Frontal Lobe RYHUDOO ی PDOLJQDQW ی YHUDJHDJH\HDUVROG$ ی UHDWHVWLQFLGHQFHLV!\HDUVROG* ی

Frontal Lobe RYHUDOO ی PDOLJQDQW ی YHUDJHDJH\HDUVROG$ ی UHDWHVWLQFLGHQFHLV!\HDUVROG* ی

NEURO-OPTOMETRY NEURO Who Gets Brain Tumors and Why ONCOLOGY OPTOMETRY Ŷ *HQHV*HQHWLFSUHGLVSRVLWLRQLVOHVVWKDQPRVW Ŷ RIDOOSDWLHQWVVHHNLQJPHGLFDOWUHDWPHQW LQYROYHFKURPRVRPH 3JHQH KDYHQHXURORJLFDOSUREOHPVHLWKHUDVWKH Ŷ ,OOQHVV1HJKLVWRU\RI+=RUFKLFNHQSR[DQGQHJ Primary Brain Tumors and their Clinical SUHVHQWLQJFRPSODLQWRUDVDQDVVRFLDWHG FRQGLWLRQFRPSOLFDWLQJWKHSULPDU\LOOQHVV KLVWRU\RIDOOHUJLHVDQGFROGVOHDGVWRDQLQFUHDVHLQ Manifestations WKHULVNRIJOLRPD""",PPXQHV\VWHP""" Ŷ 1HXURVFLHQFHSULQFLSOHVDQGQHUYRXVV\VWHP GLVHDVHPXVWEHZHOOXQGHUVWRRGGXHWRLWVFORVH Ŷ 7UDXPD+HDGLQMXU\Ĺ ULVNRIPHQLQJLRPD UHODWLRQVKLSWRWKHYLVXDOV\VWHPDQGYLVXDO Ŷ 3HVWLFLGHVĹLQFLGHQFHLQWXPRUVLQFKLOGUHQH[SRVHG '5'$9,'$//*22'2')$$2 SDWKZD\V EHIRUHELUWK )OHDWLFNHVSHFLDOO\ %,%%&2817<(<(&$5( Ŷ (\HFDUHIDFLOLWLHVDUHIUHTXHQWO\WKHILUVWSODFH Ŷ 3HWURFKHPLFDOĹULVN«HWLRORJ\""" 3,(5621$9( SDWLHQWVJRZLWKV\PSWRPVRIFHQWUDOQHUYRXV &(175(9,//($/ V\VWHPGLVHDVH Who Gets Brain Tumors and Why ANATOMICAL STRUCTURES OF THE BRAIN Ŷ $SSUR[LPDWHO\QHZFDVHVRUSULPDU\EUDLQWXPRUV GLDJQRVHGSHU\HDUZLOOGLH Ŷ ,QFLGHQFH Frontal Lobe RYHUDOO ی PDOLJQDQW ی YHUDJHDJH\HDUVROG$ ی UHDWHVWLQFLGHQFHLV!\HDUVROG* ی Ŷ (WKQLF-DSDQOHVVòRILQFLGHQFHVRIQRUWKHUQ(XURSH Ŷ *OLRPDV:KLWHV!%ODFNV 0HQLQJLRPDV%ODFNV!:KLWH Ŷ *OLRPDV0HQ!:RPHQ 0HQLQJLRPDV:RPHQ!0HQ :0 *OLRPD%) 0HQLQJLRPD Frontal Lobe )URQWDO Foster Kennedy Syndrome Ŷ &RQWDLQVPRVWRIWKHGRSDPLQHVHQVLWLYHQHXURQVLQ Ŷ RIDOOWXPRUVRFFXULQWKHIURQWDOOREH Frontal Lobe WKHFHUHEUDOFRUWH[7KHGRSDPLQHV\VWHPLV DVVRFLDWHGZLWKUHZDUGDWWHQWLRQORQJWHUPPHPRU\ Ŷ 7KHUHLVDQLQFUHDVHLQVHL]XUHVDQGUHVXOWLQ Ŷ )RVWHU.HQQHG\6\QGURPH