Inflamm. Res. (2010) 59 (Suppl 1):S1–S8 DOI 10.1007/s00011-010-0169-5 Inflammation Research 8th World Congress on Trauma, Shock, Inflammation and Sepsis in conjunction with 23rd SIS-Europe Congress on Surgical Infections and the 2nd Interdisciplinary Summit on Inflammation TSIS 2010 March 9th–13th 2010, Munich, Germany Book of Abstracts S2 Inflamm. Res. Inflamm. Res. S3 Further on, novel concepts and targets of vaccination technology for Editorial treatment and prevention of acute septic disease as well as for chronic inflammatory morbidities will be discussed. Special emphasis is also given at TSIS 2010 to the discussion of the On behalf of the Scientific Program Committee we welcome all problem of antibiotic resistance, ‘superbugs’ and the need for shrewd congress delegates to Munich/Germany for the 8th World Congress approaches to develop new antibiotics. on Trauma, Shock, Inflammation and Sepsis – TSIS 2010 – from The scientific program of the 23rd SIS-Europe Congress on Sur- Tuesday, March 9th until Saturday, March 13th, 2010. gical Infection is highlighted with the presentation of extensive TSIS 2010 is held in conjunction with the 23rd SIS-Europe Con- information on the management of -severe intraabdominal infec- gress on Surgical Infections and the 2nd Interdisciplinary Summit tions,-intestinal failure and -complicated surgical site infections. on Inflammation (ISOI). The TSIS 2010 special conference on the Interdisciplinary Man- ISOI, organized in cooperation with the International Association of agement of Obesity is presenting a comprehensive overview on Inflammatory Societies (ISIS), is convening prominent basic and novel insights into the biology of adipose tissue, a driving force of clinical scientists to present a most up-to-date exchange on the current systemic inflammation, as well as on the therapeutic approaches and future perspectives of this most complex disease entity. towards the unhappy ‘triad’ of insulin resistance, obesity and hyper- During the recent years our understanding, predominantly of innate glycemia, specifically focussing on the role of metabolic and bariatric immune response mechanisms, and thus in parallel also the insight surgery. into the pathogenesis at the cellular and molecular level of chronic TSIS 2010 – a worldwide unique medical conference with special and acute inflammatory diseases has been revolutionized. And yet, emphasis on translational research and the biomedical sciences – will notwithstanding these developments, we have to accept that still in again present a unique platform of discussion between scientists from many facets of inflammatory morbidity major disparities exist, basic and clinical research from academic institutions and industry between the novel advances of immunobiologic science and its con- alike. version into clinically relevant progress of patient treatment. The most complex conference program comprises clase to 780 science We need to pursue new avenues for the assessment, monitoring and reports, distributed in 90 symposia and free communication sessions. treatment of inflammatory diseases. Thus, the illumination of The Scientific Committee greatly appreciates the fact that the Inter- numerous unsolved but critically important issues in acute sterile national Association of Inflammation Societies (IAIS) together with (major tissue injury) and non-sterile (sepsis) inflammation, as well as numerous distinguished international Scientific Societies and Insti- of chronic inflammatory diseases like autoimmunity induced cell tutions have contributed to the program composition. dysfunction, autoinflammation, atherosclerosis, metabolic syndrome, The Scientific Committee of TSIS 2010 is grateful to all its endorsing represents the major focus of the ISOI at TSIS 2010. scientific partners for their most supportive cooperation and for taking Better patient care, in my conviction, will only occur if we pursue the congress under their auspices. keen, close-mesh monitoring of the clinical diagnosis via compelling Further on, I do express my profound gratitude to so many loyal assessment of meaningful biomarkers together with the synchronous friends and colleagues that have been giving their strong and use of molecular imaging. unflagging support to bring this huge program to life. This novel in-vivo technology will allow us to spot non-invasively I do thank the Editors, the Editorial Board and the Publisher of intraorgan defects and otherwise undetectable tissue inflammation, INFLAMMATION RESEARCH for their interest and efforts in the which should then enable us to define the therapeutic targets preparation of this issue. unerringly. For the readers of INFLAMMATION RESEARCH, who will not be The Scientific Program of TSIS 2010 will also comprise a wide able to attend the