PRELIMINARY SCIENTIFIC PROGRAM Thursday July 14th 13:30-17:30 SPECIAL WORKSHOP WS01 WORKSHOP ON COMMUNICATION OF RESEARCH RESULTS Chaired by: Michael J. Zigmond (Pittsburgh, USA) and Beth A. Fischer (Pittsburgh, USA) 16:00-17:30 SINS SPECIAL FEATURE FOUR ITALIAN NEUROSCIENTISTS 17:30-18:30 OPENING CEREMONY EDAB PRESIDENT’S LECTURE Fifty Years of IBRO Albert J. Aguayo (Montreal, Canada) IBRO PLENARY SESSION IBRO Past Presidents & Secretary Generals awarded by Carlos Belmonte (Alicante, Spain) & Pierre Magistretti (Lausanne, Switzerland) 18:30-19:30 OPENING PLENARY LECTURE PL1 Optical technologies for probing neural signals and systems Karl Deisseroth (Stanford, USA) 19:30-20:30 WELCOME RECEPTION 1 Friday July 15th 08:30-09:30 PLENARY LECTURE PL2 Regulation and function of adult neurogenesis in the hippocampal formation Fred H. Gage (La Jolla, USA) 09:30-11:30 SYMPOSIUM S01 INTEGRATION OF NEW NEURONS IN THE ADULT BRAIN: LESSONS FOR BRAIN REPAIR Chaired by: Alejandro Fabian Schinder (Buenos Aires, Argentina) Temporal expression of neurotrophin receptors regulates newborn neuron integration into hippocampal circuits Marco Canossa (Genoa, Italy) Local network activity controls maturation and functional integration of adult-born hippocampal neurons Alejandro Fabian Schinder (Buenos Aires, Argentina) Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats Veronica Martinez-Cerdeno (Sacramento, USA) Voluntary versus forced metamorphosis of astroglia into neurons Benedikt Berninger (Munich, Germany) 09:30-11:30 SYMPOSIUM S02 MOLECULAR AND CELLULAR DETERMINANTS OF NEURON/GLIA SPECIFICATION Chaired by: Flávia Carvalho Alcantara Gomes (Rio de Janeiro, Brazil) Glial cells generating neurons: molecular and cellular mechanisms Magdalena Gotz (Munich, Germany) Radial glial polarity and its contributions to neuronal migration in cerebral cortex Eva Anton (Chapel Hill, USA) Intra- and extra-cellular factors regulating neural stem cell differentiation during brain development Kinichi Nakashima (Ikoma, Japan) Cellular determinants of radial glia commitment and astrocyte differentiation: implications for synapse formation Flávia Carvalho Alcantara Gomes (Rio de Janeiro, Brazil) 09:30-11:30 SYMPOSIUM S03 ELIMINATION OF AMYLOID FROM THE AGEING AND ALZHEIMER DISEASE BRAIN: UNCLOGGING THE DAM Chaired by: Roxana Octavia Carare (Southampton, UK) 2 The prion-like aspect of cerebral amyloidosis Yvonne Eisele (Tubingen, Germany) The role of perivascular drainage in ageing Roxana Octavia Carare (Southampton, UK) Immunotherapy in Alzheimer's Disease James Nicoll (Southampton, UK) Dissolving the fibrils and targeting the phagocytes of the Alzheimer's brain JoAnne McLaurin (Toronto, Canada) 09:30-11:30 SYMPOSIUM S04 BLINDSIGHT IN ACTION: RESIDUAL VISUOMOTOR FUNCTIONS AFTER LESIONS OF PRIMARY VISUAL CORTEX Chaired by: Carlo Alberto Marzi (Verona, Italy) Goal-directed grasping and obstacle avoidance after lesions of V1 Melvyn Goodale (London, Canada) Disynaptic routes from superior colliculus to dorsal stream visual areas Ed Callaway (La Jolla, USA) Sensory-motor blindsight in the physical and social world Beatrice de Gelder (Tilburg, The Netherlands) Is blindsight mediated by the lesioned or the intact hemisphere? Carlo Alberto Marzi (Verona, Italy) 09:30-11:30 SYMPOSIUM S05 COMPUTATIONAL STUDY OF MEMORY INFORMATION PROCESSING: DATA ANALYSIS AND MODELING OF CORTICO-HIPPOCAMPAL INTERACTION Chaired by: Masami Tatsuno (Lethbridge, Canada) Cortical reactivation of recent neuronal activity patterns in the subsequent sleep is related to hippocampal activity Francesco Battaglia (Amsterdam, The Netherlands) Memory reactivation during slow-wave sleep and REM sleep Masami Tatsuno (Lethbridge, Canada) Role of the cognitive map during navigation planning: from place cells to direction cells – a computational model Colin Molter (Lausanne, Switzerland) Dynamical representation of environments in the brain Yoko Yamaguchi (Wako City, Japan) 11:30-14:30 POSTER SESSION 3 12:30-14:00 SPECIAL EVENT SE01 IPSEN FOUNDATION PRIZE AWARDS 12:30-14:00 SPECIAL EVENT SE02 MOLECULAR AND SYSTEMS NEUROBIOLOGY IN DEVELOPMENT AND DISEASE: CONTRIBUTIONS FROM IBRO ALUMNI WORLDWIDE Chaired by: Susan J. Sara (Paris, France) and Pierre Magistretti (Lausanne, Switzerland) Herbal compounds in the treatment of drug abuse: Fruit essential oil of Cuminum cyminum attenuates morphine-induced conditioned place preference Abbas Haghparast (Teheran, Iran) Herbal compounds in the treatment of psychiatric disorders:The aqueous extract of leaves of Piliostigma reticulatum possesses anxiolytic and antipyretic activity in mice Elisabeth Ngo Bum (Ngaoundere, Cameroon) In search of organizing principles during synapse elimination: Correlation between motoneuron size