Anti-FCER1A monoclonal antibody, clone DSB3 [FITC] (DCABH-1306) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to Fc epsilon RI (FITC) Antigen Description Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. Immunogen Recombinant fragment: FEDSGEYKCQ HQQVNESEPV YLEVFSDWLL LQASAEVVME GQPLFLRCHG WRNWDVYKVI YYKDGEALKY WYENHNISIT NATVEDSG, corresponding to amino acids 85-172 of Human Fc epsilon RI Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone DSB3 Purity IgG fraction Purification This antibody was purified from serum free culture medium of mouse hybridoma (CRA2) by propriety chromatography under mild conditions. Filter sterilized Conjugate FITC Applications ICC, Flow Cyt, Inhibition Assay Positive Control CHO/alpha beta gamma cells Procedure Conjugated Antibodies Format Liquid Size 50 μg Buffer pH: 7.40; Constituents: 49% PBS, 50% Glycerol Preservative None Storage Store at +4°C. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens ] Official Symbol FCER1A Synonyms FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypep Entrez Gene ID 2205 Protein Refseq NP_001992 UniProt ID P12319 Chromosome Location 1q23 Pathway Asthma, organism-specific biosystem; Asthma, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; Function IgE binding; receptor activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.