New York State Department of Health – Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – May 9, 2011 Summary of Participant Performance (Mean and Standard Deviation) Acetaminophen (mg/L) Specimen: T51 Specimen: T52 Specimen: T53 Specimen: T54 Specimen: T55 Number [Code] Instrument or Reagent System -------------- -------------- -------------- -------------- -------------- ------- ------------------------------------- 56.65 ± 2.65 165.18 ± 10.82 76.70 ± 3.84 31.81 ± 1.92 29.78 ± 2.41 n = 216 [---] All Methods & Instruments 51.9 159.9 75.0 29.6 26.9 [---] Weigh-in value <Instruments> 48.11 ± 1.23 149.36 ± 1.61 68.00 ± 0.55 26.50 ± 1.40 24.50 ± 1.02 n = 6 [ABJ] Abbott Architect c System 52.45 ± 3.44 165.25 ± 11.14 75.28 ± 4.23 29.72 ± 2.07 27.40 ± 1.50 n = 10 [ABB] Abbott AxSym 51.30 ± 3.07 158.15 ± 8.27 73.21 ± 1.64 28.72 ± 1.08 26.78 ± 1.46 n = 12 [OLC] Beckman Coulter AU Chemistry System 57.91 ± 3.01 170.08 ± 7.79 81.43 ± 3.05 34.52 ± 1.17 30.50 ± 2.36 n = 8 [BCX] Beckman Coulter LX-20 56.68 ± 1.99 168.42 ± 5.66 79.57 ± 4.10 32.97 ± 1.29 29.66 ± 1.82 n = 11 [BCG] Beckman Coulter UniCel DxC 600 55.36 ± 3.07 167.68 ± 6.34 78.54 ± 4.30 32.26 ± 2.07 29.23 ± 2.82 n = 17 [BCH] Beckman Coulter UniCel DxC 800 59.53 ± 1.86 175.84 ± 1.54 79.28 ± 0.51 31.28 ± 0.51 29.72 ± 0.51 n = 3 [JJE] Ortho Vitros 250/350/950 58.27 ± 1.00 175.17 ± 2.06 79.22 ± 1.15 31.08 ± 0.59 29.00 ± 0.00 n = 20 [JJF] Ortho Vitros 5,1FS 57.83 ± 0.92 175.03 ± 1.50 78.95 ± 1.01 31.00 ± 0.00 29.00 ± 0.47 n = 7 [JJG] Ortho Vitros 5600 38.70 ± 0.93 134.22 ± 0.42 56.73 ± 1.04 18.97 ± 0.69 17.27 ± 0.91 n = 8 [ROC] Roche cobas c501 39.53 ± 1.55 132.60 ± 4.46 59.97 ± 1.75 20.73 ± 0.98 19.29 ± 0.72 n = 13 [ROT] Roche Cobas INTEGRA 34.08 ± 0.87 118.58 ± 2.11 51.20 ± 1.26 17.49 ± 0.49 15.98 ± 0.68 n = 11 [ROD] Roche MODULAR D/P 56.96 ± 3.14 174.24 ± 8.27 81.09 ± 3.88 32.82 ± 1.87 29.88 ± 1.78 n = 7 [BYE] Siemens ADVIA 1800 55.40 ± 3.54 167.47 ± 11.02 78.30 ± 3.56 31.00 ± 1.53 29.02 ± 1.33 n = 3 [BYB] Siemens ADVIA 2400 57.66 ± 1.02 165.31 ± 1.95 76.54 ± 0.76 33.02 ± 1.02 31.81 ± 0.65 n = 7 [DUE] Siemens Dimension EXL 57.53 ± 1.31 165.46 ± 2.36 75.92 ± 1.58 32.53 ± 1.06 31.50 ± 0.84 n = 30 [DUR] Siemens Dimension RxL 56.74 ± 1.24 164.09 ± 2.14 75.46 ± 1.52 32.29 ± 1.12 31.06 ± 0.82 n = 26 [DUT] Siemens Dimension Vista 56.86 ± 1.12 163.63 ± 2.10 75.05 ± 0.93 32.12 ± 0.72 31.13 ± 0.67 n = 10 [DUX] Siemens Dimension Xpand <Reagents> 50.47 ± 3.64 158.18 ± 11.35 72.17 ± 5.09 28.43 ± 2.45 26.34 ± 2.02 n = 16 [AB1] Abbott 56.05 ± 2.89 167.45 ± 6.80 79.02 ± 4.26 32.86 ± 2.01 29.50 ± 2.27 n = 40 [BC1] Beckman Coulter 50.64 ± 2.94 156.13 ± 8.86 73.28 ± 1.16 28.79 ± 0.97 26.40 ± 1.10 n = 7 [OL1] Beckman Coulter AU Series 58.21 ± 1.02 175.18 ± 1.92 79.16 ± 1.06 31.05 ± 0.51 29.09 ± 0.45 n = 30 [JJ1] Ortho Clinical Diagnostics 38.70 ± 0.93 134.22 ± 0.42 56.73 ± 1.04 18.97 ± 0.69 17.27 ± 0.91 n = 8 [RO4] Roche cobas c311/c501/c502/c701 34.08 ± 0.86 118.58 ± 2.11 51.21 ± 1.26 17.49 ± 0.49 15.98 ± 0.68 n = 10 [RO2] Roche Hitachi and Modular D/P 39.53 ± 1.55 132.60 ± 4.46 59.97 ± 1.75 20.73 ± 0.98 19.29 ± 0.72 n = 13 [RO1] Roche Integra and MIRA 56.37 ± 1.33 171.60 ± 2.25 79.85 ± 0.66 32.22 ± 1.29 29.27 ± 0.58 n = 11 [BY1] Siemens ADVIA/ADVIA Centaur 57.16 ± 1.30 164.71 ± 2.36 75.71 ± 1.46 32.44 ± 1.07 31.33 ± 0.85 n = 72 [DA5] Siemens Dimension 49.86 ± 3.61 157.88 ± 6.58 71.92 ± 4.37 28.71 ± 1.33 26.44 ± 1.02 n = 3 [SY5] Syva Emit tox New York State Department of Health – Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – May 9, 2011 Summary of Participant Performance (Mean and Standard Deviation) Carbamazepine (mg/L) Specimen: T51 Specimen: T52 Specimen: T53 Specimen: T54 Specimen: T55 Number [Code] Instrument or Reagent System -------------- -------------- -------------- -------------- -------------- ------- ------------------------------------- 8.15 ± 0.62 7.49 ± 0.57 14.37 ± 1.10 5.38 ± 0.46 4.93 ± 0.47 n = 244 [---] All Methods & Instruments 8.4 7.9 14.9 5.6 5.1 [---] Weigh-in value <Instruments> 8.59 ± 0.13 8.06 ± 0.13 15.22 ± 0.20 5.64 ± 0.13 5.10 ± 0.15 n = 5 [ABJ] Abbott Architect c System 8.04 ± 0.40 7.42 ± 0.34 14.31 ± 0.69 5.55 ± 0.22 5.05 ± 0.21 n = 12 [ABB] Abbott AxSym 8.50 ± 0.65 7.88 ± 0.46 15.46 ± 0.78 5.62 ± 0.36 5.15 ± 0.43 n = 15 [OLC] Beckman Coulter AU Chemistry System 8.32 ± 0.24 7.45 ± 0.19 13.87 ± 0.59 5.43 ± 0.14 4.96 ± 0.10 n = 3 [BCS] Beckman Coulter CX 8.10 ± 0.13 7.22 ± 0.23 13.64 ± 0.72 5.26 ± 0.20 4.84 ± 0.28 n = 8 [BCX] Beckman Coulter LX-20 8.03 ± 0.24 7.20 ± 0.17 13.40 ± 0.65 5.31 ± 0.16 4.92 ± 0.22 n = 9 [BCG] Beckman Coulter UniCel DxC 600 8.08 ± 0.23 7.23 ± 0.29 13.52 ± 0.55 5.35 ± 0.17 4.92 ± 0.15 n = 20 [BCH] Beckman Coulter UniCel DxC 800 5.91 ± 0.37 5.21 ± 0.33 11.76 ± 0.85 3.64 ± 0.13 3.35 ± 0.22 n = 