The 9th Annual Conference of the International Chemical Biology Society ICBS2020VIRTUAL Addressing Therapeutic Challenges Together with Chemical Biology November 11, 2020 7:30 PM to 11:30 PM EST November 12, 2020 9:30 AM to 2:00 PM EST November 13, 2020 9:30 AM to 2:40 PM EST 9th Annual Conference | November 11-13, 2020 | Virtual Table of Contents Table of Contents ............................................................ 1 Session 3: Academic-Industry Partnerships Acknowledgements ........................................................ 1 case studies .................................................................... 23 ICBS Board of Directors ................................................ 2 Session 4: Chemical Biology of Small Molecule About ICBS ...................................................................... 2 Protein Degraders ........................................................ 28 ICBS International Advisory Board ............................. 3 EFMC Speaker .............................................................. 32 ICBS Global Council ...................................................... 4 Session 5: Chemical Technologies to Promote Welcome Letter ............................................................... 5 Drug Discovery ............................................................. 33 Trainee Pre-Conference Program ................................ 6 Rising Stars Session ...................................................... 37 Detailed Program ........................................................... 7 Opening Day Trainee Forum ...................................... 41 Session 1: In-Cell Chemistry ...................................... 16 Presenter Index ............................................................. 51 Session 2: COVID-19, Disease Modeling, and Thank you to our conference sponsors ...................... 52 Drug Discovery ............................................................. 19 Acknowledgements ICBS2020 Virtual Host Biological Discovery through Chemical Innovation Initiative (BDCI), Emory University ICBS2020 Program Committee Huw Davies (co-chair), Haian Fu (co-chair), Douglas Auld, Jonathan Baell, Shuibing Chen, Jen Heemstra, Zaneta Nikolovska-Coleska, Tom Pfeifer ICBS2020 Local Organizing Committee Dennis Liotta, Jae Won Chang, Yuhong Du, M.G. Finn, Jen Heemstra, Shafiq Khan, Kojo Mensa-Wilmot, Eddie Morgan, Binghe Wang, Daqing Wu, Bill Wuest, Y. George Zheng ICBS2020 Virtual Operations Team Tiffany R. Bell-Horwath, Andrey A. Ivanov, Rachel Commander, Kun Qian, Rio Febrian ICBS2020 Trainee Forum Organizing Committee Kun Qian, Danielle Cicka, Amber Scharnow, Andre Mahoney, Ashley Modell, Jana Flegel, Jessica Nowacki, Aylin Binici, Kirujan Jeyakumar, Yuting Shuai Page 1 www.chemical-biology.org 9th Annual Conference | November 11-13, 2020 | Virtual ICBS Board of Directors Douglas S. Auld Jonathan Baell Rathnam Chaguturu (USA) President (Aus) Treasurer (USA) Haian Fu Zaneta Nikolovska-Coleska Hiroyuki Osada Chair of Board (USA) President-Elect (USA) (Japan) Tom Pfeifer Siddhartha Roy Lixin Zhang Secretary (Can) (India) Past President (China) About ICBS The International Chemical Biology Society (ICBS) is an independent, nonprofit organization dedicated to promoting research and educational opportunities at the interface of chemistry and biology. ICBS provides an important international forum that brings together cross-disciplinary scientists from academia, nonprofit organizations, government, and industry to communicate new research and help translate the power of chemical biology to advance human health. Page 2 www.chemical-biology.org 9th Annual Conference | November 11-13, 2020 | Virtual ICBS International Advisory Board Stephen Benkovic Sir Philip Cohen Jian Ding Chris Lipinski Penn State University of Dundee Shanghai Institute of Melior Discovery Materia Medica Ferid Murad Bernard Munos Litao Zhang Stuart Schreiber George Washington InnoThink Bristol-Myers Squibb Harvard University Paul Workman Tetsuo Nagano Leonard Zon Herbert Waldmann ICR-London University of Tokyo HHMI/Harvard Max Planck Institute of Molecular Physiology Junying Yuan Harvard Page 3 www.chemical-biology.org 9th Annual Conference | November 11-13, 2020 | Virtual ICBS Global Council Seung Bum Park William Pomerantz Xiaoguang Lei Sally-Ann Poulsen Mahabir Gupta Bridget Wagner Chair Co-Chair Mikiko Sodeoka Jiaoyang Jiang Ratmir Derda Changlin Tian Jason Micklefield Hanne Ingmer Christian Richard Pyane Kamyar Hadian Shi Chen Ottmann Haitao Zhang Eliezer J. Barreiro Qi Zhang Toru Kamatsu Evripidis Gavathiotis Page 4 www.chemical-biology.org 9th Annual Conference | November 11-13, 2020 | Virtual Welcome Letter Dear ICBS2020 Participants: On behalf of the ICBS leadership and