SODQQLQJDQGGULYH SDSLOODHGHPD LSVHODWHUDORSWLFDWURSK\DQG Ŷ (PRWLRQDOFRQWUROFHQWHUKRPHWRRXUSHUVRQDOLW\ FRQWUROVRXUVRFLDOEHKDYLRUDQGLQKLELWVWKHOLPELF Ŷ /HVLRQVLQWKHIURQWDOOREHIUHTXHQWO\UHVXOWLQ FRQWUDODWHUDOSDSLOODHGHPD DSDWK\GHSUHVVLRQDQGDEXOLD ODFNRI V\VWHPWKHUHE\FRQWUROOLQJLPSXOVLYHEHKDYLRU VSRQWDQHLW\ OHWKDUJ\IHHOLQJVRILQGLIIHUHQFH PHQLQJLRPDVWXPRURIROIDFWRU\ Ŷ 0RWRUIXQFWLRQRULJLQDWHVLQWKHIURQWDOOREHDVGRHV V\VWHPJOLRPDV SUREOHPVROYLQJPHPRU\ODQJXDJHDQGMXGJPHQW Ŷ /HVLRQVFDQSURGXFHH[DJJHUDWHGSHUVRQDOLW\ WUDLWV Ŷ )URQWDOOREHDOVRFRQWDLQV%URFD¶VDUHDZKLFKJLYHVXV RXUDELOLW\WRYHUEDOL]H OLFACTORY AREAS Neoplasms and Related Lesions Temporal Lobe 7HPSRUDO/REH Temporal Lobe Lesions Ŷ 3ULPDU\DXGLWRU\SHUFHSWLRQ Ŷ 6LPLODUWR)URQWDO SHUVRQDOLW\FKDQJHV Ŷ *UHDWHVWIUHTXHQF\LQFRQYXOVLRQV -DFNVRQLDQ Ŷ &RQWDLQV:HUQLFNH¶VDUHDZKLFKVSDQV WKHUHJLRQEHWZHHQWHPSRUDODQGSDULHWDO Ŷ 9LVXDOKDOOXFLQDWLRQV Ŷ 'RPLQDQW:HUQLFNH¶V$VSKDVLDĻ ZULWHRUXQGHUVWDQG OREHZKLFKLQWDQGHPZLWK%URFD¶VDUHD PHDQLQJRIVSRNHQZRUGVĻ FRPSUHKHQVLRQ LVUHVSRQVLEOHIRURXUDELOLW\WRXQGHUVWDQG PHDQLQJOHVVVSHHFK DQGUHVSRQGWRVSRNHQZRUGV Ŷ 1RQ'RPLQDQWĻ PHQWDOIXQFWLRQDELOLW\WRMXGJH VSHFLDOUHODWLRQVKLS Ŷ &HQWHUIRUDEVWUDFWWKRXJKW Ŷ ,PSDLUHGORQJWHUPPHPRU\ Ŷ 7HPSRUDOOREHFRQWDLQVWKHKLSSRFDPSXV DQGSOD\VDNH\UROHLQWKHIRUPDWLRQRI Ŷ $OWHUHGSHUVRQDOLW\DQGDIIHFWLYHEHKDYLRU ORQJ DQGVKRUWWHUPPHPRU\ Ŷ $OWHUHGVH[XDOEHKDYLRU Ŷ RIDOOWXPRUV Parietal Lobe Ŷ 0DMRUDUHDIRUVHQVRU\VWLPXOLLQWHUSUHWDWLRQDQG Parietal Lobe LQWHUSUHWDWLRQRIYLVXDOV\PEROV Ŷ ,QWHJUDWHVVHQVRU\LQSXWSULPDULO\ZLWKWKH YLVXDOV\VWHP Ŷ &RQVWUXFWVDVSDWLDOFRRUGLQDWHV\VWHPWR UHSUHVHQWWKHZRUOGDURXQGXV Ŷ &HQWHUIRUQDYLJDWLRQ Ŷ 0DMRUDIIHUHQWHIIHUHQWFRPPXQLFDWLRQZLWK WKDODPXVFHUHEHOOXPDQGEUDLQVWHP 3DULHWDO Damage to the Parietal Lobe Damage to the Parietal Lobe (Left