Curriculum Vitae Zachary L. Fuller, Ph.D. Department of Biological Sciences Columbia University 606 Fairchild Center, New York, NY 10027 Email: [email protected] Website: www.zfullergenomics.com Education: 2012-2017 Ph.D. (Biology), The Pennsylvania State University 2008-2012 B.S. (Biology), Creighton University Research & Work Experience: 2017- Postdoctoral Research Fellow, Columbia University Advised by Dr. Molly Przeworski, Department of Biological Sciences, Columbia University, New York, NY 2015-2017 National Geographic Young Explorer Advised by Dr. Christina Grozinger, Department of Entomology, The Pennsylvania State University, University Park, PA 2012-2017 Ph.D. Candidate, The Pennsylvania State University Advised by Dr. Stephen Schaeffer, Department of Biology, The Pennsylvania State University, University Park, PA 2012-2013 Rotation Student, The Pennsylvania State University Advised by Dr. Webb Miller, Bioinformatics and Genomics Institute, The Pennsylvania State University, University Park, PA 2009-2012 Undergraduate Researcher, Creighton University Advised by Dr. Soochin Cho, Department of Biology, Creighton University, Omaha, NE Peer-Reviewed Publications: Zachary L. Fuller, Veronique Mocellin, Luke Morris, Neal Cantin, Julie Peng, Yi Liao, Jihanne Shepherd, Joseph Pickrell, Peter Andolfatto, Mikhail Matz, Line Bay, Molly Przeworski. (2020) Towards a genomic predictor of bleaching in the coral Acropora millepora. Science (in press) bioRxiv Preprint: https://doi.org/10.1101/867754 Zachary L. Fuller, Jeremy Berg, Hakhamanesh Mostafavi, Guy Sella, Molly Przeworski. (2019) Measuring Intolerance to Mutation in Human Genetics. Nature Genetics. DOI: 10.1038/s41588-019-0383-1 Zachary L. Fuller, Spencer Koury, Nitin Phadnis, Stephen Schaeffer. (2018) How Chromosomal Rearrangements Shape Adaptation and Speciation: Case Studies in Drosophila pseudoobscura and its sibling species D. persimils. Molecular Ecology. DOI: 10.1111/mec.14923 Zachary L. Fuller, Christopher Leonard, Randee Young, Stephen Schaeffer, Nitin Phadnis. (2018) Ancestral Polymorphisms Explain the Role of Chromosomal Inversions in Speciation. PLoS Genetics. DOI: 10.1371/journal.pgen.1007526 David Galbraith, Zachary L. Fuller, Axel Brockmann, Maryann Frazier, Mary Gikungu, Karen Kapheim, Jeffrey Kerby, Sarah Kocher, Oleksiy Losyev, Elliud Muli, Harland Patch, Joyce Sakamoto, Scott Stanley, Anthony Vaudo, Christina Grozinger. (2018) Investigating the Viral Ecology of Global Bee Communities with High-throughput Metagenomics. Scientific Reports. 10.1038/s41598-018-27164-z Zachary L. Fuller, Gwilym Haynes, Stephen Richards, Stephen Schaeffer. (2017) Genomics of Natural Populations: Evolutionary Forces that Establish New Gene Arrangements in Drosophila pseudoobscura. Molecular Ecology. DOI: 10.1111/mec.14381 Zachary L. Fuller, Gwilym Haynes, Stephen Richards, Stephen Schaeffer. (2016) Genomics of Natural Populations: How Differentially Expressed Genes Shape the Evolution of Chromosomal Inversions in Drosophila pseudoobscura. Genetics. DOI: 10.1534/ genetics.116.191429 Zachary L. Fuller, Elina Nino, Harland Patch, Oscar Bedoya-Reina, Tracey Baumgarten, Elluid Muli, Fiona Mumoki, Aakrosh Ratan, John McGraw, Maryann Frazier, Daniel Masiga, Stephen Schuster, Christina Grozinger, Webb Miller. (2015) Genome-wide Analysis of Signatures of Selection in Populations of African Honey-bees (Apis mellifera). BMC Genomics. DOI: 10.1186/s12864-015-1712-0 Zachary L. Fuller, Gwilym Haynes, Dianhui Zhu, Matthew Batterton, Hsu Chao, Shannon Duggan, Stephen Richards, Stephen Schaeffer. (2014) Evidence for Stabilizing Selection on Codon Usage in Chromosomal Rearrangements of Drosophila pseudoobscura. G3: Genes, Genomes & Genetics. DOI: 10.1534/g3.114.014860 Preprints and In-Review Publications: William Milligan, Zachary L. Fuller, Ipsita Agarwal, Michael Eisen, Molly Przeworski, Guy Sella. (2020) Impact of Essential Workers in the Context of Social Distancing for Epidemic Control. medRxiv Preprint: https://doi.org/10.1101/2020.05.05.20092262 Maurizio Mauro, Shan Wei, Andrzej Breborowicz, Xin Li, Claudia Bognanni, Zachary L. Fuller, Tom Philipp, Zev Williams. (2019) Pervasive, but reversible, catastrophic DNA damage caused by LINE-1 retrotransposons in human primary trophoblasts. (In Review at Fertility & Sterility) Zachary L. Fuller, Spencer Koury, Christopher Leonard, Randee Young, Kobe Ikegami, Jonathan Westlake, Stephen Richards, Stephen Schaeffer, Nitin Phadnis. (2018) Extensive recombination suppression and chromosome-wide differentiation of a segregation distorter in Drosophila. (In Revision at Genetics). bioRxiv Preprint: https://doi.org/10.1101/504126 Grants: Agouron Institute (July 2019-July 2021) “Precision Medicine for Corals: Predicting Bleaching Response from