MASSACHUSETTS INSTITUTE OF TECHNOLOGY Chemical Hygiene Plan Revision 22: Aug 11, 2020 Institute for Soldier Nanotechnologies Table of Contents PART I. Getting Started ......................................................................................................................... 4 1. INTRODUCTION ...................................................................................................................................... 4 1.1. Purpose, Policy, and Scope ................................................................................................................................................. 4 1.2. Plan Organization ................................................................................................................................................................ 4 2. ROLES AND RESPONSIBILITIES ................................................................................................................ 5 2.1. The DEPARTMENT, LAB, or CENTER CHAIR .................................................................................................................. 5 2.2. The CHEMICAL HYGIENE OFFICER ................................................................................................................................ 5 2.3. The EHS COORDINATOR ................................................................................................................................................ 5 2.4. The PRINCIPAL INVESTIGATOR or LABORATORY SUPERVISOR .................................................................................. 6 2.5. The EHS REPRESENTATIVE ............................................................................................................................................ 7 2.6. The ENVIRONMENT, HEALTH and SAFETY (EHS) OFFICE ............................................................................................ 8 2.7. EMPLOYEES, STAFF, STUDENTS .................................................................................................................................... 8 2.8. VISITORS, TOURS and PETS ........................................................................................................................................... 9 3. TRAINING ............................................................................................................................................... 9 3.1. Training Requirements ........................................................................................................................................................ 9 3.2. Training Records ................................................................................................................................................................ 10 4. INFORMATION REQUIREMENTS .......................................................................................................... 10 4.1 Basic Requirements ..................................................................................................................................................... 10 4.2 Chemical Safety Information Sources ........................................................................................................................ 10 4.3. Guidance and resources for COVID-19 response ...................................................................................................... 12 PART II. General Chemical Hygiene Practices ...................................................................................... 14 1. INTRODUCTION .................................................................................................................................... 14 2. IDENTIFICATION AND CLASSIFICATION OF HAZARDOUS CHEMICALS ................................................. 15 2.1. Possible Animal Carcinogens ...................................................................................................................................... 15 2.2. Corrosive Substances................................................................................................................................................... 16 2.3. Irritants ......................................................................................................................................................................... 16 2.4. Sensitizers ..................................................................................................................................................................... 16 2.5. Flammable, Highly Reactive and Explosive Substances ............................................................................................ 16 2.6. Hazardous Substances with Toxic Effects on Specific Organs ................................................................................... 16 2.7. Particularly Hazardous Substances/Select Carcinogens ............................................................................................ 17 3. STANDARD OPERATING PROCEDURES FOR WORK WITH HAZARDOUS CHEMICALS .......................... 20 3.1. Preliminary Steps and Procedures .............................................................................................................................. 20 3.2. Essential Laboratory Work Practices .......................................................................................................................... 24 3.3. Additional Procedures for Work with Particularly Hazardous Substances .............................................................. 29 3.4. Additional Requirements for Work with Select Toxins ............................................................................................. 31 3.5. Special Precautions for Work with Hydrofluoric Acid ............................................................................................... 32 3.6. Special Precautions for Work with Formaldehyde .................................................................................................... 32 3.7 Special Precautions for Work with Nanomaterials .................................................................................................... 32 3.8 Special Precautions for Work with Cyanide Salts and Compounds .......................................................................... 33 3.9 Special Precautions for Work with Pyrophoric and Water-Reactive Materials ....................................................... 33 3.10 Special Precautions for Work with Cytotoxic Drugs .................................................................................................. 34 4. PERSONAL PROTECTIVE EQUIPMENT .................................................................................................. 34 5. OTHER SAFETY AND STORAGE EQUIPMENT ........................................................................................... 35 5.1. Laboratory Fume Hoods/Ventilation .......................................................................................................................... 35 ___________ PAGE 1 5.2. Fire Extinguishers, Safety Showers, and Eyewash Stations ....................................................................................... 36 5.3. Safe Use of Warm and Cold Environmental Rooms .................................................................................................. 37 6. CHEMICAL CONTAINER LABELING GUIDELINES ................................................................................... 37 7. COMPRESSED GAS CYLINDERS ............................................................................................................. 37 8. CHEMICAL WASTE MANAGEMENT ...................................................................................................... 38 8.1. Waste Management Responsibility ........................................................................................................................... 38 8.2. Training ......................................................................................................................................................................... 38 8.3. Procedures for Hazardous Waste Generators ........................................................................................................... 38 8.4 Sink Discharges/Wastewater ...................................................................................................................................... 40 9. SHIPPING HAZARDOUS AND DANGEROUS MATERIALS ...................................................................... 41 10. APPENDICES ......................................................................................................................................... 42 10.1. Appendix II-A OSHA Permissible Exposure Limits (PELs) ........................................................................................... 42 10.2. Appendix II-B ACGIH Threshold Limit Values (TLVs) .................................................................................................. 42 10.3. Appendix II-C How to Determine if a Chemical is a Particularly Hazardous Substance .......................................... 42 PART III. DLC or Laboratory Specific Chemical Hygiene Practice or Lab Specific Standard Operating Procedures .......................................................................................................................................... 45 1. INTRODUCTION .................................................................................................................................... 45 2. LAB SPECIFIC