Dominant Side) (Right non-Dominant Side) Ŷ *HUVWPDQQ¶V6\QGURPH Ŷ 1HJOHFWLQJSDUWVRIERG\RUVSDFH FRQWUDODWHUDO Occipital Lobe 'LIILFXOW\ZLWKZULWLQJ DJUDSKLD QHJOHFW 'LIILFXOW\ZLWKPDWKHPDWLFV DFDOFXOD Ŷ ,PSDLUVPDQ\VHOIFDUHVNLOOVVXFKDVZDVKLQJ DQGGUHVVLQJ 'LVRUGHUVRIODQJXDJH DSKDVLD Ŷ 'HQLDORIGHILFLWV $JQRVLD 9LVXDOILHOGGHIHFWV JRXQQRWLFHGYVWHPSRUDOOREHGHIHFWVZKLFK Ŷ 6HQVRU\DJQRVLDDEQRUPDOLWLHVLQVHQVRU\ DUHQRWLFHG SHUFHSWLRQGHVSLWHQRUPDOVHQVRU\SDWKZD\V Ŷ 'HFUHDVHLQGUDZLQJDELOLWLHVDOVRORVVRI &ORVHH\HV«REMHFWLQKDQGFRQIXVLRQDVWR RULHQWDWLRQ«QDYLJDWLRQ SRLQW$WRSRLQW% LGHQWLW\ 2FFLSLWDO/REH 2FFLSLWDO/REH \EHJLQFHQWUDOO\ H[SDQGSHULSKHUDOOݱ0LJUDLQH XVXDOO\KHDGDFKHLQYROYHVVLGHRSSRVLWHILHOGORVV ݱ$QWRQ¶V6\QGURPH ެ$XUDV 'HQLDORI&RUWLFDO%OLQGQHVV ެ'HFUHDVH9LVXDO$FXLW\ &RPSOHWHORVVRIYLVLRQRIWHQZLWKRXWDZDUHQHVV 1RUPDOSXSLOODU\UHDFWLRQ ެ9LVXDO)LHOG'HIHFWV 1RUPDORSWKDOPRVFRS\ /RVVRIUHIOH[FORVXUH 3DULHWDO Occipital Lobe Cerebellum &KDUOHV%RQQHW6\QGURPH :HOOIRUPHGYLVXDOKDOOXFLQDWLRQVGXHWRVHQVRU\ GHSULYDWLRQ &RPPRQLQHOGHUO\SDWLHQWVZLWKYLVLRQORVV RIORZYLVLRQSDWLHQWV (DUO\PDUNHUIRUGHPHQWLD 3DULHWDO Cerebellum Tissues of the Central Ŷ 3RVWXUHPXVFOHWRQHFRRUGLQDWLRQ Nervous System Ŷ 3OD\VDQLPSRUWDQWUROHLQPRWRUFRQWURO Tumors Ŷ ,QYROYHGLQFRJQLWLYHIXQFWLRQVVXFKDVDWWHQWLRQ Ŷ *OLRPDV DQGODQJXDJH OOSULPDU\WXPRUVRIWKHEUDLQDQGVSLQDO$ی Ŷ 'RHVQRWLQLWLDWHPRYHPHQWEXWGRHVFRQWULEXWHWR FRRUGLQDWLRQSUHFLVLRQDQGDFFXUDWHWLPLQJ FRUGDUHFRPSRVHGRIJOLDOFHOOVWKLVLV ZKHUHWXPRUVGHYHORS Ŷ %HFDXVHRIILQHWXQLQJIXQFWLRQGDPDJHWRWKH GXOWQHUYHFHOOVFDQQRWGLYLGH± KHQFH$ ی EXWLQVWHDGFHUHEHOOXPGRHVQRWFDXVHSDUDO\VLV SURGXFHVGLVRUGHUVLQILQHPRYHPHQWHTXLOLEULXP WKH\FDQQRWIRUPWXPRUV SRVWXUHDQGPRWRUOHDUQLQJ Ŷ ,SVHODWHUDOVWUXFWXUH Tissues of the Central Nervous Tumors: Destruction Astrocytes System Ŷ )XQFWLRQVLQFOXGH ELRFKHPLFDOVXSSRUWRIHQGRWKHOLDOFHOOVZKLFKIRUP ی SUHVVXUHIURPJURZLQJPDVVEORFNVŶ ,QYDVLRQ WKHEORRGEUDLQEDUULHU Ŷ 1HXURJOLD&HOOVRU6XSSRUWLYH&HOOV EORRGYHVVHOVFDXVHVORFDOWLVVXHGHDWK WKHSURYLVLRQRIQXWULHQWVWRQHUYRXVWLVVXH ی ZKLFKUHVXOWVLQDGHFUHDVHLQPHFKDQLFDO PDLQWHQDQFHRIH[WUDFHOOXODULRQEDODQFH ی VWURF\WHV&HOOV UHVLVWDQFHDQGIXUWKHUVWKHVSUHDG$ ی DSULQFLSDOUROHLQWKHUHSDLUDQGVFDUULQJSURFHVV ی 2OLJRGHQGURJOLD&HOOV ی Ŷ 7XPRUFHOOVKLJKOHYHOVRIK\GURODVHV RIWKHEUDLQDQGVSLQDOFRUGIROORZLQJWUDXPDWLF SURWHDVHDQGFROODJHQDVHV FDXVHO\WLF LQMXULHV SHQG\PDO&HOOV) ی \6FKZDQQ&HOOV GDPDJHWRDGMDFHQWQRUPDOWLVVXH Ŷ 3DWKRORJ ی 7XPRUV ی Ŷ 'HSULYHVXUURXQGLQJFHOOVRIYLWDOQXWULHQWV 7XPRUOLNHQRGXOHVRIWKH7XEHURXVVFOHURVLV ی QHFHVVDU\IRUVXUYLYDO EUDLQ Astrocytoma of the TUMORS OF ASTROCYTE CELLS Low Grade Astrocytoma Grade I & II Temporal Lobe $VWURF\WRPD7KUHHW\SHV 7\SLFDOO\QRQLQILOWUDWLQJEXWFDQLQYDGH /RZJUDGH 3LORF\VWLFDQG6XEHSHQG\PDO VXUURXQGLQJWLVVXH 0LGJUDGH $QDSODVWLF$VWURF\WRPD 0HWDVWDVLVLV5DUH +LJKJUDGH *OLREODVWRPD0XOWLIRUPHDQG 2FFXU0DLQO\LQ&KLOGUHQ *OLREODVWRPD&HUHEUL /RFDWLRQ&HUHEHOOXP 2SWLF7UDFW 237,&1(59($1'&+,$60$/ 237,&1(59($1'&+,$60$/ Astrocytoma of the Optic $6752&<720$ $6752&<720$ Nerve Ŷ 2SWLF1HUYH*OLRPDV 0RVWDUHORZJUDGHDVWURF\WRPD ی Ŷ *OLRPDVRIYLVXDOV\VWHPRIRUELWDO KDYHUHFXUUHQFHV ی WXPRUV GLH ی VXUYLYH\HDUV ی Ŷ RISDWLHQWVDUHXQGHUDJH Ŷ 6XEVWDQWLDOYLVXDOORVV Ŷ &KLDVPDO*OLRPDV /HVV)DYRUDEOH Ŷ ,QYROYHFKLDVP!RSWLFQHUYHV KDYHUHFXUUHQFHV ی VXUYLYH\HDUV ی HDWKGXHWRORFDOH[WHQVLRQ' ی Astrocytoma of the Optic Astrocytoma of the Optic Nerve Mid-Grade Astrocytoma Chiasma Ŷ *UDGH,,, *URZ0RUH5DSLGO\ 5HFXU0RUH)UHTXHQWO\ 6XUYLYH<HDU 6XUYLYH<HDUV 6XUYLYH<HDUVRU0RUH High Grade Astrocytoma Glioblastoma Multiforme Glioblastomas Grade IV Ŷ )DLUO\FRQVWDQWRFFXUDQFHZRUOGZLGH Ŷ /LWWOHFKDQJHLQPRUELGLW\LQSDVWWZRGHFDGHV Ŷ $JH:!