CandidatusNanobsidianus stetteri Candidatus Nanobsidianus stetteri MethanothermococcusMethanocaldococcus okinawensis bathoardescens Methanocaldococcus fervens AG86 Methanocaldococcus sp. FS406-22 Nanoarchaeum equitans Kin4-M Methanocaldococcus fervens Methanocaldococcus jannaschii Methanocaldococcus villosus MethanocaldococcusMethanocaldococcus infernus villosus Methanocaldococcus vulcanius Fervidobacterium thailandense Thermococcales archaeon 44_46 Candidatus Korarchaeota archaeon Korarchaeota Candidatus Methanotorris formicicus Methanothermus fervidus Methanotorris igneus Methanopyrus sp. KOL6 Methanopyrus kandleri Candidatus Marsarchaeota G2 archaeon ECH_B_2 archaeon G2 Marsarchaeota Candidatus Candidatus Marsarchaeota G2 archaeon ECH_B_SAG-C16 archaeon G2 Marsarchaeota ECH_B_3 archaeon Candidatus G2 Marsarchaeota Candidatus Candidatus Marsarchaeota G2 archaeon OSP_D archaeon G2 Marsarchaeota Candidatus Candidatus Marsarchaeota G2 archaeon ECH_B_SAG-F08 archaeon G2 Marsarchaeota Candidatus Candidatus Marsarchaeota G1 archaeon OSP_D archaeon G1 Marsarchaeota Candidatus Aciduliprofundum sp. MAR08-339 Candidatus Marsarchaeota G1 archaeon BE_D archaeon G1 Marsarchaeota Candidatus archaeon Korarchaeota Candidatus Candidatus Bathyarchaeota archaeon B24-2 Archaeoglobus sulfaticallidus Candidatus Korarchaeum cryptofilum OPF8 cryptofilum Korarchaeum Candidatus Aciduliprofundum boonei Candidatus Korarchaeum cryptofilum CandidatusKorarchaeum Aciduliprofundum boonei Aigarchaeota archaeon NZ13_MG1 Thermococcus sp. PK Thermococcus litoralis Archaeoglobus fulgidus Archaeoglobus fulgidus Thermococcus sp. 2319x1 Archaeoglobus fulgidus DSM 4304 Thermococcus litoralis ArchaeoglobusGeoglobus fulgidus acetivorans DSM 4304 Thermococcus sp. 40_45 Geoglobus ahangari FerroglobusArchaeoglobus placidus profundus Thermococcus sibiricus Archaeoglobus veneficus Thermococcus sibiricus Candidatus Geothermarchaeota archaeon ex4572_27 Thermococcus sp. EP1 Thermococcus barophilus Thermococcus barophilus ThermococcusThermococcus celericrescens paralvinellae CandidatusThermofilum Geothermarchaeota sp. ex4484_82 archaeon ex4572_27 Thermofilum Thermofilum pendens Hrk 5 Thermofilum pendens Thermococcus sp. 4557 Thermofilum sp. NZ13 Thermofilum uZonense Methanothermococcus okinawensis Methanocaldococcus bathoardescens Thermococcus profundus Thermofilum uZonense Methanocaldococcus fervens AG86 Spirochaetes bacterium GWB1_36_13 Methanocaldococcus sp. FS406-22 Thermofilum pendens Hrk 5 Thermococcus siculi Methanocaldococcus fervens Thermococcus pacificus Methanocaldococcus jannaschii Thermosipho africanus Thermofilum sp. ex4484_82 Thermococcus cleftensis Thermococcus radiotolerans ThermotogaThermosipho sp. 4484_232 atlanticus Methanocaldococcus villosus MethanocaldococcusMethanocaldococcus infernus villosus Methanocaldococcus vulcanius Thermotoga sp. KOL6 ThermococcusThermococcus pieZophilus sp. 5-4 Thermotoga sp. SG1 Thermotoga neapolitana Methanopyrus sp. KOL6 Thermococcus onnurineus Thermofilum Thermotoga neapolitana LA10 Thermosipho atlanticus Thermosipho Fervidobacterium thailandense africanus Thermosipho Methanopyrus kandleriMethanotorris formicicus Thermotoga sp. RQ7 Methanotorris