CHU CHEN, MS, PhD, NRCC, DABCC PERSONAL DATA Address: Chu Chen, MS, PhD, NRCC, DABCC Full Member Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, Mail Stop M5-C800 P.O. Box 19024 Seattle, Washington 98109-1024 Tel: (206) 667–6644 Fax: (206) 667–2537 E–mail: [email protected] Citizenship: USA Gender: Female EDUCATION 2003 Fifth Annual Seattle Epidemiology & Biostatistics Summer Section at University of Washington, sponsored by Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs, and Department of Epidemiology and Department of Biostatistics, University of Washington. 2000 New England Epidemiology Institute Summer Course, Tufts University. 1990-1992 Senior Fellow, Division of Clinical Chemistry, Department of Laboratory Medicine, University of Washington, Seattle, Washington. Second Year Specialty Training: Clinical Toxicology. 1987-1990 Postdoctoral Research Associate, Laboratory of Maxine Linial, Ph.D., Member, Program in Molecular Virology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1983-1986 Individual National Research Service Award Postdoctoral Fellow, Laboratory of Sen–itiroh Hakomori, M.D., Ph.D., Member, Program in Biochemical Oncology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington and Professor, Department of Pathobiology, University of Washington. 1982 Ph.D. in Biochemistry, University of Washington, Seattle, Washington. Dissertation: "Structure and Reactivity of the Small Spherical High Density Lipoproteins in Familial Lecithin: Cholesterol Acyltransferase Deficiency as Compared with the Structure and Reactivity of Artificially Formed Lipoproteins." Dissertation Advisor: John A. Glomset, M.D., PhD., Professor, Department of Biochemistry and Investigator, Howard Hughes Medical Institute, University of Washington. 1971 M.S. in Botany, Specialization: Medical Mycology, Ohio State University, Columbus, Ohio. Thesis: "The Effect of Chlorination on the Survival of Candida albicans (strains #8314, 8329, 8335, 8282)." Thesis Advisor: John A. Schmidt, Ph.D. 1968 B.S. in Botany, National Taiwan University, Taipei, Taiwan, Republic of China. PROFESSIONAL POSITIONS Chu Chen Page 1 of 56 2006-present Affiliate Professor, Department of Epidemiology, School of Public Health and Community Medicine and Department of Otolaryngology/Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington. 2005–present Full Member, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 2002–present Member, Fred Hutchinson Cancer Research Center/ University of Washington Cancer Consortium, Seattle, Washington 2001-2006 Affiliate Associate Professor, Department of Otolaryngology/Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington. 2000-2006 Affiliate Associate Professor, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington. 1999-2005 Associate Member, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1999 Assistant Member, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1997-present Graduate School Faculty, Department of Epidemiology, University of Washington, Seattle, Washington. 1995-1999 Assistant Member, Program in Cancer Biology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1992-1997 Founder and Director of Public Health Sciences Core Laboratory, Program in Cancer Biology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 1992, 1996 Clinical Laboratory Inspector, College of American Pathologists. 1992-1993 Clinical Chemist, Providence Hospital, Everett, Washington. 1974-1976 Research Technician II, Division of Ophthalmology, Department of Surgery, Case Western Reserve University, Cleveland, Ohio. Project: Chemistry of Rhodopsin. 1972-1974 Senior Research Technician, Michigan State University/Atomic Energy Commission Plant Research Laboratory, East Lansing, Michigan. Project: Physiology of Abscisic Acid and Xanthoxin. 1972 Medical Mycologist/Microbiologist, Clinical Laboratory, W.A. Foote Memorial Hospital, Jackson, Michigan. CURRENT GRANT SUPPORT 1. FFPE Validation of a Survival Gene Signature in HPV-Negative Oral Cavity Cancer NIH/NCI RO1 CA177736-01A 1/1/2015-12/31/2017 Award: $723,600 (Y1) Role on Project: Principal Investigator The goal of this study is to conduct a multicenter study to transport the testing of a prognostic gene expression signature from using fresh frozen tumors to hospital paraffin-embedded tumor blocks and from using Affymetrix gene expression arrays to the NanoString platform. Chu Chen Page 2 of 56 2. Salivary Metabolite Biomarkers for Diagnosing Nodal Metastasis in Oral Cancer NIH/NCI R21 CA187151 7/01/2015-6/30/2017 Award: $248,717 Role on Project: Principal Investigator Using advanced metabolomics profiling methods and a well-characterized biorepository, this project will test the hypothesis that a saliva-based metabolite profile can distinguish patients with squamous cell oral cavity cancer who do and do not have lymph node metastases. 