414 Current Topics in Medicinal Chemistry, 2015, Vol. 15, No. 5 Editorial Editorial Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 3 Over the last years it has been recognized that a diversity of exogenous and endogenous sources can induce oxidative stress and that free radicals overproduction can cause oxida- tive damage to biomolecules. These events have been linked to several diseases, such as atherosclerosis and other cardiovascular dysfunctions, cancer, diabetics, rheumatoid arthri- tis, chronic inflammation, stroke, aging and neurodegenerative disorders. In oxidative-stress related diseases the endogenous antioxidant defenses have been found to be insufficient to prevent the oxidative damage and as consequence different efforts are currently be under- taken to increase the levels of antioxidants as they can minimize the injury caused by oxida- tive stress. Therefore, the increment of the pool of endogenous antioxidants or the intake of exogenous antioxidants can be an effective therapeutic solution. In this special issue the progresses towards the understanding of the mechanisms of oxi- dative damage and of natural or synthetic antioxidants (lipoic acid and a diversity of pheno- lic systems, namely those based on coumarin and chromone scaffolds) and their interaction with the redox-sensitive signaling pathways involved in the pathophysiology of oxidative- stress related diseases (cancer and neurodegenerative events) are reported. Furthermore the potential of spin-traps for assessing progress in the field is also highlighted. Fernanda Borges Jorge Garrido Guest Editor Guest Editor Current Topics in Medicinal Chemistry Current Topics in Medicinal Chemistry Department of Chemistry and Biochemistry Department of Chemical Engineering Faculty of Sciences, University of Porto School of Engineering (ISEP) 4169-007 Porto Polytechnic of Porto Portugal 4200-072 Porto Portugal Luciano Saso Sibel Suzen Guest Editor Guest Editor Current Topics in Medicinal Chemistry Current Topics in Medicinal Chemistry Department of Physiology and Pharmacology “Vittorio Erspamer” Department of Pharmaceutical Chemistry Sapienza University of Rome Faculty of Pharmacy 00185 Rome Ankara University, 06100 Tandogan, Ankara Italy Turkey .