VOLUME 12, ISSUE 1 SPRING 2012 A new era dawns in cancer care and research at Duke 14 Introducing the new Duke Cancer Center 22 Then, now & next: Evolving cancer care 29 Finding better cancer therapies A new home for cancer care—as it should be After years of diligent planning and the efforts of hundreds For the first time, we have brought oncology clinicians of members of the Duke and North Carolina communities, I and support staff from across the medical center together am proud to report that Duke’s new cancer center welcomed under one roof, and organized them into dedicated, its first patients on February 27, 2012. The opening of integrated teams focused on specific cancer types. Our this landmark facility is truly a historic milestone for patients will benefit from more convenient access to a full Duke Medicine, and perhaps the most tangible symbol of spectrum of specialists—and from an array of thoughtful a new era in cancer care and research at Duke that began amenities and services designed with their total health, in November 2010 with the launch of the Duke Cancer comfort, and well-being in mind. Institute—a strategic reorganization of our cancer care and At the same time, this facility will magnify the clinical research programs designed to accelerate progress against and research impact of the Duke Cancer Institute (DCI), the disease. which is uniting laboratory scientists with physicians We’ve devoted much of this issue of and patient-care staff to forge DukeMed Magazine to these exciting new collaborations that will drive developments, because we believe advances in care. As the primary they are a thrilling advance in our clinical site for DCI, the cancer center teaching, research, and clinical care is a place where patients can access missions—an essential step toward the latest therapies through clinical true transformation in the way that trials—while in turn our clinician- cancer patients are cared for, at Duke scientists glean insights that inform and everywhere. further advances in research. We built the Duke Cancer Center I consider the establishment facility to meet the growing need for of the DCI to be among our most high-quality cancer services in our important and transformative Chancellor Dzau with philanthropist Jonathan Tisch region, where the number of people initiatives during my time as (left) and North Carolina governor Bev Perdue (right) diagnosed with cancer is rising by at the Duke Cancer Center ribbon-cutting ceremony chancellor. To me, this discovery- double-digit percentages every five on February 23, 2012. For more coverage of the care continuum is the promise of grand opening celebration, see page 34. years. We didn’t just consider the Duke Medicine, and what makes us a need in terms of population growth source of real hope to every patient and statistics, though. As anyone who has been touched we serve. To paraphrase Michael B. Kastan, MD, PhD—a by cancer knows, it’s hard to adequately convey the stress renowned cancer scientist whom I appointed as the DCI’s that cancer can put on a patient and his or her family. Apart inaugural director in 2011—at Duke we don’t simply seek to from the physical and mental impact of the disease itself, provide great care, we seek to provide cures. the rigors of the treatment process—from chemotherapy to In terms of cancer, the word cure is an ambitious one— endless appointments and paperwork—can be a gauntlet of perhaps even an outrageous one. But it is true that for the its own. first time in the generation since we launched the war on Through the Duke Cancer Institute, we are working to cancer, we’ve got not only better tools to fight with but also change that reality in two ways: first, by redesigning cancer an environment designed to encourage hope and healing. care to improve each patient’s experience, and second, by We have great expectations. This is an exciting time for facilitating the development and delivery of more effective Duke Medicine, and we look forward to sharing it with you. therapies that will bring new hope for patients everywhere. This new building supports both goals: It is designed to be at once a welcoming, healing environment for patients and a nexus of research and treatment innovation. Victor J. Dzau, MD Chancellor for Health Affairs, Duke University President and CEO, Duke University Health System James B. Duke Professor of Medicine 14 DukeMed MAGAZINE VOLUME 12, ISSUE 1, SPRING 2012 22 29 FEATURES 14 Introducing the new Duke Cancer Center Look inside a landmark 22 Then, now, next Transforming cancer care from generation to generation 29 Found in translation Duke’s design to deliver better cancer therapies DEPARTMENTS 2 DukeMed Now Campus construction, advancing medical education in Tanzania, taking blood-pressure management into the community, more 8 Clinical Update Myth-busting kidney donation, detecting prostate cancer in the obese, less is more in knee replacement