15 [JJF] Ortho Vitros 5,1FS 5.95 ± 0.46 5.19 ± 0.44 11.86 ± 0.74 3.84 ± 0.32 3.30 ± 0.29 n = 7 [JJG] Ortho Vitros 5600 8.71 ± 0.47 8.12 ± 0.38 14.80 ± 0.56 5.79 ± 0.40 5.47 ± 0.28 n = 12 [ROC] Roche cobas c501 7.99 ± 0.22 7.42 ± 0.21 14.22 ± 0.55 5.19 ± 0.18 4.82 ± 0.10 n = 16 [ROT] Roche Cobas INTEGRA 8.89 ± 0.32 8.13 ± 0.42 15.07 ± 0.37 6.04 ± 0.31 5.59 ± 0.34 n = 16 [ROD] Roche MODULAR D/P 8.31 ± 0.68 7.97 ± 0.54 15.44 ± 1.14 5.60 ± 0.42 5.57 ± 0.59 n = 4 [BYE] Siemens ADVIA 1800 8.85 ± 0.63 7.94 ± 0.38 15.60 ± 1.09 5.72 ± 0.31 5.24 ± 0.32 n = 16 [COB] Siemens ADVIA Centaur 8.17 ± 0.23 7.46 ± 0.18 14.58 ± 0.41 5.35 ± 0.23 4.67 ± 0.21 n = 7 [DUE] Siemens Dimension EXL 7.89 ± 0.34 7.25 ± 0.28 14.33 ± 0.48 5.11 ± 0.25 4.62 ± 0.19 n = 32 [DUR] Siemens Dimension RxL 8.04 ± 0.35 7.36 ± 0.35 14.52 ± 0.54 5.26 ± 0.27 4.80 ± 0.24 n = 28 [DUT] Siemens Dimension Vista 7.82 ± 0.30 7.18 ± 0.35 14.38 ± 0.85 5.22 ± 0.25 4.86 ± 0.22 n = 6 [DUX] Siemens Dimension Xpand <Reagents> 8.22 ± 0.43 7.62 ± 0.43 14.64 ± 0.86 5.59 ± 0.18 5.06 ± 0.19 n = 17 [AB1] Abbott 8.10 ± 0.25 7.24 ± 0.27 13.59 ± 0.69 5.34 ± 0.19 4.93 ± 0.17 n = 43 [BC1] Beckman Coulter 8.21 ± 0.80 7.61 ± 0.51 15.78 ± 0.53 5.47 ± 0.39 4.92 ± 0.35 n = 6 [OL1] Beckman Coulter AU Series 9.04 ± 0.33 8.31 ± 0.35 15.15 ± 0.45 6.19 ± 0.35 5.73 ± 0.30 n = 10 [MG1] Microgenics CEDIA 5.93 ± 0.40 5.20 ± 0.36 11.78 ± 0.82 3.73 ± 0.28 3.34 ± 0.25 n = 22 [JJ1] Ortho Clinical Diagnostics 8.61 ± 0.54 8.01 ± 0.47 14.71 ± 0.59 5.77 ± 0.42 5.38 ± 0.37 n = 12 [RO4] Roche cobas c311/c501/c502/c701 8.87 ± 0.30 8.12 ± 0.31 15.04 ± 0.12 5.99 ± 0.19 5.59 ± 0.26 n = 11 [RO2] Roche Hitachi and Modular D/P 7.99 ± 0.22 7.42 ± 0.21 14.22 ± 0.55 5.19 ± 0.18 4.82 ± 0.10 n = 16 [RO1] Roche Integra and MIRA 8.88 ± 0.64 7.97 ± 0.42 15.69 ± 1.11 5.74 ± 0.32 5.26 ± 0.32 n = 18 [BY1] Siemens ADVIA/ADVIA Centaur 8.25 ± 0.63 7.97 ± 0.65 15.05 ± 0.88 5.58 ± 0.38 5.33 ± 0.49 n = 8 [BY5] Siemens ADVIA/Syva Emit 2000 7.96 ± 0.35 7.31 ± 0.32 14.41 ± 0.53 5.20 ± 0.27 4.72 ± 0.24 n = 71 [DA5] Siemens Dimension 8.28 ± 0.53 7.97 ± 0.42 15.58 ± 0.87 5.53 ± 0.16 5.06 ± 0.30 n = 4 [SY4] Syva Emit 2000 New York State Department of Health – Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – May 9, 2011 Summary of Participant Performance (Mean and Standard Deviation) Digoxin (µg/L) Specimen: T51 Specimen: T52 Specimen: T53 Specimen: T54 Specimen: T55 