Chicago | October 17-21 Friday to Saturday Scienti ic Session Listings 1–95 Information at a Glance Important Phone Numbers Annual Meeting Headquarters Office Mercy Hospital Key to Poster Floor by Themes Logistics and Programming 2525 S Michigan Avenue The poster floor begins with Theme A and ends Logistics Chicago, IL 60616 with Theme H. Refer to the poster floor map at McCormick Place: Hall A, (312) 791‑6700 (312) 567‑2000 the end of this booklet. Programming Physicians Immediate Care Theme McCormick Place: Hall A, (312) 791‑6705 811 S. State Street A Development Chicago, IL 60605 B Neural Excitability, Synapses, and Glia: Volunteer Leadership Lounge (312) 566‑9510 Cellular Mechanisms McCormick Place: S505A, (312) 791‑6735 Walgreens Pharmacy C Disorders of the Nervous System General Information Booths (closest to McCormick Place) D Sensory and Motor Systems McCormick Place: 3405 S. Martin Luther King Drive E Integrative Systems: Neuroendocrinology, Gate 3 Lobby, (312) 791‑6724 Chicago, IL 60616 Neuroimmunology and Homeostatic Challenge Hall A (312) 791‑6725 (312) 326‑4064 F Cognition and Behavior Press Offices Venues G Novel Methods and Technology Development Press Room McCormick Place H History, Teaching, Public Awareness, and McCormick Place: Room S501ABC 2301 S. Martin Luther King Drive Societal Impacts in Neuroscience (312) 791‑6730 Chicago, IL 60616 Exhibit Management Fairmont Chicago, Millennium Park Hotel Note: Theme H Posters will be located in Hall A McCormick Place: Hall A, (312) 791‑6740 200 N. Columbus Drive beginning at 1 p.m. on Saturday, Oct. 17, and will Chicago, IL 60601 remain posted until 5 p.m., Sunday, Oct. 18. First Aid and Hospital Numbers (312) 565‑8000 First Aid Station McCormick Place: Level 2.5S, (312) 791‑6060 Hyatt Regency Chicago Downtown Hotel (not connected to McCormick Place) 151 E. Wacker Drive Chicago, IL 60601 (312) 565‑1234 Cover Image: This image shows a transverse section of mouse lumbar spinal cord taken 7 d after partial sciatic nerve ligation. The section is stained for microglial markers Iba1 (red) and phosphorylated p‑38 MAPK (green), as well as the nuclear marker DAPI (blue). The orphan G‑protein receptor 84 (GPR84) is markedly induced in macrophages and microglia during inflammation, and it contributes to the development of mechanical and thermal hypersensitivity. Louise S.C. Nicol, John M. Dawes, Federica La Russa, Athanasios Didangelos, Anna K. Clark, Clive Gentry, John Grist, John B. Davies, Marzia Malcangio, and Stephen B. McMahon, 2015, The Journal of Neuroscience, 35(23): 8959‑8969. Preregistration Required Course Fee Networking Friday Workshops Professional Development Public Outreach Online Content Professional Development, Advocacy, and Networking Resources WORKSHOP FEES SHORT COURSE 1 short course will explore how current genomic Neurobiology of Disease Workshop ........$35 Partially supported by an educational grant from Otsuka America Pharmaceutical, Inc and Lundbeck tools and platforms are used for rare and common Short Courses 1 and 2 Using iPS Cells and Reprogramming to Model disorders, describe what analytic tools and (Includes electronic syllabus and lunch) Neural Development and Disease approaches might be most appropriate for specific Student member .......................................... $150 Organizer: Kevin Eggan, PhD questions, and consider how genomic, phenotypic, Student nonmember ....................................$225 8 a.m.–6 p.m. and functional evidence can accelerate both Postdoctoral member ..................................$225 McCormick Place: S401 fundamental discovery and application. Faculty member ...........................................$295 Contact: [email protected] SHORT COURSE 3 Faculty nonmember .....................................$445 Stem cell and reprogramming technologies offer Optimizing Experimental Design for Short Course 3 exciting opportunities to access human brain cell High-Quality Science (Includes electronic syllabus) types and even tissues for studies of development Organizers: Mara Dierssen, MD, PhD; Magda Student member ..........................................$100 and disease. As methods and techniques for both Giordano, PhD; Chris McBain, PhD; Charles Mobbs, Student nonmember .................................... $150 stem cell differentiation and transcription factor PhD; John Ngai, PhD; Rae Nishi, PhD Postdoctoral member .................................. $150 induced reprogramming evolve, the robustness, 1–5:30 p.m. Faculty member ...........................................$200 reproducibility, and utility of these methods McCormick Place: N227 Faculty nonmember .....................................