Hazardous Chemical Agents (anti-neoplastic, carcinogens, reproductive hazards, neurotoxic) Hazard Class / Exposure Controls *refer to Exp. Chemical name CAS: Synonyms Category Hazards Controls tab Notes: Hazardous drug, hormone, Theraputic (NIOSH Table 2 (similar (-)-Epinephrine 51-43-4 Adrenaline neurotransmitter, GHS Cat. 2 Acute toxicity effects)) Chemical review not required, unless used as an experimental drug L(-)-3-(N-Methyl)-α- pyrrolidyl)pyridin, (-)-1-Methyl- (-)-Nicotine 54-11-5 2-(3-pyridyl)pyrrilidine Toxic chemical Acute oral, dermal hazard NIOSH Table 2 (similar effects) (+)-Tetrahydro-4β-hydroxy- N,N,N,5α-tetramethyly-2α- GHS Cat. 1 acute toxicity (+)-Muscarine 2303-35-7 furanmethanaminium chloride hazardous chemical (inhalation), GHS Cat. 2 (dermal) NIOSH Table 2 (similar effects) Isopto Carpine, Sanpilo, GHS Cat. 2 acute toxicity (oral and (+)-Pilocarpine (hydrochloride) 54-71-7 Salageno Hazardous drug inhalation), NIOSH Table 2 (similar effects) 2,2'-bis(8-Formyl-1,6,7- trihydroxy-5-isopropyl-3- (±) Gossypol, from cotton seeds 303-45-7 methylnaphthalene Carcinogen GHS Cat. 2 carcinogen Carcinogen (±)-Nicotine 22083-74-5 Toxic chemical Acute oral, dermal hazard NIOSH Table 2 (similar effects) 1,2-Dimethylhydrazine 306-37-6 Carcinogen Carcinogenicity(Category 1B) Carcinogen IARC Group 2A carcinogen, 1,3 Propanesultone 1120-71-4 Carcinogen / toxic chemical Neurological and behavior effects, Carcinogen TPA, tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12- 12-0-tetra-decanoylphorbol-13-acetate 16561-29-8 myristate 13-acetate (PMA) Carcinogen potent tumor promoter UCAR provided list - Carcinogen Diazomethane precursorMNNGN-Methyl-N′- 1-Methyl-3-nitro-1-nitrosoguanidine 70-25-7 nitro-N-nitrosoguanidine Carcinogen Carcinogenicity(Category 1B), Carcinogen *MPTP produces irreversible lesions of the brain dopaminergic system 1-methyl-4phenyl-1,2,3,4- Permanent symptoms of involved in psychomotor functioning with symptoms closely resembling tetrahydropyridine 28289-54-5 MPTP Neurotoxic agent Parkinson's diesease MPTP Parkinson's disease. Refer to detailed exposure control recommendations. 1-Nitrosopyrrolidine 930-55-2 NPYRN-Nitrosopyrrolidine Carcinogen Carcinogenicity(Category 2) Carcinogen 2,3,7,8-tetrachlorodibenz-o-p-dioxin (TCDD) 1746-01-6 TCDD, "Dioxin" Carcinogen IARC Group 1, teratogen, mutagen Carcinogen 9/20/2021 Page 1 of 29 Hazardous Chemical Agents (anti-neoplastic, carcinogens, reproductive hazards, neurotoxic) Hazard Class / Exposure Controls *refer to Exp. Chemical name CAS: Synonyms Category Hazards Controls tab Notes: Germ cell mutagenicity(Category 2), H341Carcinogenicity(Category 1B), H350Reproductive toxicity(Category 2), H361Specific target organ toxicity -repeated 2,4-Dinitrotoluene 121-14-2 Hazardous Drug exposure(Category 2), NIOSH Table 2 (similar effects) Germ cell mutagenicity(Category 2), H341Carcinogenicity(Category 1B), H350Reproductive toxicity(Category 2), H361Specific target organ toxicity -repeated 2,6-Dinitrotoluene 606-20-2 Hazardous Drug exposure(Category 2) NIOSH Table 2 (similar effects) 2-acetylaminofluorene 53-96-3 2-Acetaminofluorene Carcinogen / toxic chemical mutagen, OSHA - Carcinogen UCAR provided list - Carcinogen 1-methyl-6-phenyl-1H- 2-Amino-1-methyl-6-phenylimidazo[4,5- imidazo[4,5-b]pyridin-2-amine; b]pyridine 105650-23-5 PhlP; Carcinogen Carcinogenicity, Category 2 Carcinogen Germ Cell Mutagenicity, Category 2 Carcinogenicity, Category 2 Specific 3-methyl-3H-imidazo[4,5- Target Organ Toxicity (repeated 2-Amino-3-methylimidazo[4,5-f]quinoline 76180-96-6 f]quinolin-2-amine; Hazardous Drug exposure), Category 2 NIOSH Table 2 (similar effects) Germ cell mutagenicity(Category 2), 2-Nitropropane 79-46-9 Carcinogen Carcinogenicity(Category 1B) Carcinogen 3,3',4',4',5 Pentachlorobiphenyl 57465-28-8 PCB 126 Hazardous Chemical STOT RE 2 NIOSH Table 2 (similar effects) Special waste water requirements. Contact UR Env. Compliance / Waste β-aminopropionitrile fumarate Hazardous chemical, potential GHS Cat 1B Reproductive hazard, Management Group. Need to collect any leftover drinking water to dispose of 3-Aminopropionitrile fumarate salt 2079-89-2 salt , BAPN fumarate salt, BAPN anti-neoplastic teratogen NIOSH Table 1 (similar effects) as HazWaste (no cutoff amt) Acute dermal toxicityCategory 2Germ Cell MutagenicityCategory 1BCarcinogenicityCategory 1BSpecific target organ toxicity (single exposure)Category 1Specific 4,4'- target organ toxicity - (repeated 4,4'-Methylenedianiline 101-77-9 Diaminodiphenylmethane Hazardous Drug exposure)Category 2 NIOSH Table 2 (similar effects) 4-Biphenylamine4- Biphenylylamine4- 4-Aminobiphenyl 92-67-1 Phenylaniline Carcinogen Carcinogenicity(Category 1A) Carcinogen 9/20/2021 Page 2 of 29 Hazardous Chemical Agents (anti-neoplastic, carcinogens, reproductive hazards, neurotoxic) Hazard Class / Exposure Controls *refer to Exp. Chemical name CAS: Synonyms Category Hazards Controls tab Notes: 4-Hydroxytamoxifen 68047-06-3 Afimoxifene, 4-OHT, Tamogel Anti-neoplastic drug GHS Cat. 2 Reproductive toxicity NIOSH Table 1 (similar effects) 4-nitroquinoline 1-oxide 56-57-5 4-Nitroquinoline 1-oxide Carcinogen Carcinogenicity (Category 1B), H350 Carcinogen Reproductive toxicity(Category 2), 4-Nonylphenol 104-40-5 p-Nonylphenol Hazardous Chemical H361 NIOSH Table 3 (similar effects) GHS Carcinogen Cat. 2, GHS Acute Toxicity Dermal Cat.2, Acute 4α-Phorbol 12,13-didecanoate 27536-56-7 4α-Phorbol 12-13-dicaprinate Carcinogen Toxicity Inhalation Cat. 1 NISOH Table 2/Carcinogen Special waste water requirements. Contact UR Env. Compliance / Waste BrdU, Broxuridine, GHS Cat. 2 Reproductive hazard, Management Group. Need to collect any leftover drinking water to dispose of 5-bromo-2' deoxyuridine 59-14-3 Bromodeoxyuridine Toxic chemical GHS Cat 1B germ cell mutageb NIOSH Table 3 (similar effects) as HazWaste (no cutoff amt) Special waste water requirements. Contact UR Env. Compliance / Waste Management Group. Need to collect any leftover drinking water to dispose of 5-chloro-2'-deoxyuridine 50-90-8 CldU Toxic chemical GHS Cat. 2 carcinogen Carcinogen as HazWaste (no cutoff amt) Special waste water requirements. Contact UR Env. Compliance / Waste 61135-33-9 EdU GHS Cat. 2 Reproductive hazard, Management Group. Need to collect any leftover drinking water to dispose of 5'-ethynyl-2'-deoxyuridine Toxic