Number [Code] Instrument or Reagent System -------------- -------------- -------------- -------------- -------------- ------- ------------------------------------- 1.117 ± 0.128 1.679 ± 0.141 1.938 ± 0.150 3.176 ± 0.202 2.927 ± 0.195 n = 291 [---] All Methods & Instruments 1.1 1.7 1.9 3.3 3.0 [---] Weigh-in value <Instruments> 1.209 ± 0.057 1.793 ± 0.061 2.051 ± 0.049 3.164 ± 0.069 2.948 ± 0.083 n = 4 [ABJ] Abbott Architect c System 1.090 ± 0.113 1.582 ± 0.075 1.869 ± 0.108 3.104 ± 0.132 2.785 ± 0.125 n = 5 [ABH] Abbott Architect i System 1.145 ± 0.128 1.716 ± 0.118 1.953 ± 0.125 3.203 ± 0.226 2.991 ± 0.177 n = 11 [ABB] Abbott AxSym 1.255 ± 0.082 1.654 ± 0.084 1.859 ± 0.097 3.100 ± 0.134 2.931 ± 0.139 n = 12 [SAA] Beckman Coulter ACCESS 0.991 ± 0.135 1.514 ± 0.171 1.747 ± 0.193 3.092 ± 0.254 2.785 ± 0.233 n = 17 [OLC] Beckman Coulter AU Chemistry System 1.100 ± 0.075 1.700 ± 0.075 1.915 ± 0.041 3.070 ± 0.082 2.784 ± 0.127 n = 4 [BCS] Beckman Coulter CX 1.059 ± 0.127 1.619 ± 0.061 1.751 ± 0.128 3.000 ± 0.329 2.766 ± 0.249 n = 6 [BCX] Beckman Coulter LX-20 1.101 ± 0.077 1.677 ± 0.120 1.947 ± 0.095 3.153 ± 0.108 2.924 ± 0.123 n = 13 [BCG] Beckman Coulter UniCel DxC 600 1.067 ± 0.064 1.590 ± 0.073 1.867 ± 0.076 3.054 ± 0.088 2.800 ± 0.083 n = 17 [BCH] Beckman Coulter UniCel DxC 800 1.174 ± 0.112 1.580 ± 0.150 1.784 ± 0.102 3.043 ± 0.186 2.831 ± 0.196 n = 4 [BCU] Beckman Coulter UniCel DxI 800 0.915 ± 0.041 1.400 ± 0.075 1.616 ± 0.127 2.913 ± 0.113 2.700 ± 0.150 n = 4 [JJE] Ortho Vitros 250/350/950 0.968 ± 0.119 1.491 ± 0.103 1.739 ± 0.095 2.990 ± 0.123 2.790 ± 0.126 n = 20 [JJF] Ortho Vitros 5,1FS 0.919 ± 0.073 1.400 ± 0.090 1.626 ± 0.097 2.860 ± 0.094 2.681 ± 0.073 n = 6 [JJG] Ortho Vitros 5600 1.138 ± 0.087 1.695 ± 0.064 1.941 ± 0.079 3.223 ± 0.098 2.964 ± 0.110 n = 15 [ROC] Roche cobas c501 1.143 ± 0.093 1.691 ± 0.099 1.959 ± 0.097 3.247 ± 0.144 2.998 ± 0.110 n = 10 [ROT] Roche Cobas INTEGRA 1.165 ± 0.099 1.736 ± 0.106 1.967 ± 0.118 3.216 ± 0.120 2.917 ± 0.113 n = 17 [ROD] Roche MODULAR D/P 1.202 ± 0.004 1.798 ± 0.004 1.997 ± 0.068 3.111 ± 0.105 2.907 ± 0.094 n = 4 [BYE] Siemens ADVIA 1800 1.217 ± 0.079 1.796 ± 0.081 2.055 ± 0.100 3.299 ± 0.090 3.062 ± 0.128 n = 20 [COB] Siemens ADVIA Centaur 1.114 ± 0.026 1.703 ± 0.050 1.981 ± 0.061 3.320 ± 0.253 3.009 ± 0.165 n = 3 [BYP] Siemens ADVIA Centaur CP 1.216 ± 0.083 1.757 ± 0.076 2.012 ± 0.082 3.308