the host organization, we would like to welcome each of you to this global virtual event, the 9th Annual Conference of the International Chemical Biology Society! It is an extraordinary time in the midst of the COVID-19 pandemic, which has impacted the lives of people across the world and led to major social and economic disruptions. We strongly believe that the chemical biology community can play important roles in addressing the challenges of today and beyond. Although we are unable to meet in person as we originally planned, we are excited to utilize the virtual platform to highlight the power of chemical biology to bring the community together to exchange ideas, present discoveries, and discuss emerging concepts to advance science. In particular, our program is organized to showcase the impact of collaborations and partnerships on driving chemical biology research to accelerate therapeutic discovery. We appreciate the enthusiastic participation of the thought leaders in the field as keynote speakers as they share their perspectives and inspire others. We hope that you will enjoy the presentations, thoughtfully put together by session chairs, that describe cutting edge chemical technologies and mechanistic interrogation strategies for disease biology insights. During the Opening Day Trainee Forum, which is organized by ICBS Student Chapters, ICBS2020 will feature discoveries by students and postdocs and a career discussion session to advance the professional development of trainees. We hope you will show your support and join this forum. We will also continue our tradition of showcasing emerging leaders of the field with the Rising Stars Special Session. Four outstanding ICBS Young Chemical Biologist awardees have been selected from a record number of incredible nominees. Let us come together to congratulate the rising stars of chemical biology. We would like to thank each of you, ICBS2020 participants, for your heartening response to this virtual conference. As of the day prior to ICBS2020 opening day, the number of registered participants from around the world has surpassed 1,500, representing over 50 countries and more than 300 cities. Your participation will define the success of this conference. We encourage you to engage in discussions and use the Chat and Q&A channels as well as the networking sessions to communicate with each other and the speakers. Join, connect, and inspire as a collaborative community to advance chemical biology and to address therapeutic challenges together! Enjoy the ICBS2020 Virtual Conference. Sincerely, Huw Davies, Ph.D. Professor of Chemistry, Emory University Haian Fu, Ph.D. Professor of Pharmacology & Chemical Biology, Emory University Co-Chairs, ICBS2020 Page 5 www.chemical-biology.org 9th Annual Conference | November 11-13, 2020 | Virtual 10:00 AM to 1:00 pm, November 11, 2020 (EST) Trainee Pre-Conference Program The ICBS2020 trainee forum features presentations from students and postdocs in the field of chemical biology as well as a career talk and panel discussion session with academic and industry experts! The forum aims to unite young researchers from the ICBS network, facilitate communication of new research, improve collaborative endeavors, and provide educational opportunities to the trainees in the field of chemical biology. 10:00 AM - 10:05 AM Welcome & Opening by the Trainee Forum Organizing Committee 10:05 AM - 10:55 AM Trainee Presentations Session A 10:05 AM - 10:17 AM Maria L. Adrover-Castellano, University of Michigan “Thioesterase directed evolution approach for yield improvement and expansion of the substrate scope to generate macrolactones” 10:17 AM - 10:30 AM Jiang Lan, East China University of Science and Technology “Fungal multi-functional cytochrome-P450 responsible for the biosynthesis of unprecedented BFTS-related norditerpenoids” 10:30 AM - 10:42 AM Hyungyu Lee, Emory University “Comparison of covalent delivery methods and their effects for immune-mediated killing of Helicobacter pylori” 10:42 AM - 10:55 AM Beverly Y. Mok, Broad Institute of MIT and Harvard “A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing” 11:00 AM - 11:55 PM Career Talk and Panel Discussion Dr. Colleen Keohane, Scientist, Discovery Chemistry, Janssen Dr. Luca Laraia, Assistant professor, Technical University of Denmark Dr. Kathryn Hosbein, Postdoctoral Associate & Chemistry Education Researcher, University of Michigan 12:00 PM - 1:00 PM Trainee Presentations Session B 12:00 PM - 12:12 PM Pragya Jatoo, Lead Discovery Center GmBH (LDC) “A Chemical Biology approach to decipher the Tubulin Code” 12:12 PM - 12:24 PM Dacheng Fan, University of Wisconsin-Madison “Targeted covalent inhibition of O-GlcNAc transferase in cells” 12:24 PM - 12:36 PM Shwetha Srinivasan,