congress, this volume will present to you cutting- spectrum of information related to emerging therapeutics strategies edge information on a wide spectrum of basic research and innovative such as extracorporeal immunotherapeutic procedures, the use of patient care in systemic inflammatory disease, as it will be presented compounds to harness defective innate immune responses, as well as during TSIS 2010. the application of stem cells/progenitor cell therapies for multiple organ reprogramming and regeneration in critically ill patients Prof. Dr. Eugen Faist, MD, FACS with multiple organ dysfunction (MODS). Congress Chairman S4 Inflamm. Res. Supplement 8th World Congress on Trauma, Shock, Inflammation and Edited by: Sepsis - TSIS 2010 Eugen Faist, MD, FACS in conjunction with 23rd SIS-Europe Congress on Surgical Infections and the 2nd Interdisciplinary Summit on Inflammation Tuesday, March 9th until Saturday, March 13th 2010 Munich, Germany Scientific Program Committee Chairman: Faist Eugen, Munich, Germany Hirsawa Hiroyuki, Chiba City, Japan Abraham Edward, Birmingham, USA Hoffmann, Johannes, Munich, Germany Alverdy John C., Chicago, USA Holst Otto, Borstel, Germany Anderson Annaliessa, Pearl River, USA Hotchkiss Richard S., St. Louis, USA Angele Martin K., Munich, Germany Jauch Karl-Walter, Munich, Germany Ayala Alfred, Providence, USA Jochum Marianne, Munich, Germany Balogh Zsolt, Newcastle, Australia Karin Michael, San Diego, USA Barbul Adrian, Baltimore, USA Keith Jr. James C., Cambridge, USA Barie Philip S, New York, USA Kovacs Elizabeth J., Maywood, USA Berger Frank, Munich, Germany Kreis Martin, Munich, Germany Bierhaus Angelika, Heidelberg, Germany Kunkel Steven L., Ann Arbor, USA Billiar Timothy R., Pittsburgh, USA Lang Reinhold, Munich, Germany Blueher Matthias, Leipzig, Germany Levi Marcel, Amsterdam, Netherlands Brohi Karim, London, United Kingdom Lotze Michael T., Pittsburgh, USA Buchman Timothy G., Atlanta, USA Maier Ronald V., Seattle, USA Buurman Wim A., Maastricht, Netherlands Mangge Harald, Graz, Austria Cakmakci Metin, Gebze, Turkey Mannick John A., Weston, USA Calandra Thierry, Lausanne, Switzerland Marshall John, Toronto, Canada Cavaillon Jean-Marc, Paris, France Marzi Ingo, Frankfurt, Germany Champion Brian, Kent, United Kingdom Moldawer Lyle L., Gainesville, USA Chaudry Irshad, Birmingham, USA Moore Ernest E., Denver, USA Cheadle William, Louisville, USA Munford Robert S., Dallas, USA Cobb J. Perren, Boston, USA Netea Mihai G., Nijmegen, Netherlands Cox Jr. Charles S., Stanford, USA O’Keefe Grant E., Seattle, USA Cross Alan S., Baltimore, USA O’Neill Luke, Dublin, Ireland De Waal Malefyt Rene´, Palo Alto, USA Opal Steven M., Pawtucket, USA Dellinger E. Patchen, Seattle, USA Oppenheim Joost, Frederick, USA Dellinger R. Phillip, Camden, USA Orlikowsky Thorsten W., Aachen, Germany Dinarello Charles A., Denver, USA Parhofer Klaus G., Munich, Germany Domdey Horst, Martinsried/Munich, Germany Radbruch Andreas, Berlin, Germany Durum Scott K., Frederick, USA Redl Heinz, Vienna, Austria Eisele Bernd, Hannover, Germany Redmond Paul, Cork, Ireland Emmrich Frank, Leipzig, Germany Reinhart Konrad, Jena, Germany Endres Stefan, Munich, Germany Reiser Maximilian, Munich, Germany Ezekowitz Alan, Rahway, USA Rock Kenneth L., Worcester, USA Fraunberger Peter, Feldkirch, Austria Rossignol Daniel P., Woodcliff Lake, USA Fry Donald E., Chicago, USA Roth Johannes, Muenster, Germany Fuchs Dietmar, Innsbruck, Austria Rotstein Ori, Toronto, Canada Gerlach Herwig, Berlin, Germany Schmitz Gerd, Regensburg, Germany Gnaiger Erich, Innsbruck, Austria Scholz Martin, Frankfurt/Main, Germany Golenbock Douglas T., Worcester, USA Schroeder Joerg, Bergisch Gladbach, Germany Gottwald Thomas, Tuebingen, Germany Singer Mervyn, London, United Kingdom Grabein Beatrice, Munich, Germany Solbach Werner, Luebeck, Germany Green Douglas R., Memphis, USA Solomkin Joseph S., Cincinnati, USA Hackam David J., Pittsburgh, USA Stueber Frank, Bern, Switzerland Hartl Wolfgang, Munich, Germany Thiemermann Christoph, London, United Kingdom Hartmann Gunther, Bonn, Germany Tracey Kevin J., Manhasset, USA Inflamm. Res. S5 Trentzsch Heiko, Munich, Germany Werdan Karl, Halle/Saale, Germany Tschopp Juerg, Epalinges, Switzerland West Michael, San Francisco, USA Van der Meer Jos W.M., Nijmegen, Netherlands Xiao Wenzhong, Stanford, USA Van der Poll Tom, Amsterdam, Netherlands Yaffe Michael B., Cambridge, USA Van Griensven Martijn, Vienna, Austria Yoshida Yuichi, Fuefuki-City, Japan Vanderheyden Jean-Luc, Waukesha, USA Zacharowski Kai, Frankfurt/Main, Germany Vogel Stefanie, Baltimore, USA Zedler Siegfried, Munich, Germany Wagner Hermann, Munich, Germany Zwissler Bernhard, Munich, Germany Wahl Hans G., Luedenscheid, Germany Wang Haichao, Manhasset, USA Ward Peter A., Ann Arbor,