EUROPEAN SOCIETY OF ENDOCRINE SURGEONS ESES Review of Recently Published Literature Collection: T. Clerici, F. Triponez, K. Lorenz, M. Elwerr, J. Hein, L. Osmak, G. Franch-Arcas & C. Martinez-Santos Compilation and design: U. Beutner, [email protected] Affiliations see next page Jan- Apr 2014 Data retrival from Pubmed: June 5th, 2014 Contents CTRL-click on category or count number jumps to the according page Publication count: SR/MA RCT CG Other Page Thyroid ............................ 12 .......... 2 ........... 5 ...... 183 ..................... 4 Parathyroid......................... 0 .......... 2 ........... 1 ........ 36 ................... 77 Adrenals ............................. 1 .......... 0 ........... 0 ........ 40 ................... 92 NET ..................................... 0 .......... 0 ........... 0 ........ 27 ................. 106 GI and General ................... 0 .......... 0 ........... 0 ........ 15 ................. 116 SR: systematic review, MA: meta-analysis, RCT: randomized controlled trial, CG: consensus statement/guidelines Pubmed-ID: PubMed-Identifier (unique number for each Pubmed entry) blue underline: Hyperlink to PubMed entry or web site of publisher. 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Collectors Thomas Clerici, MD Department of Surgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland Frédéric Triponez, MD Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Geneva, Switzerland Kerstin Lorenz, MD Malik Elwerr Janine Hein, MD Department of General-, Visceral-, and Vascular Surgery, Martin-Luther University of Halle- Wittenberg, Germany Liliana Osmak, MD Department of Endocrine Surgery, University Hospital Dijon, Dijon, France Guzmán Franch-Arcas, MD Endocrine Surgery, Department of General and Digestive Tract Surgery, University Hospital Salamanca, Salamanca, Spain Cristina Martinez-Santos, MD Endocrine Surgery, Hospital Costa del Sol Marbella, Málaga, Spain Compilation and Coordination Ulrich Beutner, PhD Department of Surgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland [email protected] ESES Review of Recently Published Literature 2014-1 Page 2 of 121 Journals covered Journal IF2012 Journal IF2012 Acta Cytol 0.69 J Clin Endocrinol Metab 6.430 Am J Kidney Dis 5.294 J Clin Oncol 18.038 Am J Nephrol 2.623 J Endocrinol 4.058 Am J Surg 2.516 J Endocrinol Invest 1.654 Am Surgeon 0.92 J Nephrol 2.015 Ann Surg 6.329 J Nucl Med 5.774 Ann Surg Oncol 4.12 J Surg Oncol 2.644 Anz J Surg 1.098 Lancet 39·06 JAMA Otolaryngol Head Neck Surg 1.779 Langenbecks Arch Surg 1.891 (prev: Arch Oto …..) JAMA Surg (prev: Arch Surg) 4.42 Laryngoscope 1.979 Br J Surg 4.839 N Engl J Med 51.658 Nat Rev Endocrinol Cancer 5.201 11.025 (prev: Nat Clin Pract Endocrinol Metab) Nat Rev Clin Oncol Chirurg 0.517 15.031 (prev: Nat Clin Pract Oncol) Clin Endocrinol Oxf 3.396 Nephrol Dial Transplant 3.371 Clin Nucl Med 2.955 Nephron Clin Pract 1.652 Curr Opin Oncol 4.027 Neuroendocrinology 3.537 Endocr Relat Cancer 5.261 Oncologist 4.10 Endocr Rev 14.873 Otolaryngol Head Neck Surg 1.625 Eur Arch Otorhinolaryngol 1.458 Surg Clin North Am 2.019 Eur J Endorcrinol 3.136 Surg Endosc 3.427 Eur J Surg Oncol 2.614 Surg Laparosc Endosc Percutan Tech 0.876 Head Neck 2.833 Surg Oncol 2.136 Horm Metab Res 2.145 Surg Oncol Clin N Am 1.22 Int J Cancer 6.198 Surgery 3.373 J Am Coll Surg 4.5 Thyroid 3.544 J Am Soc Nephrol 8.98 Updates In Surgery --- J Bone Miner Metab 2.219 World J Surg 2.228 J Bone Miner Res 6.128 Journal names are links to the journal’s homepage!, IF2012: Impact factor 2012 ESES Review of Recently Published Literature 2014-1 Page 3 of 121 Thyroid Meta-Analyses Classification of Aerodigestive Tract Invasion From Thyroid Cancer. Langenbecks Arch Surg, 399(2):209-16. Brauckhoff M. 2014. BACKGROUND: Widely invasive extrathyroidal thyroid cancer invading the aerodigestive tract (ADT) including larynx, trachea, hypopharynx, and/or esophagus occurs in 1-8 % of patients with thyroid cancer and is classified as T4a (current UICC/AJCC system). The T4a stage is associated with impaired tumor-free survival and increased disease-specific mortality. Concerning prognosis and outcome, further subdivisions of the T4a stage, however, have not been made so far. METHODS: This study is based on a systematic review of the relevant literature in the PubMed database. RESULTS: Retrospective studies suggest a better outcome in patients with invasion of the trachea or the esophagus when compared to laryngeal invasion. Regarding surgical strategies, ADT invasion can be classified based on a three-dimensional assessment determining surgical resection options. Regardless of the invaded structure, tumor infiltration of the ADT can be subdivided into superficial, deep