USOO8840869B2 (12) United States Patent (10) Patent No.: US 8,840,869 B2 Friedman et al. (45) Date of Patent: Sep. 23, 2014 (54) BODY CAVITY FOAMS (56) References Cited (75) Inventors: Doron Friedman, Karmei Yosef (IL); U.S. PATENT DOCUMENTS Alex Besonov, Rehovet (IL); Dov 1,159,250 A 11/1915 Moulton Tamarkin, Maccabim (IL); Meir Eini, 1,666,684 A 4, 1928 Carstens Ness Ziona (IL) 1924,972 A 8, 1933 Beckert 2,085,733. A T. 1937 Bird (73) Assignee: Foamix Ltd., Rehovot (IL) 2,390,921 A 12, 1945 Clark 2,524,590 A 10, 1950 Boe 2,586.287 A 2/1952 Apperson (*) Notice: Subject to any disclaimer, the term of this 2,617,754 A 1 1/1952 Neely patent is extended or adjusted under 35 2,767,712 A 10, 1956 Waterman U.S.C. 154(b) by 1533 days. 2.968,628 A 1/1961 Reed 3,004,894 A 10/1961 Johnson et al. (21) Appl. No.: 11/116,761 3,062,715 A 11/1962 Reese 3,067,784. A 12/1962 Gorman 3,092.255. 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Nonsteroidal Immunomodulating Kit and Com A6 IK9/46 position and Uses Thereof, U.S. Appl. No. 11/078.902, filed Mar. 11, (2006.01) 2005. A6 IK 8/04 (2006.01) Tamarkin, D., etal. Steroid Kit and Foamable Composition and Uses, A61O 702 (2006.01) U.S. Appl. No. 1 1/114,410, filed Apr. 26, 2005. (52) U.S. C. CPC .............. A61K 9/0007 (2013.01); A61O 19/04 (Continued) (2013.01); A61K 9/12 (2013.01); A61O 700 Primary Examiner — Suzanne Ziska (2013.01); A61O 19/02 (2013.01); A61K 8/60 (74) Attorney, Agent, or Firm — Fish & Richardson P.C. (2013.01); A61 K9/122 (2013.01); A61O 1702 (2013.01); A61 K9/0014 (2013.01); A61O (57) ABSTRACT 1704 (2013.01); A61 K 2800/75 (2013.01); The invention relates to an alcohol-free cosmetic ortherapeu A61K 8/046 (2013.01); A61 K9/0034 tic foam carrier comprising water, a hydrophobic organic (2013.01); A61O 702 (2013.01) carrier, a foam adjuvant agent, a Surface-active agent and a USPC ............................................................ 424/47 gelling agent. The cosmetic or therapeutic foam carrier does (58) Field of Classification Search not contain aliphatic alcohols, making it non-irritating and CPC ... A61K 8/046; A61 K9/0014: A61 K9/0034; non-drying. The alcohol-free foam carrier is suitable for A61 K9/12: A61 K9/122 inclusion of both water-soluble and oil soluble therapeutic USPC ............................................................ 424/47 and cosmetic agents. 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