<Curriculum Vitae - 2011 Japan Prize Laureate> Dr. Tadamitsu Kishimoto Professor Emeritus, Osaka University Nationality: Japan Date of Birth: May 7, 1939 (71 years old) Academic Degrees: 1964 Bachelor of Medicine, Osaka University 1969 Ph.D. in Medicine, Osaka University Professional Career: 1969 Assistant researcher of Biochemistry in Faculty of Dental Science, Kyushu University 1970 Research fellow and Visiting Assistant Professor, Johns Hopkins University, U.S.A 1974 Assistant Professor of Medicine, Osaka University 1979 Professor of Medicine, Osaka University 1983 Professor at Institute for Molecular and Cellular Biology, Osaka University 1991 Professor of Medicine, Osaka University 1995 Dean of Faculty of Medicine, Osaka University 1997 President of Osaka University 2004 Member of Council for Science and Technology Policy 2006 Endowed Chair Professor at School of Frontier Biosciences, Osaka University 2007 President, Senri Life Science Foundation Affiliation: Graduate School of Frontier Bioscience, Osaka University 1-3, Yamada-oka, Suita, Osaka 565-0871 Tel: 06-6879-4431 Fax: 06-6879-4437 Major Publications: 1. Hirano T, Yasukawa K, Harada T, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324: 73-76. 2. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988; 332:83-85. 3. Yamasaki K, Taga T, Hirano Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T. Cloning and expression of human interleukin 6 (BSF-2/IFNb2) receptor. Science 1988; 241: 825-828. 4. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M, Kishimoto T. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol. 1988; 18: 1797-1801. 5. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989; 58: 573-581. 6. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149-1157. 7. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992; 258: 593-597. 8. Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 antibody: a multicenter double-blind, placebo-controlled trial. Arthritis Rheum 2004; 50: 1761-1769. 9. Nishimoto N, Kishimoto T. Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol. 2006; 2: 619-626. 10. Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, Tomiita M, Nishimoto N, Kishimoto T. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 2008; 371: 998-1006. Major Honors: 1982 Behring-Kitasato Prize 1983 Osaka Science Prize 1986 Erwin von Bälz Prize 1988 Takeda Prize, Asahi Prize 1990 Prize of the Japanese Medical Association, Person of Cultural Merits JAPAN 1991 Scientific Achievement Award from the International Association of Allergology and Clinical Immunology 1992 Imperial Prize from the Japan Academy Sandoz Prize for Immunology from the International Union of Immunological Society (along with Dr. Toshio Hirano) 1995 Member, the Japan Academy 1996 The Avery-Landsteiner Prize from the German Immunology Society 1998 The Order of Culture from Emperor 1999 The Donald Seldin Award from the International Society of Nephrology 2000 ISI Citation Laureate Award, 1981-1988 2003 Robert Koch Gold Medal from the Koch Foundation of Germany 2006 Honorary Life Time Achievement Awards (International Cytokine Society) 2009 The Crafoord Prize from the Royal Swedish Academy of Sciences (along with Dr. Toshio Hirano) 2010 President’s Award from the Clinical immunology society of United States Membership: 1991 Foreign Associate of the US National Academy of Sciences 1991 President of the Japanese Society for Immunology 1991 President of the International Congress of Immunopharmacology 1992 Honorary member of The American Association of Immunologists 1994 President of the International Society for Interferon and Cytokine Research 1995 Member of the Japan Academy 1997 President of the Japanese Society for Immunology 1997 President of the Japanese Society of Allergology 1997 President of the Japan Society for Clinical Immunology 1997 Honorary member of the American Society of Hematology 1997 Foreign member of the Institute of Medicine of the US National Academy of Sciences 2002 Vice President of the Japanese Medical Association 2005 Member, Deutsche Akademie der Naturforscher Leopoldina 2007 President of the 27th General Assembly of the Japanese Medical Association 2010 President of the 14th International Congress of Immunology (January 2011) 2 .