chemical GHS Cat 1B germ cell mutageb NIOSH Table 3 (similar effects) as HazWaste (no cutoff amt) FRDU, Floxuridine; FUDR; 2`- Special waste water requirements. Contact UR Env. Compliance / Waste 50-91-9 Deoxy-5-fluorouridine Management Group. Need to collect any leftover drinking water to dispose of 5-Fluoro-2`-deoxyuridine Toxic chemical GHS Cat 2 Germ cell mutagen NIOSH Table 3 (similar effects) as HazWaste (no cutoff amt) 2,4-Dihydroxy-5- 51-21-8 fluoropyrimidine 5-Fluorouracil Carcinogen Carcinogenicity, GHS Cat.2 NIOSH Table 1 Special waste water requirements. Contact UR Env. Compliance / Waste GHS Cat. 2 Reproductive hazard, Management Group. Need to collect any leftover drinking water to dispose of 5-lodo-2'-deoxyuridine 54-42-2 IdU Toxic chemical GHS Cat 2 germ cell mutageb NIOSH Table 3 (similar effects) as HazWaste (no cutoff amt) GHS Cat. 3 carcinogen, GHS Cat. 1B 5α-Dihydrotestosterone 521-18-6 DHT Hazardous drug Reproductive hazard Carcinogen 7,12-dimethylbenzyl(a)anthracene 57-97-6 DMBA Carcinogen GHS Cat 1B carcinogen Carcinogen Reproductive hazard, FDA Special waste water requirements. Contact UR Env. Compliance / Waste pregnancy category C, GHS Management Group. Need to collect any leftover drinking water to dispose of Abacavir 136470-78-5 Dihydrofolliculin Anti-viral, hazardous drug carcinogenicity Cat. 2 NIOSH Table 2 as HazWaste (no cutoff amt) Abiraterone 154229-19-3 17β-Estradiol anti-neoplastic drug Reproductive hazard NIOSH Table 1 GHS Cat. 2 c Carcinogen, GHS Cat. 1B Reproooductive toxicity, GHS Abraxane NA Albumin bound Paclitaxel Anti-neoplastic drug Cat 2 Germ cell mutagen Carcinogen Acetohydroxamic Acid 546-88-3 AHA Hazardous Chemical Reproductive toxicity(Category 1BNIOSH Table 3 (similar effects) Acrylic acid amide, 2- GHS Carcinogen Cat. 1B, GHS Acrylamide 79-06-1 Propenamide Carcinogen, Reproductive Hazard Reproductive toxicity Cat. 2 Carcinogen 9/20/2021 Page 3 of 29 Hazardous Chemical Agents (anti-neoplastic, carcinogens, reproductive hazards, neurotoxic) Hazard Class / Exposure Controls *refer to Exp. Chemical name CAS: Synonyms Category Hazards Controls tab Notes: Highly toxic, mutagen, FDA Actinomycin 50-76-0 D actinomycin Hazardous drug, anti-neoplastic Prgnancy Cat. B NIOSH Table 1 antineoplastic Monoclonal Ado-trastuzumab emtansine 1018448-65-1 Kadcyla Antibodies Reproductive hazard NIOSH Table 1 Afatinib 850140-72-6 Gilotrif anti-neoplastic drug Reproductive hazard NIOSH Table 1 Acute Toxicity: Inhalation, Category 2,3,6aR,9aS-tetrahydro-4- 2 methoxy-1H,11H- Acute Toxicity: Oral, Category 1 cyclopenta[c]furo[3',2':4,5]furo Acute Toxicity: Skin, Category 1 [2,3-h][1]benzopyran1,11- Germ Cell Mutagenicity, Category dione; AFB1; HSDB 3453; NSC 1B Aflatoxin B1 1162-65-8 529592; Hazardous Drug Carcinogenicity, Category 1B NIOSH Table 2 (similar effects) Alefacept 222535-22-0 Amevive Immunosuppresant increased risk of malignancies NIOSH Table 2 Acute Tox.(O) 4: H302Skin Corr. 2: monosodium salt trihydrate H315Eye Damage 1: H318STOT (SE) (1:1:3);Adronat; Fosamax; G- 3: H335 H336Toxic Repro. 2: Alendronate (sodium hydrate) 121268-17-5 704650; MK-21 Hazardous Drug H361STOT (RE) 2: H373 NIOSH Table 2 (similar