Marijuana (THC) 11-nor-Δ9-THC-9 COOH 4 MTD: Methadone is a synthetic analgesic drug originally used for the Oral Fluid Drug Test treatment of narcotic addiction. In addition to use as a narcotic agonist, methadone is being used more frequently as a pain management agent. The Marijuana (THC) Δ9-THC 50 Package Insert psychological effects induced by using methadone are analgesia, sedation, and respiratory depression. Based on the saliva/plasma ratio calculated over Package insert for testing of the following drugs: > 0.02 % Alcohol (ALC) Alcohol salivary pH ranges of 6.4-7.6 for therapeutic or recreational doses of Amphetamine,Cocaine,Marijuana,Methamphetamine,Opiate,Methadone, B.A.C methadone, a cut-off <50 ng/mL is suggested. Due to this recommendation, Phencyclidine,Oxycodone,Benzodiazepine,Buprenorphine,Barbiturates, the cut-off level of the methadone test was calibrated to 30 ng/mL. Cotinine,EDDP,MDMA,6-MAM,Propoxyphene ,Fentanyl,ETG and Alcohol Tramadol(TRA) 50 Tramadol PCP: Phencyclidine is a hallucinogen and, can be detected in oral fluid as a INTENDED USE & SUMMARY result of the exchange of the drug between the circulatory system and the oral cavity.5 Fentanyl(FEN) 10 The Oral Fluid Drug And Alcohol Test is intended for screening for the Norfentanyl presence of drugs and alcohol and their metabolites in oral fluid. For professional in vitro diagnostic use only. OXY: Oxycodone is a semi-synthetic opioid with a structural similarity to Ethyl codeine. The drug is manufactured by modifying thebaine, an alkaloid found in 150 The Oral Fluid Pipette Test is a lateral flow chromatographic immunoassay for Glucuronide(ETG) the opium poppy. Oxycodone, like all opiate agonists, provides pain relief by the qualitative detection of drugs and drug metabolites in oral fluid at the Ethyl-β-D-glucuronide acting on opioid receptors in the spinal cord, brain, and possibly directly in the following cut-off concentrations: affected tissues. Oxycodone is prescribed for the relief of moderate to high pain. The approximate half- life in serum is averaged about 14 hours. Test Calibrator Cut-off This test will detect other related compounds, please refer to the Analytical (ng/mL) Specificity table in this package insert. BZO: Benzodiazepines are central nervous system (CNS) depressants commonly prescribed for the short-term treatment of anxiety and insomnia. In general, Amphetamine (AMP) D-Amphetamine 50 benzodiazepines act as hypnotics in high doses, as anxiolytics in moderate doses and as sedatives in low doses. The use of benzodiazepines can result in Barbiturate(BAR) Barbiturate 50/300 AMP: Amphetamine is a sympathomimetic amine with therapeutic drowsiness and confusion. Psychological and physical dependence on indications. The drug is often self-administered by nasal inhalation or oral Benzodiazepine benzodiazepines can develop if high doses of the drug are given over a prolonged Oxazepam 10/50 (BZO) ingestion.1 period. Benzodiazepines are taken orally or by intramuscular or intravenous injection, and are extensively oxidized in the liver to metabolites. Benzodiazepines Buprenorphine(BUP) Buprenorphine 5/10 can be detected in oral fluid after use. Cocaine (COC) Cocaine 20 COC: Cocaine is a potent central nervous system (CNS) stimulant and a local anesthetic derived from the coca plant (erythroxylum coca).1 Cotinine(COT) Cotinine 30/50 BUP: Buprenorphine is a semisynthetic opioid analgesic derived from thebain, a component of opium. It has a longer duration of action than morphine when Ketamine(KET) Ketamine 50 indicated for the treatment of moderate to severe pain, peri-operative THC: Tetrahydrocannabinol, the active ingredient in the marijuana plant analgesia, and opioid dependence.Low doses buprenorphine produces 2-Ethyliden-1,5-Dimethyl-3,3- (cannabis sativa), is detectable in oral fluid shortly after use. The detection of sufficient agonist effect to enable opioid-addicted individuals to discontinue EDDP(EDDP) 20 Diphenylpyrrolidine the drug is thought to be primarily due to the direct exposure of the drug to the misuse of opioids without experiencing withdrawal symptoms. the mouth (oral and smoking administrations) and the subsequent Buprenorphine carries a lower risk of abuse, addiction,and side effects Methadone (MTD) Methadone 30/75 sequestering of the drug in the buccal cavity.2 compared to full opioid agonists because of the “ceiling effect”, which means no longer continue to increase with further increases in dose when reaching a Methamphetamine D-Methamphetamine 50 plateau at moderate doses.However, it has also been shown that (MET) Buprenorphine has abuse potential and may itself cause dependency. MET: Methamphetamine is a potent stimulant chemically related to Buprenorphine was rescheduled from Schedule V to Schedule III drug Ecstasy（MDMA） 3,4-Methylenedioxymethamphetamine 50 amphetamine but with greater CNS stimulation properties. The drug is often justbefore FDA approval of Suboxone and Subutex. self-administered by nasal inhalation, smoking or oral ingestion.1 Heroin Test (6-MAM) 6-Monoacetylmorphine 10 BAR: Barbiturates are central nervous system depressants. They are used OPI(MOP): The drug class opiates refers to any drug that is derived from the therapeutically as sedatives, hypnotics, and anticonvulsants. Barbiturates are No cross with opium poppy, including naturally occurring compounds such as morphine and Morphine! almost always taken orally as capsules or tablets. The effects resemble those codeine and semi-synthetic drugs such as heroin. Opiates control pain by of intoxication with alcohol. Chronic use of barbiturates leads to tolerance and Opiates (OPI) Morphine 40 depressing the CNS, and demonstrate addictive properties when used for physical dependence. Short acting Barbiturates taken at 400 mg/day for 2-3 sustained periods of time. Opiates can be taken orally or by injection routes months can produce a clinically significant degree of physical dependence. Oxycodone(OXY) Oxycodone 50/20 including intravenous, intramuscular and subcutaneous; illegal users may Withdrawal symptoms experienced during periods of drug abstinence can be also take the intravenously or by nasal inhalation.3 severe enough to cause death. Only a small amount (less than 5%) of most Morphine (MOP) Morphine 15 Barbiturates are excreted unaltered in the urine. *The window of detection varies for different opiates. Codeine can be 50 detected within one hour and up to 7-21 hours after a single oral dose. The approximate detection time limits for Barbiturates are: Propoxyphene(PPX) Propoxyphene Morphine is detectable for several days after a dose. Short acting (e.g. Secobarbital) 100 mg PO (oral) 4.5 days Long acting (e.g. Phenobarbital) 400 mg PO (oral) 7 days. pain. It is a synthetic analog of codeine, but has a low binding affinity to the strip by capillary action. A drug, if present in the oral fluid specimen below its cut-off concentration, will not saturate the binding sites of its specific antibody. The COT: Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that mu-opioid receptors. It has been prescribed off-label for the treatment of antibody will then react with the drug-protein conjugate and a visible coloured line produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a diabetic neuropathy and restless leg syndrome.2 Large doses of Tramadol will show up in the test line region of the specific drug strip. The presence of drug tobacco-smoking society is exposed whether through direct contact or could developtolerances and physiological dependency and lead to its abuse. above the cut-off concentration in the oral fluid specimen will saturate all the second-hand inhalation. In addition to tobacco, nicotine is also commercially Both Δ (d) and L forms of the isomers are controlled substances. The major binding sites of the antibody. Therefore, the coloured line will not form in the test available as the active ingredient in smoking replacement therapies such as pathways appear to be N- and O- demethylation, glucoronidation or line region.A drug-positive oral fluid specimen will not generate a coloured line in nicotine gum, transdermal patches and nasal sprays. the specific test line region of the strip because of drug competition, while a EDDP: Methadone (MTD) is a synthetic analgesic drug that is originally used sulfation in the liver. drug-negative oral fluid specimen will generate a line in the test line region in the treatment of narcotic addicts. Among the psychological effects induced because of the absence of drug competition. To serve as a procedural by using methadone are analgesia, sedation and respiratory depression. The One Step Tramadol (TRA) Test Dipcard yields a positive result when the control, a coloured line will always appear at the control line region, indicating Overdose of methadone may cause coma or even death. It is administered Tramadol in saliva exceeds 50 ng/ml that proper volume of specimen has been added and membrane wicking has orally or intravenously and is metabolized in the liver. The kidneys are a major route of methadone excretion. Methadone has a biological half-life of 16-50 occurred. hours. EDDP (2-Ethyliden-1,5-Dimethyl-3,3-Diphenylpyrrolidine) is the most important metabolite of methadone. It is excreted into the bile and urine (2) Alcohol Test: A pad coated with enzymes, turns to color shades of green together with the other metabolite EMDP (2-Ethyl-5-Methyl-3,3- ALCOHOL(ACL) and blue on contact with alcohol in the oral fluids. The alcohol pad employs a Diphenylpyrrolidine). EDDP is formed by N-demethylation and cyclization of methadone in the liver. The part of the unchanged excreted methadone is solid phase chemistry which uses the following highly specific enzymatic variable and depends on the urine’s pH value, dose and the patient’s Alcohol intoxication can lead to loss of alertness, coma, death and as well as birth reaction: metabolism. Therefore, the detection of the metabolite EDDP instead of defects.