation. 1967-1970 Department of Tumor Biology, Karolinska Institutet. Mechanisms of activation of defective enzymes by antibody. Competition among different antigenic determinants on the same protein molecular. Presence of viral antigens on functional antibody-forming cells in Moloney leukemia virus infected mice. 1970 Department of Molecular Biology of the Pasteur Institut (Director: Prof. Jacques Monod). Antibody as an allosteric effector: facilitation of Omega complementation in ß-galactosidase of E. coli. 1971 Laboratorio di Biologia Cellulare, Rome, Italy. Conformational activities of antibodies on enzyme antigens. Cell cooperation in vivo and in vitro in anti-ß-galactosidase response. Enzyme-immunoassay of tumor specific antigens. 1975-1976 Departments of Biological Chemistry and Bacteriology, UCLA. Antigenic- immunogenic "map" of the ß-galactosidase molecule, utilizing mutant gene products and fragments obtained by chemical cleavage: definition of quaternary conformation- dependent and of cryptic sequential epitopes. Mechanisms of alpha-complementation and of antibody-induced conformational changes. 1977-2006 Department of Immunology, University of Genova, Transplantation Immunology Service, Hospital S. Martino, Genova. Organization of a Basic and Applied Immunology laboratory (Staff: 4 M.D.s, 8 Ph.D.s, 5 Technicians, 5 Students), including HLA typing and immune complexes determination. Research: measure of circulating immune complexes in serum of patients by a new immunoenzymatic methods. Mechanism of ab-mediated conformational changes, by means of monoclonal enzyme activating antibodies. T cell clones and difference of repertoire between T and B cells. Demonstration of preferential help by individual T and B cell clones depending on the topology of "T" and "B" epitopes in a protein antigen. Human B cell clones, antigen specific and stimulated by alloreactive T cells. Human monoclonal antibodies anti-tetanus and anti-Dr. specificities obtained by EBV transformation and cellular hybridization of anti-graft sensitized B cells. 1986 Mount Sinai Medical Center. Targeting of T cytotoxic cells on selected antigens by means of bi-specific antibodies produced by hybrid-hybridomas. Anti-idiotype as internal image of a conformation-dependent epitope of ß-galactosidase. 1988-present NYU-Hospital for Joint Diseases. T cell help for anti-idiotype and anti-interstitial image responses. Effect of CD4-gp120 binding on processing and on the fine specificity of the antibody response. Development, in association with Dr. Philip Seiden of IBM, of a computer model of the immune system based on cellular automata, capable of simulating the humoral and cellular immune response and performing in machina experiments. AWARDS AND HONORS 2005 Honorary Member, Societe Royale de Sciences de Liège Franco Celada, M.D., Ph.D. CURRICULUM VITAE Page 4 SCIENTIFIC SOCIETIES AND INTERNATIONAL ORGANIZATIONS Scandinavian Society of Immunology (1967). Group of Cooperation in Immunology (Italy), 1972-1986 (Founder, President, Member of the Organizing Committee, Vice-President). Federation of the Italian Immunological Societies, member of the Committee (1982-1986). EMBO (European Molecular Biology Organization), 1974 – present. EMBO, Member of the Courses and Workshops Committee, 1976-82. Italian Society of Biophysics and Molecular Biology, 1976. Organizer of the Immunology Club of Genova, 1977-1982. IUIS (International Union of Immunological Societies) Chairman of Education Committee (1986-1993). American Association of Immunologists (AAI) (1989 – present) European Association for Higher Education in Biotechnology (HEduBT), Secretary General (1994 – 2000). MAJOR COMMITTEE ASSIGNMENTS 1976–1982 Member, EMBO Courses and Workshops Committee 1986–1993 Chairman, Education Committee, International Union of Immunological Societies (IUIS) 1994–2000 Founder and Secretary General, European Doctorate in Biotechnology 2001–2004 Coordinator, European Strategic Action on Biotechnology Ethics (Bio-T-ethics) 2005–2008 Coordinator of Bio-T-Ethics action extended to 16 European Union Members EDITORIAL BOARDS The Journal of the Reticuloendothelial Society, Associate Editor, 1967. Immunochemistry, member of the Advisory Board, 1976. Scandinavian Journal of Immunology, member of Editorial Board, 1972. Immunology Letter, Editor, 1979.