%0!: *%0RI$OO3ULPDU\7XPRUV Ŷ (WLRORJ\LVXQNQRZQKRZHYHU GXOWOHVLRQVDSSHDUWRKDYHGHIHFWRQ$ی DQ'RXEOHLQ6L]H(YHU\'D\V& FKURPRVRPHWHQ KLOGUHQKDYHDWUDQVIRUPDWLRQRIDORZHU&ی 6HL]XUHV2FFXULQRI&DVHV 6\PSWRPV+HDGDFKH3HUVRQDOLW\&KDQJHV JUDGHWXPRU 3DSLOODHGHPD9RPLWLQJ Ŷ 3(7VFDQ 3RVLWURQ(PLVVLRQ7RPRJUDSK\ Ŷ $YHUDJHVXUYLYDORYHUDJHLVPRQWKV )HZHU7KDQ6XUYLYH0RQWKV XQGHULVPRQWKV Glioblastomas Glioblastomas Disseminating Glioblastoma Crossing the Corpus Callosum Glioblastoma &KHPRWKHUDS\)RU *OLDGHO:DIHUFRQW *OLREODVWRPDV .LOOV7XPRU&HOOV,PPHGLDWHO\ Ŷ *OLDGHO:DIHU .LOOV7XPRU&HOOVRQ5HSOLFDWLRQ QLWURVRXUHD &\WRWR[LF 8VHGWRGHOLYHUFDUPXVWLQHی RQFRO\WLFDJHQW 1LWURVRXUHDV %&18&&18 ON\ODWLRQRI'1$DQG51$ 0RVW)UHTXHQW$ی ;8VHGLQWUHDWPHQWRI*OLREODVWRPD 1R+DLU/RVV&7ی 0XOWLIRUPH *,0XFRVDO7LVVXH,UULWDWLRQ New t/x For Glioblastoma Multiforme Ŷ */,$'(/:$)(5 *OLDGHO:DIHU &DUPXVWLQH W[ DYHUDJHLVPRQWKVVXUYLYDO Ŷ &OHYHODQG&OLQLFXWLOL]HV05,JXLGHGODVHU Ŷ 7KLQSUREHLQVHUWHGWKURXJKVPDOOKROHLQVNXOO YVSODFHERDWPRQWKV ZKLFKGHOLYHUVKHDWWRWXPRUVZLWKRXWKDUPLQJ KHDOWK\WLVVXH NEW TREATMENT PVS-RIPO a genetically engineered Poliovirus PVS-RIPO Ŷ 3UHVWRQ5REHUW7LVFK%UDLQ7XPRU Ŷ $UHFRPELQDQWOLYHDWWHQXDWHG Ŷ 1DWXUDOO\LQIHFWVDOPRVWDOOFDQFHU &HQWHU QRQSDWKRJHQLFRQFRO\WLFYLUXV7KH FHOOVEHFDXVHWKHUHFHSWRUIRUWKH LQWHUQDO5LERVRPDOHQWU\VLWH ,5(6 LV 3ROLRYLUXVLVDEQRUPDOO\SUHVHQWLQ Ŷ &OLQLFDOWULDOVIRUUHFXUUHQW UHSODFHGZLWK ,5(6 IURP+XPDQ PRVWWXPRUFHOOV *OLREODVWRPD 5KLQRYLUXVW\SHZLWKSRWHQWLDO Ŷ 'XHWR+HWHURORJRXV+59RQO\ DQWLQHRSODVWLFDFWLYLW\ SURSDJDWHVLQVXVFHSWLEOHQRQ QHXURQDOFHOOV DVWURF\WHFHOOV *%0 Oligodendrocyte Continued: Ŷ 0DLQIXQFWLRQLQVXODWLRQRID[RQV WKHORQJSURMHFWLRQ RIQHUYHFHOOV LQWKHFHQWUDOQHUYRXVV\VWHPRIKLJKHU Ŷ 