Conference schedule Day 1: Monday 27 March 2017 08:30 – 08:50 Registration 08:50 – 09:00 Opening Remarks Prof. Michael Wakelam, Babraham Institute 09:00 – 09:45 Plenary; New discoveries about ageing in C.elegans Prof. David Gems, Institute of Healthy Ageing, University College London Session 1: The Ageing Stem Cell Chair: Dr. Elisa Laurenti, Wellcome Trust - MRC Cambridge Stem Cell Institute 09:45 – 10:15 Epigenetic stress response and stem cell aging Dr. Karl Lenhard Rudolph, Leibniz Institute on Aging (FLI) 10:15 – 10:45 DNA methyltransferase 3A in hematopoiesis Prof. Margaret (Peggy) Goodell, Baylor College of Medicine 10:45 – 11:15 Coffee Break 11:15 – 11:45 Novel epigenetic biomarker and its clinical utility in diagnostics of Alzheimer's disease Dr. Victoria V. Lunyak, Aelan Cell Technologies 11:45 – 12:15 Autophagy and metabolism of aged hematopoietic stem cells Dr. Emmanuelle Passegué, UCSF School of Medicine 12:15 – 12:30 Singe cell sequencing reveals age-dependent emergence of pre-malignant haematopoietic stem cells Dr. Kristina Kirschner, Institute of Cancer Sciences, University of Glasgow - Selected Short Talk 12:30 – 13:00 Impaired immunoglobin repertoire and epigenetic alterations in ageing B cell development Dr. Anne Corcoran, Babraham Institute 13:00 – 14:15 Lunch Session 2: The Ageing Immune System Chair: Prof. Janet Lord, Institute of Inflammation and Ageing, University of Birmingham 14:15 – 14:45 The epigenetic landscape of CD8 T cells in differentiation and ageing Prof. Jörg J. Goronzy, Stanford School of Medicine 14:45 – 15:15 A global MAPK activation complex coordinated by Sestrins inhibits immunity during ageing Prof. Arne Akbar, Windeyer Institute, University College London 15:15 – 15:45 Ageing and the germinal centre response Dr. Michelle Linterman, Babraham Institute 15:45 – 16:15 Afternoon Tea 16:15 – 16:30 Age-Related Functional Defects in Naïve CD8 T Cells Due to Defective TCR Signaling and Inhibition of Cell Cycle Dr. Kylie Quinn, Monash University - Selected Short Talk 16:30 – 17:00 Mechanisms for inflammation and obesity reducing B cell function in the elderly and old mice Dr. Bonnie Blomberg, University of Miami, Miller School of Medicine 17:00 – 17:30 mTOR inhibition improves immune function in the elderly Dr. Joan Mannick, Novartis 17:30 – 18:30 Poster Session 19:30 Conference Dinner Conference schedule Day 2: Tuesday 28 March 2017 Session 3: Signalling and the Ageing Cell Chair: Prof. Michael Wakelam, Babraham Institute 09:00 – 09:45 Plenary; Nutrition and ageing Prof. Dame Linda Partridge, Institute of Healthy Ageing, University College London 09:45 – 10:15 Robust and reproducible chemical interventions in ageing Dr. Mark Lucanic, Buck Institute for Research on Ageing The SKN-1 transcription factor can protect against oxidative damage and increase lifespan in C. elegans 10:15 – 10:30 by distinct mechanisms Dr. Jennifer Tullet, School of Biosciences, University of Kent - Selected Short Talk 10:30 – 11:00 Coffee Break 11:00 – 11:15 Signalling pathways during cell senescence and upon senescence reversal by mTOR inhibition revealed by proteomics analysis Prof. Lynne Cox, University of Oxford - Selected Short Talk 11:15 – 11:45 Correcting signaling dysregulation in neutrophils and improving immunity in older adults Prof. Janet Lord, Institute of Inflammation and Ageing, University of Birmingham 11:45 – 12:15 Dynamics of autophagy starting from mTOR Dr. Nick Ktistakis, Babraham Institute 12:15 – 13:30 Lunch 13:00 – 13:30 Industry Session (optional) Short talks from Cambridge Epigenetix, Camlab and ChemoMetec Session 4: Epigenetics of the Ageing Cell Chair: Dr Olivia Casanueva and Dr Len Stephens, Babraham Institute 13:30 – 14:00 Genetic studies of the epigenetic clock Prof. Steve Horvath, University of California, Los Angeles 14:00 – 14:30 Convergent mechanisms of longevity Prof. Adam Antebi, Max Planck Institute for Biology of Ageing 14:30 – 15:15 Plenary; Regulation of Growth by the mTOR Pathway Prof. David Sabatini, Whitehead Institute, Massachusetts Institute of Technology 15:15 – 15:45 Afternoon Tea 15:45 – 16:00 Mouse epigenetic age and prediction Mr. Thomas Stubbs, Babraham Institute - Selected Short Talk 16:00 – 16:30 It’s not all down to the egg: Maternal age effects on development and reproductive success Dr. Myriam Hemberger, Babraham Institute 16:30 – 17:00 Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP) Prof. Jesús Gil, Imperial College London 17:00 – 17:15 Closing remarks 17:15 Depart.