Anti-Histone H3 (mono methyl K4) polyclonal antibody (CABT-LM00401) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chroma Target Histone H3K4me2 Immunogen A synthetic methylated peptide corresponding to residues surrounding K4 of human histone H3 Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Antibodies were produced by immunizing rabbits and were purified by antigen affinity- chromatography. Conjugate Unconjugated Applications WB,IHC,IF,IP,ChIP Molecular Weight 15kDa Format Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Preservative 0.02% Sodium Azide Storage Store at -20°C or -80°C. Avoid freeze / thaw cycles. GENE INFORMATION Gene Name HIST3H3 histone cluster 3, H3 [ Homo sapiens (human) ] Official Symbol HIST3H3 Synonyms HIST3H3; histone cluster 3, H3; H3 histone family, member T , H3FT, histone 3, H3; histone H3.1t; H3/g; H3t; H3/t; histone 3, H3; H3 histone family, member T; H3.4; H3FT; MGC126886; MGC126888; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Entrez Gene ID 8290 Protein Refseq NP_003484 UniProt ID Q16695 Chromosome Location 1q42 Pathway Alcoholism; Cell Cycle; Cellular Senescence; Cellular responses to stress; Chromosome Maintenance; DNA Damage/Telomere Stress Induced Senescence; EGFR1 Signaling Pathway; FSH signaling pathway; Meiosis; Meiotic Recombination; Meiotic Synapsis; Packaging O Function DNA binding; protein binding; protein heterodimerization activity References 1. Workman, J.L. and Kingston, R.E. (1998) Annu Rev Biochem 67, 545-79. 2. Hansen, J.C. et al. (1998) Biochemistry 37, 17637-41. 3. Strahl, B.D. and Allis, C.D. (2000) Nature 403, 41-5. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.