$300 continues to improve. In this short course, leaders Contact: [email protected] (breakfast, lunch, and reception) in developing and implementing these approaches The scientific community has become will discuss their work with a view to help Note: Preregistration is required for Short Courses increasingly concerned about issues related to attendees utilize these approaches in their own and the Neurobiology of Disease Workshop. data reproducibility and experimental design. research. Specifically, we will cover the generation Register at SfN.org/registration. Issues include, but are not limited to: bias of neural cell types from pluripotent stem cells and, for positive results, the “p‑hacking” effect, by direct reprogramming/trans‑differentiation, new Friday, October 16 lack of sufficient replication of experiments, methods for three dimensional culture, genome pooling data from different experiments, lack NEUROBIOLOGY OF DISEASE WORKSHOP editing and use of these approaches in the design of randomization and/or blinding, chance Support contributed by the National Institute of of disease‑relevant assay systems. Neurological Disorders and Stroke of the National observations, data selection, group compilation, Institutes of Health under Award Number R25N5054767. SHORT COURSE 2 and lack of rigorous training in statistics and The content does not necessarily represent the official views of the National Institutes of Health. The Impact of Human Genetics and Genomics analysis. Attendees will learn experimental and in Neurobiology: From Disease Discovery to analytical design elements that are crucial for the Human Brain Malformations: From Fundamental Mechanisms (and Back) interpretation of neuroscience research results, Genetics to Therapeutics Organizer: Nicholas Katsanis, PhD such as methodological parameters that can Organizers: Peter Crino, MD, PhD; 8:30 a.m.–6 p.m. introduce bias, influence robustness, or may be Mustafa Sahin, MD, PhD McCormick Place: S406A subject to biological variability, and the biological 8 a.m.–5 p.m. Contact: [email protected] and sociological underpinnings of scientific McCormick Place: S100B bias. Existing policies on data deposition Contact: [email protected] The accessibility of whole exome and whole and presentation will additionally be covered. genome sequencing for a variety of clinical Brain malformations, especially those affecting Lectures will be interspersed with small group indications is a significant scientific achievement. the cerebral cortex, are common causes of discussion opportunities to allow ample time for These technologies have already produced intellectual disability and epilepsy. Recent the examination of case studies. thousands of exomes and partial genomes from advances in genetics, imaging, and cell biology humans and model organisms, showing the have substantially increased our knowledge amount and types of genetic variation that exists of the mechanisms underlying cortical between individuals and within populations. The development and how it can go awry. In this sheer number of individuals sequenced has begun workshop, leading experts will review some to offer the statistical power needed to understand of the genes, cellular pathways, processes, the genetic architecture of both rare and complex and structures commonly affected in brain disorders. The use of these technologies around malformations including PI3K/mTOR signaling, the globe has changed the types of questions tubulin, reelin, and cilia. being asked and the method by which these questions are being pursued. However, significant conceptual and technical challenges remain. This Complete Session Listing Sat. PM Saturday PM DIALOGUES BETWEEN NEUROSCIENCE SYMPOSIUM McCormick Place AND SOCIETY McCormick Place 003. How Does the Brain Implement Adaptive Decision 001. Neuroscience and the Law: Strange Bedfellows Making to Eat? — CME Sat. 11:00 AM - 1:00 PM — Hall B1 Sat. 1:30 PM - 4:00 PM — S100B Speaker: J. S. RAKOFF, U.S. District Court, Southern Chair: V. COMPAN District of New York. Adaptive decision-making to eat is crucial for survival, but in Support contributed by: Elsevier anorexia nervosa, the brain persistently supports reduced food intake despite a growing need for energy. How the Neuroscience is a hot topic with lawyers and judges, as brain persists in reducing food intake to the point of death recent advances in our understanding of the brain have despite the evolution of mechanisms to ensure survival raised important and unexpected implications for the by governing adaptive eating behaviors remains just as development and application of legal principles. These mysterious as the switch from anorexia to bulimia. Neural implications, however, can sometimes be overstated, substrates belong to the reward-habit system and could which presents a potential for abuse and warrants caution. differ from overeating-induced