igneus Thermotoga sp. SG1 Thermococcales archaeon 44_46 Thermotoga neapolitana Thermococcus barossii Thermotoga naphthophila Thermotoga sp. 4484_232 sp. Thermotoga Thermotoga neapolitana LA10 Thermotoga sp.Thermotoga KOL6 Thermotoga sp. RQ7 Thermococcus thioreducens Spirochaetes bacterium GWB1_36_13 bacterium Spirochaetes Thermotoga petrophila Thermotoga naphthophilaThermotoga petrophila Thermotoga sp. RQ2 Thermotoga maritima Thermotoga sp. Mc24 Thermotoga Methanothermus fervidus Thermotoga sp. Cell2 Thermotoga sp. RQ2 Thermofilum uZonense Thermofilum Thermofilum uZonense Thermofilum Thermotoga Thermotoga maritima Thermotoga sp. TBYP3.1.4.1 Thermofilum sp. NZ13 sp. Thermofilum Thermotoga sp. TBXY761 Thermococcus sp. P6 Thermofilum pendens Thermofilum Thermotoga Caldanaerobacter subterraneus Caldanaerobacter subterraneus Thermotoga sp. Mc24 Dictyoglomus sp. NZ13-RE01Caldanaerobacter subterraneus Thermococcus sp. PK ThermococcusThermococcus peptonophilus celer Caldicellulosiruptor morganii Thermotoga sp. Cell2 Thermococcus litoralis Caldicellulosiruptor danielii Caldicellulosiruptor saccharolyticus Thermotoga ThermococcusThermococcus sp. 2319x1 litoralis Caldicellulosiruptor sp. F32 Thermococcus kodakarensis Caldicellulosiruptor naganoensis Thermotoga sp. TBYP3.1.4.1 Thermococcus sp. 40_45 Caldicellulosiruptor hydrothermalis Thermotoga sp. TBXY761 Caldicellulosiruptor owensensis Thermococcus gorgonarius Thermococcus sibiricus Caldicellulosiruptor kronotskyensis Caldicellulosiruptor obsidiansis Thermococcus sibiricus Caldicellulosiruptor kristjanssonii Caldicellulosiruptor lactoaceticus Thermococcus Zilligii Dictyoglomus sp. NZ13-RE01 Thermococcus sp. EP1 Caldicellulosiruptor acetigenus Thermococcus barophilus Caldicellulosiruptor bescii Thermococcus sp. EXT12c Caldanaerobacter subterraneus Caldicellulosiruptor bescii Caldanaerobacter subterraneus Thermococcus barophilus Caldicellulosiruptor bescii Thermococcus eurythermalis ThermococcusThermococcus celericrescens paralvinellae Caldanaerobacter subterraneus Caldicellulosiruptor morganii Thermococcus nautili Thermococcus gammatolerans Caldicellulosiruptor danielii Thermococcus sp. 4557 Caldicellulosiruptor saccharolyticus Caldicellulosiruptor sp. F32 ThermococcusThermococcus profundus siculi Thermococcus sp. AM4 Caldicellulosiruptor naganoensis Thermococcus guaymasensis Thermococcus pacificus Caldicellulosiruptor hydrothermalis Thermococcus cleftensis Candidatus Nanobsidianus stetteri Caldicellulosiruptor owensensis Thermococcus radiotolerans NanoarchaeumCandidatus equitans Nanobsidianus Kin4-M stetteri Palaeococcus pacificus Caldicellulosiruptor kronotskyensis Caldicellulosiruptor bescii Candidatus Korarchaeota archaeon Palaeococcus ferrophilus ThermococcusThermococcus pieZophilus sp. 5-4 Caldicellulosiruptor bescii Candidatus Korarchaeum cryptofilum OPF8 Pyrococcus yayanosii Caldicellulosiruptor bescii Thermococcus onnurineus Candidatus Korarchaeum cryptofilum Tree scale: 1 Caldicellulosiruptor obsidiansis Aciduliprofundum sp. MAR08-339 Pyrococcus sp. NA2 Caldicellulosiruptor kristjanssonii ThermococcusThermococcus thioreducens barossii Aciduliprofundum boonei Caldicellulosiruptor lactoaceticus