and position at spinal cord and motor unit innervation patterns Cristina Guatimosim (Belo Horizonte, Brazil) Molecular architecture of the hippocampal dendritic spine Bence Racz (Budapest, Hungary) 12:30-14:00 SPECIAL EVENT SE03 SINS-SDN JOINT MINISYMPOSIUM 1 14:30-16:00 WORKSHOP W01 BERGMANN GLIA CELLS IN SYNAPTIC FUNCTION Chaired by: Arturo Ortega (Mexico City, Mexico) Insights into the biological roles of Bergmann glia by transcriptional profiling Gabriel Corfas (Boston, USA) Plasticity of neuron to Bergmann glial cell transmission Tomas Bellamy (Cambridge, UK) The role of Bergmann glia for purinergic modulation of the cerebellar network Joaquim Deitmer (Kaiserslautern, Germany) Translational control of Bergmann glia/neuronal coupling Arturo Ortega (P, Mexico City, Mexico) 4 14:30-16:00 WORKSHOP W02 NEXT GENERATION SEQUENCING STRATEGIES IN NEUROGENETICS Chaired by: Guy A. Rouleau (Montreal, Canada) Personal genome analyses to elucidate the molecular pathogenesis of neurodegenerative diseases Shoji Tsuji (Tokyo, Japan) Using next generation sequencing to identify candidate genes for neurogenetic disorders Iscia Lopez-Cendes (Campinas, Brazil) Is exome sequencing the answer for definitive molecular diagnosis of the many rare hereditary neuropathies? Garth Nicholson (Sydney, Australia) Next sequencing generation in rare monogenic disorders: An experience in spinocerebellar degenerations Alexis Brice (Paris, France) 14:30-16:00 WORKSHOP W03 BASAL GANGLIA CONTROL OF SLEEP-WAKE REGULATION Chaired by: Yoshihiro Urade (Osaka, Japan) Sources and actions of adenosine in the basal ganglia Bertil Fredholm (Stockholm, Sweden) The role of adenosine A2A receptors in the nucleus accumbens for sleep-wake regulation Michael Lazarus (Osaka, Japan) Dopamine D2 receptors in the basal ganglia are essential in the maintenance of wakefulness Zhi-Li Huang (Shanghai, China) Basal ganglia control of sleep-wake behavior and cortical activation Jun Lu (Boston, USA) 14:30-16:00 WORKSHOP W04 GENETIC MOUSE MODELS TO UNDERSTAND SCHIZOPHRENIA Chaired by: Raul R. Gainetdinov (Genoa, Italy) Mouse models for genes associated with risk for psychosis: a platform for identification of novel antipsychotic targets Colm O'Tuathaigh (Dublin, Ireland) DISC1 mouse models of schizophrenia: a comparative analysis and future developments Mikhail Pletnikov (Baltimore, USA) Role of glutamatergic neurotransmission in the mechanism of action of antipsychotics Fabio Fumagalli (Milan, Italy) 5 Animal models to identify therapeutic mechanisms of antipsychotics Jean-Martin Beaulieu (Quebec, Canada) 14:30-16:00 WORKSHOP W05 ACTIVITY-DEPENDENT TRAFFICKING OF NMDA AND KAINATE RECEPTORS IN SYNAPTIC PLASTICITY Chaired by: R. Suzanne Zukin (New York, USA) Regulation of NMDA receptor trafficking by palmitoylation Richard L. Huganir (Baltimore, USA) SNAP25 is a target of PKC phosphorylation critical to NMDA receptor trafficking R. Suzanne Zukin (P, New York, USA) A role for SNAP25 in kainate receptor internalization and synaptic plasticity Juan Lerma (Alicante, Spain) Bidirectional plasticity expressed by NMDA receptors at hippocampal mossy fiber synapses Pablo E. Castillo (New York, USA) 16:00-17:30 WORKSHOP W06 REMODELLING OF NEURAL EXTRACELLULAR MATRIX IN HEALTH AND DISEASE Chaired by: Alexander Dityatev (Genoa, Italy) Extracellular matrix of perineuronal nets and neuroplasticity Alexander Dityatev (Genoa, Italy) Matrix metalloproteinase MMP-9 in synaptic plasticity, elipeptogenesis and drug addiction Leszek Kaczmarek (Warsaw, Poland) The neurotrypsin/agrin system – its roles in mental retardation and activity-dependent structural plasticity in the CNS Peter Sonderegger (Zurich, Switzerland) Plasminogen activating system in post-injury recovery and epileptogenesis Asla Pitkanen (Kuopio, Finland) 16:00-17:30 WORKSHOP W07 NEUROBIOLOGICAL BASIS OF EMERGING THERAPIES IN DRUG ADDICTION Chaired by: Gaetano Di Chiara (Cagliari, Italy) The dopamine hypothesis of drug addiction Marco Diana (Sassari, Italy) The human dopamine system in addiction Diana Martinez (New York, USA) Interaction between 5-HT and DA in relation to the treatment of psychostimulant dependence Valentina Valentini (Cagliari, Italy) 6 Forgetting to be addicted by brain stimulation: from animal models to human application Abraham Zangen (Rehovot, Israel) 16:00-17:30 WORKSHOP W08 HABILITATION OF HEARING IN THE 21ST CENTURY Chaired by: Edwin W. Rubel (Seattle, USA) Challenges for hair cell regeneration as a therapy for deafness Andrew Forge (London, UK) Novel therapies for noise-induced hearing loss based on the actions of insulin-like growth factor 1 and transforming growth factor β2 Isabel Varela (Madrid, Spain) Targeting cell cycle molecules and tumor suppressors for therapeutic