extraluminal, and intraluminal invasion. In contrast to superficial ADT invasion, allowing tangential incomplete wall resection (shaving/extramucosal esophagus resection), deeper wall and intraluminal invasions require complete wall resection (either window or sleeve). Based on the Dralle classification (types 1-6), particularly airway invasion, can be further classified according to the vertical and horizontal extents of tumor invasion. CONCLUSIONS: The Dralle classification can be considered as a reliable subdivision system evaluated regarding surgical options as well as oncological outcome. However, further studies determining the prognostic impact of this technically oriented classification system are required. PubMed-ID: 24271275 http://dx.doi.org/10.1007/s00423-013-1142-x The Accuracy of Thyroid Nodule Ultrasound to Predict Thyroid Cancer: Systematic Review and Meta- Analysis. J Clin Endocrinol Metab, 99(4):1253-63. Brito JP, Gionfriddo MR, Al NA, Boehmer KR, Leppin AL, Reading C, Callstrom M, Elraiyah TA, Prokop LJ, Stan MN, Murad MH, Morris JC, Montori VM. 2014. CONTEXT: Significant uncertainty remains surrounding the diagnostic accuracy of sonographic features used to predict the malignant potential of thyroid nodules. OBJECTIVE: The objective of the study was to summarize the available literature related to the accuracy of thyroid nodule ultrasound (US) in the prediction of thyroid cancer. METHODS: We searched multiple databases and reference lists for cohort studies that enrolled adults with thyroid nodules with reported diagnostic measures of sonography. A total of 14 relevant US features were analyzed. RESULTS: We included 31 studies between 1985 and 2012 (number of nodules studied 18,288; average size 15 mm). The frequency of thyroid cancer was 20%. The most common type of cancer was papillary thyroid cancer (84%). The US nodule features with the highest diagnostic odds ratio for malignancy was being taller than wider [11.14 (95% confidence interval 6.6-18.9)]. Conversely, the US nodule features with the highest diagnostic odds ratio for benign nodules was spongiform appearance [12 (95% confidence interval 0.61-234.3)]. Heterogeneity across studies was substantial. Estimates of accuracy depended on the experience of the physician interpreting the US, the type of cancer and nodule (indeterminate), and type of reference standard. In a threshold model, spongiform appearance and cystic nodules were the only two features that, if present, could have avoided the use of fine-needle aspiration biopsy. CONCLUSIONS: Low- to moderate-quality evidence suggests that individual ultrasound features are not accurate predictors of thyroid cancer. Two features, cystic content and spongiform appearance, however, might predict benign nodules, but this has limited applicability to clinical practice due to their infrequent occurrence. PubMed-ID: 24276450 http://dx.doi.org/10.1210/jc.2013-2928 Quantification of Cancer Risk of Each Clinical and Ultrasonographic Suspicious Feature of Thyroid Nodules: a Systematic Review and Meta-Analysis. Eur J Endocrinol, 170(5):R203-R211. Campanella P, Ianni F, Rota CA, Corsello SM, Pontecorvi A. 2014. OBJECTIVE: In order to quantify the risk of malignancy of clinical and ultrasonographic features of thyroid nodules (TNs), we did a systematic review and meta-analysis of published studies. METHODS: We did a ESES Review of Recently Published Literature 2014-1 Page 4 of 121 literature search in MEDLINE for studies published from 1st January 1989 until 31st December 2012. Studies were considered eligible if they investigated the association between at least one clinical/ultrasonographic feature and the risk of malignancy, did not have exclusion criteria for the detected nodules, had histologically confirmed the diagnoses of malignancy, and had a univariable analysis available. Two reviewers independently extracted data on study characteristics and outcomes. RESULTS: The meta-analysis included 41 studies, for a total of 29678 TN. A higher risk of malignancy expressed in odds ratio (OR) was found for the following: nodule height greater than width (OR: 10.15), absent halo sign (OR: 7.14), microcalcifications (OR: 6.76), irregular margins (OR: 6.12), hypoechogenicity (OR: 5.07), solid nodule structure (OR: 4.69), intranodular vascularization (OR: 3.76), family history of thyroid carcinoma (OR: 2.29), nodule size >/=4 cm (OR: 1.63), single nodule (OR: 1.43), history of head/neck irradiation (OR: 1.29), and male gender (OR: 1.22). Interestingly, meta-regression analysis showed a higher risk of malignancy for hypoechoic nodules in iodine-sufficient than in iodine-deficient geographical areas. CONCLUSIONS: The current meta-analysis verified and weighed out each suspicious