3. Integration of a prognostic gene signature and UW OncoPlex test to define the mutational landscape of head and neck cancer (HNC) with poor survival Oncoscape Specimen Utilization Grant, Solid Tumor Translational Research Program, Fred Hutchinson Cancer Research Center 7/01/2015-6/30/2017 (NCE), Principal Investigator: Eduardo Mendez Award: $100,000 Role on Project: Co-Principal Investigator This project will test 100 samples in our HNC biorepository for our poor prognosis 131 gene signature test and determine the mutational landscape in genes included in the Oncoplex platform of OSCCs with high risk score for the 131 gene signature profile; and validate gene signature-associated mutational profile in a panel of 303 tumors from TCGA. 4. Clinical Coordinating Center for the Clinical Trial and Observation of the Women’s Health Initiative NIH/NHLBI N01-WH-11-11, Principal Investigator: Garnet Anderson 9/1/2011-3/31/2016 Award: $6,435,608 Role on Project: Co-Investigator The major goal of this project is to establish and operate a Clinical Coordinating Center to support the Women’s Health Initiative Clinical Trial and Observational Study. 5. Integrative Genomics Approach Therapeutic Target Selection in Oral Cancer Metastasis. American Cancer Society FDN RSG 13 0661 01 TBG, Principal Investigator: Eduardo Mendez 1/1/2013-12/31/2016 Award: $150,000 Role on Project: Co-Investigator The purpose of this grant is to identify genes whose expression is associated with abnormal copy number which are unique to metastatic oral squamous cell carcinoma (OSCC). In addition, this study will determine which of these candidate genes have the highest association with OSCC survival and which have the highest effect on cell survival and tumor biology in in vitro models of OSCC metastasis. 6. Post GWA Studies in Testicular Germ Cell Tumors NIH/NCI R01 CA164947, Principal Investigator: Kate Nathanson 9/1/2012-8/31/2016 Award: $80,120 Role on Project: Co-Investigator The results of this project will provide new information on the contribution of risk alleles to the etiology of TGCT. Knowledge gained also will serve to heighten our understanding of the underlying biology of TGCT and its related conditions. We expect that ultimately this information may provide for novel advances in determining risk assessment for this early onset cancer. PREVIOUS GRANT SUPPORT 1. GM3 Sialytransferase and Cell Transformation. Individual National Research Service Award, F32 CA07491 11/03/1983-11/02/1986 Chu Chen Page 3 of 56 Award: $59,736 Role on Project: Principal Investigator 2. Glutathione S–Transferase and Anogenital Cancers. NIH R01 ES06728, 5/1/1994-11/30/1997 Award: $725,988 Role on Project: Principal Investigator 3. Effects of Soy and Wheat Bran Feeding on Serum and Urinary Steroid Hormone Levels in Premenopausal Women: A Pilot Project. Parent Project: Seattle Breast Cancer Research Program, Principal Investigator: David Thomas NIH/NCI R21 CA66186 1/1/1996-12/31/1996 Award: $15,000 Role on Project: Principal Investigator 4. Estrogen Receptor Polymorphisms and Breast Cancer in Young Women: A Pilot Project Parent Project: Seattle Breast Cancer Research Program, Principal Investigator: David Thomas. NIH/NCI R21 CA66186 1/1/1998-12/31/1998 Award: $15,415 Role on Project: Principal Investigator 5. Prostate Cancer in Chinese Men Laboratory component of a case–control study conducted by Dr. Ann Hsing of the Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute. NCI Contract 263–MQ–822580 2/1/1999–8/31/1999 Award: $80,080 Role on Project: Principal Investigator 6. Phytoestrogens, Organochlorines, and Fibroid Risk NIH/NIEHS 5 R01 ES08305, Principal Investigator: Stephen Schwartz 9/1/1996-8/31/2001 Award: $665,420 Role on Project: Co–Investigator 7. Diet, Cell Proliferation, and Breast Cancer in Shanghai NIH/NCI R01 CA75332, Principal Investigator: David Thomas 7/1/1997-6/30/2002 Award: $363,782 Role on Project: Co–Investigator 8. Oral Cancer: DNA Polymorphisms in Carcinogen Metabolism NIH R01 DE 12609, Principal Investigator: Stephen Schwartz 9/1/1998-6/30/2002 Award: $1,058,643 Role on Project: Co–Investigator
Details
-
File Typepdf
-
Upload Time-
-
Content LanguagesEnglish
-
Upload UserAnonymous/Not logged-in
-
File Pages56 Page
-
File Size-