7KH\DUHLQIXVHGGLUHFWO\LQWRWKH YHUWHEUDWHV WXPRUNLOOLQJFHOOVDQGFDXVLQJ Ŷ 3DWKRORJ\ LPPXQHV\VWHPWRDWWUDFWWXPRU 7XPRUV ی FHOOV LVHDVHVWKDWUHVXOWLQLQMXU\WRWKHROLJRGHQGURJOLDO' ی Ŷ )XWXUHWULDOVLQRWKHUFDQFHUVVXFK FHOOVLQFOXGH DVSDQFUHDWLFSURVWDWHOXQJDQG HP\HOLQDWLQJGLVHDVHVVXFKDVPXOWLSOHVFOHURVLV' ۻ FRORQ GDPDJHWRGHYHORSLQJ HUHEUDO3DOV\& ۻ ROLJRGHQGURF\WHVLQWKHEUDLQDUHDVDURXQGWKHFHUHEUDO YHQWULFOHV Oligodendroglioma RI*OLRPDV \UVRUDERYH 0DOHV!)HPDOHV /RFDWLRQ)URQWDO/REH +LVWRU\RI&KURQLF6HL]XUH'LVRUGHU 8VXDOO\PL[HGZLWKPDOLJQDQWDVWURF\WHV 0HDQVXUYLYDOUDWHLV\HDUV Oligodendroglioma Oligodendroglioma Mixed Glioma Cerebellar Tumors Ɣ 0RUHIUHTXHQWLQFKLOGUHQ JOLRPDV Ɣ 'LVWXUEDQFHV 5HVXOWLQGHILFLWV Ɣ 3RVWXUH &RQWDLQERWKDVWURF\WHVDQGROLJRGHQGURF\WHV Ɣ 0XVFOH7RQH Ɣ &RRUGLQDWLRQ Ɣ 3DSLOODHGHPD $OPRVWFRQVWDQWVLJQ Ɣ /HVLRQVLQYHUPLV %HKDYLRULVVLPLODUWRWXPRUVFRPSRVHGRI Ɣ $IIHFWVODUJHPRYHPHQWVRIHQWLUHERG\ KLJKHVWJUDGHFHOOIRXQGLQWXPRU SRVWXUH Ɣ /HVLRQVLQKHPLVSKHUHV

View Full Text

Details

  • File Type
    pdf
  • Upload Time
    -
  • Content Languages
    English
  • Upload User
    Anonymous/Not logged-in
  • File Pages
    26 Page
  • File Size
    -

Download

Channel Download Status
Express Download Enable

Copyright

We respect the copyrights and intellectual property rights of all users. All uploaded documents are either original works of the uploader or authorized works of the rightful owners.

  • Not to be reproduced or distributed without explicit permission.
  • Not used for commercial purposes outside of approved use cases.
  • Not used to infringe on the rights of the original creators.
  • If you believe any content infringes your copyright, please contact us immediately.

Support

For help with questions, suggestions, or problems, please contact us