PPrrootteeaasseess Proteases, also known as peptidases, include various enzymes that catalyze the hydrolytic breakdown of proteins. Cathepsins Cysteine proteases (such as cathepsins) are involved in collagen / elastin degradation at sites of inflammation, and Enzyme Cat. # Amount are drug targets for diseases such as atherosclerosis and Cathepsin B 80001 10 µg emphysema. Similarly, caspase inhibitors are promising therapeutics for a number of cancers and neurological Cathepsin F 80003 10 µg diseases, including Alzheimer's, Huntington's and Cathepsin L 80005 10 µg Parkinson's. Inhibitors of viral proteases are also being Cathepsin S 80008 10 µg studied as tools for fighting HIV and HCV infections. Cathepsin V 80009 10 µg BPS Bioscience provides an extensive line of highly active, full-length human peptidase enzymes suitable for enzymatic profiling, inhibitor screening assays, and drug discovery. Caspases Protease Enzymes Enzyme Cat. # Amount Caspase-3 80500 50 µg Enzyme Catalog # Amount Activated Protein C (PROC) 70019 20 µg Caspase-6 80113 50 µg HCV1a (D168V) 80103 20 µg Caspase-7 70000 50 µg HCV1a (D168E), FLAG-His-tags 80102 20 µg Caspase-8 80114 50 µg HCV1a, FLAG-His-tags 80010 20 µg Caspase-9 80115 50 µg HCV1a (R155K), FLAG-His-tags 80101 20 µg HCV1b (D168V) 80110 20 µg HCV1b (NS3/NS4A) 80107 20 µg HCV1b (R155K) 80109 20 µg HCV1b (R155Q) 80104 20 µg HCV2a 80108 20 µg HRV3c 50319 1,000 units Human alpha Thrombin 80111 1,000 units Human Factor Xa 80112 100 units IDE 70002 20 μg MMP1 80214 20 µg MMP2 (HEK293) 80213 20 µg MMP9 (Q279R) 80215 20 µg MME 80212 20 µg PrCP 80380 10 µg Activated Renin (human) 80200 100 µg Renin (rat) 80201 100 µg Turbo3C Protease 50309 1 mg TurboTEV Protease 50308 1 mg Activity and purity of DPP4, Catalog # 80040. Substrates Protease substrates are designed for use with the BPS Dipeptidyl Peptidase Enzymes Dipeptidyl peptidases (DPPs) are emerging as an important Assay Kits for sensitive detection of peptidase activity. protease family with key roles in the regulation of signaling by peptide hormones. Substrate Catalog # Amount Fluorogenic Cathepsin F 80350 50 nmol Enzyme Catalog # Amount Substrate DPP3 80030 10 µg Fluorogenic Cathepsin V 80349 50 nmol Substrate DPP4 (CD26) 80040 10 µg DPP7 80070 10 µg Fluorogenic DPP Substrate 1 80305 50 nmol DPP8 80080 10 µg Fluorogenic DPP Substrate 2 80332 50 nmol DPP9 80090 10 µg FAP (Fibroblast Activation 80100 10 µg Protein) Inhibitors BPS offers inhibitors for screening small molecule activity. POP (Prolyl Oligopeptidase) 80105 20 µg /PREP Inhibitors of protease enzymes are important drug discovery targets for diabetes, obesity, and cancer. Inhibitor Catalog # Amount Ac-DEVD-CMK 27315 5 mg Protease Assay Kits Aliskiren hydrochloride 27300 1 mg The Protease Assay Kits are designed to measure activity BMS-790052 27054 5 mg using purified enzyme or cell extracts containing specific Bortezomib 27028 5 mg proteins. These homogeneous assays are performed in a 10 mg single 96-well plate, without time-consuming washes, for Brefeldin A 27042 10 mg rapid, specific detection of protease activity. Camostat Mesilate (FOY- 27055 305) Danoprevir 27052 2 mg Assay Kit Catalog # Amount DPP3 Assay Kit 80203 96 rxns Obatoclax 27044 5 mg 5 mg DPP4 Assay Kit 80204 96 rxns Oxyresveratrol 27318 10 mg DPP7 Assay Kit 80207 96 rxns PAC-1 27043 50 mg DPP8 Assay Kit 80208 96 rxns PCI 34051 27316 200 mg DPP9 Assay Kit 80209 96 rxns Sitagliptin 27106 5 mg FAP Assay Kit 80210 96 rxns Telaprevir (VX-950) 27051 50 mg POP Assay Kit 80106 96 rxns Trimidox 27319 100 mg Caspase-3 Assay Kit 80700 96 rxns Trimidox 27320 5 mg Caspase-6 Assay Kit 80703 96 rxns VX-222 27053 5 mg Caspase-7 Assay Kit 80701 96 rxns Z-DEVD-FMK 27314 51mg Caspase-8 Assay Kit 80704 96 rxns Z-VAD-FMK, Free Acid 27018 1 mg Renin Assay Kit 80211 96 rxns Z-VAD-FMK, Methyl Ester 27017 Z-VAD(OMe)-FMK 27313 5 mg 6044 Cornerstone Ct. West, Suite E San Diego, CA 92121 Ph: 858.829.3082 Fax: 858.481.8694 TThhee ##11 SSoouurrccee fffoorr AAcctttiiivvee EEnnzzyymmeess www.bpsbioscience.com Rev. May 2015 .