Genomes” Co-Principal Investigator, $440,ooo Direct NIH Ruth L. Kirschstein National Research Service Award (May 2018-May 2020) “Characterizing and Mapping Deleterious Mutations in Humans” Grant Number: F32 GM128318 National Geographic Society (July 2015-July 2017) “High throughput viral metagenomics in Kenyan honeybees” Principal Investigator, $10,000 Direct Oral Presentations: *Invited Speaker Zachary Fuller, Joe Pickrell, Peter Andolfatto, Mikhail Matz, Line Bay, Molly Przeworski. “Genome-wide association study (GWAS) of bleaching tolerance in a Great Barrier Reef coral”. The Allied Genetics Conference. Virtual. April 23, 2020 Zachary Fuller*, Molly Przeworski. “Towards a genomic predictor of bleaching in the coral Acropora millepora” American Museum of Natural History Comparitive Biology Seminar Series. New York, NY. April 13, 2020 Zachary Fuller, Julie Peng, Jihanne Shepherd, Peter Andolfatto, Joseph Pickrell, Mikhail Matz, Line Bay, Molly Przeworski. “Towards the genetic prediction of bleaching response in Acropora millepora”. Evolution Meeting. Providence, RI. June 25, 2019 Mikhail Matz, Groves Dixon, Yi Liao, Zachary Fuller. “Rampant Cryptic Speciation and Environmental Specialization in Two Massive Coral Species from the Florida Keys.” Society for Integrative and Comparative Biology (SICB) 2019 Annual Meeting. Tampa Bay, FL. January 4, 2019. Zachary Fuller, Yi Liao, Line Bay, Mikhail Matz, Molly Przeworski. “Towards the genetic prediction of bleaching response in coral.” Global Invertebrate Genomics Alliance Research Conference and Workshop. Willemstad, Curacao. October 20, 2018. Zachary Fuller, Christopher Leonard, Randee Young, Stephen Schaeffer. “The Role of Chromosomal Inversions in Speciation.” The New York Population Genetics Conference. Cold Spring Harbor, NY. January 10, 2018 Zachary Fuller, Gwilym Haynes, Stephen Richards, Stephen Schaeffer. “Local Adaptation and the Establishment of Inversions in Natural Populations of Drosophila pseudoobscura Through the Indirect Effects of Suppressed Recombination.” The Allied Genetics Conference. Orlando, FL. July 15, 2016 Christopher Leonard, Zachary Fuller, Randee Young, Stephen Schaeffer, Nitin Phadnis. “Evidence for the Interspecies Transfer of a Driving X Chromosome.” The Allied Genetics Conference. Orlando, FL. July 15, 2016 Zachary Fuller, Gwilym Haynes, Stephen Richards, Stephen Schaeffer. “The Evolutionary Mechanisms that Establish Chromosome Rearrangements in Natural Populations of Drosophila pseudoobscura.” Evolution Meeting (Hamilton Award Symposium). Austin, TX. June 11, 2016 Zachary Fuller, Randee Young, Nitin Phadnis, Stephen Schaeffer. “The Genomic Consequences of Segregation Distortion in Drosophila pseudoobscura.” Penn State Annual Bioinformatics & Genomics Retreat. University Park, PA. August 2015 Zachary Fuller, Gwilym Haynes, Stephen Richards, Stephen Schaeffer. “Unusual Haplotype Structure and Reduced Recombination in Chromosomal Rearrangements of Drosophila pseudoobscura.” Genetics Society of America’s 55th Annual Drosophila Conference. San Diego, CA. March 28th 2014 Zachary Fuller, Gwilym Haynes, Stephen Richards, Stephen Schaeffer. “Identifying the Evolutionary Forces Behind the Maintenance and Origin of Chromosomal Rearrangements in Populations of Drosophila pseudoobscura.” 2013 SMBE Conference. Chicago, IL. July 9th 2013 Upcoming Oral Presentations: Zachary Fuller, Molly Przeworski. “Genomic Tools for Understanding Coral Bleaching” Pacific Symposium for Biocomputing. Waimea, HI. January 2021 [Invited Speaker] Poster Presentations: Zachary Fuller, Joe Pickrell, Peter Andolfatto, Mikhail Matz, Line Bay, Molly Przeworski. “Genome-wide association study (GWAS) of bleaching tolerance in a Great Barrier Reef coral”. The Biology of Genomes. Cold Spring Harbor (Virtual). May 2020 Mikhail Matz, Zachary Fuller. “LD Networks: Unsupervised Detection of Polygenic Selection”. Society for Integrative and Comparative Biology (SICB) 2020 Annual Meeting. Austin, TX. January 2020 Zachary Fuller, Julie Peng, Jihanne Shepherd, Peter Andolfatto, Joseph Pickrell, Mikhail Matz, Line Bay, Molly Przeworski. “Toward the genetic prediction of bleaching response in Acropora millepora”. 2019 SMBE Conference. Manchester, UK. July 2019. Zachary Fuller, Jeremy Berg, Hakhamanesh Mostafavi, Guy Sella, Molly Przeworski. “A Population Genetics Perspective on Measures of Intolerance to Mutation”. 2018 SMBE Conference. Yokohama, Japan. July 2018. Zachary Fuller, Stephen Schaeffer “Selection Across Environmental Gradients Leads to the Establishment of Chromosomal Inversions in Populations”. Genetics Society of America’s 58th Annual Drosophila Conference. San Diego, CA. April 2017 Christopher Leonard, Zachary Fuller, Randee Young, Stephen Richards, Stephen Schaeffer,