Aciduliprofundum boonei Pyrococcus abyssi Caldicellulosiruptor acetigenus Archaeoglobus sulfaticallidus Thermococcus sp. P6 Pyrococcus horikoshii Archaeoglobus fulgidus Thermococcus chitonophagus ThermococcusThermococcus peptonophilus celer Archaeoglobus fulgidus Archaeoglobus fulgidus DSM 4304 Pyrococcus kukulkanii Thermococcus kodakarensis Archaeoglobus fulgidus DSM 4304 Candidatus Bathyarchaeota archaeon B24-2 Pyrococcus sp. ST04 Thermococcus gorgonarius Aigarchaeota archaeon NZ13_MG1 Pyrococcus furiosus Thermococcus Zilligii Geoglobus acetivorans Geoglobus ahangari Thermococcus sp. EXT12c Pyrococcus furiosus DSM 3638 Desulfurococcales archaeon ex4484_217_2 Thermococcus eurythermalis Ferroglobus placidus Archaeoglobus profundus Archaeoglobus veneficus Candidatus Kryptonium thompsoni Thermococcus nautili Thermococcus guaymasensis Candidatus Kryptonium thompsoni Candidatus Kryptobacter tengchongensis Thermococcus gammatolerans Candidatus Kryptobacter tengchongensis Candidatus Kryptobacter tengchongensis Thermococcus sp. AM4 Desulfurococcales archaeon ex4484_217_2 Candidatus Kryptobacter tengchongensis Palaeococcus pacificus Candidatus Kryptonium thompsoni Candidatus Kryptonium thompsoni Palaeococcus ferrophilus Candidatus Kryptobacter tengchongensis Thermocladium sp. ECH_B Candidatus Kryptobacter tengchongensis Caldivirga maquilingensis Tree scale: 1 Pyrococcus yayanosii Candidatus Kryptobacter tengchongensis Caldivirga sp. MU80 Candidatus Kryptobacter tengchongensis Thermococcus chitonophagus Vulcanisaeta thermophila Vulcanisaeta sp. EB80 Pyrococcus kukulkanii Candidatus Korarchaeota archaeon Vulcanisaeta distributa Pyrococcus sp. ST04 Vulcanisaeta moutnovskia Candidatus Marsarchaeota G1 archaeon BE_D Pyrococcus sp. NA2 Candidatus Marsarchaeota G1 archaeon OSP_D Thermoproteus tenax Candidatus Marsarchaeota G2 archaeon ECH_B_SAG-F08 Pyrococcus abyssi Thermoproteus uZoniensis Candidatus Marsarchaeota G2 archaeon OSP_D Pyrococcus horikoshii Topoisomerase:Rhodopseudomonas palustris BisB18 Thermoproteus sp. JCHS_4 Candidatus Marsarchaeota G2 archaeon ECH_B_SAG-C16 Topoisomerase:Agrobacterium fabrum str. C58 Candidatus Marsarchaeota G2 archaeon ECH_B_2 Pyrobaculum arsenaticum DSM 13514 Pyrococcus furiosus Pyrobaculum oguniense TE7 Candidatus Marsarchaeota G2 archaeon ECH_B_3 Topoisomerase:Geobacter sulfurreducens PCA Topoisomerase:Rhodobacter sphaeroides ATCC 17025 Pyrobaculum calidifontis JCM 11548 Pyrococcus furiosus DSM 3638 Pyrobaculum aerophilum str. IM2 Topoisomerase:Synechococcus sp. CC9902 Pyrobaculum ferrireducens Thermocladium sp. ECH_B Pyrobaculum islandicum Caldivirga maquilingensis Topoisomerase:Trichodesmium erythraeum IMS101 Pyrobaculum neutrophilum V24Sta Caldivirga sp. MU80 Pyrobaculum sp. WP30 Vulcanisaeta thermophila Topoisomerase:SynechocystisTopoisomerase:HaemophilusTopoisomerase:Escherichia sp.Topoisomerase:Vibrio PCC 6803 substr. influenZae KaZusa colicholerae CFT073R2866 MO10 Candidatus Bathyarchaeota archaeon B24 Candidatus Bathyarchaeota archaeon ex4484_135 Vulcanisaeta sp. EB80 Topoisomerase:Bacillus cereus G9241 Vulcanisaeta distributa Vulcanisaeta moutnovskia Topoisomerase:Aquifex aeolicus VF5 Thaumarchaeota archaeon