Appendix Procedure for Determining Whether an Article Contained Renal Information • Assessments were made using the full-text of each article. • An article contained renal information if any content area described in Part A was the main purpose / focus / patient population of the article. • If the only mention of a content area in Part A was in the patient exclusion criteria then the article did not contain renal information. • Content areas described in Part B by themselves were NOT considered to be renal information unless they were the main focus / purpose / patient population of the article and a content term from Part A was also mentioned. Part A Content Areas 1. Kidney Failure: a) Acute renal Acute kidney failure End-stage renal failure Acute kidney injury disease (ESRD) Acute renal injury End-stage renal Acute kidney insufficiency failure Acute renal insufficiency End-stage kidney Acute tubular necrosis failure Acute on chronic renal failure Nephrotoxicity Prerenal azotemia Renal toxicity Prerenal disease Renal failure b) Acute or chronic Artificial kidney Uremia/ Uremic dialysis Continuous renal replacement therapy Dialy* (dialysis, dialysate, dialyser, dialyzer, dialysis adequacy, dialysis solutions) Extracorporeal dialysis Hemodialysis (any type – conventional hemodialysis, nocturnal hemodialysis, daily hemodialysis, frequent hemodialysis, quotidian dialysis, venovenous hemodialysis, also spelled haemo-) Hemodiafiltration Hemofiltration Home dialysis Peritoneal dialysis (any type – continuous ambulatory peritoneal dialysis, automated peritoneal dialysis i.e. cycler, cycling, tidal peritoneal dialysis) Peritoneal equilibration test Renal dialysis Slow continuous ultrafiltration c) Kidney Allograft (must be kidney) (i.e. kidney allograft, renal transplant allograft). recipients, Donor or donation (must be kidney) (i.e. cadaveric kidney kidney donor, deceased kidney donor, donor transplantation nephrectomy, extended criteria donor, expanded criteria donor, kidney donor, living kidney donor, live kidney donor, living kidney donation, non-heart beating donor, renal donor) Graft or grafting (must be kidney graft) (i.e. delayed graft function, graft failure, kidney graft, renal graft etc.) Kidney rejection Recipient (must be kidney) (i.e. renal recipient, kidney recipient) Solid organ transplantation (must include kidney transplant patients, most solid organ transplants are kidneys, although they can be heart, liver, lung etc.) Transplant or transplantation (must be kidney) (i.e. kidney transplant, kidney transplantation, renal transplant, renal transplantation) Xenotransplantation (must be kidney, not another organ) d) Metabolic, The study must describe these conditions in the context of inflammatory renal patients having/ developing them. For example: conditions Acidosis which are Anemia associated with Calciphylaxis renal disease Hyperparathyroidism Osteodystrophy 2. Chronic Kidney a) Reduced kidney [Kidney function is a common test performed in many Disease: function types of studies. Measuring kidney function by itself . does not make a study eligible unless some of the patients assessed have reduced kidney function or kidney function was a main study outcome] Chronic kidney disease Chronic renal failure Chronic renal insufficiency Elevated creatinine (> 135 umol/L [1.5 mg/dL] in men, > 105 umol/L [1.2 mg/dL] in women) Glomerular filtration rate < 60 mL/min per 1.73 m2, Pre-dialysis Reduced (kidney or renal) creatinine clearance Reduced glomerular filtration rate Reduced kidney function b) Proteinuria [Microalbuminuria by itself is not eligible] Overt proteinuria Random urine albumin to creatinine ratio > 33 mg/mmol 24 hour urine protein > 300 mg / day 24 hour urine albumin > 300 mg/day c) For outcome May be monitoring changes in kidney function / studies proteinuria, or development of new onset