rehab, new option for heart valve replacement, how stress damages DNA, more 34 Cancer Center Grand Opening Events 38 DukeMed Giving 39 DukeMed People 43 New Physicians 52 CME Calendar DUKE MEDICINE ADMINISTRATION Victor J. Dzau, MD Psychiatry and Behavioral Sciences: Chancellor for Health Affairs, Sarah Hollingsworth Lisanby, MD DukeMed Duke University Radiation Oncology: President and CEO, Duke University Christopher Willett, MD Health System (DUHS) Radiology: Duke University Hospital William J. Fulkerson Jr., MD NOW Geoffrey D. Rubin, MD Executive Vice President, DUHS Surgery: Kenneth C. Morris Danny O. Jacobs, MD Senior Vice President, Chief Financial Officer, and Treasurer, DUHS DUKE UNIVERSITY HEALTH SYSTEM Nancy C. Andrews, MD, PhD BOARD OF DIRECTORS Thomas M. Gorrie, PhD, Chair Bell Emergency Department Dean, School of Medicine Building Vice Chancellor for Academic Affairs Peter Van Etten, Vice Chair Nancy C. Andrews, MD, PhD Catherine L. Gilliss, DNSc, RN Daniel T. Blue Jr. Dean, School of Nursing Jack O. Bovender Jr. Vice Chancellor for Nursing Affairs Richard H. Brodhead, PhD K. Ranga Krishnan, MB ChB Victor J. Dzau, MD Dean, Duke-NUS Graduate Medical Frank E. Emory Jr. School Singapore James F. Goodmon Carolyn E. Henderson Monte D. Brown, MD Danny O. Jacobs, MD Vice President for Administration, Duke University Rebecca Trent Kirkland, MD School of Nursing Duke University Health System Richard D. Klausner, MD Robert M. Califf, MD John H. McArthur, PhD Vice Chancellor for Clinical Research Lloyd B. Morgan Theodore N. Pappas, MD Karen Frush, MD Carl E. Ravin, MD Chief Patient Safety Officer, DUHS Duke Clinic Steven Scott, MD Mary Ann Fuchs, DNP, RN Susan M. Stalnecker Chief Nursing and Patient Care Katherine Keith Thomas Services Officer, DUHS G. Richard Wagoner Jr. Art Glasgow DUKE UNIVERSITY BOARD OF Vice President and Chief Information TRUSTEES MEDICAL CENTER Officer, Duke Medicine ACADEMIC AFFAIRS COMMITTEE Ellen Medearis Thomas M. Gorrie, PhD, Chair Vice President, Development and Anne T. Bass, Vice Chair Alumni Affairs, Duke Medicine Julie Barroso, PhD Adrienne Clough Construction over the past few years has dramatically reshaped Michael Merson, MD Paul E. Farmer, MD, PhD the medical center campus. (above left to right: June 2009 and Vice Chancellor for Duke-NUS Affairs Donald P. Frush, MD December 2011) Paul Newman Xiqing Gao, JD Executive Director, Felicia Hawthorne (GPSC Student) Private Diagnostic Clinic and Patient Elizabeth Kiss, DPhil Revenue Management Organization Cynthia Kuhn, PhD Michael Marsicano, PhD Thomas A. Owens, MD Alan D. Schwartz Chief Medical Officer, DUHS Laurene Sperling Carl E. Ravin, MD Nancy C. Andrews, MD, PhD* President, Private Diagnostic Clinic Monte Brown, MD* Kevin Sowers, RN Victor J. Dzau, MD* President, Duke University Hospital Catherine L. Gilliss, DNSc, RN* Peter Lange, PhD* Douglas B. Vinsel DukeMed Magazine welcomes comments from our Navid Pourtaheri* President, Duke Raleigh Hospital William G. Anlyan, MD** readers. Write to us via e-mail ([email protected]) Kerry Watson Eugene W. Cochrane Jr.** President, Durham Regional Hospital Jean G. Spaulding, MD** or postal mail: * Ex officio member DEPARTMENT CHAIRS ** Observer DukeMed Magazine Anesthesiology: Mark Newman, MD DUKE MEDICINE BOARD OF VISITORS DUMC 3687 Leslie E. Bains, Chair Biochemistry: Durham, NC 27710 William G. Anlyan, MD* Richard Brennan, PhD Kirk J. Bradley Biostatistics and Bioinformatics: Santo J. Costa Elizabeth DeLong, PhD Duncan M. Faircloth* VOLUME 12, ISSUE 1, SPRING 2012 Cell Biology: Michael Fields Michael T. Gminski Brigid Hogan, PhD Editorial Advisory Board: Thomas M. Gorrie, PhD* Community and Family Medicine: George L. Grody Martha Adams, MD J. Lloyd Michener, MD Charles R. Hughes DukeMed Kathryn Andolsek, MD Dermatology: Robert A. Ingram MAGAZINE Dan Blazer, MD Russell P. Hall III, MD Richard S. Johnson Nelson Chao, MD John D. Karcher Immunology: Sally Kornbluth, PhD David L. Katz, MD Editor: Minnie Glymph Michael S. Krangel, PhD Ted Kunstling, MD David P. King Designer: Jennifer Sweeting Ellen Luken Medicine: Garheng Kong, MD, PhD Mary E. Klotman, MD Donald R. Lacefield Creative Director: Kevin Kearns Lloyd Michener, MD Harry Phillips, MD Molecular Genetics and Microbiology: Milton Lachman* Production Manager: Margaret Epps Joseph St. Geme III, MD Joseph Heitman, MD, PhD Roslyn Schwartz Lachman* Nicholas J. Leonardy, MD Contributing Writers: Douglas Stokke Neurobiology: Brandt C. Louie Sarah Chun Robert Taber, PhD Stephen G. Lisberger, PhD Christy King Mack Carol Harbers Obstetrics and Gynecology: Thom A. Mayer, MD* Greg Jenkins DukeMed Magazine is published twice a year by Charles C. McIlvaine Haywood Brown, MD Kathleen Yount the Office of Marketing and Creative Services. Robert B. Mercer Contributing Photographers: Ophthalmology: Stelios Papadopoulos, PhD DukeMed Magazine David L. 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