reduced kidney function or proteinuria 4) Glomerular Diseases: a) Nephrotic/Nephritic Glomerulo- syndrome nephropathy Glomerulopathy Glomerulonephriti s Glomerulosclerosis Glomerular diseases Glomerulo- nephritides Nephropathy b) Biopsy Anti-GBM antibody disease classification Balkan nephropathy of glomerulo- Bright’s disease nephritis Benign familial hematuria Collapsing glomerulosclerosis Focal (segmental) glomerulosclerosis Glomerular hematuria Hereditary nephritis IgA Nephropathy (aka Berger’s disease) Membranoproliferative glomerulonephritis Membranous nephropathy Mesangiocapillary glomerulonephritis Minimal change disease Post-infectious glomerulonephritis Post-streptococcal glomerulonephritis Rapidly progressive glomerulonephritis Thin basement membrane disease 5) Other Renal Diabetic nephropathy Pathology Diabetic glomerulosclerosis / nephrosclerosis Diabetic glomerulopathy Kimmelstiel-Wilson disease / syndrome / nephropathy Nodular/ Intercapillary glomerulosclerosis Cystinosis Nephrosclerosis - Hypertensive /vascular nephrosclerosis - Kidney / renal nephrosclerosis / arteriosclerosis Hemolytic uremic syndrome Interstitial nephritis Lupus nephritis Lupus / lupoid nephritis / glomerulonephritis Lupus nephropathy Medullary cystic kidney disease Myeloma kidney / cast nephropathy Obstructive uropathy / obstructive nephropathy Polycystic kidney disease Renal agenesis Renal atheroemboli Renal papillary necrosis Renal tubulointerstitial disease Renal tubular acidosis Renovascular / renal hypertension Renal artery disease Renal artery stenosis Scleroderma renal crisis Thrombotic thrombocytopenia purpura 6) Vesicoureteral reflux and reflux nephropathy (VUR) 7) Metabolic acid/base, Diabetes insipidius (nephrogenic, NOT central only) water disturbance Renal tubular acidosis Metabolic acidosis Metabolic alkalosis 8) Procedures/ care for a) Personnel Nephrology kidney patients Nephrologists other than dialysis: Renal care b) Procedure related to dialysis or Hemodialysis catheter insertion (NOT kidney biopsy catheters used for reasons other then dialysis). Hemodialysis vascular access Hemodiaylsis fistula Hemodialysis (access) graft • Part B Content Areas Systemic illness or genetic conditions which are Alport’s Syndrome almost always associated with renal disease: Anti-GBM antibody disease Goodpasture’s Syndrome Systemic illness or agents which have Amyloidosis historically been associated with renal diseases Anti-neutrophil cytoplasmic antibody / ANCA (Note: this list is not exhaustive): Churg Strauss Syndrome Cryoglobulinemia Cystinosis Endocarditis Fabry’s disease Henoch-Schönlein purpura Hyperoxaluria HIV Lithium Microscopic polyangitis Multiple myeloma Non-steroidal anti-inflammatories Paraproteinemia Polyarteritis nodosa Rheumatoid arthritis Sepsis Sickle cell disease Systemic lupus erythematosus Vasculitis von Hippel-Lindau disease Plasma exchange / plasmapheresis / Apheresis (relevant if used to treat renal conditions) Blood electrolyte disturbances Hyper/Hypocalcemia Hyper/Hypokalemia Hyper/Hypomagnesiumemia Hyper/Hyponatremia Hyper/Hypophosphatemia Hyperuricemia Hyperhomocysteinemia Metabolic acidosis Metabolic alkalosis Respiratory acidosis Respiratory alkalosis Hematuria (by itself without any other relevant renal terms) Polyuria (by itself without any other relevant renal terms) Kidney neoplasms / cancers / tumors / Renal cell carcinoma / adenocarcinoma carcinoma Nephroid carcinoma Wilms tumor Mesoblastic nephroma Kidney stones Calcium stones Procedure related to renal stone treatment Calculi (renal) Cystine stones Kidney calculi / calculus Medullary sponge kidney Nephrolithiasis Lithotripsy (NOT gall stones) Phosphate calculi Renal calculi Staghorn calculi Struvite stones Uric acid stones Ureter or prostate disease Urinary tract infection or pyelonephritis Pregnancy Eclampsia Preeclampsia .